Article
Multidisciplinary Sciences
Yuki Onozato, Takahiro Nakajima, Hajime Yokota, Jyunichi Morimoto, Akira Nishiyama, Takahide Toyoda, Terunaga Inage, Kazuhisa Tanaka, Yuichi Sakairi, Hidemi Suzuki, Takashi Uno, Ichiro Yoshino
Summary: This study utilized radiomic features and machine learning to establish a predictive model for STAS, which might be helpful in selecting appropriate NSCLC patients for sublobar resection.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Yeon Bi Han, Hyojin Kim, Mari Mino-Kenudson, Sukki Cho, Hyun Jung Kwon, Ki Rim Lee, Soohyeon Kwon, Jeonghyo Lee, Kwhanmien Kim, Sanghoon Jheon, Choon-Taek Lee, Jong-Seok Lee, Woong Kook, Jin-Haeng Chung
Summary: The study investigated the association between the extent of tumor spread through air spaces (STAS) and patient outcomes in resected non-small cell lung cancers (NSCLCs). It was found that in adenocarcinoma (ADC) patients, STAS II significantly affected recurrence free survival (RFS) and lung cancer specific survival (LCSS). Moreover, STAS II was identified as an independent poor prognostic factor in both limited and radical resection groups.
Article
Oncology
Sami Dagher, Abdulrazzaq Sulaiman, Sophie Bayle-Bleuez, Claire Tissot, Valerie Grangeon-Vincent, David Laville, Pierre Fournel, Olivier Tiffet, Fabien Forest
Summary: This study identified extensive Spread Through Air Spaces (STAS) as an independent prognostic factor for poor outcomes in lung squamous cell carcinoma (LUSC), which is correlated with other poor prognostic factors such as emboli and pleural invasion, indicating greater tumor aggressiveness.
Article
Oncology
Lu Han, Zhida Huang, Jing Zhang, Yan Chen, Jue Wang, Yicheng Xiong, Wangchao Yao, Likun Hou, Liping Zhang, Huansha Yu, Nan Song, Zhonghong Zhang, Yuming Zhu
Summary: This study found that small cell lung cancer (SCLC) patients with spread through air space (STAS) have worse disease-free survival (DFS) compared to those without STAS. STAS is an independent prognostic factor in SCLC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Li-Wei Chen, Mong-Wei Lin, Min-Shu Hsieh, Shun-Mao Yang, Hao-Jen Wang, Yi-Chang Chen, Hsin-Yi Chen, Yu-Hsuan Hu, Chi-En Lee, Jin-Shing Chen, Yeun-Chung Chang, Chung-Ming Chen
Summary: The study aimed to establish a radiomic prediction model for tumor spread through air spaces (STAS) in lung adenocarcinoma, which could help guide preoperative prediction of STAS in early-stage lung adenocarcinoma and relevant surgeries. The proposed model achieved good performance in both test cohorts.
ANNALS OF THORACIC SURGERY
(2022)
Article
Genetics & Heredity
Ronghao Ye, Yongfeng Yu, Ruiying Zhao, Yuchen Han, Shun Lu
Summary: The aim of this study was to investigate the integrative genomic spectra of stage I-III lung adenocarcinoma with tumor spread through air spaces (STAS). Through next-generation sequencing, significant differences in gene alterations were found between STAS-positive and STAS-negative patients, but no significant differences were observed in signaling pathways and 1-year disease-free survival.
FRONTIERS IN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Woohyun Jung, Jin-Haeng Chung, Sungwon Yum, Kwhanmien Kim, Choon Taek Lee, Sanghoon Jheon, Sukki Cho
Summary: STAS presence independently increased recurrence risk in pT1b/cNoMo adenocarcinoma patients after lobectomy, but not in pT2a patients. STAS in pT1b/cNoMo adenocarcinoma was associated with a similar recurrence risk to pT2aNoMo patients.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Pathology
Jasna Metovic, Enrico C. Falco, Elena Vissio, Federica Santoro, Luisa Delsedime, Federica Massa, Alessandra Pittaro, Simona Osella-Abate, Paola Cassoni, Marco Volante, Luisella Righi, Mauro Papotti
Summary: The study investigated the impact of gross sampling procedures on causing Spread Through Air Spaces (STAS) in lung cancer cases. The findings showed that STAS distribution was not affected by the cutting process, indicating it is not an artifact caused by pathologists during specimen handling, but a phenomenon preexisting to surgical tissue processing.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Pathology
Juan Carlos Alvarez Moreno, Abed Alhalim Aljamal, Hisham F. Bahmad, Christopher A. Febres-Aldana, Negar Rassaei, Monica Recine, Robert Poppiti
Summary: The occurrence of STAS is higher in adenocarcinoma, frequently observed in wedge resections, and significantly associated with advanced pN stage and lymphovascular invasion. Right lower lobe tumors, micropapillary adenocarcinoma, and pN2 tumor stage were identified as independent predictors for STAS.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Weiqiu Jin, Leilei Shen, Yu Tian, Hongda Zhu, Ningyuan Zou, Mengwei Zhang, Qian Chen, Changzi Dong, Qisheng Yang, Long Jiang, Jia Huang, Zheng Yuan, Xiaodan Ye, Qingquan Luo
Summary: This study developed and validated a deep-learning and radiomics model to predict spreading through air spaces (STAS) in primary lung cancer. The model showed good predictive performance in both internal and external validation cohorts, and had interpretable core feature sets and feature maps.
BIOMARKER RESEARCH
(2023)
Article
Oncology
Zixuan Chen, Xianqiao Wu, Tianzheng Fang, Zhen Ge, Jiayuan Liu, Qinglong Wu, Lin Zhou, Jianfei Shen, Chengwei Zhou
Summary: Spread through air spaces (STAS) is a pattern of invasion in non-small cell lung cancer (NSCLC) that has been recently identified and has a poor prognosis. This study aimed to assess the prognostic impact of STAS in stage IB NSCLC. The results showed that STAS was a significant prognostic factor, with STAS-positive patients having a significantly lower overall survival (OS) and recurrence-free survival (RFS) compared to STAS-negative patients. Additionally, STAS was associated with poor differentiation, adenocarcinoma, and vascular invasion.
Article
Oncology
Chihiro Yoshida, Kyuichi Kadota, Kaede Yamada, Syusuke Fujimoto, Emi Ibuki, Ryo Ishikawa, Reiji Haba, Hiroyasu Yokomise
Summary: This study investigated the influence of M2 macrophages and CD25+ TILs on STAS and postoperative recurrence in patients with stage I lung adenocarcinoma. The results showed that a higher density of CD163+ TAMs is an independent predictor of a higher STAS incidence. Furthermore, a high CD25+/high CD163+ immune cell infiltration ratio is a significant prognostic factor for stage 0-I lung adenocarcinoma.
Article
Oncology
Fabian Stoegbauer, Manuela Lautizi, Mark Kriegsmann, Hauke Winter, Thomas Muley, Katharina Kriegsmann, Moritz Jesinghaus, Jan Baumbach, Peter Schueffler, Wilko Weichert, Tim Kacprowski, Melanie Boxberg
Summary: This study aimed to determine prognostic parameters for patients with squamous cell carcinomas of the lung (SCC-L). The study found that tumor cell budding (TCB), spread through air spaces (STAS), and immune cell infiltration were significant prognostic factors. These findings provide insights for prognostic evaluation in SCC-L patients.
Review
Oncology
Toshihiro Ikeda, Kyuichi Kadota, Tetsuhiko Go, Reiji Haba, Hiroyasu Yokomise
Summary: STAS is a newly recognized pattern of invasion in lung adenocarcinoma, associated with prognosis in lung cancer. However, there are technical challenges such as distinguishing between in vivo phenomenon and artifact, assessing STAS in frozen specimens, and establishing the relationship between morphological and molecular properties of STAS.
Review
Oncology
Yun Wang, Deng Lyu, Li Fan, Shiyuan Liu
Summary: In 2015, the World Health Organization officially defined spread through air spaces (STAS) as the fourth type of lung adenocarcinoma invasion. Predicting STAS for lung cancer patients is clinically significant. CT, 18F-FDG PET/CT, radiomics, and DL have been found to be valuable in predicting STAS.
TRANSLATIONAL CANCER RESEARCH
(2023)