The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows Reduced Fear-Promoting Effects in Mice

Peripheral modulation of the endocannabinoid system in metabolic disease

(2018) Nirajan Shrestha et al.   DRUG DISCOVERY TODAY

The therapeutic potential of targeting the peripheral endocannabinoid/CB 1 receptor system

(2018) Joseph Tam et al.   European Journal of Internal Medicine

New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents

(2018) Mayank Kumar Sharma et al.   Scientific Reports

Extinction of avoidance behavior by safety learning depends on endocannabinoid signaling in the hippocampus

(2017) Vincenzo Micale et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The CB1Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability

(2016) Aliou B. Gueye et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

(2015) Alvaro Llorente-Berzal et al.   PSYCHOPHARMACOLOGY

Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice

(2014) Ana Luisa B. Terzian et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Peripherally restricted CB1 receptor blockers

(2013) Robert J. Chorvat   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lack of interaction of endocannabinoids and 5-HT3 neurotransmission in associative fear circuits of the amygdala: Evidence from electrophysiological and behavioural experiments

(2013) D. Höfelmann et al.   BRAIN RESEARCH

Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects

(2013) Linda E. Klumpers et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade

(2013) L. Bellocchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: A PET study

(2013) Akihiro Takano et al.   SYNAPSE

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors

(2012) M. Metna-Laurent et al.   JOURNAL OF NEUROSCIENCE

Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity

(2012) F J Meye et al.   MOLECULAR PSYCHIATRY

Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety

(2012) Yi-Chun Yen et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo

(2012) Wolfgang Jacob et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission

(2012) Alejandro Aparisi Rey et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid system and mood disorders: Priming a target for new therapies

(2012) Vincenzo Micale et al.   PHARMACOLOGY & THERAPEUTICS

Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model

(2012) Stephan Direnberger et al.   Nature Communications

CB1 receptor antagonists: new discoveries leading to new perspectives

(2011) E. Kirilly et al.   Acta Physiologica

Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk

(2011) David R Janero et al.   Expert Opinion on Drug Discovery

Fear relief—toward a new conceptual frame work and what endocannabinoids gotta do with it

(2011) C.J. Riebe et al.   NEUROSCIENCE

Rimonabant Redux and Strategies to Improve the Future Outlook of CB1 Receptor Neutral-Antagonist/Inverse-Agonist Therapies

(2011) Sara Jane Ward et al.   Obesity

Peripheral effects of the endocannabinoid system in energy homeostasis: Adipose tissue, liver and skeletal muscle

(2011) Cristoforo Silvestri et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors

(2011) Ana Luisa Terzian et al.   Frontiers in Behavioral Neuroscience

An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity

(2010) F. D. Christopoulou et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Dissociation of within- and between-Session Extinction of Conditioned Fear

(2010) W. Plendl et al.   JOURNAL OF NEUROSCIENCE

The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats

(2010) K.S. Sink et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142

(2009) K.S. Sink et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission

(2009) W. Jacob et al.   GENES BRAIN AND BEHAVIOR

The future of endocannabinoid-oriented clinical research after CB1 antagonists

(2009) Bernard Le Foll et al.   PSYCHOPHARMACOLOGY

The psychiatric side-effects of rimonabant

(2009) Fabrício A. Moreira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling

(2008) K. Kamprath et al.   GENES BRAIN AND BEHAVIOR