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Long non-coding RNA in osteogenesis A NEW WORLD TO BE EXPLORED

BONE & JOINT RESEARCH (2019)

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Journal

BONE & JOINT RESEARCH
Volume 8, Issue 2, Pages 73-80

Publisher

BRITISH EDITORIAL SOC BONE JOINT SURGERY
DOI: 10.1302/2046-3758.82.BJR-2018-0074.R1

Keywords

lncRNA; Molecular mechanism; Osteogenesis; Osteogenic differentiation

Categories

Cell & Tissue Engineering Orthopedics

Funding

  1. National Natural Science Foundation of China [81772440, 81371915, 81572094]

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Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with limited coding potential, which have emerged as novel regulators in many biological and pathological processes, including growth, development, and oncogenesis. Accumulating evidence suggests that lncRNAs have a special role in the osteogenic differentiation of various types of cell, including stem cells from different sources such as embryo, bone marrow, adipose tissue and periodontal ligaments, and induced pluripotent stem cells. Involved in complex mechanisms, lncRNAs regulate osteogenic markers and key regulators and pathways in osteogenic differentiation. In this review, we provide insights into the functions and molecular mechanisms of lncRNAs in osteogenesis and highlight their emerging roles and clinical value in regenerative medicine and osteogenesis-related diseases.

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