Review
Clinical Neurology
Yang Liu, Lingxiao Qi, Zhe Li, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a disease caused by cerebrovascular damage, leading to hematoma enlargement, brain edema, and physical injury in the brain parenchyma. Matrix metalloproteinases (MMPs) are a group of endopeptidases that can degrade components of the extracellular matrix and promote neuroinflammation. After ICH, several MMPs are upregulated and may have different functions at different stages. The glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) induces the production of MMPs. The interactions between MMPs and EMMPRIN/CD147 in ICH are complex.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sabrina Giofre, Antonio Renda, Silvia Sesana, Beatrice Formicola, Barbara Vergani, Biagio Eugenio Leone, Vanna Denti, Giuseppe Paglia, Serena Groppuso, Valentina Romeo, Luca Muzio, Andrea Balboni, Andrea Menegon, Antonia Antoniou, Arianna Amenta, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
Summary: Dual functionalized liposomes with modified peptides and MMP-sensitive moieties have the ability to cross BBB and release drugs in MMP-rich microenvironment. These liposomes display good biocompatibility and efficiently release encapsulated fluorescent dyes.
Article
Clinical Neurology
Gary A. Rosenberg
Summary: Binswanger disease is a type of vascular cognitive impairment and dementia. Biomarkers can aid in early diagnosis, such as using magnetic resonance imaging and cerebrospinal fluid or positron emission tomography to detect vascular disease-related proteins. Vascular disease accelerates cognitive decline, which is associated with misfolded proteins and inflammation. Early detection and treatment of dementia can be improved by advancements in plasma biomarker detection techniques and technologies like machine learning.
Article
Environmental Sciences
Ziyang Guo, Zhengzheng Ruan, Dongdong Zhang, Xiaohui Liu, Liyan Hou, Qingshan Wang
Summary: This study reveals that rotenone induces cognitive impairments in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis via MMP-2/-9, providing a novel aspect for the pathogenesis of pesticide-induced neurotoxicity and Parkinson's disease-related dementia.
Article
Biochemistry & Molecular Biology
Diede W. M. Broekaart, Till S. Zimmer, Sophie T. Cohen, Rianne Tessers, Jasper J. Anink, Helga E. de Vries, Jan A. Gorter, Roger Prades, Eleonora Aronica, Erwin A. van Vliet
Summary: The gelatinase inhibitor ACT-03 has shown disease-modifying effects in epilepsy models by reducing neuroinflammation and preserving blood-brain barrier integrity. Further evaluation of its effects in clinical trials is warranted.
Article
Immunology
Caio Andreeta Figueiredo, Johannes Steffen, Lorena Morton, Sushmitha Arumugam, Oliver Liesenfeld, Maria A. Deli, Andrea Kroeger, Thomas Schueler, Ildiko Rita Dunay
Summary: Our study demonstrates that T. gondii initially infects endothelial cells in the choroid plexus, triggering early local immune responses and barrier disturbances which ultimately affect BCSFB function.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Surgery
Guang Yang, Yingya Cao, Ping Wang, Lin Mei, Jinbao Chen, Weihua Lu
Summary: The study aimed to investigate the mechanism by which minocycline protects the blood-brain barrier (BBB) in septic rats. The results showed that minocycline pretreatment could inhibit microglial activation, decrease MMP-9 expression, increase the expression of ZO-1 and occludin, and improve the permeability of the BBB.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Chemistry, Analytical
Akshata Anchan, Graeme Finlay, Catherine E. Angel, James J. W. Hucklesby, Scott E. Graham
Summary: Previous studies have shown that human melanoma cells can weaken the brain endothelial barrier, but the expression of MMPs and proteases released by melanoma cells may not directly contribute to the initial disruption of the brain endothelium.
Review
Biochemistry & Molecular Biology
Kathryn E. Sanchez, Gary A. Rosenberg
Summary: COVID-19 primarily affects the peripheral symptoms, but it can also impact the central nervous system (CNS). The association between stroke and COVID-19 suggests overlapping molecular mechanisms. This study proposes that SARS-CoV-2 infection leads to the upregulation of inflammatory proteins in peripheral macrophages, resulting in various negative effects on endothelial function, leading to disruption of the blood-brain barrier (BBB). This disruption alters CNS function by affecting astrocyte function and inflammasome activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Taylor E. Branyan, Amutha Selvamani, Min Jung Park, Kriti E. Korula, Kelby F. Kosel, Rahul Srinivasan, Farida Sohrabji
Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Food Science & Technology
Yu-Ting Zhou, Ya-Ning Xu, Xi-Yun Ren, Xiao-Feng Zhang
Summary: This study found that suppressing microglia-mediated inflammation can alleviate dopaminergic neurodegeneration caused by paraquat in mice with Parkinson's disease, and this mechanism may be related to the improvement of blood-brain barrier function.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fulvio Tartara, Andrea Montalbetti, Emanuela Crobeddu, Daniele Armocida, Eleonora Tavazzi, Andrea Cardia, Marco Cenzato, Davide Boeris, Diego Garbossa, Fabio Cofano
Summary: This paper provides a practical review of the pathophysiological events following subarachnoid hemorrhage (SAH). The complex cascade of pathophysiological events involves various interconnected but distinct pathways. The use of heparin, with its anticoagulant effect and ability to interfere with secondary events, may be an interesting therapeutic strategy for SAH management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Milton H. Hamblin, Jean-Pyo Lee
Summary: Neural stem cell transplantation shows promise in treating ischemic stroke by potentially therapeutic actions against neurovascular injury. By secreting factors that stimulate endogenous repair mechanisms, NSCs can promote self-recovery in early-stage ischemic stroke and improve short-term and long-term stroke outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Yang Liu, Yanling Mu, Zhe Li, Voon Wee Yong, Mengzhou Xue
Summary: This review explores the role of EMMPRIN in stroke and its pathological mechanisms. It discusses the regulation of matrix metalloproteinase expression, exacerbation of blood-brain barrier dysfunction and microvascular thrombosis, and promotion of neuroinflammation. Additionally, it summarizes various stroke treatments targeting the EMMPRIN signaling pathway, and suggests the potential of EMMPRIN as a biomarker of stroke injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wenjing Hou, Yingzong Jiang, Guangchao Xie, Lu Zhao, Fangshi Zhao, Xuejun Zhang, Shao-Kai Sun, Chunshui Yu, Jinbin Pan
Summary: BM NPs, with high T-1 relaxivity and good biocompatibility, show potential as a biocompatible MR contrast agent for noninvasive BBB permeability imaging, allowing for timely visualization and prediction of HT onset in stroke patients.
Article
Materials Science, Ceramics
Yao Yang, Yanli Shi, Junjing Duan, Kailei Lu, Gang Cheng, Yiding Zhao, Zhangyi Huang, Peitong Li, Nian Wei, Xinghua Zhu, Jianqi Qi, Tiecheng Lu
Summary: This study aimed to enhance the photoluminescence characteristics of a red-emitting Gd2Zr2O7:Eu3+ phosphor by co-doping with Al3+, resulting in a nanophosphor with significantly stronger emission intensity. The synthesized Gd1.93Zr1.97O7:Eu0.073+Al0.033+ phosphors show promise for applications in w-LEDs.
CERAMICS INTERNATIONAL
(2021)
Editorial Material
Cell Biology
Xiu-Min Shi, Rui-Ping Hu, Pei-Tong Li, Wei Han, Su-Jun Gao
Summary: HLA-A*30:170 differs from HLA-A*30:01:01:01 with a nucleotide change at position 755, resulting in a change of Threonine (T) at position 228 to Methionine (M).
Editorial Material
Cell Biology
Xiu-Min Shi, Pei-Tong Li, Rui-Ping Hu, Dan Zhang, Su-Jun Gao
Summary: HLA-A*11:361:02 differs from HLA-A*11:01:01:01 with one nucleotide change at position 486, resulting in a change of one amino acid.
Article
Optics
Quan Wang, Chengtao Cai, Weidong Zhang, Peitong Li, Boyu Xin
Summary: This paper proposes a new three-step adaptive enhancement method for underwater images, which addresses the problems of color cast, lack of detail, and low visibility. The method includes adaptive color correction, denoise and restore details, and global contrast improvement.
Article
Chemistry, Physical
Jing Zuo, Wei Wang, Dongxu Zhang, Xikun Wang, Yanling Ma, Peitong Li, Yifan Li, Wen Sun, Youlin Zhang, Langping Tu, Yulei Chang, Qiqing Li, Hong Zhang
Summary: Water-sensitive detection is important in various fields. This study demonstrates a high level of water sensitivity using a novel nanophosphor, providing a new strategy for nanophosphor-based sensors.
APPLIED SURFACE SCIENCE
(2022)
Editorial Material
Cell Biology
Xiu-Min Shi, Pei-Tong Li, Rui-Ping Hu, Wei Han, Su-Jun Gao
Summary: This statement describes two non-synonymous nucleotide changes at positions 368 and 379 in exon 3, which differentiate HLA-C*01:212 from HLA-C*01:02:01:01.
Editorial Material
Cell Biology
Xiu-Min Shi, Pei-Tong Li, Rui-Ping Hu, Wei Han, Su-Jun Gao
Summary: HLA-A*24:516 has one nucleotide change from HLA-A*24:02:01:01 at nucleotide 194 where Alanine (41) is changed to Glycine.
Editorial Material
Cell Biology
Xiu-Min Shi, Rui-Ping Hu, Pei-Tong Li, Wei Han, Su-Jun Gao
Summary: HLA-B*40:482 is a variant with a nucleotide change from HLA-B*40:06:01:01 at nucleotide 430, resulting in a glycine to arginine substitution at residue 120.
Editorial Material
Cell Biology
Xiu-Min Shi, Pei-Tong Li, Rui-Ping Hu, Wei Han, Su-Jun Gao
Summary: HLA-B*35:251:02 differs from HLA-B*35:22:01:01 with a nucleotide change at position 363, resulting in a substitution of serine to arginine at residue 97.
Editorial Material
Cell Biology
Xiu-Min Shi, Rui-Ping Hu, Pei-Tong Li, Wei Han, Su-Jun Gao
Summary: This sentence describes the difference between HLA-C*15:244 and HLA-C*15:05:01:01, where a nucleotide change at position 308 results in the change of amino acid 79 from Arginine to Glutamine.
Editorial Material
Cell Biology
Xiu-Min Shi, Rui-Ping Hu, Pei-Tong Li, Wei Han, Su-Jun Gao
Summary: A single nucleotide replacement at position 728 of the HLA-A*02:07:01 sequence results in the formation of a novel allele, HLA-A*02:981.
Editorial Material
Cell Biology
Xiu-Min Shi, Pei-Tong Li, Rui-Ping Hu, Wei Han, Su-Jun Gao
Summary: HLA-A*11:398 differs from HLA-A*11:01:01:01 by a single nonsynonymous nucleotide change at position 709, resulting in a substitution of isoleucine 213 to valine.
Editorial Material
Cell Biology
Xiu-Min Shi, Rui-Ping Hu, Pei-Tong Li, Wei Han, Su-Jun Gao
Summary: This sentence describes a mutation in the HLA-B gene that changes tyrosine to phenylalanine at residue 84.
Review
Chemistry, Analytical
Jing Wang, Rongfeng Zhao, Peitong Li, Zhiqiang Fang, Qianqian Li, Yanling Han, Ruyan Zhou, Yun Zhang
Summary: This paper reviews the clinical application of visual prostheses and artificial visual perception of implant recipients, discusses the importance of computer vision in optimizing visual information processing, and summarizes the development direction and emphasis issues for improving the performance of visual prosthesis devices.
Article
Chemistry, Analytical
Jiawang Ma, Guanlin Qiu, Weichen Guo, Peitong Li, Gan Ma
Summary: This paper proposes a method to enhance the dynamic performance of a legged robot by transmission mechanism. The unique six-link leg mechanism can achieve a large output motion using a small drive motion, improving the robot's dynamic motion capability.
