Article
Medicine, General & Internal
Kuo-Wei Kao, Weiming Cheng, Yi-Chin Chang
Summary: Bladder chondroma is a rare benign tumor that mainly affects older patients. It manifests as urinary symptoms and abdominal pain, and transurethral resection is the preferred treatment.
Review
Pharmacology & Pharmacy
Shilpi Singh, Waseem Raza, Shahnaz Parveen, Abha Meena, Suaib Luqman
Summary: miRNAs, as non-coding nucleotide sequences, play a crucial role in cancer development, with evidence suggesting that their deregulation is associated with tumorigenesis. Flavonoids are known to modulate miRNAs expression, potentially serving as chemopreventive agents by targeting miRNAs involved in cancer progression. While extensively studied in pre-clinical settings, more research is needed to explore the clinical implications of flavonoids in targeting miRNAs for cancer prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Yogaambikai Paramanantham, Ivy Chung, Nur Akmarina B. M. Said
Summary: The resistance of muscle-invasive bladder cancer cells to chemotherapy presents a significant challenge in successful treatment. The interplay between the bladder tumor and its microenvironment plays a crucial role in understanding chemoresistance. MicroRNAs have emerged as potential tools in managing chemoresistance by regulating this interplay.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Medicine, General & Internal
Andrea Coppola, Tonia Gatta, Giacomo Maria Pini, Giorgia Scordi, Federico Fontana, Filippo Piacentino, Roberto Minici, Domenico Lagana, Antonio Basile, Federico Deho, Giulio Carcano, Francesca Franzi, Silvia Uccella, Fausto Sessa, Massimo Venturini
Summary: This study analyzed the radiologic appearance of Neuroendocrine Carcinoma of the Urinary Bladder (NECB) on CT images and compared them with a control group. Typical features of NECB on CT images, such as male patients, large masses, and trigonal area involvement, were identified. Radiomic features showed significant correlation with NECB, which could aid in the diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Valentina Angerilli, Francesca Galuppini, Gianluca Businello, Luca Dal Santo, Edoardo Savarino, Stefano Realdon, Vincenza Guzzardo, Lorenzo Nicole, Vanni Lazzarin, Sara Lonardi, Fotios Loupakis, Matteo Fassan
Summary: The introduction of precision therapies targeting specific gene mutations in neoplasms is revolutionizing oncology, but resistance mechanisms developed by tumors pose challenges to the effectiveness of these drugs over time. Identifying indicators for monitoring and overcoming drug resistance is crucial. MicroRNAs, as stable molecules easily detectable in tissues and biofluids, are ideal biomarkers for identifying patients with resistance to targeted therapies.
Review
Biochemistry & Molecular Biology
Fernando Mendes, Eurico Pereira, Diana Martins, Edgar Tavares-Silva, Ana Salome Pires, Ana Margarida Abrantes, Arnaldo Figueiredo, Maria Filomena Botelho
Summary: Bladder cancer is a common cancer of the urinary tract, presenting a significant challenge despite advancements in treatment. Recent research suggests that cancer cells experience increased stress associated with oncogenic transformation, leading to changes in metabolic activity and generation of ROS. The close link between oxidative stress and bladder cancer has implications for prevention, carcinogenesis, prognosis, and treatment.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Oncology
Rina Masadah, Syahrul Rauf, Muhammad Yogi Pratama, Claudio Tiribelli, Devis Pascut
Summary: miRNAs play a fundamental role in the drug and radioresistance of cervical cancer, with evidence suggesting their potential application in clinical settings. Understanding the mechanisms by which miRNAs affect resistance and exploring new combined therapies could improve outcomes for cervical cancer patients.
Article
Urology & Nephrology
Ruiyun Zhang, Jingyu Zang, Feng Xie, Yue Zhang, Yiqiu Wang, Ying Jing, Yi Zhang, Zhaoxiong Chen, Akezhouli Shahatiaili, Mei-Chun Cai, Zhixin Zhao, Pan Du, Shidong Jia, Guanglei Zhuang, Haige Chen
Summary: The study evaluated the concordance between tDNA profiling and utDNA or ctDNA assays in UBC patients, showing high accuracy of utDNA testing and similarity with tDNA, while ctDNA originated from clonal hematopoiesis. Higher preoperative utDNA or tDNA abundance correlated with worse relapse-free survival, and actionable variants were identified in utDNA.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Wenjiao Tang, Juan Xu, Caigang Xu
Summary: Multiple myeloma (MM) is a common but incurable hematological malignancy. The bone marrow microenvironment plays a crucial role in MM, and noncoding RNAs are emerging as important regulators of intercellular communication within the microenvironment. This review summarizes recent advances in the regulatory mechanisms of noncoding RNAs in MM and discusses their therapeutic potential.
Article
Medicine, Research & Experimental
Wen Tian, Xiaoying Niu, Feifei Feng, Xin Wang, Jiaqiang Wang, Weitao Yao, Peng Zhang
Summary: Osteosarcoma, the most common malignant bone sarcoma in children, is hindered by chemotherapy drugs resistance. Exosomal miRNAs play an important role in the occurrence, development, and drug resistance of osteosarcoma. Exploration of exosome biogenesis and role of exosomal miRNAs provides new strategies and targets for understanding the pathogenesis of osteosarcoma and overcoming drug resistance. Engineering modification of exosomes enhances their targeting ability, making them more effective in delivering cargos to recipient cells. This review focuses on the mechanisms of exosomal miRNAs in osteosarcoma and their potential as tumor biomarkers, as well as recent advances in the clinical application of engineering exosomes to overcome chemotherapy resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Shaoming Zhu, A-Hong Ma, Zheng Zhu, Elio Adib, Ting Rao, Na Li, Kaiyuan Ni, Veera Chandra Sekhar Reddy Chittepu, Rao Prabhala, Juan Garisto Risco, David Kwiatkowski, Kent Mouw, Guru Sonpavde, Fan Cheng, Chong-Xian Pan
Summary: The study found that genetic alterations along the PI3K pathway are common in advanced bladder urothelial cancer, and PI3K inhibition has a significant inhibitory effect on cancer cells. Combination therapy of pan-PI3K inhibition, anti-PD1 therapy, and PI3K inhibition combined with anti-PD1 therapy improved overall survival in mouse models with PTEN-deleted tumors, stimulating an immune response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Se Young Choi, Moon Soo Ha, Byung Hoon Chi, Jin Wook Kim, In Ho Chang, Tae-Hyoung Kim, Soon Chul Myung, Myoungsuk Kim, Kyung-Eun Lee, Yuwon Kim, Hyun-Ki Woo, Dae-Sung Kyoung, Hasung Kim
Summary: This study compared the perioperative outcomes, overall survival, and treatment trends in patients with bladder cancer who underwent radical cystectomy and received either neoadjuvant or adjuvant chemotherapy. The findings suggest that neoadjuvant chemotherapy is associated with better overall survival and lower administration of granulocyte colony-stimulating factor when compared to adjuvant chemotherapy. Therefore, neoadjuvant chemotherapy should be considered as a treatment option for bladder cancer patients undergoing radical cystectomy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Clint Cary, Yan Tong, Susan Linsell, Khurshid Ghani, David C. Miller, Michael Weiner, Michael O. Koch, Susan M. Perkins, Gregory Zimet
Summary: This study aimed to understand the importance of environmental and clinical dimensions in the decision to offer postoperative immediate chemotherapy. The results showed that the recovery room protocol for instilling and disposing of chemotherapy was the most influential attribute, while tumor grade was the strongest preference for giving chemotherapy.
JOURNAL OF UROLOGY
(2022)
Article
Oncology
Tomonari Suetsugu, Ryutaro Mori, Manabu Futamura, Masahiro Fukada, Hideharu Tanaka, Itaru Yasufuku, Yuta Sato, Yoshinori Iwata, Takeharu Imai, Hisashi Imai, Yoshihiro Tanaka, Naoki Okumura, Nobuhisa Matsuhashi, Takao Takahashi, Kazuhiro Yoshida
Summary: Fluorouracil (5FU) is converted to its active metabolite fluoro-deoxyuridine monophosphate (FdUMP) through different pathways in different cells, contributing to varying mechanisms of resistance. When overcoming 5FU resistance, both the synthesized amount of FdUMP and sensitivity to FdUMP should be taken into consideration.
Review
Pharmacology & Pharmacy
Pooja Jain, Himanshu Kathuria, Munira Momin
Summary: Bladder cancer is the 10th most common malignancy worldwide with a 5-year survival rate of 75%, but 70% of the cases develop chemoresistance and progress to the muscle invasive stage. Nanotechnology has shown promise in targeted drug delivery to bladder cancer cells, offering potential for better treatment management.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Urology & Nephrology
Di Niu, Qihang Xu, Hanjiang Xu, Shuiping Yin, Zongyao Hao, Haoqiang Shi, Jun Zhou, Sheng Tai, Zhihui Zou, Cheng Yang, Chaozhao Liang
Summary: A new wireless high-definition endoscopic system (WHES) was developed, which provides similar image resolution as a Storz laparoscopic system with acceptable colour resolution, at a lower cost. Expert evaluation showed no significant difference in resolution, brightness, and colour for cystoscopy between WHES and Storz system, but WHES scored higher in ergonomics. The overall cost of WHES was much lower compared to Storz system, and there was 100% general satisfaction in the survey.
Letter
Surgery
Hanjiang Xu, Song Fan, Chaozhao Liang, Zongyao Hao
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Xiangbin Kong, Weiwei Hu, Zhilong Dong, Junqiang Tian, Yuhan Wang, Chen Jin, Chaozhao Liang, Zongyao Hao, Zhiping Wang
Summary: This systematic review and meta-analysis found that Li-ESWT, combined with or without medications, is an effective and safe treatment option for patients with Chronic prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS). The study included 12 randomized controlled trials with a total of 651 patients. The results showed significant improvements in symptom scores, including pain, quality of life, and erectile function, in the Li-ESWT group compared to the control group at various time points. The subgroup analysis also demonstrated longer-lasting and greater reductions in symptom scores when Li-ESWT was combined with medications. Overall, Li-ESWT should be recommended for widespread use in clinical practice for CP/CPPS patients.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Andrology
Bing Zhao, Jing Wang, Li Chen, Hong Wang, Chao-Zhao Liang, Jiaoti Huang, Ling-Fan Xu
Summary: Reprogramming of metabolism is a characteristic of tumors and has been investigated for therapeutic purposes. Prostate cancer, especially advanced and therapy-resistant cases, exhibits unique metabolic properties. Targeting the metabolic vulnerabilities of prostate cancer, specifically focusing on glutamine metabolism alterations, may offer new treatment options and improve clinical outcomes. This review summarizes the metabolic landscape of prostate cancer, highlights the influence of glutamine metabolism on therapeutic resistance and disease progression, and proposes novel therapeutic strategies.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Cell Biology
Zhengyao Song, Chen Jin, Zichen Bian, Chaozhao Liang
Summary: In this study, researchers found that the combination treatment of radial extracorporeal shock wave therapy (rESWT) and Resveratrol (Res) derivative can effectively reduce inflammation and fibrosis in chronic nonbacterial prostatitis (CNP) rats. This combination treatment works by regulating the expression of SIRT1 and NF-kappa B.
Article
Cell Biology
Yang Su, Tianxiang Zhang, Jinsen Lu, Lei Qian, Yang Fei, Li Zhang, Song Fan, Jun Zhou, Jieqiong Tang, Haige Chen, Chaozhao Liang
Summary: The study aimed to identify key tumor-infiltrating immune cells (TIICs) affecting distant metastasis and prognosis in patients with clear cell renal cell carcinoma (ccRCC). A three-gene panel consisting of CFB, PPP1R18, and TOM1L1 was established and validated for predicting distant metastasis and immunotherapy response. High-risk patients exhibited lower infiltration of RMCs, higher tumor mutation burden (TMB), and worse prognosis. The panel provided new insights for the treatment of advanced ccRCC.
Article
Biochemistry & Molecular Biology
Zichen Bian, Jia Chen, Chang Liu, Qintao Ge, Meng Zhang, Jialin Meng, Chaozhao Liang
Summary: This study presents a classification system, called Bladder Cancer Immune Prognostic Index (BCIPI), based on the intratumoral microenvironment to predict the prognosis and immunotherapeutic response of bladder cancer patients. Analysis of expression profiles from 1554 bladder cancer cases established the BCIPI and showed its effectiveness in predicting overall survival. Patients in the BCIPI-High subgroup exhibited different immunophenotypic outcomes and increased sensitivity to anti-PD-L1 immunotherapy compared to the BCIPI-Low subgroup.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Microbiology
Kunyu Zhang, Lei Chen, Chenyu Zhu, Meng Zhang, Chaozhao Liang
Summary: T helper 22 (Th22) cells, characterized by their distinct cytokine profile, play variable roles in human immunity. The main effector molecule secreted by Th22 cells is IL-22, which has both protective and deleterious effects on infectious diseases. Th22/IL-22 may be a promising therapeutic target and an effective treatment strategy for various infections.
Article
Chemistry, Multidisciplinary
Hui Wang, Yu Guan, Chun Li, Jia Chen, Shaoyu Yue, Jieying Qian, Bangshun Dai, Changqin Jiang, Chenghao Wen, Longping Wen, Chaozhao Liang, Yunjiao Zhang, Li Zhang
Summary: This study designed magnetic PEGylated manganese-zinc ferrite nanocrystals (PMZFNs) to actively attract and retain the drug in prostate cancer by implanting micromagnets into tumor tissues. The PMZFNs accumulate in prostate cancer and elicit potent ferroptosis and the activation of cGAS-STING pathway, achieving targeted therapy.
Article
Oncology
Jialin Meng, Jingjing Gao, Xiao Li, Rui Gao, Xiaofan Lu, Jun Zhou, Fangrong Yan, Haitao Wang, Yi Liu, Zongyao Hao, Xiansheng Zhang, Chaozhao Liang
Summary: This study aims to investigate the prognosis and therapeutic targets for testicular germ cell tumors (TGCTs), and defined the tumor immune microenvironment activation status (TIMEAS). By classifying patients into immune-activated and immune-exhausted subgroups, different treatment strategies could be applied to achieve better outcomes.
Article
Urology & Nephrology
Junyue Tao, Qintao Ge, Jialing Meng, Chaozhao Liang, Zongyao Hao, Jun Zhou
Summary: This study reveals that high expression of DDX49 predicts a poor prognosis in prostate cancer. Knockdown of DDX49 inhibits cell proliferation and migration, induces cell cycle arrest, and promotes cell apoptosis. Therefore, DDX49 knockdown may be a promising novel therapy for treating patients with prostate cancer.
Article
Green & Sustainable Science & Technology
R. Zhong, R. Chu, J. Zhu, J. Ling, L. Zhang, Y. Zhou, M. Yin, Z. Hao, C. Liang, S. Cao, T. Xu, S. Ye, S. Fan
Summary: Prostate diseases are common in males, and nanomedicine provides opportunities for the biomedical field by designing and manufacturing biomaterials. Gels have various applications in drug delivery, anti-inflammation, tissue regeneration, and wound healing. This review focuses on the current research on gels-based nanocomposites in the diagnostics and therapy of prostate diseases, pointing out their shortcomings and suggesting a broader prospect for future clinical application.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Urology & Nephrology
Hanjiang Xu, Di Niu, Cheng Yang, Zongyao Hao, Chaozhao Liang
Summary: This study introduced a new wireless endoscopic system based on fifth-generation transmission technology. The visual discomfort induced by this system was compared with that induced by a conventional endoscopic system during laparoscopic pelvic surgery. The results showed that experienced surgeons did not experience additional visual discomfort when using the wireless endoscopic system compared to the conventional system.
Article
Oncology
Wei Xu, Meiyi Lu, Siqi Xie, Dangui Zhou, Mei Zhu, Chaozhao Liang
Summary: Mounting evidence suggests that endoplasmic reticulum stress (ERS) plays a crucial role in modulating tumor-associated macrophages (TAMs) and shaping the immunosuppressive microenvironment. The communication between ER-stressed tumor cells and TAMs remains unclear, but exosomes have been identified as important mediators in intercellular communication. Therefore, this study aimed to investigate the impact of ER stress-related exosomes on prostate cancer cells in promoting macrophage infiltration and polarization. The findings demonstrated that TG-treated exosomes downregulated PD-L1 expression on macrophages and altered the expression of inflammatory cytokines and the PI3K/AKT pathway.
Article
Urology & Nephrology
Qiao Qi, Yongtao Hu, Yang Chen, Qunsheng Yan, Yuexian Xu, Hu Liang, Chaozhao Liang, Zongyao Hao
Summary: This study aimed to determine the risk factors and establish a nomogram for predicting postoperative fever after RIRS in patients with negative preoperative urine culture. The study found that urinary leukocyte esterase, operative time, and intraoperative hypotension were independent risk factors of postoperative fever, and a nomogram was constructed for assessing the risk of infection in these patients.
WORLD JOURNAL OF UROLOGY
(2023)
