Article
Sport Sciences
Haley M. Chizuk, Barry S. Willer, Adam Cunningham, Itai Bezherano, Eileen Storey, Christina Master, Rebekah Mannix, Doug J. Wiebe, Matthew F. Grady, William P. Meehan, John J. Leddy, Mohammad N. Haider
Summary: There is growing evidence that adherence to personalized subsymptom threshold aerobic exercise can lead to faster recovery from sport-related concussions (SRC). Initial exercise intolerance, but not initial symptom severity, affects adherence to aerobic exercise prescriptions within 10 days of SRC.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Critical Care Medicine
Cathlyn Corrado, Barry S. Willer, Jacob I. McPherson, Eileen P. Storey, Sue Ann Sisto, Christina L. Master, Douglas J. Wiebe, Mathew F. Grady, Rebekah C. Mannix, William P. Meehan, John J. Leddy, Mohammad N. Haider
Summary: Early targeted aerobic exercise can reduce recovery time and incidence of persistent symptoms in sport-related concussions. This study explores the effectiveness of aerobic exercise for more severe cases with oculomotor and vestibular presentations. The results suggest that prescribed sub-symptom threshold aerobic exercise may be effective for adolescents with these symptoms, but further validation is needed.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Orthopedics
Itai Bezherano, Mohammad N. Haider, Barry S. Willer, John J. Leddy
Summary: Exercise intolerance is a biomarker of physiological dysfunction after sport-related concussion. Subsymptom threshold aerobic exercise within 1 week of injury has been shown to be effective. This article presents 3 methods of exercise prescription for patients with SRC, emphasizing the importance of symptom and exercise monitoring for timely recovery assessment.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Sport Sciences
Stanley Herring, W. Ben Kibler, Margot Putukian, Gary S. Solomon, Lori Boyajian-O'Neill, Katherine L. Dec, R. Robert Franks, Peter A. Indelicato, Cynthia R. LaBella, John J. Leddy, Jason Matuszak, E. Barry McDonough, Francis O'Connor, Karen Michelle Sutton
Summary: This document is part of a series of annual consensus documents written for practicing team physicians, aiming to provide optimal medical care for athletes with sports-related concussion. It outlines selected medical issues important to team physicians responsible for athletes with SRC and was developed by the Team Physician Consensus Conference (TPCC), an alliance of six major professional associations.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Clinical Neurology
Xiaotian Shen, Bixi Gao, Zilan Wang, Yanbo Yang, Zhouqing Chen, Lelin Yu, Zhong Wang
Summary: Aerobic exercise has a positive impact on the recovery of adolescents with mild traumatic brain injury, reducing symptom scores and recovery time, but does not significantly help with neurocognitive function recovery.
WORLD NEUROSURGERY
(2021)
Letter
Medicine, General & Internal
Steven P. Broglio, Spencer W. Liebel, Wenxian Zhou, Chengyun Li, Paul Pasquina, Thomas McAllister, Michael A. McCrea, Jaroslaw Harezlak
Summary: In a study of 2842 collegiate athletes with concussion, the majority of clinical tests showed recovery to baseline within 1 week, with visual and reaction times taking up to 2 weeks to recover.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Runhua Wang, Yuanyuan Cai, Jing Li, Suk-yu Yau, Weicong Lu, Brendon Stubbs, Kuan-pin Su, Guiyun Xu, Kwok-fai So, Kangguang Lin, Lian-wen Qi
Summary: The study revealed that aerobic exercise had an impact on gut microbiota in both asymptomatic and subthreshold symptomatic adolescents, but a 12-week moderate-intensity aerobic exercise intervention did not show significant benefits in either group.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Orthopedics
Michael Popovich, Andrea Almeida, Jeremiah Freeman, James T. Eckner, Bara Alsalaheen, Matthew Lorincz, Andrew Sas
Summary: This retrospective cohort study found that supervised exercise in acute sport-related concussion is safe and associated with earlier return to sport, suggesting that early exercise intervention may be beneficial for recovery.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Reinaldo Maeneja, Claudia R. Silva, Ines S. Ferreira, Ana Maria Abreu
Summary: This study confirms that aerobic physical exercise has greater benefits for cognitive recovery in stroke patients.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Sport Sciences
Michael Makdissi, Meghan L. Critchley, Robert C. Cantu, Jeffrey G. Caron, Gavin A. Davis, Ruben J. Echemendia, Pierre Fremont, K. Alix Hayden, Stanley A. Herring, Sidney R. Hinds, Barry Jordan, Simon Kemp, Michael McNamee, David Maddocks, Shinji Nagahiro, Jon Patricios, Margot Putukian, Michael Turner, Stacy Sick, Kathryn J. Schneider
Summary: This review systematically examines factors to consider when advising athletes about retirement after sport-related concussion (SRC) and defines contraindications for children/adolescents participating in contact or collision sports following SRC. The study found no evidence to support absolute indications for retirement or discontinuation from contact or collision sport based on patient-specific, injury-specific or other factors (such as imaging findings).
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paulo Gentil, Lucas Raphael Bento e Silva, Daniela Espindola Antunes, Luciana Barbosa Carneiro, Claudio Andre Barbosa de Lira, Gislene Batista, Jordana Campos Martins de Oliveira, John Sebastiao Cardoso, Daniel CostaCosta Souza, Ana Cristina Silva Rebelo
Summary: This study compared the effects of different aerobic training protocols on cardiometabolic variables in patients with type 2 diabetes mellitus (T2DM). The results showed that low-volume high-intensity interval training (HIIT) can improve cardiorespiratory capacity more effectively than low-volume moderate intensity continuous training (MICT). Other variables also showed improvements with all three training protocols.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Samuel A. Bobholz, Benjamin L. Brett, Lezlie Y. Espana, Daniel L. Huber, Andrew R. Mayer, Jaroslaw Harezlak, Steven P. Broglio, Thomas McAllister, Michael A. McCrea, Timothy B. Meier
Summary: A study on the acute and early long-term associations of sport-related concussion (SRC) and subcortical and cortical structures in collegiate contact sport athletes showed that a single SRC had minimal associations with grey matter structure across a 6-month time frame.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Psychology, Clinical
Keith H. Nuechterlein, Sarah C. McEwen, Joseph Ventura, Kenneth L. Subotnik, Luana R. Turner, Michael Boucher, Laurie R. Casaus, Margaret G. Distler, Jacqueline N. Hayata
Summary: Aerobic exercise enhances the impact of cognitive training on cognition and functional outcome in first-episode schizophrenia, apparently driven by the amount of exercise completed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Lars-Johan V. Valaas, Helene L. Soberg, Mari S. Rasmussen, Sophie E. Steenstrup, Nada Andelic, Ingerid Kleffelgard
Summary: This study aims to evaluate the effectiveness of sub-symptom threshold aerobic exercise (SSTAE) on persistent post-concussion symptoms (PPCS) after mild traumatic brain injury (mTBI). It also examines whether SSTAE can lead to clinically meaningful improvement in symptom burden, exercise tolerance, physical activity, health-related quality of life, and activity limitations. The study design is a randomized controlled single-blind parallel-group trial with three measurement times. Outcome measures include the Rivermead post-concussion symptoms questionnaire, Buffalo Concussion Treadmill Test, and other measures related to health and symptoms.
Review
Sport Sciences
John J. Leddy, Joel S. Burma, Clodagh M. Toomey, Alix Hayden, Gavin A. Davis, Franz E. Babl, Isabelle Gagnon, Christopher C. Giza, Brad G. Kurowski, Noah D. Silverberg, Barry Willer, Paul E. Ronksley, Kathryn J. Schneider
Summary: This study synthesized evidence on the risks and benefits of physical activity, prescribed aerobic exercise treatment, rest, cognitive activity, and sleep during the first 14 days after sport-related concussion (SRC). It found that early prescribed aerobic exercise, reduced screen time, and appropriate physical activity were beneficial for recovery after SRC. Strict physical rest until symptom resolution was not effective, and sleep disturbance hindered recovery.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Sport Sciences
Samuel R. Walton, Benjamin L. Brett, Avinash Chandran, J. D. Defreese, Rebekah Mannix, Ruben J. Echemendia, William P. Meehan, Michael Mccrea, Kevin M. Guskiewicz, Zachary Y. Kerr
Summary: The study found higher prevalence of mild cognitive impairment (MCI) and dementia among former National Football League (NFL) players, which were associated with self-reported history of concussions, mood-related disorders, and other personal factors.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Health Care Sciences & Services
Aditi P. Sen, Yashaswini Singh, Mark K. Meiselbach, Matthew D. Eisenberg, Gerard F. Anderson
Summary: Washington State introduced the nation's first health insurance public option in 2021, offering a low-premium choice for residents. However, voluntary participation of private insurers and providers, along with associated uncertainty, may have hindered the widespread adoption and premium reductions of the public option plan.
Article
Clinical Neurology
Cassandra C. Daisy, Speros Varinos, David R. Howell, Katherine Kaplan, Rebekah Mannix, William P. Meehan, Francis Wang, Brant Berkstresser, Richard S. Lee, John W. Froehlich, David Zurakowski, Marsha A. Moses
Summary: This study aims to discover and validate noninvasive biomarkers for diagnosing and monitoring sport-related concussions. The findings show that IGF-1 and IGFBP5 are downregulated in the urine of athletes with concussions, indicating potential for accurate diagnosis and monitoring of concussions.
Article
Sport Sciences
Samuel R. Walton, Zachary Y. Kerr, Rebekah Mannix, Benjamin L. Brett, Avinash Chandran, Jonathan D. DeFreese, Michael A. McCrea, Kevin M. Guskiewicz, William P. Meehan, Ruben J. Echemendia
Summary: Former National Football League players show significant concerns about the potential long-term effects of their past concussions on brain health, with these concerns being more prevalent now than when they were actively playing football. Cognitive and mental health concerns are identified as important targets for clinical intervention.
Article
Clinical Neurology
Benjamin L. Brett, Zachary Y. Kerr, Neelum T. Aggarwal, Avinash Chandran, Rebekah Mannix, Samuel Walton, J. D. DeFreese, Ruben J. Echemendia, Kevin M. Guskiewicz, Michael A. McCrea, William P. Meehan
Summary: This study found that the prevalence of stroke among former National Football League players aged >= 50 years was lower than the general population, with significantly increased risk among those with 10 or more prior concussions. The findings add to the evidence suggesting that traumatic brain injuries are associated with increased risk of stroke. Clinically, management of cardio- and cerebrovascular health may be pertinent to those with a history of multiple prior concussions.
Article
Orthopedics
Robyn M. Mullins, Rebecca E. Mannix, Nicole J. Marshall, Virginia J. Lewis
Summary: This study demonstrates the importance of a public health service in reaching and addressing foot and ankle problems of people experiencing homelessness who may not seek care on their own. Simplified pathways to care, including outreach, prove effective in providing immediate podiatric treatment and building trust and connections for accepting other health and welfare services.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2022)
Article
Emergency Medicine
Arianne L. Baker, Rebekah Mannix, Alexandra H. Baker
Summary: This article reports a case of isolated Lyme radiculoneuritis in a child in Massachusetts characterized by fever and allodynia of the upper back. Laboratory investigation demonstrated elevated inflammatory markers and positive Lyme testing. MRI examination revealed nerve root enhancement in C5-C6 and C6-C7. The symptoms resolved with oral doxycycline.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Neurosciences
Zachary Yukio Kerr, Avinash Chandran, Benjamin L. Brett, Samuel R. Walton, J. D. DeFreese, Rebekah Mannix, Ruben J. Echemendia, Michael A. McCrea, Kevin M. Guskiewicz, William P. Meehan
Summary: Despite minor variations over time, the recall of professional football concussion history remains relatively stable. Better cognitive and psychological functioning is associated with greater stability in concussion recall.
Article
Psychology, Clinical
Zachary Yukio Kerr, Samuel R. Walton, Benjamin L. Brett, Avinash Chandran, J. D. DeFreese, Rebekah Mannix, Ruben J. Echemendia, Michael A. McCrea, Kevin M. Guskiewicz, William P. Meehan
Summary: This study examined the associations between self-reported concussion history and depression, and found significant correlations between the two variables, with the degree of association varying based on different variable characterizations.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Editorial Material
Critical Care Medicine
Rebekah Mannix, Keisuke Kawata, Jeffrey J. Bazarian
Summary: There is growing concern over the impact of repetitive head impacts (RHIs) on long-term brain health. Establishing RHI thresholds is being considered to mitigate the potential long-term effects, but the combination of biomedical research and societal standards has yet to inform policy making effectively.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Emergency Medicine
Caitlin Farrell, Megan Hannon, Michael C. Monuteaux, Rebekah Mannix, Lois K. Lee
Summary: This study analyzed national trends in pediatric fracture epidemiology, emergency department (ED) disposition, and resource utilization from 2010 to 2015. The incidence rate of pediatric fractures slightly decreased while the utilization of ED resources increased over time.
PEDIATRIC EMERGENCY CARE
(2022)
Article
Clinical Neurology
Masen L. Boucher, Grace Conley, Jordan Nowlin, Jianhua Qiu, Keisuke Kawata, Jeffrey J. Bazarian, William P. Meehan, Rebekah Mannix
Summary: Recently, there has been increasing attention in the scientific community to the phenomenon of sub-concussive impacts, which are hits to the head that don't cause symptoms of a concussion. This study used a mouse model to investigate the effects of low-level repetitive head impacts. The results showed that even without noticeable behavioral changes, the impacts caused pathology in the brain, as well as downregulation of inflammatory pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jonathan Savitz, Bryna D. Goeckner, Bart N. Ford, T. Kent Teague, Haixia Zheng, Jaroslaw Harezlak, Rebekah Mannix, L. Tugan Muftuler, Benjamin L. Brett, Michael A. McCrea, Timothy B. Meier
Summary: This study suggests that cytomegalovirus infection may contribute to structural brain abnormalities in individuals with concussion. The researchers evaluated the effect of cytomegalovirus serostatus on brain structure in athletes with concussion, finding significant differences in white and grey matter structure between athletes with and without cytomegalovirus infection.
Article
Emergency Medicine
Kelsey A. A. Miller, Sarah Cavallaro, Alexander Hirsch, Joel Hudgins, Jason Levy, Joyce Li, Galina Lipton, Ashley Marchese, Rebekah C. C. Mannix, Michael C. C. Monuteaux, Sara Schutzman, Andrew F. F. Miller
Summary: This study investigated the impact of recent trends in increased pediatric patients and behavioral health complaints on the clinical exposure of residents in pediatric emergency medicine. The results showed that alternative care sites can address capacity challenges without decreasing the volume or variety of patients seen by residents.
AEM EDUCATION AND TRAINING
(2023)
Article
Psychology, Applied
J. D. DeFreese, Erianne A. Weight, Landon B. Lempke, Samuel R. Walton, Zachary Yukio Kerr, Benjamin L. Brett, Avinash Chandran, Rebekah Mannix, Ruben J. Echemendia, Michael A. McCrea, William P. Meehan III, Kevin M. Guskiewicz
Summary: Transitioning from professional football life has significant implications for the health and well-being of former NFL players. This study examined the experiences of former NFL players during this transition, identifying factors that facilitated the process and factors that made it difficult. The most commonly reported facilitators were having a career transition plan/options and social support, while difficulties related to structure and identity were identified as challenges. These findings highlight targeted intervention areas to enhance the well-being of NFL players during their transition from sport.
JOURNAL OF CLINICAL SPORT PSYCHOLOGY
(2023)