Review
Medicine, Research & Experimental
Fan Ding, Qili Hu, Yixing Wang, Min Jiang, Zhengyu Cui, Run Guo, Liping Liu, Fang Chen, Hai Hu, Gang Zhao
Summary: The motility of the gallbladder involves the storage, concentration, and delivery of bile. Multiple factors control gallbladder motor functions, such as innervation, humoral factors, and neuropeptides. Gallbladder emptying is the result of coordinated contractions of the muscular layers of the gallbladder wall, mediated by rhythmic contractions of smooth muscle cells, GB neurons, telocytes, and interstitial cells of Cajal. This article introduces the STIN syncytium as a new motor unit in the gallbladder, providing pacemaker activity and propagation pathways for contractions.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Wenchang Zhao, Liwen Zhang, Leonid G. Ermilov, Maria Gabriela Colmenares Aguilar, David R. Linden, Seth T. Eisenman, Michael F. Romero, Gianrico Farrugia, Lei Sha, Simon J. Gibbons
Summary: This study revealed a significant role for the Na+/HCO3- cotransporter NBCe1 in electrical activity of the mouse small intestine, indicating that the regulation of intracellular acid-base balance contributes to the generation of normal pacemaker activity in the gastrointestinal tract.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Pharmacology & Pharmacy
Yoshihiro Otsuka, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa
Summary: The interstitial cells of Cajal (ICCs) play a central role in DMPP-induced relaxation through membrane hyperpolarization via the activation of anoctamin-1. ATP may serve as a neurotransmitter for inhibitory enteric neurons that stimulate ICCs. ICCs act as the interface for neurotransmission of nicotinic acetylcholine receptor to induce LES relaxation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Physiology
Bernard T. Drumm, Keith D. Thornbury, Mark A. Hollywood, Gerard P. Sergeant
Summary: Urinary continence is maintained by the contracture of urethral sphincters, including the role of Ano1 channels expressed in urethral ICC in increasing smooth muscle excitability. However, the specific role of urethral Ano1 channels remains unclear due to differences in species and experimental approaches. Clarifying this situation is crucial for developing new treatments for urinary incontinence.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chihiro Sakai, Mei Mikawa, Takeshi Yamamoto, Tomoyuki Uchida, Yoshihide Nakamura, Hideaki Akase, Takeshi Suetomi, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Takayuki Okamura, Shigeki Kobayashi, Masafumi Yano
Summary: This study investigated the inhibitory effect of Dantrolene on smooth muscle cell proliferation and migration, and found that Dantrolene effectively suppressed vascular smooth muscle cell proliferation, migration, and neointimal formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Ji-Ting Liu, Han Bao, Yang-Jing Fan, Zi-Tong Li, Qing-Ping Yao, Yue Han, Ming-Liang Zhang, Zong-Lai Jiang, Ying-Xin Qi
Summary: The study demonstrated that platelet-derived microvesicles (PMVs) released by activated platelets after endothelial injury promote VSMC dedifferentiation via the Src/Lamtor1/mTORC1 signaling pathway, suggesting Lamtor1 as a potential therapeutic target for intimal hyperplasia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Shan-Shan Li, Shuang Gao, Yi Chen, Han Bao, Zi-Tong Li, Qing-Ping Yao, Ji-Ting Liu, Yingxiao Wang, Ying-Xin Qi
Summary: The study found that platelet-derived microvesicles (PMVs) released by activated platelets can promote VSMC migration, contributing to the neointimal hyperplasia during intimal restenosis. PMVs induced calcium dynamics changes in VSMCs, involving the membrane calcium channel TRPV4 in VSMC migration.
Article
Gastroenterology & Hepatology
Chih-Hsiang Alexander Chan, Zahra Aghababaie, Niranchan Paskaranandavadivel, Recep Avci, Leo K. Cheng, Timothy R. Angeli-Gordon
Summary: This study identifies temporary dysrhythmic ectopic pacemakers in the distal stomach caused by localized gastric distension. These distension-induced dysrhythmias are interesting physiological phenomena that can inform the design of new interventional and electrophysiological protocols, and contribute to the understanding of stretch-sensitivity in the gut and postprandial physiology.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Cell Biology
Han Bao, Zi-Tong Li, Lei-Han Xu, Tong-Yue Su, Yue Han, Min Bao, Ze Liu, Yang-Jing Fan, Yue Lou, Yi Chen, Zong-Lai Jiang, Xiao-Bo Gong, Ying-Xin Qi
Summary: The study revealed a potential association between increased vascular stiffness following neointimal hyperplasia and the PTEN/PIP3/Akt pathway mediated by platelet-derived extracellular vesicles (pEVs), which promote the production and secretion of Col8a1. These findings suggest that pEVs and key molecules could serve as potential therapeutic targets for treating neointimal hyperplasia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pathology
Fang Cheng, Tao Lu, Yicheng Wang, Didi Yuan, Zehong Wei, Yongguo Li, Jianbo Li, Renkuan Tang
Summary: The present study investigated the expression of alpha-SMA and SM22 alpha in the airway smooth muscle of children with acute interstitial pneumonia (AIP). The findings suggest that enhanced ASM contractile function is involved in the death mechanism of children with AIP.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zahra Aghababaie, Leo K. Cheng, Niranchan Paskaranandavadivel, Recep Avci, Chih-Hsiang Alexander Chan, Ashton Matthee, Satya Amirapu, Samuel J. Asirvatham, Gianrico Farrugia, Arthur Beyder, Gregory O'Grady, Timothy R. Angeli-Gordon
Summary: This study introduces gastric ablation as a new tool for modulating gastric bioelectrical activation, including eliminating both normal and abnormal pacemaker sites underlying gastric dysrhythmias. Targeted radiofrequency ablation successfully eliminated these pacemaker sites without disrupting the surrounding conduction capability or tissue structure. Gastric ablation presents a powerful new research tool for modulating gastric electrical activation and may hold therapeutic potential for disorders of gastric function.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nathan Grainger, Kenton M. Sanders, Bernard T. Drumm
Summary: This paper describes a new method for preparing intact segments of mouse PKJ to more accurately study the mechanisms responsible for normal urine transport contractions, overcoming limitations of previous research.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Physiology
Siyuan Fan, Cheng Wang, Kai Huang, Minglu Liang
Summary: The study found that myricanol can inhibit the proliferation and migration of Vascular smooth muscle cells (VSMCs) and suppress intimal hyperplasia. This provides a new strategy for the prevention and treatment of coronary atherosclerosis and post-stent stenosis in the future.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pediatrics
Fatima Safira Alatas, Kouji Masumoto, Kouji Nagata, Antonius Hocky Pudjiadi, Muzal Kadim, Tomoaki Taguchi, Tatsuro Tajiri
Summary: This study evaluated the diagnostic criteria of hypoganglionosis using immunohistochemistry and described its morphological features. The results showed variations in the muscular layers and a reduction in nerve fibers in the intestinal segments of hypoganglionosis patients. Further research on the definition, etiology, diagnosis, and treatment of this disease is needed to improve prognosis.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Kil-yong Lee, Tae Sik Sung, Byoung H. Koh, Seung-Bum Ryoo, Jung Nyeo Chun, Shin-Hye Kim, Kyu Joo Park, Insuk So
Summary: Purines can regulate inhibitory neurotransmission and reduce the contractility of the human colon through PDGFR alpha+ cells.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Neurosciences
C. A. Cobine, E. E. Hannah, M. H. Zhu, H. E. Lyle, J. R. Rock, K. M. Sanders, S. M. Ward, K. D. Keef
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Education, Scientific Disciplines
Benjamin E. Rembetski, Caroline A. Cobine, Bernard T. Drumm
ADVANCES IN PHYSIOLOGY EDUCATION
(2018)
Article
Neurosciences
Bernard T. Drumm, Benjamin E. Rembetski, Caroline A. Cobine, Salah A. Baker, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Kenton M. Sanders
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Physiology
Salah A. Baker, Bernard T. Drumm, Caroline A. Cobine, Kathleen D. Keef, Kenton M. Sanders
FRONTIERS IN PHYSIOLOGY
(2018)
Correction
Education, Scientific Disciplines
B. E. Rembetski, C. A. Cobine, B. T. Drumm
ADVANCES IN PHYSIOLOGY EDUCATION
(2018)
Article
Neurosciences
C. A. Cobine, M. McKechnie, R. J. Brookfield, K. I. Hannigan, K. D. Keef
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Gastroenterology & Hepatology
Caroline A. Cobine, Karen I. Hannigan, Megan McMahon, Emer P. Ni Bhraonain, Salah A. Baker, Kathleen D. Keef
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Multidisciplinary Sciences
Karen Hannigan, Aaron P. Bossey, Holly J. L. Foulkes, Bernard T. Drumm, Salah A. Baker, Sean M. Ward, Kenton M. Sanders, Kathleen D. Keef, Caroline A. Cobine
SCIENTIFIC REPORTS
(2020)
Article
Biology
Salah A. Baker, Wesley A. Leigh, Guillermo Del Valle, Inigo F. De Yturriaga, Sean M. Ward, Caroline A. Cobine, Bernard T. Drumm, Kenton M. Sanders
Summary: Interstitial cells of Cajal (ICC) produce pacemaker activity that is responsible for rhythmic contractions in colon, while ICC along the submucosal border (ICC-SM) contribute to more complex patterns of colonic motility. Our study demonstrates how ICC-SM exhibit rhythmic firing of Ca2+ transients, which play a crucial role in driving smooth muscle activity and overall colonic contractions. This intricate process is organized and dependent on specific Ca2+ channels, highlighting the complexity of colonic pacemaker ICC-SM function.
Editorial Material
Medicine, General & Internal
Benjamin L. Bosse, Victoria J. Palacios, Dustin W. Dutcher, Emily J. Etter, Peter C. Lim, Caroline A. Cobine, Gillian L. Moritz
Summary: Variations in vascular anatomy are important for surgeons in order to reduce the risk of complications during surgeries and improve patient outcomes. This article focuses on the obturator artery (OA) and highlights its irregular branching pattern and potential vulnerability during intrapelvic surgeries. The first image of an unconventional nutrient artery arising from the OA is presented, emphasizing its significance in specific procedures.
Meeting Abstract
Gastroenterology & Hepatology
Bernard T. Drumm, Karen I. Hannigan, Caroline A. Cobine, Kenton M. Sanders
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Bernard T. Drumm, Caroline A. Cobine, Kenton M. Sanders
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Karen I. Hannigan, Kathleen D. Keef, Caroline A. Cobine
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
C. Cobine, K. Hannigan, M. McMahon, E. Ni Bhraonain, K. Keef
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)