Review
Biochemistry & Molecular Biology
Ankita Durge, Isha Sharma, Rashmi Santosh Tupe
Summary: The glycation of biomolecules is a major factor in diabetic nephropathy and end-stage kidney disease. Advances in noncoding RNA research, particularly the long noncoding RNAs (lncRNAs), have provided new insights into potential therapies for glycation-related conditions. However, there are still methodological constraints in the study of lncRNAs. This review discusses the role of lncRNAs in glycation and the possible use of lncRNA-based therapeutics.
Review
Endocrinology & Metabolism
Viviana Casagrande, Massimo Federici, Rossella Menghini
Summary: Diabetic kidney disease is characterized by albuminuria, glomerulosclerosis and progressive loss of renal function. Loss of TIMP3 in the kidney is a hallmark of diabetic nephropathy, while noncoding RNA also plays a significant role in its progression.
ACTA DIABETOLOGICA
(2021)
Review
Endocrinology & Metabolism
Wenguang Chang, Mengyang Li, Lin Song, Suo Miao, Wanpeng Yu, Jianxun Wang
Summary: This article reviews the role of small extracellular vesicles (sEVs) and noncoding RNAs in diabetes and its complications. Noncoding RNA sorting into sEVs is selective, and the function of sEVs varies according to their tissue origin. Understanding the roles of sEVs from different tissues is important for studying their molecular mechanisms and applying them as therapeutic agents for diabetes treatment.
MOLECULAR METABOLISM
(2022)
Review
Urology & Nephrology
Juan D. Coellar, Jianyin Long, Farhad R. Danesh
Summary: Recent advances in large-scale RNA sequencing and genome-wide profiling projects have identified a diverse group of RNAs known as long noncoding RNAs (lncRNAs), which play important roles in various biological processes. Their aberrant expression has been associated with human pathologies, including kidney diseases, suggesting that lncRNAs could serve as potential therapeutic targets. Further research is needed to fully understand the functionality of lncRNAs and their impact on kidney diseases.
Review
Immunology
Saeedeh Salehi, Shima Afzali, Abbas Shahi, Ali Akbar Amirzargar, Yaser Mansoori
Summary: Organ transplantation is the preferred treatment for end-stage organ diseases, but allograft rejection remains a major obstacle to long-term survival. Long noncoding RNAs (lncRNAs) have been proposed as potential targets for prediction, prognosis, diagnosis, and treatment of graft rejection. Noninvasive predictive biomarkers hold promise to overcome the limitations of traditional tissue biopsy. This review provides a comprehensive overview of lncRNAs and their role in facilitating the diagnosis, prognosis, and prediction of graft rejection, and suggests therapeutic choices after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Elzbieta Wanowska, Klaudia Samorowska, Michal Wojciech Szczesniak
Summary: Breast carcinogenesis involves genetic and epigenetic changes. Dysregulated epigenetic changes in breast cancer are accompanied by epitranscriptomic changes within RNA molecules. Long noncoding RNAs (lncRNAs) participate in various aspects of breast cancer biology and hold potential as biomarkers and therapeutic targets. However, the medical application of lncRNAs still faces challenges.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ghulam Mohammad, Renu A. Kowluru
Summary: Diabetes damages retinal mitochondria, leading to degenerative capillaries. Long noncoding RNAs like LncMALAT1 and LncNEAT1 play a crucial role in this process, influencing mitochondrial homeostasis and protecting mitochondrial structural and genomic integrity.
Article
Plant Sciences
Ning Li, Tongtong Liu, Feng Guo, Jinwen Yang, Yugang Shi, Shuguang Wang, Daizhen Sun
Summary: This study identified lncRNAs, miRNAs, and genes related to drought stress in wheat through whole-transcriptome sequencing and explored their regulatory modules. The results revealed the potential role of these regulatory modules in wheat drought tolerance.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Binyuan Jiang, Yeqin Yuan, Ting Yi, Wei Dang
Summary: Antisense long noncoding RNA (as-lncRNA) is a reverse transcription product that is partially or completely complementary to the corresponding sense protein-coding or noncoding genes. As-lncRNAs, also known as natural antisense transcripts (NATs), can regulate the expression of adjacent sense genes through various mechanisms, influencing cellular activities and participating in the development of various tumors. This study aims to explore the functional roles of as-lncRNAs in cis-regulating protein-coding sense genes and provide a theoretical basis for lncRNA-targeted tumor therapy by comprehensively understanding the occurrence and development of malignant tumors.
Review
Immunology
Hai-Di Li, Yong-Ke You, Bao-Yi Shao, Wei-Feng Wu, Yi-Fan Wang, Jian-Bo Guo, Xiao-Ming Meng, Haiyong Chen
Summary: Diabetic nephropathy is the most common chronic kidney disease, and the activation and transition of resident macrophages play a crucial role in causing renal inflammation and fibrosis. Inhibiting macrophage activation and macrophage-cell interactions may be a promising approach to attenuate diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitham G. Abo-Al-Ela
Summary: ncRNAs play crucial roles in regulating and controlling cellular processes and trafficking pathways, with lncRNAs having more diverse regulatory functions compared to microRNAs. Studies in fish have highlighted the potential of harnessing these RNA types to further understand biology and utilize technologies such as RNA interference and microRNA delivery for applications in aquaculture productivity, fish health, and overall understanding of fish biology.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Oncology
Yi-Chun Cheng, Li-Yu Su, Li-Han Chen, Tzu-Pin Lu, Eric Y. Chuang, Mong-Hsun Tsai, Li-Ling Chuang, Liang-Chuan Lai
Summary: This study identified a novel mitochondria-encoded lncRNA, MTORT1, which functions as a tumor suppressor by regulating proliferation and migration in breast cancer cells. MTORT1 acts as a sponge for miR-26a-5p, leading to upregulation of target genes CREB1 and STK4. These findings suggest that MTORT1 may serve as a potential therapeutic target to inhibit breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Qimei Luo, Xi Xia, Qingqing Luo, Yue Qiu, Lan Dong, Chen Zhao, Fenfen Peng, Jing Yu, Fengxian Huang, Feng He
Summary: This study investigates the role and mechanism of lncRNA MEG3-205 in renal inflammation and fibrosis in diabetic nephropathy (DN). The results show that lncRNA MEG3-205 is significantly upregulated in renal tissues of DN patients and in mesangial cells treated with advanced glycation end products (AGEs). Overexpression of lncRNA MEG3-205 promotes the secretion of pro-inflammatory cytokines and synthesis of extracellular matrix proteins. It is also found that lncRNA MEG3-205 can act as a competing endogenous RNA by binding with let-7a to regulate MyD88 expression. Knockdown of lncRNA MEG3-205 alleviates albuminuria and attenuates renal inflammation and fibrosis in DN.
Article
Medicine, Research & Experimental
Yuxi Wu, Xiaoying Wu, Jiahuan Wang, Sifan Chen, Hongxing Chen, Jing Liu, Tingting Zeng, Mengdie Hu, Ying Liang, Kan Sun, Chuan Yang, Li Yan, Meng Ren
Summary: The enrichment of long noncoding RNA upregulated in diabetic skin (lnc-URIDS) in fibroblast-derived extracellular vesicles (Fib-EVs) was induced by high glucose, facilitating the transfer of lnc-URIDS to primary rat epidermal keratinocytes and increasing the expression of matrix metalloproteinase-9. Mechanistically, lnc-URIDS binding to YTH domain family protein-2 enhanced its degradation in the lysosomes, resulting in increased translational activity of matrix metalloproteinase-9 mRNA and ultimately leading to collagen degradation for diabetic wound healing.
LABORATORY INVESTIGATION
(2023)
Review
Virology
Sasidharanpillai Sabeena
Summary: This review discusses the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancer. The existing studies on microRNA signatures in body fluids and cervical cancer tissues lack consistency and lack validated assays. The precise evaluation of immune-associated long noncoding RNA signatures in clinical samples is necessary. Research on the safe delivery methods, toxicities, and side effects of lncRNAs to tumor tissues is needed. Prospective studies on the diagnostic and prognostic roles of circulating lncRNAs and Piwil RNAs in cervical cancer cases are crucial. Comprehensive research is required for the clinical application of lncRNA-based biomarkers, as the impact of noncoding transcripts on molecular pathways is complex. Standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are essential.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yan Li, Jiawen Wang, Chunyan Huang, Meng Shen, Huakui Zhan, Keyang Xu
CELL AND BIOSCIENCE
(2020)
Review
Andrology
Sixiang Chen, Xiaoping Sun, Suliu Wu, Jing Jiang, Chenfeng Zhu, Kechen Xu, Keyang Xu
Article
Biotechnology & Applied Microbiology
Shourong Liu, Ruihong Guo, Xiaoli Hou, Yue Zhang, Xiawei Jiang, Tiantian Wang, Xiaoyu Wu, Keyang Xu, Xiaoping Pan, Liang Qiao
Article
Endocrinology & Metabolism
Yan Li, Lei Wang, Bojun Xu, Liangbin Zhao, Li Li, Keyang Xu, Anqi Tang, Shasha Zhou, Lu Song, Xiao Zhang, Huakui Zhan
Summary: This study explored the therapeutic mechanisms of Cordyceps sinensis in diabetic nephropathy (DN) through network pharmacology analysis. Seven active ingredients were identified in Cordyceps, with potential therapeutic targets such as TNF, MAPK1, EGFR, ACE, and CASP3. Gene Ontology and KEGG pathway analyses showed that Cordyceps primarily affects inflammatory response, apoptosis, oxidative stress, and insulin resistance in treating DN.
JOURNAL OF DIABETES RESEARCH
(2021)
Review
Oncology
L. Zhu, L. Zhao, Q. Wang, S. Zhong, X. Guo, Y. Zhu, J. Bao, K. Xu, S. Liu
Summary: miRNAs are small non-coding ribonucleic acids that play key roles in cancer development and can be encapsulated in exosomes released into the circulatory system. Circulating exosome-derived miRNAs have the potential to replace conventional biomarkers for early cancer diagnosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Cell Biology
Xianjing Hu, Sarwat Fatima, Minting Chen, Keyang Xu, Chunhua Huang, Rui-Hong Gong, Tao Su, Hoi Leong Xavier Wong, Zhaoxiang Bian, Hiu Yee Kwan
Summary: The study identified the master regulator TLR4 in CRC growth under high-fat diet, showing that palmitic acid and TLR4 play key roles in promoting cancer growth. Furthermore, palmitic acid regulates TLR4 expression in a PU.1-dependent manner, and TLR4 controls cancer metabolism to enhance CRC growth under HFD conditions.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Bojun Xu, Lei Wang, Huakui Zhan, Liangbin Zhao, Yuehan Wang, Meng Shen, Keyang Xu, Li Li, Xu Luo, Shasha Zhou, Anqi Tang, Gang Liu, Lu Song, Yan Li
Summary: Novel biomarkers for early diagnosis and targeted treatment of diabetic nephropathy were identified through bioinformatics analysis.
JOURNAL OF DIABETES RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Hiu Yee Kwan, Minting Chen, Keyang Xu, Baisen Chen
Summary: This article critically reviews the impact of obesity on the exosomal cargo contents and the biogenesis of adipocyte-derived exosomes. It also discusses the differences in exosomal contents in different adipose depots, as well as the impact of obesity on exosomes derived from stromal vascular fraction components. The review also touches upon the development and potential application of exosome-based therapy for obesity and its comorbidities.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Zhe Wen Zhou, Wei Zheng, Zheng Xiang, Cun Si Ye, Qiao Qiao Yin, Shou Hao Wang, Cheng An Xu, Wen Hao Wu, Tian Chen Hui, Qing Qing Wu, Ling Yun Zhao, Hong Ying Pan, Ke Yang Xu
Summary: Exosomes, as a crucial intercellular communication method, participate in the development of liver diseases by carrying nucleic acids, proteins, and other substances. Exosome-derived ncRNAs have significant potential and clinical implications in the diagnosis and treatment of liver diseases.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Wei Zheng, Guo-Liang Shen, Ke-Yang Xu, Qiao-Qiao Yin, Tian-Chen Hui, Zhe-Wen Zhou, Cheng-An Xu, Shou-Hao Wang, Wen-Hao Wu, Ling-Fei Shi, Hong-Ying Pan
Summary: Lnc524369 is significantly upregulated in liver cancer cells and human HCC tissues, and its overexpression is associated with the proliferation, migration, and invasion of liver cancer cells. YWHAZ and RAF1 proteins, as well as YWHAZ mRNA, are overexpressed in liver cancer, and their overexpression can be attenuated by Lnc524369 overexpression. Lnc524369 and its downstream target YWHAZ and RAF1 are negatively associated with overall survival time.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Plant Sciences
Lin An, Mi Zhang, Yuefang Lin, Ting Jiang, Keyang Xu, Shilin Xiao, Liming Cai, Hiu Yee Kwan, Zhongqiu Liu, Tao Su
Summary: This study suggests for the first time that LAL is a novel biomarker for liver fibrosis, and morroniside exerts its anti-liver fibrosis effects by targeting GATA3 and LAL.
Article
Biochemistry & Molecular Biology
Minting Chen, Fan Zhang, Baisen Chen, Condon Lau, Keyang Xu, Tiejun Tong, Chuying Huo, Quanbin Han, Tao Su, Hiu Yee Kwan
Summary: Obesity affects the cargo packaging of adipocyte-derived exosomes. Different adipose tissues have different genetic makeup, resulting in different protein profiles of exosomes under obesity conditions, which in turn influences the pathophysiological conditions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xueying Fan, Mingjing Meng, Baoting Li, Hui Chen, Jincheng Tan, Keyang Xu, Shilin Xiao, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su
Summary: This study found that the interaction between colorectal cancer cells and hepatic stellate cells, as well as the transformation of hepatic stellate cells into carcinoma-associated fibroblasts, further promoted the development of colorectal cancer. Furthermore, the critical signaling molecule involved in these processes was discovered. Brevelin A was shown to inhibit colorectal liver metastasis through the VEGF-IL6-STAT3 axis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhong-Han Lou, Ke-Yang Xu, Liang Qiao, Xiao-Qian Su, Yuan Ou-Yang, Liang-Bin Miao, Fang Liu, Yi Wang, Ai Fu, Xian-Hua Ren, Jing-Song Huang, Zhao-Yi Li, Jian-Feng Bao
Summary: This study investigated the potential application of three long noncoding RNAs (HOTAIR, BRM, and ICR) in hepatocellular carcinoma (HCC). The results showed that serum levels of these lncRNAs were associated with the occurrence and prognosis of HCC, and correlated with clinical indicators. The combination of these lncRNAs with alpha-fetoprotein (AFP) improved the diagnostic accuracy for HCC.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
