Article
Public, Environmental & Occupational Health
Aino K. Rantala, German Tapia, Maria C. Magnus, Lars C. Stene, Jouni J. K. Jaakkola, Ketil Stordal, Oystein Karlstad, Wenche Nystad
Summary: Maternal antibiotic use and infections during pregnancy are associated with an increased risk of offspring asthma. The use of antibiotics during pregnancy is linked to asthma at the age of 7, while maternal infections during pregnancy are associated with asthma at both 7 and 13 years old. However, the effect of antibiotics may reflect a shared underlying susceptibility rather than a direct cause.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
Luke E. Grzeskowiak, Moni R. Saha, Hedvig Nordeng, Eivind Ystrom, Lisa H. Amir
Summary: The use of antidepressants in late pregnancy is associated with a reduced likelihood of breastfeeding initiation but not breastfeeding duration or exclusivity. In contrast, initiating or restarting antidepressants postpartum is associated with poorer breastfeeding outcomes. Women taking antidepressants and women with a mental disorder may benefit from additional education and support to improve breastfeeding rates and promote maternal and infant health and wellbeing.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Nutrition & Dietetics
Dominika Modzelewska, Pol Sole-Navais, Anne Lise Brantsaeter, Christopher Flatley, Anders Elfvin, Helle Margrete Meltzer, Verena Sengpiel, Malin Barman, Bo Jacobsson
Summary: Proper intake of selenium during pregnancy is crucial for neonatal health, with low dietary intake associated with increased risk of neonatal morbidity and mortality. Following dietary recommendations may help ensure adequate selenium supply for a healthy pregnancy and optimal fetal development.
Article
Nutrition & Dietetics
Anna Amberntsson, Linnea Barebring, Anna Winkvist, Lauren Lissner, Helle Margrete Meltzer, Anne Lise Brantsaeter, Eleni Papadopoulou, Hanna Augustin
Summary: There is a moderate to high prevalence of insufficient vitamin D status among pregnant women in Norway. Vitamin D intake is mainly from supplements, fish, and fortified margarine. Factors associated with higher 25OHD concentrations include season, use of solarium, income, weight, age, food intake, smoking during pregnancy, education, and energy intake. Adequate vitamin D intake can achieve sufficient 25OHD concentrations during months without dermal synthesis of vitamin D.
FRONTIERS IN NUTRITION
(2023)
Article
Obstetrics & Gynecology
Olga Basso, Maria C. Magnus, Lise A. Arge, Siri E. Haberg
Summary: The study suggests that daughters born to young mothers or older fathers may have slightly lower fecundability, highlighting the potential impact of parental age on female fertility.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Linn K. L. Oyri, Jacob J. J. Christensen, Sylvain Sebert, Magne Thoresen, Trond M. M. Michelsen, Stine M. M. Ulven, Hilde K. K. Brekke, Kjetil Retterstol, Anne Lise Brantsaeter, Per Magnus, Martin P. P. Bogsrud, Kirsten B. B. Holven
Summary: This study found that maternal total cholesterol and high-density lipoprotein cholesterol levels were associated with offspring weight gain during childhood, indicating the importance of lipid metabolism during pregnancy in influencing the growth of offspring.
Article
Nutrition & Dietetics
Kristine Vejrup, Elisabet R. Hillesund, Neha Agnihotri, Christine Helle, Nina C. Overby
Summary: There is increasing concern about population mental health. This study found that a healthy and sustainable antenatal and early childhood diet was associated with lower depression and anxiety symptoms at age 8, as well as higher extraversion, benevolence, conscientiousness, and imagination. These findings suggest that both maternal pregnancy diet and early childhood diet may have an impact on various aspects of child mental health.
Article
Obstetrics & Gynecology
Alvaro Hernaez, Tormod Rogne, Karoline H. Skara, Siri E. Haberg, Christian M. Page, Abigail Fraser, Stephen Burgess, Deborah A. Lawlor, Maria Christine Magnus
Summary: The study found a J-shaped relationship between BMI and subfertility, with individuals with low BMI potentially having an increased risk of subfertility. BMI values between 20 and 25 kg/m(2) may be optimal for minimal risk of subfertility.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Linn K. L. Oyri, Martin P. Bogsrud, Jacob J. Christensen, Stine M. Ulven, Anne Lise Brantsaeter, Kjetil Retterstol, Hilde K. Brekke, Trond M. Michelsen, Tore Henriksen, Jeanine E. Roeters van Lennep, Per Magnus, Marit B. Veierod, Kirsten B. Holven
Summary: The study shows that there are associations between maternal and paternal peri-pregnancy lipid and metabolic profile and newborn cord blood lipid and metabolic profile, which may potentially affect the offspring's long-term cardiovascular disease risk.
Article
Nutrition & Dietetics
Sofia Berglundh, Margarete Vollrath, Anne Lise Brantsaeter, Ragnhild Brandlistuen, Pol Sole-Navais, Bo Jacobsson, Verena Sengpiel
Summary: The study suggests that low to moderate caffeine consumption during pregnancy is not associated with any persistent adverse effects on the child's neurodevelopment up to 8 years of age, although some previous studies indicate an association between high caffeine consumption and negative neurodevelopment outcomes.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Jake E. Thistle, Amanda Ramos, Kyle R. Roell, Giehae Choi, Cherrel K. Manley, Amber M. Hall, Gro D. Villanger, Enrique Cequier, Amrit K. Sakhi, Cathrine Thomsen, Pal Zeiner, Ted Reichborn-Kjennerud, Kristin R. Overgaard, Amy Herring, Heidi Aase, Stephanie M. Engel
Summary: This study aims to evaluate the association between prenatal exposure to organophosphorus pesticides (OPPs) and executive function (EF) in preschool-aged children. The results show that prenatal OPP metabolite concentrations are associated with worse parent and teacher ratings of emotional control, inhibition, and working memory. The study also explores the interaction between variant alleles in OPP metabolism genes and OPP exposure. These findings are important for understanding the impact of OPPs on neurodevelopment in children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Liv Grimstvedt Kvalvik, Kari Klungsoyr, Jannicke Igland, Ida Henriette Caspersen, Anne Lise Brantsaeter, Berit Skretting Solberg, Catharina Hartman, Lizanne Johanna Stephanie Schweren, Henrik Larsson, Lin Li, Ingeborg Forthun, Stefan Johansson, Alejandro Arias Vasquez, Jan Haavik
Summary: This study investigated the association between maternal intake of sweetened carbonated beverages (SCB) during pregnancy and ADHD symptoms in the offspring. The findings suggest a weak positive relationship between prenatal exposure to SCB and offspring ADHD.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Amber M. Hall, Amanda M. Ramos, Samantha SM. Drover, Giehae Choi, Alexander P. Keil, David B. Richardson, Chantel L. Martin, Andrew F. Olshan, Gro D. Villanger, Ted Reichborn-Kjennerud, Pal Zeiner, Kristin R. overgaard, Amrit K. Sakhi, Cathrine Thomsen, Heidi Aase, Stephanie M. Engel
Summary: This study found a modest increased odds of preschool ADHD with higher DnBP and BDCIPP exposure.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Nutrition & Dietetics
Neha Agnihotri, Elisabet Rudjord Hillesund, Elling Bere, Andrew Keith Wills, Anne Lise Brantsaeter, Nina Cecilie Overby
Summary: This study aimed to develop and describe child age-specific New Nordic Diet (NND) scores based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN). The developed scores, ranging from 0 to 6 at 6 months and 3 years and from 0 to 9 at 18 months and 7 years, will be used to examine associations with childhood overweight and cognitive and mental development in future studies.
MATERNAL AND CHILD NUTRITION
(2021)
Article
Obstetrics & Gynecology
Lise A. Arge, Siri E. Haberg, Allen J. Wilcox, Oyvind Naess, Olga Basso, Maria C. Magnus
Summary: History of miscarriage is associated with decreased fecundability, while subfertility is linked to higher risk of miscarriage in subsequent pregnancies.
HUMAN REPRODUCTION
(2022)
Editorial Material
Pediatrics
Paula L. Hedley, Marie Baekvad-Hansen, Gitte Hedermann, Henrik Hjalgrim, David M. Hougaard, Mads Melbye, Morten Breindahl, Lone Krebs, Anders Hviid, Ulrik Lausten-Thomsen, Michael Christiansen
Article
Psychiatry
Marie-Louise H. Rasmussen, Gry J. Poulsen, Poul Videbech, Jan Wohlfahrt, Mads Melbye
Summary: Previous research suggests that women with endocrine disease may have an increased risk of postpartum depression (PPD) due to their sensitivity to hormonal fluctuations. This nationwide cohort study aimed to investigate the association between endocrine disease history and PPD risk. The study included 888,989 deliveries and found that women with endocrine disease history had a 42% higher risk of PPD compared to those without. Interestingly, women with a history of PPD also had a 50% higher risk of endocrine disease. These findings highlight the importance of monitoring and providing support for pregnant women with endocrine disease to prevent and address PPD.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Arvid Engstroem, Viktor Wintzell, Mads Melbye, Anders Hviid, Bjoern Eliasson, Soffia Gudbjoernsdottir, Kristian Hveem, Christian Jonasson, Henrik Svanstroem, Bjoern Pasternak, Peter Ueda
Summary: Using nationwide registers data from Denmark, Norway, and Sweden, this study demonstrates an association between the use of SGLT2 inhibitors and the risk of new-onset atrial fibrillation. Compared to GLP-1 receptor agonists, SGLT2 inhibitors are associated with a modestly reduced risk of new-onset atrial fibrillation.
Article
Peripheral Vascular Disease
Ester Kringeland, Eva Gerdts, Arve Ulvik, Grethe S. Tell, Jannicke Igland, Teresa R. Haugsgjerd, Per Magne Ueland, Helga Midtbo
Summary: The aim of this study was to examine the associations between sex-specific circulating markers of inflammation and blood pressure in midlife. The results showed that higher levels of hs-CRP were significantly associated with higher systolic and diastolic blood pressure in women, but not in men. Additionally, higher levels of neopterin were associated with higher diastolic blood pressure in women, and higher PAr index was associated with higher blood pressure in both men and women.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Medicine, General & Internal
Indu Dhar, Vegard Lysne, Arve Ulvik, Gard F. T. Svingen, Eva R. Pedersen, Espen O. Bjornestad, Thomas Olsen, Robert Borsholm, Johnny Laupsa-Borge, Per M. Ueland, Grethe S. Tell, Rolf K. Berge, Gunnar Mellgren, Kaare H. Bonaa, Ottar K. Nygard
Summary: In this study, elevated plasma MMA levels were found to be associated with increased risk of acute myocardial infarction (AMI) and mortality in patients with suspected or verified coronary heart disease (CHD). This finding provides new insights for the prevention and treatment of cardiovascular diseases.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Miriam Kristine Sandvik, Kari Sorland, Elisabeth Leirgul, Ingrid Gurvin Rekeland, Christina Saersten Stavland, Olav Mella, Oystein Fluge
Summary: This study investigated the endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and found that these patients had impaired macro- and microvascular endothelial function. This suggests that vascular homeostasis may play a role in the clinical presentation of this disease.
Article
Medicine, General & Internal
Anders Husby, Jan Wohlfahrt, Mads Melbye
Summary: A Danish study found that there is a link between gestational age at birth and cognitive outcomes. Children born before 34 weeks showed lower academic performance in language and mathematics, while those born between 34-39 weeks did not differ significantly from full-term babies. This study provides important insights into the development of preterm babies.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Peripheral Vascular Disease
Annabel Eide Ohldieck, Ester Kringeland, Helga Midtbo, Grethe S. Tell, Eva Gerdts
Summary: This study aimed to identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. The results showed that high-normal blood pressure in midlife was a significantly stronger risk factor for the development of hypertension in women than in men during follow-up, independent of body mass index.
Article
Endocrinology & Metabolism
Rohina Noorzae, Thor Gronborg Junker, Anders Peter Hviid, Jan Wohlfahrt, Sjurdur Frodi Olsen
Summary: In this study, a prospective, register-based analysis was conducted to investigate the association between SARS-CoV-2 infection and subsequent risk of type 1 diabetes in children in Denmark. The results showed no increased risk of first-time diagnosis of type 1 diabetes in children 30 days or more after a positive SARS-CoV-2 test.
Article
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson
Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.
Article
Multidisciplinary Sciences
Victoria de Knegt, Paula Hedley, Gitte N. Hedermann, Casper Wilstrup, Marie Baekvad-Hansen, Ida Thagaard, Henrik M. Hjalgrim, Jorgen Kanters, Mads Melbye, David Hougaard, Anders Hviid, Lone Krebs, Morten Breindahl, Ulrik Lausten-Thomsen, Michael Christiansen
Summary: A nationwide COVID-19 lockdown in Denmark resulted in a reduced prevalence of extremely preterm or extremely low birthweight births. This study aimed to investigate the impact of the lockdown on term birthweights in Denmark. The findings showed a small but significant increase in birthweight during the lockdown period, primarily driven by an increase in birthweight in gestational weeks 40 and 41. Additionally, the proportion of infants with a large-for-gestational-age (LGA) increased during the lockdown.
Article
Nutrition & Dietetics
Agnetha Linn Rostgaard-Hansen, Susanne Rosthoj, Carl Brunius, Sjurdur Frodi Olsen, Anne Ahrendt Bjerregaard, Janet Elisabeth Cade, Anne Tjonneland, Rikard Landberg, Jytte Halkjaer
Summary: The food frequency questionnaire (FFQ) is a commonly used method in nutritional epidemiology to assess an individual's habitual dietary intake. This study evaluated the validity and reproducibility of the FFQ used in the DCH-NG cohort. Results showed that the FFQ provided satisfactory rankings of energy, nutrient, and food group intakes, making it suitable for epidemiological studies investigating diet and disease outcomes.
Article
Medicine, General & Internal
Giulia Corn, Mads Melbye, Mark A. Hlatky, Jan Wohlfahrt, Marie Lund
Summary: A study found that low to moderate-intensity statins are more effective in reducing LDL-C levels in older adults compared to younger individuals, suggesting that they may be a more appealing initial treatment option for the elderly.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Niklas Worm Andersson, Giulia Corn, Tine Lovso Dohlmann, Mads Melbye, Jan Wohlfahrt, Marie Lund
Summary: Reducing LDL cholesterol through lipid-lowering therapy has been shown to effectively lower the risk of cardiovascular disease in individuals under 70 years old, but the evidence is less clear for older individuals. This study compared the clinical effectiveness of lowering LDL cholesterol through lipid-lowering therapy for primary prevention of cardiovascular disease in older and younger individuals, and found that the risk reduction effect was similar between the two age groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Obstetrics & Gynecology
Anders Einum, Philip von Brandis, Elisabeth Leirgul, Cathrine Ebbing
Summary: This article presents an uncommon case of a parous woman with a monochorionic twin pregnancy. One of the twins developed hydrops due to a supraventricular tachyarrhythmia, posing a severe threat to both twins' lives. The study utilizes longitudinal Doppler ultrasound to assess the hemodynamic effects of the arrhythmia and the efficacy of transplacental treatment with an antiarrhythmic medication (flecainide). The findings also demonstrate how the arrhythmia and the subsequent conversion to normal rhythm influence umbilical and liver circulation in the fetus.
JOURNAL OF FETAL MEDICINE
(2023)