Article
Gastroenterology & Hepatology
Wen-Jie Xia, Meng-Lu Xu, Xiao-Jing Yu, Meng-Meng Du, Xu-Hui Li, Tao Yang, Lu Li, Ying Li, Kai B. Kang, Qing Su, Jia-Xi Xu, Xiao-Lian Shi, Xiao-Min Wang, Hong-Bao Li, Yu-Ming Kang
Summary: Exercise has been shown to significantly decrease systolic blood pressure in spontaneously hypertensive rats, with an increase in microbial diversity, enrichment of beneficial bacterial genera, and reduction in activated microglia and neuroinflammation observed. These findings suggest that exercise can improve gut-brain axis, leading to beneficial effects on hypertension.
Article
Chemistry, Multidisciplinary
Moaz M. Abdou, Dewen Dong, Paul M. O'Neill, Eric Amigues, Magdalini Matziari
Summary: In drug discovery, molecular modification of lead molecules is crucial for drug development. This study reports the synthesis of a novel RXPA380-proline hybrid, which showed lower inhibition of ACE compared to the parent compound RXPA380.
Article
Nutrition & Dietetics
Francisca Isabel Bravo, Enrique Calvo, Rafael A. Lopez-Villalba, Cristina Torres-Fuentes, Begona Muguerza, Almudena Garcia-Ruiz, Diego Morales
Summary: Hypertension is a major contributor to premature deaths worldwide and can be prevented by managing cardiovascular diseases. Protein hydrolysates containing antihypertensive peptides derived from agri-food industry byproducts, such as chicken slaughterhouse byproducts, have shown potential in lowering blood pressure. These byproducts, including blood, bones, skins, and chicken feet, have been used to produce protein hydrolysates with angiotensin-converting enzyme (ACE) inhibitory activity. Mechanisms underlying their effects include increased levels of antioxidant compounds, reduced ACE activity, and improved endothelial dysfunction associated with hypertension. However, further clinical studies are needed to confirm these antihypertensive properties and enhance the value of these byproducts in the circular economy model of slaughterhouses.
Article
Pharmacology & Pharmacy
Shuwei Wang, Qi Han, Zhaolan Wei, Yunyi Wang, Lingfu Deng, Mingqing Chen
Summary: The study found that exposure to formaldehyde can cause an increase in blood pressure and damage to the heart, aortic vessels, and kidneys. By blocking the ACE/AT1R axis using an ACE inhibitor, the increase in blood pressure and pathological changes caused by formaldehyde exposure can be alleviated. This result improves our understanding of the impact of formaldehyde exposure on the development of hypertension.
Article
Food Science & Technology
Vijayan Raji, Chitra Loganathan, Thiyagarajan Ramesh, Palvannan Thayumanavan
Summary: This study aimed to understand the protective effect of fucoxanthin purified from brown algae against diabetes with hypertension. The results showed that fucoxanthin significantly reduced blood pressure and ACE activity, alleviated hyperglycemia, normalized enzyme activity and lipid profile, and ameliorated oxidative stress in rat models of diabetes with hypertension.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Food Science & Technology
Yu Pei, Shengxuan Cai, Bomi Ryu, Chunxia Zhou, Pengzhi Hong, Zhong-Ji Qian
Summary: This research evaluated the protective effects of polypeptides from microalgae on endothelial injury and found that they can block inflammation and apoptosis, thereby alleviating endothelial damage. Additionally, these polypeptides showed an antihypertensive effect and can potentially be used as a component in functional foods for preventing cardiovascular diseases.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Patrick Blondin Tsafack, Chen Li, Apollinaire Tsopmo
Summary: The gut microbiota plays an important role in human health, and this review focuses on its link with hypertension. The analysis shows that food peptides can prevent gut dysbiosis and display antihypertensive effects by positively affecting the production of beneficial metabolites. However, there is a lack of human studies in this area.
Review
Pharmacology & Pharmacy
Young Nam Kwon, Yong-Jae Kim
Summary: The interaction between the gut-brain axis and the gut microbiota has significant implications for hypertension development. Understanding the mechanism by which the gut-brain-microbiota regulates blood pressure can lead to novel treatment targets.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Editorial Material
Microbiology
Melanie G. Gareau
Summary: The gut microbiota plays a significant role in the development and severity of various diseases, including those affecting the central nervous system. The microbiota-gut-brain axis enables communication between gut microbes and the brain to regulate behavior. This commentary highlights recent findings on the role of gut microbiota and bacterial metabolites in sepsis-associated encephalopathy using a mouse model.
Review
Immunology
Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li
Summary: Recent investigations suggest that dietary consumption of flavonoids has neuroprotective effects by inhibiting neuroinflammatory and oxidative stress responses. Flavonoids may also shape gut microbiota composition and promote the growth of beneficial bacteria that produce neuroprotective metabolites. By influencing the microbiota-gut-brain axis, flavonoids indirectly improve brain health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci, Michele Ciliberto, Gianandrea Traversi, Georgios Demetrios Kotzalidis, Domenico De Berardis, Lucrezia Laterza, Gabriele Sani, Antonio Gasbarrini, Eleonora Gaetani
Summary: There is increasing interest in the role of intestinal microbiota and autoimmune processes in psychiatric diseases. Altered communication between the microbiota-gut-brain axis may be a cause of psychiatric disorders. This review explores the evidence for the involvement of gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Changes in gut microbiota composition can lead to increased intestinal permeability, resulting in a cytokine storm, systemic inflammation, and immune response. These events can affect neurotransmitter release, alter the hypothalamic-pituitary-adrenal axis, and reduce trophic brain factors. Further research is needed to understand the underlying mechanisms connecting gut microbiota and psychiatric disorders.
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Colin Berry, Andrew J. Morrow, Mario Marzilli, Carl J. Pepine
Summary: Ischemic heart disease is a leading global health issue, with major subtypes including coronary heart disease and vasomotor disorders. Men are more likely to have coronary heart disease, while women are more likely to have vasomotor disorders. The diagnostic accuracy of tests differs for different subtypes, emphasizing the need for personalized clinical management.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Davide Cao, Carl J. Pepine, Roxana Mehran
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Carl J. Pepine, C. Noel Bairey Merz
EUROPEAN HEART JOURNAL
(2023)
Article
Geriatrics & Gerontology
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Ilana J. Bennett, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The perforant path, connecting the entorhinal cortex with the hippocampal formation, deteriorates with age-related cognitive decline. Diffusion-weighted MRI has limitations in quantifying the perforant path integrity, so this study used ultra-high resolution diffusion imaging to investigate its structural connectivity and found that older age and poorer delayed recall are associated with reduced connectivity of the path. The findings suggest that intra-MTL connectivity may serve as new candidate biomarkers for age-related cognitive decline.
NEUROBIOLOGY OF AGING
(2023)
Article
Cardiac & Cardiovascular Systems
Steven M. M. Smith, Almut G. G. Winterstein, Matthew J. J. Gurka, Marta G. G. Walsh, Shailina Keshwani, Anne M. M. Libby, William R. R. Hogan, Carl J. J. Pepine, Rhonda M. M. Cooper-DeHoff
Summary: This study reveals significant variation in initial antihypertensive prescribing among new users, highlighting a gap between current guideline recommendations and real-world implementation in early hypertension care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Judy M. Luu, Pankaj Malhotra, Galen Cook-Wiens, Carl J. Pepine, Eileen M. Handberg, Steven E. Reis, Nathaniel Reichek, Vera Bittner, Janet Wei, Sheryl F. Kelsey, Reddy Sailaja Marpuri, George Sopko, C. Noel Bairey Merz
Review
Peripheral Vascular Disease
Pritam Bardhan, Tao Yang
Summary: The purpose of this study is to review the current literature on the effect of gut microbiota on blood pressure regulation, its interactions with antihypertensive drugs, and the role of sex differences in gut microbiota in the development of hypertension and its treatment. Recent findings suggest that gut microbiota plays a significant role in blood pressure regulation and the etiology of hypertension. It has been proposed that targeting dysbiotic microbiota could be a new therapeutic approach. Additionally, studies have shown the involvement of gut microbiota in the efficacy of antihypertensive drugs and the potential for sex differences in gut microbiota to contribute to sex-specific responses to these drugs.
CURRENT HYPERTENSION REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Scott M. Vouri, Earl J. Morris, Marta Walsh, Jessica Agalliu, Alyssa Dempsey, Leonie Hochleitner, Matthew R. Muschett, Stephan Schmidt, Carl J. Pepine, Steven M. Smith
Summary: This study aimed to comprehensively assess prescribing cascades related to statin medications. The results identified potential prescribing cascades, including laxatives, analgesics, and cephalosporins. These findings are important for reducing the occurrence of prescribing cascades.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Li, Elaine M. Richards, Ramakumar Tummala, Carl J. Pepine, Mohan K. Raizada, Tao Yang
Summary: Hypertension is associated with gut dysbiosis and altered intestinal immunity. Using sorting techniques and gene sequencing, we found significant differences in IgA(+) and IgA(-) bacteria between hypertensive and normotensive rats. We also identified several IgA-coated bacteria that were negatively correlated with various pathways involved in immune response and epithelium development.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
David L. DeRemer, Nam K. Nguyen, Avirup Guha, Faraz S. Ahmad, Rhonda M. Cooper-DeHoff, Carl J. Pepine, Michael G. Fradley, Yan Gong
Summary: This study evaluated the differences in cardiac surveillance among different racial and ethnic groups among survivors of cancer after exposure to anthracycline-based treatment. The study found that African American and Hispanic patients had lower participation rates in cardiac surveillance. These results suggest that healthcare providers need to be aware of social inequities and take measures to ensure recommended cardiac surveillance after anthracycline therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Teja Chakrala, Roshni Prakash, Carlos Valdes, Carl J. J. Pepine, Ellen C. C. Keeley
Summary: Coronary microvascular dysfunction is often unrecognized but has significant clinical implications. Circulating biomarkers can provide valuable information for the diagnosis and management of this condition, reflecting key pathological processes like inflammation, endothelial dysfunction, oxidative stress, coagulation, and others.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Robert F. Hamburger, Yasmeen Taha, Mohammed Ruzieh, James R. Clugston, Eileen M. Handberg, Fred Reifsteck, Matthew W. Martinez, Carl J. Pepine, Katherine M. Edenfield
Summary: This study investigated the effects of intense training on cardiac remodeling in American collegiate football players. The findings showed that training was associated with increases in chamber sizes, left atrial size, and aortic root diameter.
CLINICAL CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Grace Hsin-Min Wang, Earl Morris, Scott M. Vouri, Shailina Keshwani, Stephan Schmidt, Carl J. Pepine, Steven M. Smith
Summary: This study aims to identify modifiable statin characteristics associated with lower risk of prescribing cascades. The results show that compared to low-intensity statins, moderate- or high-intensity statins and the choice of individual statin agents are associated with increased risk of prescribing cascades.
Article
Medicine, General & Internal
Yasmeen K. Taha, Jennifer R. Dungan, Michael T. Weaver, Ke Xu, Eileen M. Handberg, Carl J. Pepine, C. Noel Bairey Merz
Summary: Identifying ischemic heart disease (IHD) in women based on symptoms is challenging, as women are more likely to experience non-cardiac symptoms. More than 50% of women with suspected ischemia have no obstructive coronary disease, leading to impaired outcomes during follow-up. A study aimed to identify symptoms that can predict non-obstructive coronary artery disease (INOCA) in women with clinical evidence of coronary ischemia. The study found that age, left side chest pain, chest discomfort, neck pain, and palpitations had a positive relationship with INOCA, while impending doom and pain in the jaw, left or bilateral arm, and right hand were inversely related to INOCA. The best-fit model accurately predicted INOCA based on age and symptom presentation about 72% of the time.
JOURNAL OF CLINICAL MEDICINE
(2023)