Article
Biochemistry & Molecular Biology
Yeela Talmor-Barkan, Noam Bar, Aviv A. Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K. Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S. Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal
Summary: Multi-omic profiling of patients with coronary artery disease reveals links between alterations in the serum metabolome with genetics, diet, and the microbiome. The study found that these metabolomic alterations are associated with metabolic impairment preceding clinically overt coronary artery disease. The results highlight the importance of understanding risk-factor heterogeneity in coronary artery disease through the serum metabolome.
Article
Physiology
Sandra Gegunde, Amparo Alfonso, Rebeca Alvarino, Nadia Perez-Fuentes, Jeremias Bayon-Lorenzo, Eva Alonso, Raymundo Ocaranza-Sanchez, Rosa Alba Abellas-Sequeiros, Melisa Santas-Alvarez, Mercedes R. Vieytes, Carlos Juanatey-Gonzalez, Luis M. Botana
Summary: This study revealed that serum levels of cyclophilin A and C are elevated in patients with coronary artery disease regardless of the presence of cardiovascular risk factors. On the other hand, cyclophilin B levels are increased in male patients with hypertension, type 2 diabetes, or high glucose levels. All three cyclophilins were significantly correlated with cardiovascular risk factors, with cyclophilin B specifically associated with type 2 diabetes. Multivariate analysis further demonstrated the predictive value of cyclophilin A and C in the presence of coronary artery disease, along with other cardiovascular risk factors. Additionally, high levels of cyclophilin B, combined with hypertension or dyslipidemia, increased the risk of coronary artery disease in male patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tanveer Mir, Mohammed Uddin, Khalid Changal, Waqas Qureshi, Jarrett Weinberger, Javed Wani, Kameswari Maganti, Tanveer Rab, Ehab Eltahawy, Mujeeb Sheikh
Summary: This study aimed to investigate the prevalence, outcomes, and trends of coronary artery aneurysm. Data analysis showed that the prevalence of coronary artery aneurysm was low among coronary angiography-related hospitalizations in the United States from 2012 to 2018, but patients with ACS had higher mortality. Additionally, there was an increasing trend in the prevalence and mortality of coronary artery aneurysm among patients with ACS. These findings suggest the need for further research on CAA-ACS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Surgery
Marie Bodilsen Nielsen, Jonathan Nortoft Dahl, Rasmus Laursen, Bente Jespersen, Per Ivarsen, Simon Winther, Henrik Birn
Summary: Kidney failure is linked to a higher risk of cardiovascular disease and death. This retrospective study examined the relationship between risk factors, coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), major adverse cardiovascular events (MACE), and all-cause mortality in kidney transplant candidates. The presence of multiple risk factors, high CACS, and significant artery stenosis were found to predict MACE and mortality. In a subgroup undergoing both CACS and CTA, these imaging techniques provided additional information for predicting MACE.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Jade Geerlings-Batt, Ashu Gupta, Zhonghua Sun
Summary: This study retrospectively reviewed the coronary computed tomography angiography datasets and CAD risk factor checklists of 250 patients, and found a relationship between narrow RCA-aorta angles and CAD, smoking, and increasing BMI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jona B. Krohn, Y. Nhi Nguyen, Mohammadreza Akhavanpoor, Christian Erbel, Gabriele Domschke, Fabian Linden, Marcus E. Kleber, Graciela Delgado, Winfried Maerz, Hugo A. Katus, Christian A. Gleissner
Summary: We identified four phenotypic subgroups of CAD bearing distinct demographic and biochemical characteristics with differences in prognosis, which may indicate multiple disease entities currently summarized as CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Laurits Juhl Heinsen, Gokulan Pararajasingam, Thomas Rueskov Andersen, Soren Auscher, Hussam Mahmoud Sheta, Helle Precht, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found a high prevalence of HRP in asymptomatic T2D patients, with HRP detection associated with specific patient characteristics. HRP was not correlated with high CACS, as HRP could be found even in patients with zero CACS.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gavin H. C. Richards, Kathryn L. Hong, Michael Y. Henein, Colm Hanratty, Usama Boles
Summary: This article reviews the existing evidence for the pathophysiology of coronary artery ectasia (CAE) in order to help improve detection and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Donald M. Lloyd-Jones, Cora E. Lewis, Pamela J. Schreiner, James M. Shikany, Stephen Sidney, Jared P. Reis
Summary: The CARDIA study began in 1985-1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of cardiovascular health and disease, as well as associations between neighborhood environment, lifestyle behaviors, and biological risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Henrik Bodtker, Flemming Hald Steffensen, Hans Erik Botker, Jesper Moller Jensen, Niels Peter Ronnow Sand, Michael Maeng, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Helle Kanstrup, Ron Blankstein, Michael J. Blaha, Bjarne Linde Norgaard
Summary: In young patients, there is a strong interaction between coronary artery calcium (CAC) and risk factors in predicting obstructive coronary artery disease (CAD) and future coronary heart disease (CHD) risk. Even with the presence of risk factors, a low CAC score can still be a high-risk marker. It is important to assess both risk factors and CAC simultaneously when evaluating risk in young patients.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
David Feldman, Jacqueline Latina, Jana Lovell, Roger S. Blumenthal, Armin Arbab-Zadeh
Summary: The treatment of coronary artery disease focuses on managing symptoms and preventing cardiovascular events. Coronary CTA has emerged as the first line noninvasive imaging modality for evaluating coronary atherosclerosis, improving diagnostic accuracy and patient outcomes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Amir S. Heravi, Di Zhao, Erin D. Michos, Henrique Doria De Vasconcellos, Bharath Ambale-Venkatesh, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, James M. Shikany, Cora E. Lewis, Chiadi E. Ndumele, Eliseo Guallar, Pamela Ouyang, Ron C. Hoogeveen, Joao A. C. Lima, Wendy S. Post, Dhananjay Vaidya
Summary: This study investigated the association between oxidative stress and cardiovascular diseases, finding that female individuals had higher levels of oxidative stress. Furthermore, factors such as higher body mass index, lipid levels, smoking, and lack of physical activity were also associated with higher oxidative stress. This suggests that oxidative stress may play an important role in cardiovascular diseases.
Review
Cardiac & Cardiovascular Systems
Ilana Golub, Suvasini Lakshmanan, Suraj Dahal, Matthew J. Budoff
Summary: CAC is an important factor in determining ASCVD risk, guiding preventive treatments and potentially reducing the number needed to treat for one major cardiac event. The use of CAC in clinical settings and preventative therapy applications may provide cost-effective advantages and improve patient adherence.
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
