Article
Engineering, Biomedical
Yihalem Abebe Alemayehu, Fasih Bintang Ilhami, Abere Habtamu Manayia, Chih-Chia Cheng
Summary: This study successfully designed and synthesized a new mercury-based supramolecular polymer with multifunctional properties, exhibiting selective cytotoxic effects on cancer cells without harming normal cells. The discovery of this "cytotoxicity-concealing" supramolecular system provides a promising strategy to enhance the safety and efficacy of cancer therapy and bioimaging.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Balaram Ghosh, Swati Biswas
Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Jiaqing Lei, Yajing Song, Dan Li, Mengheng Lei, Rui Tan, Yiqing Liu, Hua Zheng
Summary: The study prepared a pH-sensitive drug delivery system based on POPAA as drug carrier for Daunorubicin (DNR), obtaining a charge-reversal prodrug DA-POPAA@imine-DNR through copper-catalyzed click chemistry. The prodrug self-assembled into micelles (M(DNR)) with a mean particle size of about 132 nm, showing enhanced release of DNR at lower pH levels and efficient cytotoxicity against HeLa cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Ziyue Yang, Wei Huang, Lidong Zhang
Summary: By combining photosensitive monomers with hygroscopic monomers, the photosensitivity of polymer materials can be improved with low content of photosensitive moieties. The polymer exhibits multiple responsiveness and has applications in sensing systems, information transmission, and artificial muscles.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Polymer Science
Ji Woo Kim, Hea Ji Kim, Jieun Park, Ji Ae Chae, Hyeong-Woo Song, Eunpyo Choi, Hyungwoo Kim
Summary: This paper describes the design of poly(benzyl ether)-based amphiphiles that can achieve demicellization of polymeric micelles through depolymerization triggered by a specific stimulus. The design concept can be applied to controlled drug release and targeted delivery systems.
Review
Multidisciplinary Sciences
Yingqi Liu, Yunyun Wu, Zhong Luo, Menghuan Li
Summary: Stimuli-responsive nanomaterials have been attracting significant attention in the field of cancer therapy, as they offer the potential to deliver anticancer drugs to tumor sites with precision and on-demand. Supramolecular chemistry, which involves reversible bonding at the molecular and nanoscale levels, has advanced the design of nanotherapeutics with enhanced control and functionality. This review provides a comprehensive summary of non-covalent interaction modes, such as hydrophobic interaction, hydrogel bonding, host-guest interaction, pi-pi stacking, and electrostatic interaction, and discusses their implications for designing stimuli-responsive drug delivery systems to improve spatial, temporal, and dosage precision. The review also highlights current challenges and future opportunities in self-assembly-based stimuli-responsive drug delivery nanotechnologies for cancer therapy.
Article
Polymer Science
Huan-Huan Ding, Mu-Han Zhao, Le Zhai, Jian-Bin Zhen, Le-Yun Sun, Jia-Zhu Chigan, Cheng Chen, Jia-Qi Li, Han Gao, Ke-Wu Yang
Summary: The study shows that the quinine-based quaternized polymer QMTA has bactericidal effects on both drug-resistant Gram-negative E. coli and non-resistant Gram-positive bacteria B. subtilis, with a MIC value of 2 mu g mL(-1) and a bactericidal rate of over 95%. Additionally, bacteria treated with QMTA did not develop resistance even after multiple passages, and the polymer showed low toxicity at a dose of 128 mu g mL(-1). This provides a potential approach to develop new bactericidal reagent/polymer materials without resistance.
Review
Pharmacology & Pharmacy
Kannan Badri Narayanan, Rakesh Bhaskar, Sung Soo Han
Summary: Nanogels (NGs), a significant nanoplatform with properties of both hydrogels and nanoparticles, have been extensively used for controlled/sustained delivery of therapeutic agents in biomedical and healthcare applications. This review summarizes the synthesis and functionalization strategies of NGs and highlights their recent advances in various biomedical fields such as cancer theranostics, immunotherapy, sensing, and tissue engineering.
Article
Chemistry, Multidisciplinary
Xinyuan Xi, Fan Lei, Keliang Gao, Jingjing Li, Rihe Liu, Adam R. Karpf, Tatiana K. Bronich
Summary: Combining chemotherapeutic drugs in a single nanocarrier offers advantages in cancer treatment, including reducing toxicity, improving drug properties, and enhancing therapeutic effects. In this study, we developed functional multimodal polypeptide-based polymeric nanogels (NGs) to encapsulate a combination of drugs. These NGs exhibited selective cytotoxicity towards EGFR overexpressing ovarian cancer cells and showed preferential associations with EGFR (+) tumor cells. Furthermore, ligand-installed NGs carrying the drug combination significantly improved the treatment response of ovarian cancer xenografts compared to individual drug-loaded NGs. This work highlights the potential of our carrier system for efficient delivery of drug combinations to treat EGFR overexpressing cancers.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Xi Hu, Yu Sun, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li, Daishun Ling
Summary: Drug loading affects the rigidity of polymeric micelles, and micelles with moderate drug loading exhibit higher cellular uptake and cytotoxicity. NMR measurements reveal the impact of drug loading on micellar rigidity.
Article
Chemistry, Multidisciplinary
Nada Aljuaid, Mark Tully, Jani Seitsonen, Janne Ruokolainen, Ian W. Hamley
Summary: In aqueous solution, self-assembly of benzene-1,3,5-tricarboxamide (BTA) molecules with one alkyl chain and two PEG chains results in micelle structures, while molecules with two alkyl chains and one PEG chain form nanotapes and nanoribbons. This difference in nanostructures was observed through electron microscopy and small-angle X-ray scattering (SAXS) analysis of the synthesized derivatives.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Ziyang Xue, Rongzhan Fu, Zhiguang Duan, Lei Chi, Chenhui Zhu, Daidi Fan
Summary: In this study, a pH-responsive nanogel was prepared as a potential nanocarrier for CK to enhance its antitumor effects against lung cancer. The nanogel efficiently encapsulated CK and showed high drug loading and encapsulation efficiency. In vitro and in vivo experiments demonstrated the superior inhibitory rates of CK-loaded nanogels against tumor volume compared to CK alone.
Article
Chemistry, Multidisciplinary
Tianbao Chen, Jie Xu, Lijuan Zhu, Deyue Yan
Summary: Researchers developed a targeted nanodrug delivery system using the cationic amphiphilic chemodrug mitoxantrone (Mito), which interacts with Bcl-2 ASO through electrostatic interaction and self-assembles into nanoparticles (NP[Bcl-2/Mito]). NP[Bcl-2/Mito] protects the ASO from degradation during delivery and combines gene- and chemotherapies to improve the anticancer effect. Cancer cell membranes (CCMs) derived from homologous tumors were used to camouflage NP[Bcl-2/Mito] (NP[Bcl-2/Mito]@CCM) for immune escape and tumor targeting. Both in vitro and in vivo assessments demonstrate the excellent performance of NP[Bcl-2/Mito]@CCM for drug-resistant breast tumor therapy.
Article
Biochemistry & Molecular Biology
Abere Habtamu Manayia, Fasih Bintang Ilhami, Sin-Yu Huang, Ting-Hsuan Su, Cheng-Wei Huang, Chih-Wei Chiu, Duu-Jong Lee, Juin-Yih Lai, Chih-Chia Cheng
Summary: A new potential route to enhance the efficiency of supramolecular polymers for cancer chemotherapy was demonstrated using a photosensitive metallosupramolecular polymer. The polymer forms photo-cross-linked structures and spherical nanoparticles in aqueous solution. The irradiated nanoparticles possess unique characteristics and enhance selective cellular uptake by cancer cells, leading to higher levels of cytotoxicity without harming normal cells.
Review
Pharmacology & Pharmacy
Prabhuti Nirale, Shivani Arora, Anita Solanki, Jnanadeva Bhat, Rishi Kumar Singh, Khushwant S. Yadav
Summary: This article reviews the technological innovations in liquid-filled hard capsules and highlights their importance for complex drug molecules and light/moisture-sensitive drugs. Liquid-filled hard capsules have diverse functions, allowing for immediate and delayed drug release. The band sealing in such capsules also helps protect against tampering.
CURRENT DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Pallavi Gupta, Khushwant S. Yadav
Summary: This study compared the effectiveness of brinzolamide-loaded niosomes and niosomal in-situ gel in the treatment of glaucoma. The results showed that brinzolamide-loaded niosomes had high encapsulation efficiency and sustained release, while niosomal in-situ gel had good gelation capacity and spreadability. In in-vivo experiments on rabbits, brinzolamide-loaded niosomes sustained the reduction of intraocular pressure for 24 hours.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anubhav Wadhwa, Chetana Jadhav, Khushwant S. Yadav
Summary: This article discusses the drug delivery systems and related issues of bimatoprost (BIM) used in the treatment of glaucoma, and introduces the clinical trials and patents of novel drug delivery methods.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Darshan R. Telange, Ravindra R. Pandharinath, Anil M. Pethe, Shirish P. Jain, Prashant L. Pingale
Summary: This study successfully prepared INH-CaSP Ms, which enhanced encapsulation efficiency, bio-adhesion, controlled release, and oral bioavailability of Isoniazid. It demonstrated an effective approach to improve the effectiveness of Isoniazid through cross-linked coordinate bond interaction.
Review
Chemistry, Multidisciplinary
Karishma Shetty, Ayush Bhandari, Khushwant S. Yadav
Summary: Nanofibers, as cutting-edge drug delivery systems, have great potential for treating various diseases. By incorporating nanoparticles into nanofibers, nano-in-nano delivery techniques offer advantages such as drug protection, extended release, increased drug loading capacity, etc. This review provides an insight into the applications and current state of nano-in-nano drug delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Chetana Jadhav, Khushwant S. Yadav
Summary: The study aimed to create and test a promising sustained-release ocular insert for Bimatoprost. The results showed that these inserts were able to sustainably reduce intraocular pressure for a period of six days.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Karishma Shetty, Soma Yasaswi, Shilpee Dutt, Khushwant S. Yadav
Summary: Glioblastoma multiforme (GBM) is a lethal cancer, and RNA interference (RNAi) technology holds potential for improving its treatment by suppressing cancer-related genes. However, the challenge lies in delivering RNAi across the blood-brain barrier. Nanocarrier technology offers a solution by encapsulating RNAi entities and delivering them to glioma cells.
Article
Materials Science, Biomaterials
Ketaki Kale, Aditi Fulfager, Kapil Juvale, Khushwant S. Yadav
Summary: In this study, Gemcitabine (GEM) HCl was loaded into polymeric nanoparticles (NPs) to address the issue of rapid metabolism. The optimized NPs showed sustained drug release and demonstrated better inhibitory effects on cancer cells compared to free GEM. In vivo studies further confirmed the long circulation time of the formulated NPs.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Pharmacology & Pharmacy
Hardik Bhargave, Harsh Nijhawan, Khushwant S. Yadav
Summary: The study aimed to synthesize PEGylated mPEG-PCL block copolymer and formulate Erlotinib HCl-loaded mPEG-PCL nanoparticles to enhance the drug's bioavailability. The nanoparticles exhibited a slow and sustained release pattern and significantly improved the drug's bioavailability compared to the oral formulation. The results indicated that the developed block copolymeric nanoparticles have potential for effective encapsulation of Erlotinib HCL for an injectable formulation with increased bioavailability.
Review
Pharmacology & Pharmacy
Piyush Verma, Khushwant S. Yadav
Summary: Tranexamic acid is a drug used for the treatment of hyperpigmentation, and topical administration is the most favorable route. However, low penetration and availability at target cells limit tranexamic acid's topical administration.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Polymer Science
Prasanna Phutane, Darshan Telange, Surendra Agrawal, Mahendra Gunde, Kunal Kotkar, Anil Pethe
Summary: The limited ability of human tissues to regenerate has led to the exploration of alternatives, such as tissue engineering and regenerative medicine (TERM). Nanofibers, with their ability to mimic the extracellular matrix (ECM) and customizable structure, have emerged as a promising candidate for tissue engineering. This review discusses the use of natural and synthetic polymers in constructing nanofibers, as well as their application in various tissues.
Review
Pharmacology & Pharmacy
Harsh P. Nijhawan, Bala Prabhakar, Ambikanandan Misra, Khushwant S. Yadav
Summary: Non-small cell lung cancer (NSCLC) has a history of resistance to traditional cytotoxic treatment. Advances in biotechnology, cancer biology, and immunotherapy have led to the development of monoclonal antibodies and their smaller fragments, which can penetrate cells and tissues effectively. When combined with functional nanocarriers, these antibody fragments show improved efficacy in targeting cancer cells while minimizing off-target effects.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Piyush Verma, Khushwant S. Yadav
Summary: A LC-MS/MS based method was developed to quantitatively analyze tranexamic acid in stratum corneum lipid liposomes. QbD approach was applied to optimize the formulation, resulting in an optimized batch with encapsulation efficiency of 35.78% and mean particle size of 93.5 nm.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Khushwant S. Yadav, Hrushikesh C. Raut, Harsh P. Nijhawan
Summary: This study developed and evaluated inhalable polymeric microparticles (MPs) loaded with Sorafenib Tosylate (SRT) as a potential treatment for non-small cell lung cancer (NSCLC). The optimized MPs exhibited excellent flowability, small particle size, and high entrapment efficiency. The MPs were able to reach the secondary and terminal bronchi of the lungs, and showed a biphasic release pattern over 72 hours. Cytotoxicity studies demonstrated that the SRT-loaded MPs had significantly lower IC50 value compared to the free drug.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Piyush Verma, Rishi Kumar Singh, Anubhav Wadhwa, Bala Prabhakar, Khushwant S. Yadav
Summary: This study developed liposomes and solid lipid nanoparticles for the delivery of Bimatoprost, a drug used to lower intraocular pressure in glaucoma treatment. The optimized liposomes showed better encapsulation efficiency and drug kinetics compared to solid lipid nanoparticles, and when loaded in a thermo-sensitive hydrogel, they effectively decreased intraocular pressure for 18 hours.