Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide

From Complex Natural Products to Simple Synthetic Mimetics by Computational De Novo Design

(2016) Lukas Friedrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Actin-binding doliculide causes premature senescence in p53 wild type cells

(2016) Florian Foerster et al.   BIOORGANIC & MEDICINAL CHEMISTRY

De Novo Design at the Edge of Chaos

(2016) Petra Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Multi-objective active machine learning rapidly improves structure–activity models and reveals new protein–protein interaction inhibitors

(2016) D. Reker et al.   Chemical Science

Revealing the Macromolecular Targets of Fragment-Like Natural Products

(2015) Tiago Rodrigues et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed Hydrogenations and an Ireland-Claisen Rearrangement Linked to Evans-Tishchenko Chemistry: The Highly Efficient Total Synthesis of the Marine Cyclodepsipeptide Doliculide

(2015) Tao Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members

(2015) Joseph T. Opferman   FEBS Journal

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological characterization of actin-binding (−)-Doliculide

(2014) Florian Foerster et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Revealing the macromolecular targets of complex natural products

(2014) Daniel Reker et al.   Nature Chemistry

Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus

(2014) D. Reker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for ‘Orphan’ Molecules

(2013) Michael Reutlinger et al.   Molecular Informatics

New insights from structural biology into the druggability of G protein-coupled receptors

(2012) Jonathan S. Mason et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Prostaglandin E2 EP receptors as therapeutic targets in breast cancer

(2011) Jocelyn Reader et al.   CANCER AND METASTASIS REVIEWS

Involvement of non-conserved residues important for PGE2binding to the constrained EP3 eLP2using NMR and site-directed mutagenesis

(2008) Annirudha Chillar et al.   FEBS LETTERS