A poxvirus pseudokinase represses viral DNA replication via a pathway antagonized by its paralog kinase

Gene Drive: Evolved and Synthetic

(2018) Austin Burt et al.   ACS Chemical Biology

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

Proteotype profiling unmasks a viral signalling network essential for poxvirus assembly and transcriptional competence

(2018) Karel Novy et al.   Nature Microbiology

Genetic conflicts: the usual suspects and beyond

(2017) Richard N. McLaughlin et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2

(2017) Annabel T. Olson et al.   JOURNAL OF VIROLOGY

Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation

(2017) Matthew D. Greseth et al.   MOLECULAR & CELLULAR PROTEOMICS

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase

(2017) Sujata Jha et al.   NATURE

A maternal-effect selfish genetic element in Caenorhabditis elegans

(2017) Eyal Ben-David et al.   SCIENCE

wtf genes are prolific dual poison-antidote meiotic drivers

(2017) Nicole L Nuckolls et al.   eLife

The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation

(2017) Wondimagegnehu M. Teferi et al.   PLoS One

Prokaryotic toxin–antitoxin systems: novel regulations of the toxins

(2016) Yuichi Otsuka   CURRENT GENETICS

Barrier to Autointegration Factor (BANF1): interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria

(2015) Augusta Jamin et al.   CURRENT OPINION IN CELL BIOLOGY

Redundancy complicates the definition of essential genes for vaccinia virus

(2015) Bianca M. Dobson et al.   JOURNAL OF GENERAL VIROLOGY

Genetic Confirmation that the H5 Protein Is Required for Vaccinia Virus DNA Replication

(2015) Kathleen A. Boyle et al.   JOURNAL OF VIROLOGY

Experimental Evolution Identifies Vaccinia Virus Mutations in A24R and A35R That Antagonize the Protein Kinase R Pathway and Accompany Collapse of an Extragenic Gene Amplification

(2015) Greg Brennan et al.   JOURNAL OF VIROLOGY

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Identification of Nucleotide-Level Changes Impacting Gene Content and Genome Evolution in Orthopoxviruses

(2014) E. L. Hatcher et al.   JOURNAL OF VIROLOGY

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

(2014) Veronika Reiterer et al.   TRENDS IN CELL BIOLOGY

Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range

(2014) Greg Brennan et al.   PLoS Pathogens

Toxin-Antitoxin Systems as Multilevel Interaction Systems

(2014) Nathalie Goeders et al.   Toxins

Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity

(2014) Yurong Wen et al.   Pathogens and Disease

Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence

(2013) B. J. Ferguson et al.   JOURNAL OF GENERAL VIROLOGY

Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase

(2013) Nouhou Ibrahim et al.   VIROLOGY

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo

(2013) T P Molitor et al.   Oncogenesis

Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses

(2012) Nels C. Elde et al.   CELL

Vaccinia virus protein C4 inhibits NF- B activation and promotes virus virulence

(2012) S. W. J. Ember et al.   JOURNAL OF GENERAL VIROLOGY

Molecular Genetic and Biochemical Characterization of the Vaccinia Virus I3 Protein, the Replicative Single-Stranded DNA Binding Protein

(2012) M. D. Greseth et al.   JOURNAL OF VIROLOGY

Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis

(2012) Sonja Hansen et al.   PLoS One

NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity

(2011) Joon Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB

(2011) Camilla T. O. Benfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Characterization of the Host Defense Activity of the Barrier to Autointegration Factor against Vaccinia Virus

(2011) N. Ibrahim et al.   JOURNAL OF VIROLOGY

Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli

(2011) Tatiana G. Senkevich et al.   VIROLOGY

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

(2011) Leonie Unterholzner et al.   PLoS Pathogens

Viral Serine/Threonine Protein Kinases

(2010) T. Jacob et al.   JOURNAL OF VIROLOGY

Characterization of indels in poxvirus genomes

(2010) Danielle Coulson et al.   VIRUS GENES

Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence

(2008) A. S. Fahy et al.   JOURNAL OF GENERAL VIROLOGY

Oligomerization of ICP4 and Rearrangement of Heat Shock Proteins May Be Important for Herpes Simplex Virus Type 1 Prereplicative Site Formation

(2008) C. M. Livingston et al.   JOURNAL OF VIROLOGY