Article
Chemistry, Multidisciplinary
Hanan B. Howsaui, Abeer A. Sharfalddin, Magda H. Abdellattif, Amal S. Basaleh, Mostafa A. Hussien
Summary: Novel anti-cancer transition metal complexes were successfully synthesized and characterized using Schiff base derived from 2-aminopyrazine and salicylaldehyde. The complexes exhibited different structures and properties under different metal ions, showing promising anti-cancer activity. The Cu(II) complex showed practical results with HOP-62 cell lines, while the Zn(II) and Co(II) complexes demonstrated non-toxicity at doses up to 370 mg/kg based on LD50 values.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad
Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Laila H. Abdel-Rahman, Mohamed Shaker S. Adam, Nabil Al-Zaqri, Mohamed R. Shehata, Hanan El-Sayed Ahmed, Shaaban K. Mohamed
Summary: In this study, a new Schiff base ligand and its metal chelates were synthesized and characterized. The compounds showed anticancer, antibacterial, and antifungal activities, and exhibited good binding affinity to DNA.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Murugesan Sankarganesh, Paul Raj Adwin Jose, Jeyaraj Dhaveethu Raja, Rajadurai Vijay Solomon, Clarence Dorothy Sheela, Shunmugasundaram Gurusamy
Summary: A new octahedral platinum complex [PtLCl4] of Schiff base ligand containing pyrimidine and morpholine skeleton was synthesized and characterized. The compound exhibited interaction with DNA and BSA through electrostatic interactions and static quenching, respectively. The platinum complex showed promising anticancer activity against various cancer cell lines, while also demonstrating good radical scavenging and antimicrobial abilities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Ghada N. Rezk, Ola A. El -Gammal, Salhah H. Alrefaee, Ismail Althagafi, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: A hydrazone ligand was successfully created by combining hydrazide with 2-Acetylpyridine. Copper (II) hydrazone complexes were synthesized using various copper (II) salts and studied using analytical techniques. The complexes exhibited tridentate behavior and octahedral geometries. Their properties were analyzed through computational calculations and experimental assays, revealing potential antimicrobial and antioxidant effects.
Article
Biochemistry & Molecular Biology
Hanan B. Howsaui, Amal S. Basaleh, Magda H. Abdellattif, Walid M. Hassan, Mostafa A. Hussien
Summary: Three novel 2-aminopyrazine Schiff bases and their uranyl complexes were synthesized and characterized, with studies on DNA binding and anticancer activities showing promising results. Molecular docking analysis provided insights into interactions with cancer proteins.
Article
Chemistry, Inorganic & Nuclear
Anmol Singh, Subir Kr Maiti, Himadri Priya Gogoi, Pranjit Barman
Summary: Metal complexes of Co(II), Zn(II), and Cu(II) with purine base Schiff base ligands L1 and L2 were synthesized and characterized. The coordination of the ligands to the metal centers and their structural details were confirmed through spectroscopic and DFT studies. The binding modes of oxygen atoms in L1 and L2 complexes were found to be different. Cobalt complexes of L1 and L2 showed high DNA binding activity, with a binding constant in the order of 105 via intercalation mode. Molecular docking study provided insights into the active binding site between the metal complexes and CT-DNA.
Article
Pharmacology & Pharmacy
Burcu Saygideger Demir, Simay Ince, Mustafa Kemal Yilmaz, Aycan Sezan, Ezgi Derinoz, Tugba Taskin-Tok, Yasemin Saygideger
Summary: This study investigates the DNA-binding ability of Pd(II) and Pt(II) complexes of four phosphorus Schiff base ligands and four hydrazonoic-phosphines through in silico analyses and experimental validation. The synthesized Pd(II) complexes with the best DNA-binding potential are further characterized. The antitumor properties of these complexes are demonstrated in vitro in different cancer cells, and the mechanisms of cell death are elucidated.
Article
Chemistry, Inorganic & Nuclear
Dai-Hong Cai, Bai-Hua Chen, Qi-Yan Liu, Xue-Yi Le, Liang He
Summary: Copper complexes show potential as anticancer agents, with three new Cu(II) complexes exhibiting good antiproliferative activity against various cancer cells and DNA oxidative cleavage. The complexes also display strong binding affinity with DNA and human serum albumin. Through inducing DNA damage and ROS-mediated mitochondrial dysfunction, the Cu(II) complexes lead to cancer cell apoptosis.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Ibrahim, Hazrat Un Nabi, Niaz Muhammad, Muhammad Ikram, Momin Khan, Musadiq Ibrahim, Abdullah F. AlAsmari, Metab Alharbi, Abdulrahman Alshammari
Summary: Currently, ongoing studies are exploring the interaction between free radicals and biological systems. This study evaluated the synthesis, characterization, antioxidant properties, DNA binding, and molecular docking of Schiff base ligand and its Ni(II), Co(II), Cu(II), and Zn(II) complexes. The metal complexes showed significant dose-dependent antioxidant activities, but lower than ascorbic acid. The DNA binding constants (K-b) and molecular docking analysis supported the experimental results. The study highlights the importance of synthesis complexes as synthetic antioxidants and anticancer drugs.
Article
Chemistry, Inorganic & Nuclear
S. Sukkur Saleem, M. Sankarganesh, P. Adwin Jose, J. Dhaveethu Raja
Summary: This study synthesized and characterized a morpholine-based Schiff base ligand and its metal(II) complexes. They exhibited good free radical scavenging and antimicrobial activities, with the metal complexes showing stronger antimicrobial effects. In addition, L and its complexes may interact with DNA through an intercalative mode.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
A. K. Khedr, R. R. Zaky, E. A. Gomaa, M. N. Abd El-Hady
Summary: A series of transition metal complexes were prepared using a novel ligand and various metal cations, and their structures, properties, and biological activities were extensively studied.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed R. Shehata, Ehab M. Abdalla
Summary: In this study, five novel metal ion complexes were synthesized and characterized, showing anticancer potential with antiproliferative effects on cancer cell lines, as well as antioxidant and antibacterial activities. The binding nature of the complexes with CT-DNA was investigated to determine intercalation or replacement mode.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Environmental Sciences
Mohd Afzal, Abdullah Alarifi, Md Saquib Hasnain, Mohd Muddassir
Summary: The synthesis, structural elucidation, and DNA interaction of newly synthesized Cu(II) and Zn(II) complexes were described. Both complexes were found to avidly bind to DNA through surface and groove binding modes, with different intrinsic binding constants. Various experiments confirmed the electrostatic and groove binding modes of the complexes, paving the way for the development of DNA-targeting Cu(II)/Zn(II) metal complexes as chemotherapeutic agents.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Eyup Basaran, Hatice Gamze Sogukomerogullari, Resit Cakmak, Senem Akkoc, Tugba Taskin-Tok, Ayseguel Kose
Summary: Two chiral Schiff base ligands were synthesized and their corresponding metal complexes were prepared. The compounds were characterized by various analytical methods. The cytotoxic effects of these compounds on cancer cells and healthy cells were evaluated, and L1-Pd(II) was identified as a promising anticancer drug candidate. Molecular docking results revealed the interaction between L1-Pd(II) and colon cancer antigen protein.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Mohammad Asad, Muhammad Nadeem Arshad, Abdullah M. Asiri, Mohammed T. N. Musthafa, Salman A. Khan, Mohd Rehan, Mohammad Oves
Summary: A series of novel N-methylspiropyrrolidine hybrids were synthesized using 1,3-dipolar cycloaddition reaction, and their structures, antibacterial activity, and mechanism of action were investigated.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Physical
Naghmana Kausar, Shahzad Murtaza, Muhammad Khalid, Uzma Shoukat, Mehwish Asad, Muhammad Nadeem Arshad, Abdullah M. Asiri, Ataualpa A. C. Braga
Summary: Crystalline organic compounds (NHBPB) and (CNHBP) were synthesized through condensation reactions. Their structures were determined by SC-XRD analysis and NMR studies. Quantum chemical computations were used to investigate their NLO properties, and a good agreement was found with experimental data. NHBPB exhibited smaller HOMO/LUMO energy gap, larger softness, and greater second hyperpolarizability response compared to CNHBP. These hydrazide-based compounds showed excellent NLO properties, making them promising materials for NLO applications.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Shakeel Ahmad, Matloob Ahmad, Muhammad Khalid, Muhammad Shafiq, Muhammad Nadeem Arshad, Sadia Sultan, Abdullah M. Asiri, Ataualpa A. C. Braga, Khalid A. Alamry
Summary: A series of new bis-adducts based on the 2,1-benzothiazine 2,2-dioxide heterocyclic ring system was synthesized and studied. Among the series, compound 6a was obtained in crystalline form and its crystal structure was analyzed using XRD. The structure elucidation of the compounds was conducted using NMR and MS techniques. Furthermore, DFT-based analyses provided insights into the electronic properties and structural parameters of compound 6a, demonstrating its chemical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Nasser Mohammed Hosny, Omnia Ahmed Ibrahim, Arafa Belal, Mostafa A. Hussien, Mohamed H. Abdel-Rhman
Summary: 2-(2-hydroxybenzoyl)-N-phenylhydrazine-1-carbothioamide (H4L) and its Zn(II), Co(II), Cu(II), and Ni(II) coor-dination compounds have been synthesized. The structures of the synthesized compounds were determined using various spectroscopic techniques and elemental analyses. The electronic spectra of the compounds were simulated and the optical band gap was calculated and compared with experimental results. Molecular docking studies revealed possible interactions with proteins, and cytotoxicity testing showed H4L to have strong activity against tested cell lines.
RESULTS IN CHEMISTRY
(2023)
Article
Chemistry, Physical
Zoya Zaheer, Wafa A. Bawazir, Amal Salmin Basaleh, Basma G. Alhogbi, Soha M. Albukhari
Summary: This paper explores the effects of CTAB and SDS on the formation of silver sols through the redox reaction between coriander seeds extract and silver nitrate. The concentration of CTAB and SDS causes wavelength shifts in the silver sols. Furthermore, the antioxidant activity of the silver nanoparticles depends on their dose.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Chemical
Amal S. Basaleh, Adel A. Ismail
Summary: In this study, mesoporous BaSnO3 with superior electron mobility and large surface area was utilized to integrate PtO nanoparticles, resulting in a highly efficient photocatalytic system. The PtO/BaSnO3 nanocomposite demonstrated higher H2 production and faster photocatalytic reaction rate under visible light irradiation. This research provides a novel approach for utilizing perovskite materials with mesoporous structures and tunable bandgap in energy applications and photocatalytic reactions.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Biochemistry & Molecular Biology
Sultan Alhayyani, Abdullah Akhdhar, Amer H. Asseri, Abdelhafeez M. A. Mohammed, Mostafa A. Hussien, L. Selva Roselin, Salman Hosawi, Fahad AlAbbasi, Khadijah H. Alharbi, Roua S. Baty, Abdulaziz A. Kalantan, Ehab M. Ali
Summary: The study aimed to identify the anticancer properties of Juniperus procera leaves. The methanolic extract of J. procera leaves was found to suppress cancer cells in various cell lines. Through GC/MS analysis and molecular docking, it was determined that the active ingredient 2-imino-6-nitro-2H-1-benzopyran-3-carbothiamide has potential anticancer effects by impacting DNA conformational changes, cell membrane integrity, and proliferation. This suggests that J. procera leaves' methanolic extract may have potential as an anticancer agent.
Article
Biochemistry & Molecular Biology
Jamal Lasri, Naser E. Eltayeb, Saied M. Soliman, Ehab M. M. Ali, Sultan Alhayyani, Abdullah Akhdhar
Summary: The synthesis, characterization, and anticancer properties of three imine-type compounds 1-3 and an unexpected oxazine derivative 4 were investigated. Compound 3 was obtained through a reaction between benzil and 4-aminoantipyrine, while compound 4 was unexpectedly formed via cyclization of benzil with o-aminophenol. The structures of compounds 3 and 4 were determined by X-ray diffraction, and their crystal stability and polarity were analyzed. The compounds exhibited growth suppression on HepG2 and MCF-7 cell lines, with compound 1 showing the lowest IC50 values and considered as a promising anticancer agent.
Article
Polymer Science
Mostafa A. Hussien, Gadeer R. Ashour, Soha M. Albukhari, Tamer S. Saleh, Mahmoud A. Hussein
Summary: This research synthesized a new series of heteroaromatic thiazole-based polyurea derivatives with sulfur links in the polymers' main chains. Characterization methods confirmed the structures of the premonomer, monomer, and fully generated polymers. The polymers showed thermal stability and distinct surface morphologies. The study also evaluated the antimicrobial and antifungal activities of the polymers.
Article
Chemistry, Physical
Jamal Lasri, Naser E. Eltayeb, Saied M. Soliman, Ehab M. M. Ali, Sultan Alhayyani, Abdullah Akhdhar, Mostafa A. Hussien
Summary: The di-aryl-aldimines 3a and 3b were synthesized using 2-hydroxy-1-naphthaldehyde 1a or 9-phenanthrenecarboxaldehyde 1b reacted with 1-aminonaphthalene 2. Analysis of molecular packing using Hirshfeld calculations showed that C-H...pi and pi-pi stacking interactions were the most important. The calculated electronic aspects and NMR chemical shifts correlated well with experimental data. Compounds 3a and 3b exhibited anticancer properties, inhibiting the growth of cancer cells and affecting DNA structure and hormone production.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Muhammad Nadeem Arshad, Muhammad Khalid, Umme Hani, Abdullah M. Asiri
Summary: This study investigated the nonlinear optical properties of triarylpyrazoline-based compounds and calculated various optical parameters for PR and P1-P7. The results showed significant optical nonlinear response in these compounds, with P3 exhibiting the highest nonlinearity.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nouf E. Alshaikh, Mehvash Zaki, Abeer A. Sharfalddin, Najlaa S. Al-Radadi, Mostafa A. Hussien, Walid M. I. Hassan
Summary: Researchers synthesized five transition metal complexes of D-luciferin (LN) and studied their structures and properties. The complexes showed non-covalent binding with DNA and HSA, and exhibited significant cytotoxic activity against breast cancer and liver cancer cells.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Amal S. Basaleh, Soliman I. El-Hout
Summary: This study focuses on the synthesis and characterization of nanocomposites based on mesoporous Bi2WO6 with varying PtO content. The effect of PtO content on the structural, optical, and photocatalytic features was thoroughly described. The incorporation of 1.5wt% PtO significantly enhanced the efficiency of the developed heterojunctions in the photoreduction of Hg(II) ions due to increased light-harvesting, decreased bandgap, and improved isolation and mobility of photoexcited carriers. A 1.6 g/L of 1.5wt% PtO/Bi2WO6 nanocomposite exhibited complete photoreduction efficiency after 40 min and excellent stability after five cycles without losing its photo-catalytic activity.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Physical
Bakhitah M. Alajmi, Amal S. Basaleh, Adel A. Ismail, Reda M. Mohamed
Summary: An efficient and straightforward strategy was developed to produce mesoporous CuO/ZrO2 nanocomposite photocatalyst for thiophene desulfurization under visible exposure. The obtained CuO/ZrO2 photocatalyst exhibited superior photocatalytic ability compared to pristine ZrO2. The excellent performance was attributed to the construction of heterojunctions, large surface area, intense absorption in the visible region, easy separation of electron-hole, and the design of mesopore structure. This research provides a green and efficient method for thiophene desulfurization and offers new insights for utilizing ZrO2-based photocatalysts to treat pollutants under visible light.
SURFACES AND INTERFACES
(2023)