Journal
JOURNAL OF DIABETES
Volume 11, Issue 8, Pages 632-644Publisher
WILEY
DOI: 10.1111/1753-0407.12915
Keywords
autoimmunity; dysbiosis; gut barrier; microbiome; type 1 diabetes
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID)
- Leona M. and Harry B. Helmsley Charitable Trust
- Juvenile Diabetes Research Foundation
- J. W. Kieckhefer Foundation
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Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin-producing pancreatic beta-cells. The disease mainly affects juveniles. Changes in the composition of the gut microbiota (dysbiosis) and changes in the properties of the gut barrier have been documented in T1D subjects. Because these factors affect immune system functions, they are likely to play a role in disease pathogenesis. However, their exact role is currently not fully understood and is under intensive investigation. In this article we discuss recent advancements depicting the role of intestinal dysbiosis on immunity and autoimmunity in T1D. We also discuss therapies aimed at maintaining a healthy gut barrier as prevention strategies for T1D.
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