Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz-Schiemann Reaction

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anhydrous Tetramethylammonium Fluoride for Room-Temperature SNAr Fluorination

(2015) Sydonie D. Schimler et al.   JOURNAL OF ORGANIC CHEMISTRY

A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides

(2015) Aaron C. Sather et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Handling diazonium salts in flow for organic and material chemistry

(2015) Nicolas Oger et al.   Organic Chemistry Frontiers

Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator

(2014) Sabine Hadida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile

(2014) Chad M. Kormos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides

(2014) Hong Geun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A One-Pot Diazotation–Fluorodediazoniation Reaction and Fluorine Gas for the Production of Fluoronaphthyridines

(2014) Stefan Abele et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Copper-Mediated Fluorination of Arylboronate Esters. Identification of a Copper(III) Fluoride Complex

(2013) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu(OTf)2-Mediated Fluorination of Aryltrifluoroborates with Potassium Fluoride

(2013) Yingda Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Continuous flow reactor for Balz–Schiemann reaction: a new procedure for the preparation of aromatic fluorides

(2013) Zhi-qun Yu et al.   TETRAHEDRON LETTERS

Copper-Mediated Fluorination of Aryl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Continuous Kilogram-Scale Process for the Manufacture of o-Difluorobenzene

(2012) Zhiqun Yu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Deoxyfluorination of Phenols

(2011) Pingping Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

10′-Fluorovinblastine and 10′-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids

(2011) Hiroaki Gotoh et al.   ACS Medicinal Chemistry Letters

Convenient Electrophilic Fluorination of Functionalized Aryl and Heteroaryl Magnesium Reagents

(2010) Shigeyuki Yamada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT)

(2010) Mitja Kovac et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Silver-Catalyzed Late-Stage Fluorination

(2010) Pingping Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

(2010) Laia Malet-Sanz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Silver-Mediated Fluorination of Functionalized Aryl Stannanes

(2009) Takeru Furuya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorination of Boronic Acids Mediated by Silver(I) Triflate

(2009) Takeru Furuya et al.   ORGANIC LETTERS

A concise and efficient synthesis of flumazenil and its precursor for radiolabeling with fluorine-18

(2009) Sean R. Donohue et al.   TETRAHEDRON LETTERS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT