Article
Endocrinology & Metabolism
Na Sun, Dandan Ma, Pingping Gao, Yanling Li, Zexuan Yan, Zaihui Peng, Fei Han, Yi Zhang, Xiaowei Qi
Summary: The study aims to construct a prognostic risk prediction model combining obesity and breast cancer, identifying crucial genes through differential expression and network analysis. The final model containing 6 related genes provides an accurate prediction of survival in breast cancer patients with obesity, also related to immune cell infiltration.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Celine Ben Hassen, Caroline Goupille, Claire Vigor, Thierry Durand, Francoise Gueraud, Sandrine Silvente-Poirot, Marc Poirot, Philippe G. Frank
Summary: Cholesterol plays important roles in physiological processes and its relationship with breast cancer is complex. Some studies suggest elevated cholesterol levels may increase breast cancer risk, while others show an inverse association. Cholesterol may contribute to breast cancer risk through estrogen precursor, inflammation, oxidative stress, and signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Genetics & Heredity
Lijun Xu, Yaomin Hu, Wenwen Liu
Summary: In this study, we identified two distinct TME gene clusters in breast cancer that corresponded to hot and cold tumor phenotypes. Using TME-related signature genes, we constructed a TME-score to stratify breast cancer patients, and found that high TME-score was associated with favorable outcome and increased immune cell infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Kohei Kumegawa, Liying Yang, Kenichi Miyata, Reo Maruyama
Summary: Breast cancer biology varies greatly among patients, and basal-like breast cancer is particularly challenging to treat due to the lack of effective therapeutic targets. However, a recent study found that the transcription factor FOXD1 is associated with poor prognosis in basal-like breast cancer and plays a role in tumor progression. Through analysis of RNA sequencing data and knockdown experiments, it was discovered that FOXD1 regulates gene expression programs related to tumor progression in this subtype. These findings suggest that FOXD1 may be a promising therapeutic target for basal-like breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Elisa Agostinetto, Mattia Rediti, Danai Fimereli, Veronique Debien, Martine Piccart, Philippe Aftimos, Christos Sotiriou, Evandro de Azambuja
Summary: The study characterized PAM50 intrinsic subtypes within HER2-low breast cancer and investigated the prognostic impact of HER2-low status on survival outcomes. The distribution of HER2-enriched tumors was higher in the HER2-low/HR- group compared to the HER2-low/HR+ group. However, there were no significant differences in survival outcomes between HER2-low subtypes and each non-HER2-low subtype when paired by HR status.
Article
Endocrinology & Metabolism
Hannah R. Nieto, Caitlin E. M. Thornton, Katie Brookes, Albert Nobre de Menezes, Alice Fletcher, Mohammed Alshahrani, Merve Kocbiyik, Neil Sharma, Kristien Boelaert, Jean-Baptiste Cazier, Hisham Mehanna, Vicki E. Smith, Martin L. Read, Christopher J. McCabe
Summary: This study aims to identify potential biomarkers associated with thyroid cancer recurrence by analyzing genetic changes and construct a new prognostic risk model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Genetics & Heredity
Bo Huang, Xujun Zhang, Qingyi Cao, Jianing Chen, Chenhong Lin, Tianxin Xiang, Ping Zeng
Summary: This study successfully constructed a prognostic risk model for breast cancer patients by combining genomics and proteomics characteristics, with good predictive performance in predicting patient survival time.
BMC MEDICAL GENOMICS
(2022)
Article
Medicine, General & Internal
Xianwen Zhang, Han Lai, Fan Zhang, Yixi Wang, Li Zhang, Ni Yang, Chunrong Wang, Zheng Liang, Jieping Zeng, Jinrong Yang
Summary: Pan-cancer analysis is a method that analyzes genetic mutations and other genomic abnormalities common to multiple cancer types, providing new directions for tumor biology research. In recent years, pan-cancer research has gained widespread attention and rapid development, involving international cooperation among multiple countries. Analysis of literature and keywords reveals hotspots in pan-cancer research.
FRONTIERS IN MEDICINE
(2021)
Article
Genetics & Heredity
Jingyue Fu, Handong Sun, Feng Xu, Rui Chen, Xinyang Wang, Qiang Ding, Tiansong Xia
Summary: In this study, the authors investigated the relationship between the expression of the RUNX family and the prognosis of breast cancer. They found that the RUNX family is closely related to the prognosis of breast cancer and can modulate the functions of immune-related genes. Additionally, they established a prognostic model to predict the overall survival probability of breast cancer patients. The findings suggest that immune-related genes regulated by the RUNX family could be potential prognostic biomarkers and therapeutic targets in breast cancer.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Taohua Yue, Shanwen Chen, Jing Zhu, Shihao Guo, Zhihao Huang, Pengyuan Wang, Shuai Zuo, Yucun Liu
Summary: The study found that aging-related gene sets were significantly activated in CRC tissues, and constructed an aging-related risk signature to predict overall survival of patients. The risk score was closely associated with the prognosis of CRC patients, as well as with tumor advanced stage and immune cell infiltration.
Article
Immunology
Shengyu Pu, Yudong Zhou, Peiling Xie, Xiaoqian Gao, Yang Liu, Yu Ren, Jianjun He, Na Hao
Summary: This study identified the significant impact of NRGs on immunity and prognosis in TNBC, providing a new strategy for personalized treatment and improving clinical benefit.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lihong Zhu, Bowen Tang, Ze Zhang, Shuzhang Wei, Zhiwei Lv, Yujuan Zhang, Minlie Yang
Summary: The IL8RB rs1126579 C > T variation may be associated with cancer risk, especially in Asian populations. Different genotypes of IL8RB have varying effects on the risk of different types of cancer. The IL8RB expression is down-regulated in patients with prostate cancer.
Article
Oncology
Neelima Vidula, Christina Yau, Hope S. Rugo
Summary: GLS1 expression is highest in triple negative breast cancer (TNBC) and basal breast cancer, supporting ongoing clinical investigation of GLS1 inhibition in TNBC. GLS1 has significant positive gene correlations with immune genes, which may have implications for potential combinations of glutaminase inhibition and immunotherapy.
Review
Medicine, Research & Experimental
Hassan Yousefi, Mahsa Rostamian Delavar, Fatemeh Piroozian, Masoud Baghi, Khoa Nguyen, Thomas Cheng, Cecilia Vittori, David Worthylake, Suresh K. Alahari
Summary: This study investigates the differential expression of Hippo pathway elements and their correlation with clinicopathologic characteristics in breast cancer. The findings suggest that the Hippo pathway is dysregulated in breast cancer patients and its dysregulation is associated with methylation status and molecular subtypes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Xin Xu, Xiangyan Ruan, Ying Zhang, Guiju Cai, Rui Ju, Yu Yang, Jiaojiao Cheng, Muqing Gu
Summary: This study discovered a correlation between high expression of PGRMC1 in TNBC and poor prognosis, possibly through a mitochondria-associated pathway. Lower levels of PGRMC1 expression were associated with better survival rates.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael J. Flister, Matthew J. Hoffman, Angela Lemke, Sasha Z. Prisco, Nathan Rudemiller, Caitlin C. O'Meara, Shirng-Wern Tsaih, Carol Moreno, Aron M. Geurts, Jozef Lazar, Neeta Adhikari, Jennifer L. Hall, Howard J. Jacob
CIRCULATION-CARDIOVASCULAR GENETICS
(2015)
Article
Cardiac & Cardiovascular Systems
Michael J. Flister, Matthew J. Hoffman, Angela Lemke, Sasha Z. Prisco, Nathan Rudemiller, Caitlin C. O'Meara, Shirng-Wern Tsaih, Carol Moreno, Aron M. Geurts, Jozef Lazar, Neeta Adhikari, Jennifer L. Hall, Howard J. Jacob
CIRCULATION-CARDIOVASCULAR GENETICS
(2015)
Article
Oncology
Michael J. Flister, Bradley T. Endres, Nathan Rudemiller, Allison B. Sarkis, Stephanie Santarriaga, Ishan Roy, Angela Lemke, Aron M. Geurts, Carol Moreno, Sophia Ran, Shirng-Wern Tsaih, Jeffery De Pons, Daniel F. Carlson, Wenfang Tan, Scott C. Fahrenkrug, Zelmira Lazarova, Jozef Lazar, Paula E. North, Peter S. LaViolette, Michael B. Dwinell, James D. Shull, Howard J. Jacob
Article
Oncology
Cody Plasterer, Shirng-Wern Tsaih, Amy R. Peck, Inna Chervoneva, Caitlin O'Meara, Yunguang Sun, Angela Lemke, Dana Murphy, Jennifer Smith, Sophia Ran, Albert J. Kovatich, Jeffrey A. Hooke, Craig D. Shriver, Hai Hu, Edith P. Mitchell, Carmen Bergom, Amit Joshi, Paul Auer, Jeremy Prokop, Hallgeir Rui, Michael J. Flister
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Article
Oncology
Arash Nanbakhsh, Anupallavi Srinivasamani, Sandra Holzhauer, Matthew J. Riese, Yongwei Zheng, Demin Wang, Robert Burns, Michael H. Reimer, Sridhar Rao, Angela Lemke, Shirng-Wern Tsaih, Michael J. Flister, Shunhua Lao, Richard Dahl, Monica S. Thakar, Subramaniam Malarkannan
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Oncology
Michael J. Flister, Shirng-Wern Tsaih, Alexander Stoddard, Cody Plasterer, Jaidip Jagtap, Abdul K. Parchur, Gayatri Sharma, Anthony R. Prisco, Angela Lemke, Dana Murphy, Mona Al-Gizawiy, Michael Straza, Sophia Ran, Aron M. Geurts, Melinda R. Dwinell, Andrew S. Greene, Carmen Bergom, Peter S. LaViolette, Amit Joshi
BREAST CANCER RESEARCH AND TREATMENT
(2017)
Article
Biochemistry & Molecular Biology
AE Kwitek, J Gullings-Handley, JM Yu, DC Carlos, K Orlebeke, J Nie, J Eckert, A Lemke, JW Andrae, S Bromberg, D Pasko, D Chen, TE Scheetz, TL Casavant, MB Soares, VC Sheffield, PJ Tonellato, HJ Jacob
