Journal
CELL REPORTS
Volume 26, Issue 9, Pages 2307-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.01.104
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Funding
- Swiss National Science Foundation (SNF) [176124, 145038, 148183]
- Marie Curie Reintegration Grant [612742]
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The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leads to their early production of IFN gamma, which in turn regulates the recruitment of IL-6+ CD11b+ dendritic cells. Finally, we demonstrate that the interleukin-6 (IL-6)-mediated inflammation is important for the development of an effective humoral response against influenza virus in the draining LN.
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