Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

(2018) David Capper et al.   ACTA NEUROPATHOLOGICA

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial

(2018) Alan Mackay et al.   CANCER CELL

Mesenchymal stem cells loaded with paclitaxel–poly(lactic-co-glycolic acid) nanoparticles for glioma-targeting therapy

(2018) Xiaoling Wang et al.   International Journal of Nanomedicine

Outcome of Newly Diagnosed Glioblastoma Patients Treated by Radiotherapy plus Concomitant and Adjuvant Temozolomide: A Long-Term Analysis

(2018) Ozge Petek Erpolat et al.   TUMORI

Concise Review: Neural Stem Cell-Mediated Targeted Cancer Therapies

(2018) Rachael Mooney et al.   Stem Cells Translational Medicine

Mesenchymal Stem Cells for Severe Intraventricular Hemorrhage in Preterm Infants: Phase I Dose-Escalation Clinical Trial

(2018) So Yoon Ahn et al.   Stem Cells Translational Medicine

Histone deacetylase inhibitor panobinostat potentiates the anti-cancer effects of mesenchymal stem cell-based sTRAIL gene therapy against malignant glioma

(2018) Seung Ah Choi et al.   CANCER LETTERS

In vivo tracking of the tropism of mesenchymal stem cells to malignant gliomas using reporter gene-based MR imaging

(2017) Minghui Cao et al.   INTERNATIONAL JOURNAL OF CANCER

TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

(2017) Carlos R. Reis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear

(2016) Shyan-Yuan Kao et al.   AGING CELL

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival

(2016) Antonella Mangraviti et al.   BIOMATERIALS

Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients

(2016) Jana Portnow et al.   CLINICAL CANCER RESEARCH

Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery

(2016) Xinyi Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells

(2015) Tugba Bagci-Onder et al.   BRAIN

Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis

(2015) Justin V. Joseph et al.   CANCER LETTERS

Human Cerebrospinal Fluid Regulates Proliferation and Migration of Stem Cells Through Insulin-Like Growth Factor-1

(2015) Mingxin Zhu et al.   STEM CELLS AND DEVELOPMENT

Erratum: Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility and tropism to brain cancer

(2015) Y Feng et al.   Cell Death & Disease

Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts

(2015) Simone Pacioni et al.   Stem Cell Research & Therapy

Human amniotic mesenchymal stromal cells (hAMSCs) as potential vehicles for drug delivery in cancer therapy: an in vitro study

(2015) Arianna Bonomi et al.   Stem Cell Research & Therapy

Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival

(2014) Q. Li et al.   CLINICAL CANCER RESEARCH

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation

(2014) Anton Kichev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Combination of Systemic Chemotherapy with Local Stem Cell Delivered S-TRAIL in Resected Brain Tumors

(2014) Navid Redjal et al.   STEM CELLS

A role for TRAIL/TRAIL-R2 in radiation-induced apoptosis and radiation-induced bystander response of human neural stem cells

(2013) Vladimir N. Ivanov et al.   APOPTOSIS

TGF-  Mediates Homing of Bone Marrow-Derived Human Mesenchymal Stem Cells to Glioma Stem Cells

(2013) N. Shinojima et al.   CANCER RESEARCH

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies

(2013) K. S. Aboody et al.   Science Translational Medicine

The Promise and Perils of Stem Cell Therapeutics

(2012) George Q. Daley   Cell Stem Cell

Regulating the TRAIL of Destruction: How A20 Protects Glioblastomas from TRAIL-Mediated Death: Figure 1.

(2012) Inge Verbrugge et al.   Cancer Discovery

A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma

(2012) Anita C. Bellail et al.   Cancer Discovery

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas

(2011) Timo M Kauer et al.   NATURE NEUROSCIENCE

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy

(2010) Giulia Grisendi et al.   CANCER RESEARCH

A Dual PI3K/mTOR Inhibitor, PI-103, Cooperates with Stem Cell-Delivered TRAIL in Experimental Glioma Models

(2010) T. Bagci-Onder et al.   CANCER RESEARCH

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

(2009) M. R. Loebinger et al.   CANCER RESEARCH

Mesenchymal Stem Cell Homing: The Devil Is in the Details

(2009) Jeffrey M. Karp et al.   Cell Stem Cell

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

(2009) L. S. Sasportas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells against Intracranial Glioma

(2008) S. M. Kim et al.   CANCER RESEARCH

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY