Article
Oncology
Yixuan Hu, Yinxing Zhu, Weiwei Nie, Junfeng Shi, Xiaowei Wei, Cuiju Tang, Wenwen Zhang
Summary: This study aimed to investigate the rationality and accuracy of plasma TrxR activity as a tool for early diagnosis of gastrointestinal malignancy, and its ability to evaluate therapeutic efficacy. The results showed that plasma TrxR level was significantly higher in patients with gastrointestinal malignancy, and TrxR had a high diagnostic efficiency. Additionally, the combination of TrxR and conventional tumor markers improved diagnostic efficiency. In the treatment process, the change in plasma TrxR activity was consistent with conventional tumor markers, and significantly decreased in patients receiving chemotherapy, targeted therapy, and immunotherapy.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yinxing Zhu, Yixuan Hu, Junfeng Shi, Xiaowei Wei, Yaqi Song, Cuiju Tang, Wenwen Zhang
Summary: According to previous literature, plasma thioredoxin reductase (TrxR) level is significantly elevated in various malignant tumors and can serve as a potential biomarker for diagnosis and prognostic prediction. However, little is known about the clinical value of plasma TrxR in gynecologic malignancies. This study aims to evaluate the diagnostic accuracy of plasma TrxR in gynecologic cancer and explore its role in treatment surveillance.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Multidisciplinary Sciences
Omer F. Bay, Kelly S. Hayes, Jean-Marc Schwartz, Richard K. Grencis, Ian S. Roberts
Summary: Genome-scale metabolic model of Trichuris muris reveals the essential role of Thioredoxin Reductase (TrxR) enzyme for its survival, as well as the mechanism of glutathione reduction by TrxR enzyme. The model also predicts several essential amino acids that cannot be synthesized by T. muris.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marina Delgobo, Rosangela Mayer Goncalves, Marco Antonio Delazeri, Marcelo Falchetti, Alessandro Zandona, Raquel Nascimento das Neves, Karoline Almeida, Adriane Cristina Fagundes, Daniel Pens Gelain, Joao Isidro Fracasso, Guilherme Baroni de Macedo, Leonardo Priori, Nicklas Bassani, Alexander James Roy Bishop, Cassiano Mateus Forcelini, Jose Claudio Fonseca Moreira, Alfeu Zanotto-Filho
Summary: In NSCLC, TXNRD1 is not a key determinant of malignant phenotypes in KEAP1 mutant cells, but can serve as a surrogate marker of NRF2 pathway activation, predicting tumor recurrence and other aggressive phenotypes.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Fraser D. Johnson, John Ferrarone, Alvin Liu, Christina Brandstaedter, Ravi Munuganti, Dylan A. Farnsworth, Daniel Lu, Jennifer Luu, Tianna Sihota, Sophie Jansen, Amy Nagelberg, Rocky Shi, Giovanni C. Forcina, Xu Zhang, Grace S. W. Cheng, Sandra E. Spencer Miko, Georgia de Rappard-Yuswack, Poul H. Sorensen, Scott J. Dixon, Udayan Guha, Katja Becker, Hakim Djaballah, Romel Somwar, Harold Varmus, Gregg B. Morin, William W. Lockwood
Summary: Phenotype-based screening led to the identification of a compound called LCS3 that selectively impairs the growth of LUAD cells, induces oxidative stress, and inhibits the activity of disulfide reductases GSR and TXNRD1. The study also reveals that LCS3-sensitive LUAD cells are sensitive to the synergistic inhibition of glutathione and thioredoxin pathways. Furthermore, NQO1 loss is identified as a mechanism of LCS3 resistance through a genome-wide CRISPR knockout screen.
Article
Endocrinology & Metabolism
Hongqun Yang, Lanlan Chen, Yahui Liu
Summary: Using Mendelian randomization analysis, this study identified and validated 13 plasma proteins associated with hypothyroidism. Some of these proteins could explain the association between the coagulation system and hypothyroidism. These proteins have the potential to be used as early screening biomarkers for hypothyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biology
Libo Wang, Zaoqu Liu, Ruopeng Liang, Weijie Wang, Rongtao Zhu, Jian Li, Zhe Xing, Siyuan Weng, Xinwei Han, Yu-ling Sun
Summary: This study developed an artificial intelligence-derived prognostic signature that accurately predicts the prognosis of pancreatic cancer patients and can also classify the prognosis of other digestive system tumors.
Article
Immunology
Hongqun Yang, Lanlan Chen, Yahui Liu
Summary: In this study, three plasma proteins (ficolin-1, CD40, and protein FAM177A1) were identified and replicated as being associated with PBC, and they demonstrated significant protective effects against PBC. These proteins can serve as potential biomarkers or drug targets for PBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Toshihiro Kishikawa, Noriko Arase, Shigeyoshi Tsuji, Yuichi Maeda, Takuro Nii, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Kotaro Ogawa, Shiro Ohshima, Hidenori Inohara, Atsushi Kumanogoh, Manabu Fujimoto, Yukinori Okada
Summary: This study conducted metabolome analysis to identify metabolite biomarkers of psoriasis and its subtypes PsA and PsC, revealing significant changes in specific metabolites and differences between PsA and PsC, contributing to the understanding of psoriasis pathophysiology.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Oncology
Baibing Zheng, Xingguo Song, Li Wang, Yue Zhang, Youyong Tang, Shiwen Wang, Lei Li, Yawen Wu, Xianrang Song, Li Xie
Summary: By studying exosomal tRFs, we found that the levels of tRF-Leu-TAA-005, tRF-Asn-GTT-010, tRF-Ala-AGC-036, tRF-Lys-CTT-049, and tRF-Trp-CCA-057 were significantly downregulated in NSCLC patients, suggesting that these tRFs may serve as potential diagnostic biomarkers for NSCLC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jun Wang, Xianyu Liu, Weifang Cui, Qun Xie, Wei Peng, Heng Zhang, Yang Gao, Chunfang Zhang, Chaojun Duan
Summary: This study identified and characterized novel tsRNA biomarkers for early diagnosis of lung adenocarcinoma (LUAD) by analyzing differential expression in tissue and plasma samples. A tsRNA-mRNA regulatory network was constructed to reveal the functional pathways associated with tsRNAs. Three hub tsRNAs were identified and their diagnostic potential was validated. Moreover, one hub tsRNA was found to be negatively associated with LUAD prognosis and its inhibition reduced cancer cell proliferation, migration, and invasion.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mary E. Robbins, Hye-Youn Cho, Jason M. Hansen, Joseph R. Luchsinger, Morgan L. Locy, Markus Velten, Steven R. Kleeberger, Lynette K. Rogers, Trent E. Tipple
Summary: Cellular antioxidants protect against hyperoxic lung injury. The role of the glutathione (GSH) system in lung development and bronchopulmonary dysplasia (BPD) pathogenesis has not been systematically investigated. The current study utilized GSH reductase-deficient (Gsr-KO) neonatal mice to test the hypothesis that early disruption of the GSH system negatively impacts lung development and hyperoxic responses. Overall, our data in Gsr-KO mice implicate the GSH system as a key regulator of lung development, cellular differentiation, and hyperoxic responses in neonatal mice.
Article
Biochemistry & Molecular Biology
Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Jorrit De Waele, Christophe Hermans, Hilde Lambrechts, Bart Cuypers, Kris Laukens, Esther Bartholomeus, Vasiliki Siozopoulou, Winnok H. De Vos, Marc Peeters, Evelien L. J. Smits, Christophe Deben
Summary: Auranofin (AF), an FDA-approved antirheumatic drug, exhibits anticancer properties by inhibiting TrxR in non-small cell lung cancer cells. Mutant p53 expression enhances sensitivity to AF and leads to various cell death mechanisms including apoptosis and ferroptosis. AF also modulates the innate immune response, enhancing natural killer cell-mediated killing and dendritic cell maturation.
Article
Oncology
Yujin Kim, Bo Bin Lee, Dongho Kim, Sang-Won Um, Joungho Han, Young Mog Shim, Duk-Hwan Kim
Summary: This study analyzed samples from lung cancer patients and cancer-free patients, and found that SLIT2 gene showed aberrant methylation in tumor tissues and plasma, which could serve as a biomarker for the early detection and prognosis prediction of non-small cell lung cancer.
Article
Chemistry, Multidisciplinary
Xueying Kang, Haojie Huang, Chenyang Jiang, Longhuai Cheng, Yueqian Sang, Xuekang Cai, Yalun Dong, Lu Sun, Xin Wen, Zhen Xi, Long Yi
Summary: The importance of selenium in biology and health is becoming increasingly clear. This study demonstrates that selenocyclopropenones and selenoamides can release hydrogen selenide (H2Se) upon reaction with cysteine, and the rate of release can be tuned through structural modifications. The researchers developed a quantitative assay for direct H2Se trapping and quantification. Additionally, they found that arylselenoamide can release H2Se in cellular environments. Mechanistic investigations and density functional theory calculations provide insight into the possible pathways of Cys-activated H2Se release. The well-defined chemistries of Cys-activated H2Se donor motifs have potential for studying selenium biology and developing new H2Se donors and bioconjugate techniques.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Ruoxuan Sun, Seung-Oe Lim
Summary: This study reveals a novel mechanism for the regulation of 4-1BB at the protein level, involving polyubiquitination and degradation via the ubiquitin-proteasomal system. These findings may provide guidance for the development of targeted therapies for cancer and other immune disorders.
Article
Cell Biology
Jin Zhou, Zheming Liu, Huibo Zhang, Tianyu Lei, Jiahui Liu, Yaqi Zhao, Yi Yao, Qibin Song
Summary: This study explores the value of BACH1 in predicting the overall survival of early-stage lung adenocarcinoma. It establishes a BACH1 expression-based prognostic model that shows good predictive power and clinical applicability. Higher expression of BACH1 is associated with worse overall survival in patients with lung adenocarcinoma.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemical Research Methods
Michael J. Harris, Hao Chen, Tianyu Cai, Yuting Yi, Qaowen Deng, Yi Yao, Tianle Lan, Yanfeng Guo, Xiufang Xu, Xian Wen, Joshua E. McGee, Daniella Tatang, James Brock, Feng Shi, Li Zhou
Summary: The study demonstrates a synthetic E3 fusion protein called ReceptorTAC, which can regulate gene expression by targeting T cell antigen receptor degradation, achieving specific degradation of TCR.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Oncology
Zheming Liu, Jing Wang, Fuben Liao, Qibin Song, Yi Yao
Summary: Platelets are small anucleate cells that circulate in the blood and form thrombi. Tumor-educated platelets derived from cancer patients play a role in cancer-associated thrombosis. Studies show that tumor-educated platelets from melanoma-burdened mouse models demonstrate enhanced migration and clot formation, but are inhibited by plasma from tumor mice. RNA sequence profile of tumor-educated platelets reveals upregulation of genes associated with cell migration and cytoskeleton, shedding light on the process of thrombus formation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Haohan Zhang, Yi Yao, Jie Wu, Jin Zhou, Chen Zhao, Junju He, Bin Xu
Summary: By analyzing the scores and clustering of various cells in the tumor microenvironment of hepatocellular carcinoma, this study identified four subtypes with different biological characteristics and potential relevance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yi Dong, Yingge Li, Yi Yao, Qibin Song
Summary: In this study, a novel stratification model based on m7G-related genes was developed to successfully predict the prognosis of LUAD patients and provide guidance for clinically personalized treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ziyue Zhang, Yi Dong, Bin Wu, Yingge Li, Zehui Liu, Zheming Liu, Yanjun Gao, Likun Gao, Qibin Song, Zhongliang Zheng, Yi Yao
Summary: The study revealed that radiation can activate CAFs, which in turn, promote the proliferation, migration, radiotherapy resistance, and tumorigenesis of lung cancer cells. The findings suggest that inhibiting the activation of CAFs may be a crucial way to enhance the efficacy of clinical radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Songjiang He, Shi Zhang, Yi Yao, Bin Xu, Zhili Niu, Fuben Liao, Jie Wu, Qibin Song, Minglun Li, Zheming Liu
Summary: Glutamine metabolism is significant in the clinical outcomes of patients with pan-cancer and is closely associated with several hallmarks of a malignant tumor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yingge Li, Jie Chen, Bin Wang, Ziwen Xu, Ci Wu, Junfeng Ma, Qibin Song, Qing Geng, Jinming Yu, Huadong Pei, Yi Yao
Summary: This study aims to investigate the regulatory mechanisms of nucleotide de novo synthesis and drug resistance. By analyzing ChIP-Seq data, RNA sequencing, and luciferase-based promoter assay, the researchers identified FOXK2 as a key regulator of nucleotide de novo synthesis. FOXK2 directly regulates the expression of nucleotide synthetic genes, promoting tumor growth and cancer cell resistance to chemotherapy. In clinical analysis, elevated expression of FOXK2 is associated with increased nucleotide synthetic gene expression and poor prognosis in hepatocellular carcinoma patients.
DRUG RESISTANCE UPDATES
(2023)
Article
Chemistry, Multidisciplinary
Shuting Xiao, Yi Yao, Shuilin Liao, Bin Xu, Xue Li, Yuxiao Zhang, Lei Zhang, Qiang Chen, Haoneng Tang, Qibin Song, Ming Dong
Summary: Researchers have developed an EV-MPDS system based on FRET signals, which allows convenient diagnosis of lung cancer without the need for EV extraction and purification. In clinical samples, this system demonstrated improved accuracy and sensitivity compared to the ELISA detection method, with early screening accuracy further enhanced through machine learning analysis of five biomarkers.
Article
Oncology
Zheming Liu, Songjiang He, Zhou Huang, Jiahui Liu, Yiping Gong, Yi Yao, Xue Zhang
Summary: Drug resistance is a major challenge in immunotherapy for triple negative breast cancer patients. This study investigated the mechanisms of drug resistance using single-cell RNA sequencing data and TCGA transcriptomic data. CD8+ NKT cells and classical monocytes were found to play vital roles in the immunotherapy response, and DUSP1 was identified as a potential key factor in immunotherapy resistance.
Review
Oncology
Yingmei Wen, Yi Dong, Lina Yi, Guifang Yang, Mengxia Xiao, Qingqing Li, Chen Zhao, Dafu Ye, Yi Yao
Summary: This study reports the treatment course of a patient with advanced pulmonary sarcomatoid carcinoma. The patient initially received treatment with anlotinib, followed by the addition of Pembrolizumab, leading to partial response. The patient survived for 14 months with no significant adverse reactions during treatment. Genomic analysis revealed mutations associated with treatment efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jie Chen, Siqi Yang, Yingge Li, Xu Ziwen, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei
Summary: The de novo nucleotide biosynthetic pathway is a highly conserved and crucial biochemical pathway found in almost all organisms. Dysregulation of this pathway has been linked to the development of many human diseases, including cancer. In this review, the authors provide a comprehensive overview of the pathway, its regulatory mechanisms, its role in tumorigenesis, and potential targeting opportunities.
Meeting Abstract
Oncology
Bin Xu, Chen Zhao, Hao Zhong, Tianyu Lei, Huibo Zhang, Jie Wu, Lan Li, Yi Yao, Qibin Song
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Yi Yao, Jin Zhou, Haohan Zhang, Jie Wu, Yaqi Zhao, Zheming Liu, Bin Xu, Qibin Song
JOURNAL OF CLINICAL ONCOLOGY
(2022)