Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Engineering, Electrical & Electronic
Ziyun Chen, Rui Chen, Tingyu Deng, Yuhang Wang, Wenning Di, Haosu Luo, Tao Han
Summary: This study proposes a magnetic anomaly detection method using a self-designed high-sensitivity three-axis magnetoelectric (ME) magnetic sensor and a hybrid algorithm of particle swarm optimization (PSO) and simulated annealing (SA) algorithms. The magnetic dipole model is utilized for parameter estimation, and the proposed method is evaluated using controlled experiments, demonstrating high fitting levels and consistency with experimental design.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Analytical
Ron-Marco Friedrich, Franz Faupel
Summary: Imaging of magnetic nanoparticles is important in medical sciences. A resonant magnetoelectric sensor can measure and map the distribution of the nanoparticles, but accurate modeling and accounting for sources of uncertainty are crucial for proper reconstruction.
Article
Nanoscience & Nanotechnology
Cai Mueller, Phillip Durdaut, Rasmus B. Hollaender, Anne Kittmann, Viktor Schell, Dirk Meyners, Michael Hoeft, Eckhard Quandt, Jeffrey McCord
Summary: This study revealed the complex behavior of horizontally polarized surface shear waves in magnetoelectric surface acoustic wave based magnetic field sensor devices using time-resolved magnetooptical microscopy, uncovering partial surface wave reflections, wave front dephasing, and secondary wave generation originating from structures and magnetic domain walls.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Qisheng Yang, Weiqiu Jin, Qihang Zhang, Yuhong Wei, Zhanfeng Guo, Xiaoshi Li, Yi Yang, Qingquan Luo, He Tian, Tian-Ling Ren
Summary: The authors have developed a wearable artificial throat that can sense speech- and vocalization-related actions, providing a new technological pathway for speech recognition and interaction systems.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Engineering, Electrical & Electronic
Ziyun Chen, Wenning Di, Rui Chen, Tingyu Deng, Yuhang Wang, Haoran You, Li Lu, Tao Han, Jie Jiao, Haosu Luo
Summary: Magnetoelectric (ME) sensors have shown excellent performance in detecting weak magnetic fields. This study developed a high-performance triaxial ME sensor for magnetic anomaly detection (MAD). Experimental results demonstrated its high sensitivity for weak magnetic field detection. A finite element model was employed to analyze the magnetic anomaly induced by a ship, and the simulated results matched well with experimental data, confirming the reliability of the model.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Engineering, Electrical & Electronic
Xianfeng Liang, Alexei Matyushov, Patrick Hayes, Viktor Schell, Cunzheng Dong, Huaihao Chen, Yifan He, Alexandria Will-Cole, Eckhard Quandt, Pedro Martins, Jeffrey McCord, Marisa Medarde, Senentxu Lanceros-Mendez, Sebastiaan van Dijken, Nian X. Sun, Jordi Sort
Summary: The development of magnetoelectric materials and devices has opened up new opportunities in various technological fields, including the realization of multifunctional integrated systems. Through the advancement of multiferroic materials and other magnetoelectric mechanisms, the energy efficiency in spintronics and magnetic actuators can be greatly enhanced.
IEEE TRANSACTIONS ON MAGNETICS
(2021)
Article
Chemistry, Multidisciplinary
Staffan Hildebrand, Norbert Lowa, Hendrik Paysen, Raluca M. Fratila, Laia Reverte-Salisa, Thithawat Trakoolwilaiwan, Zheming Niu, Georgios Kasparis, Stephanie Franziska Preuss, Olaf Kosch, Jesus M. de la Fuente, Nguyen Thi Kim Thanh, Frank Wiekhorst, Alexander Pfeifer
Summary: This study quantified in vivo uptake of dietary lipids by utilizing magnetic particle imaging (MPI) and magnetic particle spectroscopy (MPS) techniques. Loading artificial chylomicrons with iron oxide nanoparticles enabled rapid detection of lipid uptake, with potential for whole-animal scans. The focus on brown adipose tissue (BAT) highlighted its correlation with leanness and cardiometabolic health.
Article
Instruments & Instrumentation
Scott Newacheck, Anil Singh, George Youssef
Summary: This study quantitatively analyzed the magnetoelectric particulate composite material system and revealed the main mechanisms responsible for the below-optimal performance of this class of materials. The experimental characterization of the composite demonstrated its multifunctional properties and quantified the interrelationship between composition and performance. The study found that the addition of magnetic particles improved the mechanical and electrical properties of the composite, but particle mobility had a detrimental effect on the overall magnetoelectric coupling performance.
SMART MATERIALS AND STRUCTURES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cong Sun, Kiarash Ghassaban, Jiaguang Song, Yufan Chen, Chao Zhang, Feifei Qu, Jinxia Zhu, Guangbin Wang, E. Mark Haacke
Summary: This study used quantitative susceptibility mapping (QSM) to evaluate calcium deposition in the fetal spine. The results showed that the magnetic susceptibility of the fetal spine decreased linearly as gestational age advanced. QSM is a reliable technique for evaluating calcium deposition and bone mineral density in the fetal spine.
EUROPEAN RADIOLOGY
(2023)
Review
Engineering, Mechanical
Junqi Gao, Zekun Jiang, Shuangjie Zhang, Zhineng Mao, Ying Shen, Zhaoqiang Chu
Summary: Multiferroic magnetoelectric (ME) materials, with the ability to couple magnetization and electric polarization, have attracted increasing attention for their diverse applications in functional devices. Among these applications, ME sensors are specifically focused in this review article, covering materials development, recent advances, and engineering applications. Challenges and future directions in sensor design and real applications need to be addressed for further development.
Article
Chemistry, Analytical
Kunyu Sun, Zhihao Jiang, Chengmeng Wang, Dongxuan Han, Zhao Yao, Weihua Zong, Zhejun Jin, Shandong Li
Summary: The magnetoelectric (ME) sensor is a new type of magnetic sensor that has ultrahigh sensitivity for measuring low-frequency weak magnetic fields. In this study, a metglas/PZT-5B ME sensor with a mechanical resonance frequency f(res) of 60.041 kHz was prepared. With the use of a frequency up-conversion technique, the sensor achieved a limit of detection (LOD) under an AC magnetic field lower than 1 nT at 8 Hz, and a minimum LOD of 0.51 nT at 20 Hz. The high-resolution ME sensor at the sub-nT level shows great potential in the field of low-frequency weak magnetic field measurement technology.
Review
Nanoscience & Nanotechnology
Cunzheng Dong, Xianfeng Liang, Jingya (Lilyn) Gao, Huaihao Chen, Yifan He, Yuyi Wei, Mohsen Zaeimbashi, Alexei Matyushov, Changxing Sun, Nian X. Sun
Summary: This article provides an overview of the applications of thin film ME sensors in biomagnetic measurement, including different types of sensors, coupling structures, materials selection, fabrication processes, and mechanisms, as well as performance and noise analysis. In addition, real-time applications of ME sensors in detecting magnetic fields from different parts of the human body are showcased.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Analytical
Dessislava Lazarova, Severina Semkova, Genoveva Zlateva, Higashi Tatsuya, Ichio Aoki, Rumiana Bakalova
Summary: Total redox capacity (TRC) and oxidative stress (OxiStress) are commonly analyzed parameters in life science, and the development of highly sensitive molecular probes and analytical methods for detecting these parameters is a rapidly growing sector of the BioTech R&D industry. This study focused on developing quantum sensors for tracking TRC and/or OxiStress in living biological objects using advanced imaging techniques, and successfully applied the sensors for cellular analysis in vitro and noninvasive imaging in vivo.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Physical
Anuj Kumar, Davinder Kaur
Summary: Magnetoelectric heterostructures have attracted attention in the material science field due to their magneto-electric coupling. Recent research has focused on improving the sensing performance of magnetoelectric-based magnetic sensors and exploring new sensing mechanisms such as signal modulation and increment E-based sensors. These sensors show potential for future applications in biomedical, geomagnetic, and magnetic anomaly detections.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Tobias Spratte, Sophie Geiger, Federico Colombo, Ankit Mishra, Mohammadreza Taale, Li-Yun Hsu, Eva Blasco, Christine Selhuber-Unkel
Summary: This study demonstrates the use of poly(N-isopropylacrylamide) (pNIPAM) as an excellent material for generating actuator systems at the micrometer scale. Two-photon direct laser writing is employed to structure thermoresponsive pNIPAM hydrogels, and it is found that the surface-to-volume ratio of the microactuators is crucial to their actuation efficiency. The phase transition of pNIPAM is also confirmed through nanoindentation experiments.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Li-Yun Hsu, Philipp Mainik, Alexander Muenchinger, Sebastian Lindenthal, Tobias Spratte, Alexander Welle, Jana Zaumseil, Christine Selhuber-Unkel, Martin Wegener, Eva Blasco
Summary: For microscale 4D photoresponsive actuators, a simple strategy is proposed to overcome the conflicting absorptions and allow for the fabrication of multi-photoresponsive 3D microstructures that can be actuated at different wavelengths of light. This is done using two-photon 3D laser printing and liquid crystalline elastomers. By incorporating different dyes into the microstructures, programmable and wavelength-selective actuations are achieved.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Shane Scott, Matthias Weiss, Christine Selhuber-Unkel, Younes F. F. Barooji, Adal Sabri, Janine T. T. Erler, Ralf Metzler, Lene B. B. Oddershede
Summary: The emergence of new tools for tracking single particles and molecules has greatly increased experimental data, providing novel insights into the physical properties of living matter. This Perspective presents tools for investigating the dynamics and mechanics of living systems at the molecular and cellular scale using single-particle techniques. It focuses on methods for measuring and interpreting complex data sets associated with forces, materials properties, transport, and organization within biological and soft-matter systems. The article outlines current approaches, challenges, and existing solutions in order to support researchers in the interface of physics and the life sciences.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Polymer Science
Stefan Schroeder, Nicolai Ababii, Mihai Brinza, Nicolae Magariu, Lukas Zimoch, Mani Teja Bodduluri, Thomas Strunskus, Rainer Adelung, Franz Faupel, Oleg Lupan
Summary: Metal oxide gas sensors have superior properties in terms of sensitivity, lifetime, cost and portability, making them highly valuable for various applications. However, their selectivity, gas response and energy consumption influenced by ambient gases still need improvement and are being extensively researched. This study presents a simple approach to enhance the selectivity of gas sensing structures using an ultrathin polymer thin film, resulting in improved selectivity to specific vapors of volatile organic compounds. This research demonstrates the possibilities of enhancing the properties of metal oxide gas sensors, which is crucial in fields such as medicine, security and food safety.
Article
Chemistry, Multidisciplinary
Oguz Han Asnaz, Jonas Drewes, Marie Elis, Thomas Strunskus, Franko Greiner, Oleksandr Polonskyi, Franz Faupel, Lorenz Kienle, Alexander Vahl, Jan Benedikt
Summary: A novel combined setup of a Haberland type gas aggregation source and a secondary radio frequency discharge is used to generate, confine, and coat nanoparticles over much longer time scales than traditional in-flight treatment. The process is precisely monitored using localized surface plasmon resonance and Fourier-transform infrared spectroscopy as in situ diagnostics. Surface coating is shown to occur in two phases: first, singular seeds appear on the particle surface which then grow to cover the entire particle surface over 3 to 5 minutes.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Igor Barg, Niklas Kohlmann, Florian Rasch, Thomas Strunskus, Rainer Adelung, Lorenz Kienle, Franz Faupel, Stefan Schroeder, Fabian Schuett
Summary: This work demonstrates a novel concept for the development of strain-invariant, highly elastic and highly water stable all-organic soft conductors, overcoming the limitations of previous strain-invariant soft conductors. The thin film structure has highly hydrophobic properties, resulting in stable electrical properties even when immersed in water for a month.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Julius Schmalz, Elizaveta Spetzler, Jeffrey McCord, Martina Gerken
Summary: In this study, magnetoelectric cantilevers consisting of strain-coupled magnetostrictive and piezoelectric layers are investigated for magnetic field measurements. The cantilevers are electrically excited and operated in a special mechanical mode, with resonance frequencies above 500 kHz, exhibiting high-quality factors and a promising limit of detection. Strategies for eliminating external effects and design guidelines to minimize unwanted oscillations are proposed.
Article
Materials Science, Biomaterials
Anna Gapeeva, Haoyi Qiu, Ala Cojocaru, Christine Arndt, Tehseen Riaz, Fabian Schuett, Christine Selhuber-Unkel, Yogendra Kumar Mishra, Ayseguel Tura, Svenja Sonntag, Stefanie Gniesmer, Salvatore Grisanti, Soeren Kaps, Rainer Adelung
Summary: The burden of glaucoma is continuously increasing and is estimated to affect over 100 million people by 2040. Minimally invasive glaucoma surgery (MIGS) has emerged as an alternative to traditional treatments, utilizing micro-sized drainage stents to minimize tissue trauma and reduce recovery time. However, the foreign body reaction and fibrosis pose a major challenge for MIGS devices.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Mohammadreza Taale, Malin Schmidt, Fereydoon Taheri, Michael Timmermann, Christine Selhuber-Unkel
Summary: Strain-stiffening is an inherent feature of many biological systems, and synthetic materials in contact with them should have the same property. However, conventional strain-stiffening materials have limitations in terms of strain-rate dependence and stiffness range. In contrast, a minimalistic structure mimicking the strain-stiffening of living cells has been developed and demonstrated to be tunable in terms of strain, stiffness, and degree of stiffening. This structure shows promise for the development of devices simulating the mechanical properties of human soft tissues.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Findan Block, Finn Klingbeil, Umer Sajjad, Christine Arndt, Sandra Sindt, Dennis Seidler, Lars Thormaehlen, Christine Selhuber-Unkel, Jeffrey McCord
Summary: Controlled transport of cells in biomedical applications can be achieved by designing soft magnetic elements to form a transport network using computational methods. This enables precise cell location and manipulation on surfaces using rotational magnetic fields. The networks allow for variable movement patterns of magnetic carriers and cells and can be integrated with CMOS-compatible materials.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Analytical
Mihai Brinza, Stefan Schroeder, Nicolai Ababii, Monja Gronenberg, Thomas Strunskus, Thierry Pauporte, Rainer Adelung, Franz Faupel, Oleg Lupan
Summary: Certain molecules in exhaled breath or outgassing vapors can act as biomarkers for various diseases and food spoilage. The development of small and reliable devices with high sensitivity for detection of these molecules is in demand. Metal-oxide gas sensors present an ideal solution, offering a tradeoff between performance and cost compared to other methods. However, selective detection of low levels of ammonia and multiple gases with one sensor remains a challenge.
Article
Engineering, Mechanical
Gowtham Arivanandhan, Zixiong Li, Sabrina M. Curtis, Lisa Hanke, Eckhard Quandt, Manfred Kohl
Summary: We propose a novel design approach to optimize the power consumption of cantilever-based shape memory alloy (SMA)/Si bimorph microactuators. By utilizing finite element simulation, additional folded beams are designed in the perpendicular direction to homogenize the temperature distribution along the cantilevers. The temperature-homogenized SMA/Si microactuators exhibit a significant reduction in power consumption compared to the conventional double-beam cantilever design, up to 48%.
Article
Engineering, Biomedical
Federico Colombo, Maria Villiou, Fereydoon Taheri, Leonard Froehlich, Mohammadreza Taale, Viktoria Albert, Qiyang Jiang, Christine Selhuber-Unkel
Summary: Using advanced imaging techniques, the effects of different molecular weights of PEG on rat embryonic fibroblast cells were studied. It was found that cell dry mass decreased and total cell weight fluctuated after exposure to PEG. Cell stiffness decreased significantly after 48 hours, highlighting the importance of maintaining cell density in cellular activities.
ADVANCED NANOBIOMED RESEARCH
(2023)
Article
Physics, Applied
G. Masciocchi, M. Fattouhi, E. Spetzler, M. -A Syskaki, R. Lehndorff, E. Martinez, J. McCord, L. Lopez-Diaz, A. Kehlberger, M. Klaeui
Summary: In this work, the authors propose a CMOS-compatible and inexpensive method for applying local strain on a Si/SiOx substrate. They demonstrate how the magnetoelastic energy landscape created by a pair of openings can be used to create pinning sites in a magnetic nanowire, leading to changes in the local magnetic anisotropy. The experimental results are supported by simulations and calculations, and the authors discuss the potential applications of this technology.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Analytical
Mohammad Sadeghi, Mohammad M. Bazrafkan, Marcus Rutner, Franz Faupel
Summary: This study investigates the dynamic behavior of a magnetoelectric microresonator using a finite element method and machine learning algorithm. The linear and nonlinear behavior of the microactuator is evaluated, and differential equations are reconstructed using a data-driven system identification procedure and simulated annealing method. Sensitivity analysis is conducted to determine the optimal range and step size for input parameters. The study finds that prediction error increases as excitation levels increase.
