Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 28, Pages 8090-8094Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602771
Keywords
alkaloids; cyclizations; natural products; palladium; total synthesis
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Funding
- Thousand Talents Plan for Young Professionals
- National Natural Science Foundation of China [21502102]
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A new method for one-step construction of the tetracyclic core structure of the indole alkaloid (+)-minfiensine was developed utilizing a palladium-catalyzed asymmetric indole dearomatization/iminium cyclization cascade. An efficient total synthesis of (+)-minfiensine was realized using this strategy. The present method enables access to the common core structure of a series of monoterpene indole alkaloids, such as vincorine, echitamine, and aspidosphylline A.
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