Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 45, Pages 14005-14008Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201607238
Keywords
copper-nitrene species; density functional calculations; hydrogen atom abstraction; mass spectrometry; nitrene transfer
Categories
Funding
- European Commission [2011-CIG-303522]
- MINECO of Spain [CTO2013-43012-P]
- Clara Immerwahr award of UniCat
- European Research Council [ERC-2011-StG-277801]
- Generalitat de Catalunya [2014 SGR 862]
- DFG
- US Department of Energy, Office of Science [DE-AC02-76SF00515, DE-SC0012704]
- US National Institutes of Health [P30-EB-009998]
Ask authors/readers for more resources
High-valent terminal copper-nitrene species have been postulated as key intermediates in copper-catalyzed aziridination and amination reactions. The high reactivity of these intermediates has prevented their characterization for decades, thereby making the mechanisms ambiguous. Very recently, the Lewis acid adduct of a copper-nitrene intermediate was trapped at -90 degrees C and shown to be active in various oxidation reactions. Herein, we describe for the first time the synthesis and spectroscopic characterization of a terminal copper(II)-nitrene radical species that is stable at room temperature in the absence of any Lewis acid. The azide derivative of a triazamacrocyclic ligand that had previously been utilized in the stabilization of aryl-Cu-III intermediates was employed as an ancillary ligand in the study. The terminal copper(II)-nitrene radical species is able to transfer a nitrene moiety to phosphines and abstract a hydrogen atom from weak C-H bonds, leading to the formation of oxidized products in modest yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available