Article
Biochemistry & Molecular Biology
Anastasia N. Vaganova, Ramilya Z. Murtazina, Taisiia S. Shemyakova, Andrey D. Prjibelski, Nataliia Katolikova, Raul R. Gainetdinov
Summary: TAAR5 receptors not only participate in odor perception but also express in brain structures, potentially related to emotional behaviors and pathogenesis of brain disorders. Research has found ubiquitous low expression of TAAR5 in various brain regions and altered expression in diseases such as Down syndrome and depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Korrina A. Duffy, Elizabeth A. Fenstermacher, John A. Thompson, Jody Tanabe, Moksha S. Patel, Steven Ojemann, Rachel A. Davis
Summary: This study provides the first indication that local field potentials may guide contact selection in patients with OCD. If validated in a larger sample, this methodology could decrease time to clinical benefit and improve accuracy in patients that are difficult to assess using traditional methods. Further research is needed to determine whether local field potentials could be used to guide finer resolution in programming parameters.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Entomology
Yi Li, Xin Wang, Haonan Dong, Qingyou Xia, Ping Zhao
Summary: A comprehensive transcriptome analysis on silkworms was conducted to investigate the influence of starvation on animal brains. Significant changes were found in pathways related to tissue structure, hormone metabolism, longevity, nucleic acid metabolism, immune response, and disease in the silkworm brain after a period of starvation. Starvation imposes significant stress on animal survival and development, resulting in organ damage within the organism. The brain, as one of the most vital organs in animals, plays a crucial role in coordinating the physiological functions of other organs.
Article
Biochemical Research Methods
Manu Kalia, Hil G. E. Meijer, Stephan A. van Gils, Michel J. A. M. van Putten, Christine R. Rose
Summary: This study investigates the key factors of synaptic failure during energy deprivation using a biophysical model, highlighting the critical role of Na+/K+-ATPase in maintaining ion gradients, membrane potentials, and cell volumes. The simulations show two stable states of the system, physiological and pathological, with a transition to the pathological state potentially leading to cell death. It is suggested that a smaller extracellular space fraction favors the transition to the pathological state, increasing susceptibility to ischemic damage, particularly in aging brains.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette McClure, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C. Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W. Poon, Ryan G. Lim, Leslie M. Thompson
Summary: Huntington disease (HD) is a neurodegenerative disorder characterized by expanded CAG repeats in the huntingtin gene, leading to altered cellular homeostasis in the striatum and cortex. Analysis of human HD patient-induced pluripotent stem cell (iPSC)-derived astrocytes and HD mouse tissue revealed disrupted maturation and glutamate signaling in HD astrocytes. Upregulated actin-mediated signaling was also observed in human HD astrocytes, suggesting potential cell-autonomous and human-specific effects. Dysregulation of astrogliogenesis transcription factors may contribute to the maturation deficits in HD astrocytes, supported by rescued climbing deficits in HD drosophila with NFIA knockdown. These findings suggest that dysfunctional astrocytic properties in HD may be attributed to dysregulated astrocyte states influenced by maturation deficits and astrogliogenesis transcription factor dysregulation.
Article
Biochemistry & Molecular Biology
Lulin Huang, Li Fang, Qian Liu, Abolfazl Doostparast Torshizi, Kai Wang
Summary: This study analyzed the behavioral features and gene expression correlations in Htt CAG knock-in mice, revealing a significant association between CAG repeat length and behavioral features. It also confirmed the role of abnormal neuronal signal transduction in the striatum in causing HD-related phenotypic behaviors. Additionally, the study identified chemicals that are related to genes enriched in these behavioral features, providing information for potential pharmacotherapeutic interventions for HD.
Article
Clinical Neurology
Jee In Kang, Jun Ho Seo, Chun Il Park, Shin Tae Kim, Yoon-Keun Kim, Jung-Kyu Jang, Cheol-O Kwon, Sumoa Jeon, Hae Won Kim, Se Joo Kim
Summary: This study examined the microbiome abundance and composition in drug-naive or drug-free patients with obsessive-compulsive disorder (OCD). The results showed significant differences in alpha and beta diversity between OCD patients and healthy controls. Additionally, specific genera were found to be less prevalent in OCD patients compared to controls. The findings suggest a potential role of the microbiota-brain interaction in the pathophysiology of OCD. Further longitudinal studies with larger sample sizes are needed to confirm these findings.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Psychology, Clinical
Xuan Wang, Yinghao Zhang, Jia Huang, Yi Wang, Yanzhe Niu, Simon S. Y. Lui, Li Hui, Raymond C. K. Chan
Summary: This systematic review and meta-analysis examined the brain dysfunction related to reward processing in individuals with schizophrenia spectrum disorders and risks. The results showed reduced functional activation across the spectrum, involving the striatum, orbital frontal cortex, cingulate cortex, and cerebellar areas.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oceanography
Jiaguo Liu, Xiaoye Wang, Zhijia Tan, Jihong Chen
Summary: This study establishes an evolutionary game model to explore the evolutionary stable strategies of Japan, other countries, and international environmental protection organization in the context of nuclear wastewater discharge. Critical factors influencing evolutionary results and trajectories are identified, and policy implications are suggested to promote Japan's non-discharge strategy to protect the marine environment and human health.
OCEAN & COASTAL MANAGEMENT
(2021)
Article
Genetics & Heredity
Tingting Li, Ruifeng Li, Xuan Dong, Lin Shi, Miao Lin, Ting Peng, Pengze Wu, Yuting Liu, Xiaoting Li, Xuheng He, Xu Han, Bin Kang, Yinan Wang, Zhiheng Liu, Qing Chen, Yue Shen, Mingxiang Feng, Xiangdong Wang, Duojiao Wu, Jian Wang, Cheng Li
Summary: The study explored the 3D genome structure of clinical lung cancer samples using Hi-C experiments and RNA sequencing analysis. It demonstrated the feasibility of studying the 3D genome of clinical lung cancer samples with a small number of cells, identified different spatial chromatin structures between normal and cancer samples, and showed that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Yinmei Ni, Jingwei Sun, Jian Li
Summary: There is evidence for positivity and optimism bias in high-level belief updates, but it is unclear if learning asymmetries exist in more elementary forms of updates like reinforcement learning (RL). In RL, the learning asymmetry refers to the difference in sensitivity between positive and negative prediction errors (PE) in value estimation. The direction of learning asymmetry is still controversial, and this study suggests that different value expectations before entering the learning environment may contribute to the controversy.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Dan Wang, Daojun Xie, Juan Zhang, Biao Cai, Bo Yang, Lei Zhou, Xiaofeng Huang
Summary: A deep sequencing study was conducted to investigate the differences in RNA transcript profiles and regulatory networks in cognitive impairment associated with Wilson's disease (WD). The study revealed differentially expressed mRNAs, long non-coding RNAs, and circular RNAs in the hippocampal tissue of tx-J mice, providing valuable insights into the regulatory genes and potential diagnostic and therapeutic approaches for WD.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Nitish K. Mishra, Pulastya Shrinath, Radhakrishna Rao, Pradeep K. Shukla
Summary: Fetal alcohol spectrum disorders (FASDs) are associated with systemic inflammation and neurodevelopmental abnormalities. A comprehensive RNA analysis was performed on the brain cortex of adult offspring exposed to fetal alcohol exposure (FAE) using high-throughput transcriptomic (RNA-seq) approach. The results showed marked sex-specific changes in RNA expression in response to FAE.
Article
Computer Science, Information Systems
Hui Zhao, Xin Liu, Yiting Wang
Summary: The study used evolutionary game model and replication dynamic equation to analyze the propagation patterns of Weibo rumors, with empirical simulation concluding the impact of reference value, psychological satisfaction, punishment value, and social unrest loss on the strategic choices of Weibo users, rumor makers, and governments.
Article
Genetics & Heredity
Eva Lindholm Carlstrom, Adnan Niazi, Mitra Etemadikhah, Jonatan Halvardson, Stefan Enroth, Craig A. Stockmeier, Grazyna Rajkowska, Bo Nilsson, Lars Feuk
Summary: The study identified an up-regulation of multiple immune response genes, including genes from the complement system, in schizophrenia patients, indicating important differences in disease etiology within the patient group. Weighted gene co-expression network analysis highlighted networks associated with both synaptic transmission and immune response activation. These findings suggest the importance of immune-related pathways in schizophrenia pathology and provide evidence for elevated expression of the complement cascade in the disease.
Review
Neurosciences
Fernanda C. Gabriel, Manoela Oliveira, Michael Berk, Elisa Brietzke, Felice N. Jacka, Beny Lafer
Summary: This review aims to summarize the relationship between nutrition and bipolar disorder (BD). Findings suggest that the intake of unsaturated fatty acids, seafood, folic acid, and zinc is associated with improved BD symptoms. The impacts of creatine, carnitine, vitamin D, inositol, or NAC supplementation on BD are variable and mainly non-significant. Promising results are associated with Coenzyme Q10 (Coq10) and probiotics. Overall, dietetic approaches might be included as part of BD treatment, and individuals with BD should choose healthy dietary lifestyles.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Developmental Biology
Kyle S. Wiley, Caroline Camilo, Gisele Gouveia, Veronica Euclydes, Catherine Panter-Brick, Alicia Matijasevich, Alexandre Archanjo Ferraro, Lislaine Aparecida Fracolli, Anna Maria Chiesa, Euripedes Constantino Miguel, Guilherme V. Polanczyk, Helena Brentani
Summary: Maternal prenatal psychosocial stress is associated with altered hypothalamic-pituitary-adrenal axis (HPAA) function among infants. This study found that altered DNA methylation, specifically in the oxytocin receptor gene, may contribute to the regulation of HPAA during infancy. Maternal distress and anxiety symptoms were negatively associated with DNA methylation and cortisol levels in infants.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Physics, Multidisciplinary
Alejandra E. Patino Hoyos, Victor Fossaluza, Luis Gustavo Esteves, Carlos Alberto de Braganca Pereira
Summary: The full Bayesian significance test (FBST) is a Bayesian alternative to traditional significance tests based on p-values, characterized by the e-value as evidence in favor of the null hypothesis (H). This work presents a method to determine a cutoff value for the e-value in the FBST by minimizing the linear combination of averaged type-I and type-II error probabilities. The methodology is compared with the test with adaptive significance level, using linear regression models under the Bayesian approach.
Article
Clinical Neurology
Paola Lavin, Soham Rej, Andrew T. Olagunju, Antonio L. Teixeira, Annemieke Dols, Martin Alda, Osvaldo P. Almeida, Kursat Altinbas, Vicent Balanza-Martinez, Izabela G. Barbosa, Hilary P. Blumberg, Farren Briggs, Cynthia Calkin, Kristin Cassidy, Brent P. Forester, Orestes V. Forlenza, Tomas Hajek, Barthomeus C. M. Haarman, Esther Jimenez, Beny Lafer, Benoit Mulsant, Stephen O. Oluwaniyi, Regan Patrick, Joaquim Radua, Sigfried Schouws, Harmehr Sekhon, Christian Simhandl, Jair C. Soares, Shang-Ying Tsai, Eduard Vieta, Luca M. Villa, Martha Sajatovic, Lisa T. Eyler
Summary: By 2030, more than 50% of individuals with bipolar disorder will be aged 50 years or older. However, there is a lack of research on older age bipolar disorder. This study developed initial recommendations for essential dimensions and variables for data collection in older age bipolar disorder, which can guide future research and clinical practice.
Article
Clinical Neurology
Luisa de Siqueira Rotenberg, Hanne Lie Kjaerstad, Cristina Varo, Maj Vinberg, Lars Vedel Kessing, Beny Lafer, Kamilla Woznica Miskowiak
Summary: In this study, the trajectories of emotional cognition subgroups in recently diagnosed bipolar disorder (BD) patients were assessed over a 16-month follow-up period. Two distinct emotional cognition subgroups were identified, with one subgroup showing heightened negative emotional reactivity and faster recognition of emotional facial expressions, while the other subgroup showed blunted reactivity in positive social scenarios, impaired emotion regulation, and poorer recognition of facial expressions. Longitudinal analysis revealed that the first subgroup exhibited improvement in emotional cognition abnormalities, while the second subgroup showed persistent impairments and poorer course of illness, indicating a need for earlier and more targeted therapeutic interventions.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcus Vinicius C. Santos, Arthur S. S. Feltrin, Isabele C. C. Costa-Amaral, Liliane R. R. Teixeira, Jamila A. A. Perini, David C. C. Martins Jr, Ariane L. L. Larentis
Summary: Network Medicine is a useful platform for studying the molecular complexity of complex diseases and identifying disease modules and pathways. It can provide insights into how environmental chemical exposures affect human cells and help monitor and prevent exposure-related diseases. In this study, benzene and malathion-exposed differentially expressed genes were used to construct interaction networks and identify important hub genes associated with these chemicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Camila Nascimento, Helena Kyunghee Kim, Paula Villela Nunes, Renata Elaine Paraiso Leite, De Oliveira Katia Cristina, Andre Barbosa, Fernanda Bernardi Bertonha, Carlos Alberto Moreira-Filho, Wilson Jacob-Filho, Ricardo Nitrini, Carlos A. Pasqualucci, Lea Tenenholz Grinberg, Claudia Kimie Suemoto, Helena Paula Brentani, Beny Lafer
Summary: In this study, gene expression changes in the hippocampus of older patients with bipolar disorder were examined, and several genes of interest were identified. These findings provide potential targets for future research to understand the pathophysiology of bipolar disorder in later life.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Matheus Ghossain Barbosa, Viviane Machado, Carolina Ziebold, Tais Moriyama, Rodrigo A. Bressan, Pedro Pan, Luis Augusto Rohde, Euripedes Constantino Miguel, Lais Fonseca, Jim Van Os, Ary Gadelha
Summary: The Brazilian High-Risk Cohort study examined the measurement invariance of the CAPE-positive scale in children and adolescents over a three-year period. The results show that the scale is not invariant over time, indicating the need for further investigation into the factors influencing its results.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Genetics & Heredity
Bethany Vibert, Patricia Segura, Louise Gallagher, Stelios Georgiades, Panagiota Pervanidou, Audrey Thurm, Lindsay Alexander, Evdokia Anagnostou, Yuta Aoki, Catherine S. Birken, Somer L. Bishop, Jessica Boi, Carmela Bravaccio, Helena Brentani, Paola Canevini, Alessandra Carta, Alice Charach, Antonella Costantino, Katherine T. Cost, Elaine A. Cravo, Jennifer Crosbie, Chiara Davico, Federica Donno, Junya Fujino, Alessandra Gabellone, Cristiane T. Geyer, Tomoya Hirota, Stephen Kanne, Makiko Kawashima, Elizabeth Kelley, Hosanna Kim, Young Shin Kim, So Hyun Kim, Daphne J. Korczak, Meng-Chuan Lai, Lucia Margari, Lucia Marzulli, Gabriele Masi, Luigi Mazzone, Jane McGrath, Suneeta Monga, Paola Morosini, Shinichiro Nakajima, Antonio Narzisi, Rob Nicolson, Aki Nikolaidis, Yoshihiro Noda, Kerri Nowell, Miriam Polizzi, Joana Portolese, Maria Pia Riccio, Manabu Saito, Ida Schwartz, Anish K. Simhal, Martina Siracusano, Stefano Sotgiu, Jacob Stroud, Fernando Sumiya, Yoshiyuki Tachibana, Nicole Takahashi, Riina Takahashi, Hiroki Tamon, Raffaella Tancredi, Benedetto Vitiello, Alessandro Zuddas, Bennett Leventhal, Kathleen Merikangas, Michael P. Milham, Adriana Di Martino
Summary: The study examined the impact of the COVID-19 pandemic on youth with autism spectrum disorder and related neurodevelopmental disorders, revealing heterogeneity in symptoms and access to services. The findings can inform recovery efforts and emphasize the importance of international data-sharing and collaborations in addressing the needs of vulnerable populations during crises.
Article
Psychiatry
Beny Lafer, Cicera Claudinea Duarte, Julia Maria D'Andrea Greve, Paulo Roberto dos Santos Silva, Karla Mathias de Almeida, Gabriel Okawa Belizario, Lucas Melo Neves
Summary: This study provides valid pilot data showing that structured physical exercise intervention has a positive therapeutic effect on depressive symptoms in patients with bipolar disorder, and also has a positive impact on muscle strength and body composition.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Tais Boeira Biazus, Gabriel Henrique Beraldi, Lucas Tokeshi, Luisa de Siqueira Rotenberg, Elena Dragioti, Andre F. Carvalho, Marco Solmi, Beny Lafer
Summary: The results of this systematic review and meta-analysis show that the risk of premature death in patients with bipolar disorder is not only related to suicide and unnatural causes, but also to physical comorbidities. Therefore, in addition to suicide prevention, promoting physical health and preventing physical conditions in individuals with bipolar disorder may reduce premature mortality risk.
MOLECULAR PSYCHIATRY
(2023)
Review
Multidisciplinary Sciences
Fabio Rosindo Daher de Barros, Caio Novais F. da Silva, Gabriel de Castro Michelassi, Helena Brentani, Fatima L. S. Nunes, Ariane Machado-Lima
Summary: Facial image analysis using image processing and machine learning techniques can help diagnose genetic syndromes and neurodevelopmental disorders. These systems offer faster and cost-effective alternatives for genotyping tests, especially for large-scale applications. However, ensuring the accuracy and reliability of computer-aided diagnosis systems remains a challenge.
Article
Psychiatry
Tatiana Cohab Khafif, Ana Kleinman, Cristiana Castanho de Almeida Rocca, Gabriel Okawa Belizario, Edmir Nader, Sheila C. Caetano, Beny Lafer
Summary: This study examines the components of self-regulation in pediatric bipolar disorder (PBD) by studying the relationship between executive functions, emotion processing, and family environmental factors. The results show that adolescents with PBD demonstrated significant deficits in all three areas compared to the control group. Emotion processing was negatively correlated with inhibition and attention, and positively correlated with mental flexibility/working memory. Family environmental factors were negatively correlated with mental flexibility/working memory and emotion processing, and positively correlated with attention and inhibition.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Nursing
Elaine Cristina Lopes da Rocha, Kayo Henrique Jardel Feitosa Sousa, Paola Alves de Oliveira Lucchesi, Magda Guimaraes de Araujo Faria, Marcos Alencar Abaide Balbinotti, Flavio Rebustini, Renata Eloah de Lucena Ferretti-Rebustini, Cristiane Helena Gallasch
Summary: This study aimed to cross-culturally adapt and assess the content validity evidence of the Cognitive Symptom Checklist-Work-21 in the Brazilian context. The final version, named "Lista de verificacao de sintomas cognitivos relacionados ao trabalho -22 itens", showed strong evidence of content validity and good linguistic equivalence in the Brazilian context.
REVISTA BRASILEIRA DE ENFERMAGEM
(2023)
