Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options

Muscle Expression of SOD1G93A Triggers the Dismantlement of Neuromuscular Junction via PKC-Theta

(2018) Gabriella Dobrowolny et al.   ANTIOXIDANTS & REDOX SIGNALING

Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial

(2018) Björn Oskarsson et al.   MUSCLE & NERVE

Metabolic Changes Associated With Muscle Expression of SOD1G93A

(2018) Gabriella Dobrowolny et al.   Frontiers in Physiology

Gene Expression Profiling in Slow-Type Calf Soleus Muscle of 30 Days Space-Flown Mice

(2017) Guido Gambara et al.   PLoS One

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

(2017) Musarrat Maisha Reza et al.   Nature Communications

Risk of Myopathy in Patients in Therapy with Statins: Identification of Biological Markers in a Pilot Study

(2017) Giulia M. Camerino et al.   Frontiers in Pharmacology

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

(2016) Sébastien S. Dufresne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination

(2016) K. E. Personius et al.   JOURNAL OF NEUROSCIENCE

FNDC5/irisin, a molecular target for boosting reward-related learning and motivation

(2016) Judit Zsuga et al.   MEDICAL HYPOTHESES

Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy

(2016) Eleonora Palma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

(2016) Giulia Maria Camerino et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography

(2016) Antonietta Mele et al.   Scientific Reports

Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis

(2016) Donald Beqollari et al.   Skeletal Muscle

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

(2015) Theo Hatzipetros et al.   Jove-Journal of Visualized Experiments

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

(2014) Antonietta Mele et al.   BIOCHEMICAL PHARMACOLOGY

Mechanisms controlling neuromuscular junction stability

(2014) Evelyne Bloch-Gallego   CELLULAR AND MOLECULAR LIFE SCIENCES

Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs

(2014) Jean-François Desaphy et al.   EXPERIMENTAL NEUROLOGY

A Computational Model of Motor Neuron Degeneration

(2014) Gwendal Le Masson et al.   NEURON

Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ

(2014) Giulia Maria Camerino et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

(2014) Cristy Phillips et al.   Frontiers in Cellular Neuroscience

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

(2013) Sabata Pierno et al.   AGE

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

(2013) Jean-François Desaphy et al.   EXPERIMENTAL NEUROLOGY

Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model

(2013) Kevin H. J. Park et al.   Nature Communications

Treatment with a coinducer of the heat shock response delays muscle denervation in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2012) Bernadett Kalmar et al.   Amyotrophic Lateral Sclerosis

PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance

(2012) Meagan A. Jenkins et al.   Channels

Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction viaN-methyl-d-aspartate receptor activation

(2012) Konstantin A. Petrov et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Understanding ALS: new therapeutic approaches

(2012) Antonio Musarò   FEBS Journal

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervation

(2011) Gabriella Dobrowolny et al.   Skeletal Muscle

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

(2010) Margaret Wong et al.   HUMAN MOLECULAR GENETICS

The “Dying-Back” Phenomenon of Motor Neurons in ALS

(2010) Michal Dadon-Nachum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles

(2010) Jean-François Desaphy et al.   PHARMACOLOGICAL RESEARCH

Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression

(2009) S Pierno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   BRAIN

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

What is principal component analysis?

(2008) Markus Ringnér   NATURE BIOTECHNOLOGY

Myogenesis in human denervated muscle biopsies

(2007) Kathrin Doppler et al.   MUSCLE & NERVE