Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-38140-y
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Funding
- Foundation for Science and Technology (FCT, Portugal)/FEDER
- Foundation for Science and Technology (FCT, Portugal) [IF/00231/2013]
- Foundation for Science and Technology (FCT)
- COMPETE [EXPL/NEU-OSD/2196/2013]
- Bial Foundation [217/12]
- Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) [NORTE-01-0145-FEDER-000013]
- FEDER funds through the Competitiveness Factors Operational Programme (COMPETE)
- National funds, through the Foundation for Science and Technology (FCT) [POCI-01-0145-FEDER-007038]
- Fundação para a Ciência e a Tecnologia [EXPL/NEU-OSD/2196/2013] Funding Source: FCT
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The continuous generation of new neurons in the adult mammalian hippocampus is a form of neural plasticity that modulates learning and memory functions, and also emotion (anxiety and depression). Among the factors known to modulate adult hippocampal neurogenesis and brain function, lipocalin-2 (LCN2) was recently described as a key regulator of neural stem cells (NSCs) proliferation and commitment, with impact on several dimensions of behaviour. Herein, we evaluated whether voluntary running, a well-known regulator of cell genesis, rescue the deficient adult hippocampal neurogenesis observed in mice lacking LCN2. We observed that running, by counteracting oxidative stress in NSCs, reverses LCN2-null mice defective hippocampal neurogenesis, as it promotes NSCs cell cycle progression and maturation, resulting in a partial reduction in anxiety and improved contextual behaviour. Together, these findings demonstrate that running is a positive modulator of adult hippocampal neurogenesis and behaviour in mice lacking LCN2, by impacting on the antioxidant kinetics of NSCs.
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