Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Metformin reduces the risk of cancer in patients with type 2 diabetes

(2018) Hae Jin Kim et al.   MEDICINE

Beyond platinum treatment for NSCLC: what does the future hold?

(2017) Mariacarmela Santarpia et al.   Expert Review of Anticancer Therapy

Targeting Hypoxia to Improve Non–Small Cell Lung Cancer Outcome

(2017) Ahmed Salem et al.   JNCI-Journal of the National Cancer Institute

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Targeting Hypoxia to Improve Non–Small Cell Lung Cancer Outcome

(2017) Ahmed Salem et al.   JNCI-Journal of the National Cancer Institute

A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase

(2016) Robert B. Piel et al.   BIOCHEMISTRY

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

(2016) Md Maksudul Alam et al.   BMC CANCER

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

(2016) Xiaojing Liu et al.   Cell Metabolism

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)

(2016) Fabrice Barlesi et al.   LANCET

Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location

(2016) Marta Vilalta et al.   MOLECULAR IMAGING AND BIOLOGY

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

(2016) Martin Reck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune Checkpoint Inhibitors in Non‐Small Cell Lung Cancer

(2016) Benjamin Herzberg et al.   ONCOLOGIST

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

(2016) Paloma Navarro et al.   Cell Reports

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

(2015) Claudia Allemani et al.   LANCET

Regulation of the oncoprotein Smoothened by small molecules

(2015) Hayley J Sharpe et al.   Nature Chemical Biology

Measurement of Heme Synthesis Levels in Mammalian Cells

(2015) Jagmohan Hooda et al.   Jove-Journal of Visualized Experiments

Bevacizumab: A Review of Its Use in Advanced Cancer

(2014) Gillian M. Keating   DRUGS

Metformin significantly reduces incident prostate cancer risk in Taiwanese men with type 2 diabetes mellitus

(2014) Chin-Hsiao Tseng   EUROPEAN JOURNAL OF CANCER

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of Smoothened for therapeutic gain

(2014) Martial Ruat et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Imaging Tumor Hypoxia to Advance Radiation Oncology

(2013) Chen-Ting Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme-related gene expression signatures of meat intakes in lung cancer tissues

(2013) Tram Kim Lam et al.   MOLECULAR CARCINOGENESIS

Structure, function, and assembly of heme centers in mitochondrial respiratory complexes

(2012) Hyung J. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission

(2012) S. B. Kaye et al.   CLINICAL CANCER RESEARCH

A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer

(2012) J. Berlin et al.   CLINICAL CANCER RESEARCH

Recurrence Dynamics for Non–Small-Cell Lung Cancer: Effect of Surgery on the Development of Metastases

(2012) Romano Demicheli et al.   Journal of Thoracic Oncology

Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis

(2012) Hiroshi Noto et al.   PLoS One

Systemic administration of bevacizumab prolongs survival in an in vivo model of platinum pre-treated ovarian cancer

(2012) DANIEL T. REIN et al.   Oncology Letters

Evaluation of combined bevacizumab and intraperitoneal carboplatin or paclitaxel therapy in a mouse model of ovarian cancer

(2011) Dhaval K. Shah et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Trends in incidence of small cell lung cancer and all lung cancer

(2011) Sharma P. Riaz et al.   LUNG CANCER

Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling

(2011) Qipeng Fan et al.   Chinese Journal of Cancer

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

(2010) Xiao Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lack of Hemodynamic Effects After Extended Heme Synthesis Inhibition by Succinylacetone in Rats

(2010) S. L. Bourque et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

(2010) R. Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Microenvironment in Non–Small-Cell Lung Cancer

(2010) Edward E. Graves et al.   SEMINARS IN RADIATION ONCOLOGY

A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks

(2009) Nataša Tasevska et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Correlation of mRNA and protein in complex biological samples

(2009) Tobias Maier et al.   FEBS LETTERS

Antidiabetic Therapies Affect Risk of Pancreatic Cancer

(2009) Donghui Li et al.   GASTROENTEROLOGY

Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking

(2009) Katie M. O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists

(2008) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular aspects of tumour hypoxia

(2008) Saskia E. Rademakers et al.   Molecular Oncology

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse

(2008) Robert J. Lipinski et al.   TOXICOLOGICAL SCIENCES