Review
Biochemistry & Molecular Biology
Matej Vicen, Ivone Cristina Igreja Sa, Katarina Tripska, Barbora Vitverova, Iveta Najmanova, Samira Eissazadeh, Stanislav Micuda, Petr Nachtigal
Summary: Membrane endoglin (Eng) and soluble endoglin (sEng) play important roles in metabolic syndrome-related disorders, including endothelial dysfunction, arterial hypertension, hyperglycemia, and diabetes. Reduced Eng expression is a hallmark of chronic pathologies related to metabolic syndrome, while sEng is considered a biomarker of preeclampsia.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Jacopo Lidonnici, Massimo M. Santoro, Roxana E. Oberkersch
Summary: Angiogenesis plays an important role in tumor growth and metastasis, and understanding the metabolic characteristics and interactions of tumor endothelial cells (TECs) with tumor cells is crucial. The metabolic differences between normal and tumor vasculature provide a basis for developing targeted therapies with higher specificity and fewer side effects, improving patient outcomes.
Article
Pharmacology & Pharmacy
Chao Zhang, Yue Wang, Fengya Huang, Yaoyuan Zhang, Yunzhu Liu, Qingbo Wang, Xiaodi Zhang, Bingyun Li, Linet Angwa, Yuting Jiang, Yanhui Gao
Summary: Endemic fluorosis is a global public health problem, and cardiovascular diseases caused by fluoride are closely related to endothelial cell injury. This study aimed to explore the alteration of endothelial cell metabolites in Human Umbilical Vein Endothelial Cells (HUVECs) exposed to NaF using LC-MS/MS technique. The findings suggest that the expression of certain metabolites was upregulated or downregulated, and these differential metabolites were primarily related to FoxO.PI3K/Akt and apoptosis signaling pathways. This study provides theories and clues for understanding the possible mechanism of fluoride-induced endothelial cell injury.
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Kaja Kiersnowska, Anna Jakubczyk
Summary: Food is not only a source of nutrients, but also a source of bioactive compounds that can play a significant role in disease prevention and treatment. Metabolic syndrome is a complex disorder that can be inhibited by bioactive peptides derived from legume seeds.
Review
Nutrition & Dietetics
Marta Garces-Rimon, Diego Morales, Marta Miguel-Castro
Summary: This study reviewed the beneficial actions of legumes proteins and peptides, with a focus on their effects on metabolic syndrome. In vitro tests have shown the promising potential of bioactive hydrolysates and peptides from pulses, but only a few animal models have validated these effects. Further research, including clinical trials, is needed to clarify the effective health implications.
Review
Biotechnology & Applied Microbiology
Piyoosh K. Babele, Amit Srivastava, Khaled A. Selim, Anil Kumar
Summary: The excessive use of nitrogen fertilizers has detrimental effects on the environment. Therefore, developing crop varieties with improved nitrogen use efficiency is necessary. Orphan crops like millets, which are adapted to lower input conditions, can serve as a source of beneficial traits for improving nitrogen use efficiency in major crops. Systems biology can help uncover the enzymes and pathways involved in nitrogen metabolism of millets, contributing to the generation of transgenic crops with improved nitrogen use efficiency.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Soile Tapio, Mark P. Little, Jan Christian Kaiser, Nathalie Impens, Nobuyuki Hamada, Alexandros G. Georgakilas, David Simar, Sisko Salomaa
Summary: The risks of radiation to health are crucial in various exposure situations, especially in relation to circulatory and metabolic diseases. Advances in treatment strategies have improved cancer survival rates, but cancer survivors may experience long-term complications. Further research on the impact of low-dose radiation is urgently needed.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Fred Kwame Ofosu, Dylis-Judith Fafa Mensah, Eric Banan-Mwine Daliri, Deog-Hwan Oh
Summary: Oxidative stress is strongly correlated with metabolic syndrome (MetS), and cereal peptides, as natural antioxidants, have gained increasing attention for their potential in preventing and managing MetS. This review explores the current production techniques for cereal peptidic antioxidants and their potential mechanism of action in the prevention and management of MetS.
Review
Food Science & Technology
Soheila Abachi, Genevieve Pilon, Andre Marette, Laurent Bazinet, Lucie Beaulieu
Summary: This article focuses on recent studies on hypoglycemic, lipid-lowering, cholesterol-lowering, and anti-obesity fish peptides. The aim is to provide more knowledge for the design and discovery of anti-MetS compounds by comparing different extraction, isolation, and purification methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Busra Baspinar, Metin Guldas
Summary: Yogurt, a fermented milk product, is a concentrated source of group B vitamins, minerals, and proteins compared to milk. It has bioactive metabolites and live enzymes from fermentation that positively impact gut microbiota. Yogurt's high-quality amino acid pattern, regulation of blood glucose and energy intake, as well as its impact on blood pressure, make it beneficial for overall health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Kirti Devi, Vibhu Kumar, Vijay Kumar, Neha Mahajan, Jasleen Kaur, Shikha Sharma, Ajay Kumar, Rehan Khan, Mahendra Bishnoi, Kanthi Kiran Kondepudi
Summary: Chemical-enzymatic processing of finger millet, kodo millet, and rice bran removes lipids and antinutrients, making them effective in preventing high fat diet-induced obesity and improving glucose homeostasis and gut health.
Article
Food Science & Technology
Diego Armando Maldonado-Torres, G. Janet Jara-Romero, Flor de Fatima Rosas-Cardenas, D. Alejandro Fernandez-Velasco, Silvia Luna-Suarez
Summary: This study successfully designed a single protein with multiple bioactive peptides for the potential treatment of metabolic syndrome, providing in vitro evidence for its effectiveness and paving the way for the development of proteins to treat other non-communicable diseases.
Review
Cell Biology
Hanlin Peng, Xiuli Wang, Junbao Du, Qinghua Cui, Yaqian Huang, Hongfang Jin
Summary: Vascular endothelial cells play a crucial role in regulating vascular function. Changes in VEC metabolism are key in processes such as angiogenesis, inflammation, and barrier maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ignazio Restivo, Alessandro Attanzio, Luisa Tesoriere, Mario Allegra
Summary: Eryptosis is a programmed cell death process that, when dysregulated, can lead to endothelial dysfunction and cardiovascular complications in metabolic syndrome. This review focuses on the involvement and mechanisms of eryptosis in metabolic syndrome, as well as the clinical evidence supporting its role in endothelial dysfunction and associated cardiovascular complications.
Article
Chemistry, Multidisciplinary
Justyna Bochnak-Niedzwiecka, Urszula Szymanowska, Michal Swieca
Summary: An innovative recipe for powdered fruit and vegetable drinks fortified with lentil proteins (AGF) and stabilized with flax seed gums (FSG) was developed. The study found that these beverages have potent antioxidant and anticancer properties, which are attributed to the bioactive peptides and phenolics released during digestion.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Dariusz Kowalczyk, Urszula Szymanowska, Tomasz Skrzypek, Monika Basiura-Cembala, Artur Bartkowiak, Katarzyna Lupina
Summary: In this study, the structural, physicochemical, and antiradical properties of GEL and WPI films incorporated with freeze-dried fireweed extract (FE) were evaluated. The results showed that GEL films had higher mechanical strength and lower permeability, while WPI films had better UV-protective potential and antiradical activity.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Szymanski, Slawomir Lewicki, Tomasz Markiewicz, Szczepan Cierniak, Jean-Pierre Tassan, Jacek Z. Kubiak
Summary: Skin wounds are a significant problem for the healthcare system, impacting clinical outcomes, patient quality of life, and financial costs. Faster wound healing could benefit both patients and the healthcare system in terms of clinical, economic, and social aspects. This study aimed to assess the potential of MELK silencing in accelerating wound healing. MELK siRNA treatment was found to lead to faster wound closure and increased collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Urszula Zlotek, Anna Jakubczyk, Kamila Rybczynska-Tkaczyk
Summary: The quality of essential oils depends on the optimized drying methods. The highest yield of essential oils was obtained from plants elicited with 0.1% yeast extract and dried traditionally. (Z)-ligustilide, alpha-terpinyl acetate, and beta-phellandrene were the main compounds identified in the samples. The most effective antioxidant activity was found in the sample obtained from plants elicited with 0.1% yeast extract and freeze-dried.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Szymanski, Krystyna Lieto, Robert Zdanowski, Slawomir Lewicki, Jean-Pierre Tassan, Jacek Z. Kubiak
Summary: Maternal embryonic leucine-zipper kinase (MELK) plays a significant role in various cellular processes and is associated with cancer proliferation. This study aimed to investigate the involvement of MELK in cell division regulation in fibroblasts and keratinocytes. The researchers examined the impact of MELK overexpression on proliferation, viability, cell cycle, and phosphorylation state of other kinases. The results suggest that abnormal expression of MELK is detrimental to the cells, challenging its potential use in accelerated wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski
Summary: Choosing the appropriate cell line is crucial for AML research, considering factors such as specific markers, genetic abnormalities, karyotype, and mutational profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Multidisciplinary
Paula Grden, Anna Jakubczyk
Summary: Pulses have been consumed by humans for centuries and also used in folk medicine for their medicinal effects. They belong to the Fabaceae family and their edible part is the fruit or pods. Different species of pulses have different edible parts such as whole pods or their parts. Legume seeds have high nutritional value with a protein content ranging from 20% to 35%. Pulses have various health-promoting properties such as low glycemic index, anti-diabetic and anti-inflammatory effects, and inhibition of pancreatic lipase.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Kamila Rybczynska-Tkaczyk, Anna Grenda, Anna Jakubczyk, Pawel Krawczyk
Summary: Despite modern treatments and personalized therapies, there is a need for new drugs in the fight against cancer. Current chemotherapeutics have unsatisfactory outcomes and burdensome side effects. Personalized therapies and immunotherapies have extended survival time in NSCLC patients, but clonal selection and acquired resistance mutations can hinder treatment effectiveness.
Article
Biochemistry & Molecular Biology
Magdalena Szydlowska-Tutaj, Urszula Szymanowska, Krzysztof Tutaj, Dorota Domagala, Urszula Zlotek
Summary: The study investigated the effects of adding 2.5% and 5% dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta. The results showed that the samples subjected to gastrointestinal digestion had significantly higher levels of phenolic compounds and exhibited increased antioxidant, anti-inflammatory, and antiproliferative properties. The analysis of phenolic compounds using LC-MS/MS technique revealed that Reishi-enriched pasta had a higher content of syringic acid, while Lion's Mane supplemented pasta had a higher content of vanillin compared to the control pasta. Ethanol extracts of the Reishi-enriched samples showed higher ABTS antiradical properties and reducing power, while Lion's Mane supplemented samples exhibited stronger lipoxygenase inhibition ability. These findings suggest that Reishi and Lion's Mane mushroom powder can be used to fortify semolina pasta, imparting slightly healthier characteristics to the product.
Review
Microbiology
Kamila Rybczynska-Tkaczyk, Anna Grenda, Anna Jakubczyk, Kaja Kiersnowska, Marta Bik-Malodzinska
Summary: Currently, the cosmetic industry is experiencing rapid growth in response to consumer demands for environmentally friendly and health-promoting products. Natural compounds with antimicrobial properties, such as polyphenolic compounds, peptides, essential oils, and plant extracts, are replacing synthetic components in cosmetics. These compounds not only offer durability and safety but also provide antioxidant, anti-inflammatory, and soothing properties, thereby increasing the value of the products. Studies have shown that the use of these natural compounds in cosmetics has a positive impact on both consumer interest and the environment.
Article
Biochemistry & Molecular Biology
Ivo Oliveira, Beatriz Marinho, Urszula Szymanowska, Monika Karas, Alice Vilela
Summary: Almonds are a highly produced nut worldwide and research has shown their nutritional and medicinal characteristics, which make them suitable for various products. This study focused on waffles supplemented with almond skins and evaluated them for polyphenol content, antioxidant capacity, flavonoids, starch, texture, color, and sensory attributes. The results indicated that waffles with 10% almond skin had the highest phenolic compounds and antioxidant activity. The study also found variations in sugar and starch content among the waffles. Sensorial evaluation showed that the waffles with 10% almond skin had higher scores for color, roasted aroma, and dissolubility. This research highlights the potential of using almond skins in the production of innovative and nutritionally valuable products.
Article
Chemistry, Multidisciplinary
Magdalena Szydlowska-Tutaj, Urszula Szymanowska, Krzysztof Tutaj, Dorota Domagala, Urszula Zlotek
Summary: The study examined the effects of adding 2.5%, 5%, 7.5%, and 10.0% of dried Enoki and Maitake mushrooms on the content of bioactive compounds and nutraceutical properties of pasta. The Maitake-supplemented pasta showed the highest amount of phenolic compounds, while the Enoki-enriched pasta exhibited higher content of α-glucans compared to the control. Gastrointestinal digestion increased the antioxidant and anti-inflammatory activities of the samples, and the ethanolic extracts from Enoki and Maitake pasta had higher antioxidant activity and lipoxygenase inhibitory potential.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Synowiec, Klaudia Brodaczewska, Gabriel Wcislo, Aleksandra Majewska, Agata Borkowska, Aleksandra Filipiak-Duliban, Aleksandra Gawrylak, Kinga Wilkus, Katarzyna Piwocka, Agata Kominek, Halina Was, Slawomir Lewicki, Jacek Siewiera, Cezary Szczylik, Jolanta Szenajch, Jacek Z. Kubiak, Claudine Kieda
Summary: Resveratrol, when used in combination with cisplatin, shows promising results as an adjuvant therapy for ovarian cancer. However, its effectiveness is limited in a hypoxic tumor microenvironment. Under hypoxia, resveratrol does not exhibit cytotoxic effects, whereas it induces apoptosis in normoxia. These findings highlight the constraints of using resveratrol as an adjuvant therapy with cisplatin in ovarian cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
