Article
Medicine, Research & Experimental
Hongzhang Yang, Lei Zhang, Huanhuan Liu, Yunming Zhang, Zhaobiao Mou, Xueyuan Chen, Jingchao Li, Fengming He, Zijing Li
Summary: 18F-labeled fluorothiophosphate (FTP) synthons with high radiochemical yields can be rapidly generated in reaction solutions using wet [18F]F- without the need for substrate pre-modification or lengthy radiosynthesis procedures. This simplified one-pot 18F-labeling method allows for the visualization and translation of a variety of biomolecules, making it valuable for modern positron emission tomography techniques.
Review
Chemistry, Multidisciplinary
Kaiqiang Zhang, Wanru Feng, Zhaobiao Mou, Jiayin Chen, Xiaoqun Tang, Zijing Li
Summary: This review provides an overview of F-18 labeling methods in aqueous media, focusing on reaction mechanisms, the effect of water, and applications in the development of F-18 radiopharmaceuticals.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Swen Humpert, Mohamed A. Omrane, Elizaveta A. Urusova, Lothar Gremer, Dieter Willbold, Heike Endepols, Raisa N. Krasikova, Bernd Neumaier, Boris D. Zlatopolskiy
Summary: This study reports the radiolabeling of thiol-containing substrates through Pd-catalyzed S-arylation using 2-[F-18]fluoro-5-iodopyridine, which is easily accessible through a minimalist radiofluorination method. The practicality of this method was confirmed through the preparation of a novel PSMA-specific PET-tracer and the labeling of various compounds.
CHEMICAL COMMUNICATIONS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tanuj Puri, Michelle L. Frost, Amelia E. B. Moore, Gary J. R. Cook, Glen M. Blake
Summary: This article introduces the method of measuring bone metabolic flux (K-i) using [F-18] sodium fluoride ([F-18]NaF) positron emission tomography (PET) scans, and proposes a simplified method that estimates K-i values from static scans and venous blood samples. By reviewing different methods of measuring arterial input functions (AIF), a non-invasive method for studying bone metabolism without arterial blood sampling is provided, which shortens scan times, simplifies procedures, and reduces costs.
Article
Engineering, Environmental
Nilesh R. Chodankar, Indrajit V. Bagal, Swati J. Patil, Seung-Kyu Hwang, Pragati A. Shinde, Amar M. Patil, Smita V. Karekar, Amal Al Ghaferi, Wenli Zhang, Sang-Wan Ryu, Yun Suk Huh, Young Kyu Han
Summary: The authors developed a solution-free dry carbon tetrafluoride plasma strategy to fabricate self-assembled nickel fluoride nanostructures for high-energy hybrid supercapacitors. The resulting NiF nanostructures exhibited high electrochemical activity, cycling stability, and rate capability in aqueous electrolytes. Additionally, an aqueous HSC cell assembled with NiF nanostructures and activated carbon showed high energy density, cycling durability, and rate capability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Beining Chen, Tingting Jiang, Heyun Fu, Xiaolei Qu, Zhaoyi Xu, Shourong Zheng
Summary: In this study, a rapid and sensitive method for detecting fluoride ions in water using a zirconium porphyrinic luminescent metal-organic framework (PCN-222) as a fluorescent probe was developed. The PCN-222 probe showed good fluorescence stability, high coordination affinity to fluoride ions, low detection limit, and fast response time. It was successfully applied for fluorescence detection of fluoride ions in real water samples, highlighting the great potential of LMOF in sensing fields.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Niannian Cao, Jiawen Ji, Changsheng Li, Meng Yuan, Xuanjun Guo, Xingxing Zong, Liqin Li, Yongqiang Ma, Chen Wang, Sen Pang
Summary: This study demonstrates that walnut shell-based biochar has a high adsorption capacity for pesticides in water, particularly for weed killers, with an adsorption rate of >70%. The biochar is effective at various pH levels and has better adsorption performance compared to other adsorbents.
Article
Engineering, Environmental
Ying Liang, Fengjie Chen, Meng Zhang, Lufeng Chen, Yu Xia, Zhen Zhou, Bolei Chen, Lixia Zhao, Yong Liang, Yawei Wang
Summary: Fluoride contamination is a significant problem for sustainable human development and requires environmental governance. In this study, calcium-doped layered yttrium hydroxides (Ca-Y LRHs) were synthesized and demonstrated to efficiently remove fluoride from aqueous solutions. The outstanding removal ability of 6% Ca-Y LRHs is attributed to the high fraction of nitrate anions in the interlayer space, which can be replaced by fluoride. The defluorination process involves electrostatic and ion exchange interactions, and oxygenated groups in interlayer spaces act as the ligands to be replaced by fluoride. The findings offer an alternative strategy for rapid and efficient treatment of fluoride contamination.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Physical
Lijie Zhou, Biao Han, Yaoyao Zhang, Bojie Li, Liansheng Wang, Jianying Wang, Xianbao Wang, Lei Zhu
Summary: It has been demonstrated that cellulosic CuI nanoparticles can efficiently catalyze the synthesis of organoboron compounds, yielding desired beta-borylation products in good to excellent yields under mild conditions. The catalyst is easily recoverable and effective for multiple runs. Moreover, asymmetric synthesis of organoboron compounds is achieved using a chiral phosphine ligand, providing an efficient and sustainable pathway for C-B bond formation and expanding the application range of cellulose.
Article
Chemistry, Analytical
Rong Li, Xinxin Feng, Yang Gao, Mingxing Zhang, Zhe Xing, Guozhong Wu
Summary: In this study, an amidoxime (AO)-based hollow gear PE fiber was fabricated through radiation grafting of acrylonitrile and methacrylic acid. The sorption efficiency of this fiber was found to be higher than that of round fiber and nonwoven fabric. The U(VI) sorption amount and rate of the hollow gear PE fiber were significantly improved, leading to effective reduction of U(VI) concentration in the environment.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Engineering, Environmental
Mingzhi Li, Yu Duan, Junqi Wei, Haiying Lin, Qingge Feng, Yongjie Tuo, Zixuan Chen, Jiatong Lv, Mingen Li, Qiuxia Wu
Summary: This study successfully prepared a high surface area porous material ZIF-8 and addressed its separation problem by anchoring it on sugarcane bagasse. ZIF-8 exhibited wide pH adaptability and efficient adsorption performance for Hg(II), enabling it to rapidly enrich a large amount of Hg(II) in a short period of time. The material has great potential for practical applications in ultra-fast and high-capacity capture of high mercury levels.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Polymer Science
Ece Akkoc, Bunyamin Karagoz
Summary: New pyrene-based polymeric microbeads were synthesized in one step and used as fluorescence chemosensor for high precision detection of nitroaromatic compounds. The microbeads could be dispersed homogeneously and stably in both aqueous and organic media, facilitating detection studies. The microbeads showed the best fluorescence quenching activities against nitroaromatic compounds in aqueous media.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Chemical
Dezai Qin, Guangrui Yang, Li Zhang
Summary: The Al-doped Fe3O4/hydroxyapatite (HAP) nanocomposites prepared in pectin matrix have shown high adsorption capacity for fluoride and possess magnetic separability and good stability. The structure and morphology of the samples were determined using X-ray diffraction and transmission electron microscopy. The pectin-coated needle-like Al-doped Fe3O4/HAP nanocrystals induced nucleation and inhibited the further growth of the nanocrystals. The obtained products were confirmed to be organic-inorganic nanocomposites, and the Al doping increased the amount of hydroxyl groups, providing more adsorption sites for fluoride. The adsorption capacity of Al-doped samples was significantly higher than that of pure HAP due to the high affinity of aluminum toward fluoride. The optimum adsorption conditions were determined by investigating the effect of reaction parameters such as pH, calcination temperature, co-existing anions, and Al/Ca molar ratio. The Al-doped Fe3O4/HAP nanocrystals exhibited a high adsorption rate for fluoride within the first 30 minutes and reached equilibrium within 80 minutes. The adsorption kinetics followed the pseudo-second-order kinetic model, and the adsorption isotherms were well-fitted by the Freundlich isotherm model. The adsorption mechanism could be mainly attributed to electrostatic attraction and ion-exchange.
DESALINATION AND WATER TREATMENT
(2022)
Article
Environmental Sciences
Samba Ndiaye, Alpha O. Toure, Falilou M. Sambe, Codou G. M. Diop, Laurent Prat, Laurent Cassayre
Summary: This study focuses on developing a process for the treatment and valorization of toxic fluorosilicic acid, a by-product of phosphoric acid production for use in fertilizer. By studying the reaction process and product characterization, the researchers proposed new steps in the conversion process, resulting in the production of pure CaF2 and a mixture of calcium silicate hydrates with low CaF2 content.
WASTE AND BIOMASS VALORIZATION
(2022)
Review
Chemistry, Medicinal
Stephen J. Archibald, Louis Allott
Summary: The [F-18]AlF radiolabelling method, which combines the favorable decay characteristics of fluorine-18 with the convenience of metal-based radiochemistry, has been widely implemented in the development of radiopharmaceuticals for the clinic. This review captures the current status of [F-18]AlF-based technology and reflects on its impact on nuclear medicine, providing insights into the future prospects of this unique radiolabelling method.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuejun Wen, Changrong Shi, Liu Yang, Xinying Zeng, Xiaoru Lin, Jinxiong Huang, Yesen Li, Rongqiang Zhuang, Haibo Zhu, Zhide Guo, Xianzhong Zhang
Summary: A novel FR-beta-targeted radiotracer was developed and shown to have potential for noninvasive detection of atherosclerosis and non-alcoholic fatty liver. Cell uptake studies and animal experiments demonstrated the high affinity and signal specificity of the tracer, suggesting its utility for imaging macrophages in advanced plaques.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhao, Bo Niu, Jianyang Fang, Yizhen Pang, Siyang Li, Chengrong Xie, Long Sun, Xianzhong Zhang, Zhide Guo, Qin Lin, Haojun Chen
Summary: Ga-68-DOTA-2P(FAPI)(2) is a promising tracer for targeted tumor diagnosis and therapy, with increased tumor uptake and retention properties compared to Ga-68-FAPI-46.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaobo Wang, Ming Zhou, Bei Chen, Huanhuan Liu, Jianyang Fang, Shijun Xiang, Shuo Hu, Xianzhong Zhang
Summary: The Ga-68-labeled D-peptide antagonist Ga-68-GP12 shows promise for PET imaging of TIGIT expression in cancers, with high affinity, specificity, and tumor uptake, indicating its potential as a companion diagnostic for anti-TIGIT therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Pharmacology & Pharmacy
Jindian Li, Juno Van Valkenburgh, Jianyang Fang, Deliang Zhang, Yingxi Chen, Quan Chen, Guorong Jia, Austin Z. Chen, Xianzhong Zhang, Kai Chen
Summary: In this study, a novel radiofluorinated riboflavin probe (18F-RFTA) was developed for specific and selective imaging of RFVT3-positive tumors. The probe demonstrated high radiochemical purity, binding affinity to RFVT3, and stability in vitro and in vivo. PET imaging showed significantly higher uptake of 18F-RFTA in RFVT3-expressing tumors compared to muscle.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Lixia Feng, Jianyang Fang, Xinying Zeng, Huanhuan Liu, Jingru Zhang, Lumei Huang, Zhide Guo, Rongqiang Zhuang, Xianzhong Zhang
Summary: This study developed a novel 68Ga-labeled tracer that can bind covalently to albumin in vivo and be used for PET imaging. The tracer showed high efficiency, good stability, and potential applications for blood pool PET imaging, bleeding, and vascular permeability alteration diseases in the clinic.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jianyang Fang, Lixia Feng, Lingxin Meng, Xiaobo Wang, Huanhuan Liu, Lumei Huang, Deliang Zhang, Jingchao Li, Rongqiang Zhuang, Zhide Guo, Xianzhong Zhang
Summary: This study developed a new radioligand, -[F-18]F-DABI, for noninvasive PET imaging to evaluate the feasibility of STING expression in the tumor microenvironment. The results demonstrated the specificity and ability of -[F-18]F-DABI for STING binding and PET imaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Optics
Yizhe Zheng, Kai Zhong, Hongzhan Qiao, Xianzhong Zhang, Fangjie Li, Yue Sun, Sijia Wang, Degang Xu, Jianquan Yao
Summary: This paper proposes a compact, efficient and power-ratio tunable 1064 nm single-wavelength laser using two Nd:YVO4 crystals and a coaxial diode-end-pumping configuration. The experimental results show that the laser has high output power and good beam quality.
OPTICS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jiali Huang, Wenyang Wang, Lei Zhang, Xiangtai Meng
Summary: This review summarizes the latest developments in the construction of benzo[b]thiophene-fused heterocycles by ring formation at the C2-C3-position of benzo[b]thiophene derivatives in the past decade. The review is divided into four parts according to the four kinds of benzo[b]thiophene derivatives used, including thioaurone, thioisatin, substituted benzo[b]thiophene, and azadiene.
CHINESE CHEMICAL LETTERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bowen Zhu, Honghui Li, Chenyi Xie, Mingyang Sun, Cong Mai, Zhuojun Xie, Zhehao Wu, Jiaqiang Zhang, Liming Nie
Summary: A dual-wavelength photoacoustic imaging approach was developed for rapid monitoring of acid-base imbalance and cerebral oxygen metabolism. The method showed good discrimination ability and could be used as a bedside monitoring method for brain protection and timely treatment of acid-base abnormalities.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Chemistry, Organic
Guixian Liu, Ling-Ling Wang, Yongzhu Zhou, Jianguo Zhou, Lei Zhang
Summary: Density functional theory calculations were used to investigate the reaction mechanism of the twofold C-H annulation of arylformamides with alkynes by Ni-Al bimetallic catalysis. The main pathway involved formyl C-H activation, phenyl C-H activation, migratory insertion, and reductive elimination steps. The annulation product was found to be the equilibrium-controlled product, while the hydrocarbamoylation product was the kinetics-controlled product. The study also highlighted the importance of a bifunctional secondary phosphine oxide ligand in enhancing reactivity and selectivity.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Wenyang Wang, Ying Wang, Xiaowei Zhao, Wenjiao Yuan, Lei Zhang, Xiangtai Meng
Summary: We developed a NaH-promoted domino reaction between an azadiene bearing an indene moiety and a Nazarov reagent, leading to the synthesis of various substituted spiro[4.5]decane derivatives with good yields and high diastereoselectivity via [4+2] cycloaddition. The reaction conditions are mild and exhibit broad substrate scope. Furthermore, gram-scale experiment and transformation of the product were successfully carried out. Finally, DFT calculations were performed to confirm the proposed reaction mechanism and analyze the observed diastereoselectivity.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Optics
Zhenhui Zhang, Wei Chen, Dandan Cui, Jie Mi, Gen Mu, Liming Nie, Sihua Yang, Yujiao Shi
Summary: A polarized photoacoustic technique (PPAT) is proposed for just-in-time quantitative evaluation of burn severity by assessing collagen fiber anisotropy. The ability of PPAT for deep imaging and accurately quantifying changes in microstructural order by thermal damage is demonstrated through phantom experiments and validated by burn skin samples. PPAT provides a just-in-time quantitative strategy for burn severity evaluation.
PHOTONICS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Fanchu Zeng, Zhijin Fan, Shiying Li, Lanqing Li, Tong Sun, Yang Qiu, Liming Nie, Guojia Huang
Summary: This study presents an all-in-one theranostic nanoprobe for precise chemotherapy and real-time immune response tracing of glioblastoma. The nanoprobe effectively targets regulatory T lymphocytes and can be monitored using photoacoustic-fluorescence imaging. The combination of chemotherapy and immunotherapy shows promising results in enhancing immune response and reducing lymphocyte infiltration.
Review
Chemistry, Organic
Jiali Huang, Lei Zhang, Xiangtai Meng
Summary: Nitrogen- and sulfur-containing heterocyclic compounds are widely found in bioactive natural products and drug molecules. Efforts have been made to develop convenient and efficient strategies for synthesizing these compounds. Pyridinium zwitterions with unique reactivity have played a significant role in the construction of heterocycles. In recent years, these zwitterions have been extensively used in cyclization reactions to synthesize novel heterocyclic compounds.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Lingxin Meng, Jianyang Fang, Xianzhong Zhang, Zhide Guo
NUCLEAR MEDICINE AND BIOLOGY
(2022)
