Article
Multidisciplinary Sciences
Susannah Holmes, Henry J. Kirkwood, Richard Bean, Klaus Giewekemeyer, Andrew Martin, Marjan Hadian-Jazi, Max O. Wiedorn, Dominik Oberthuer, Hugh Marman, Luigi Adriano, Nasser Al-Qudami, Sasa Bajt, Imrich Barak, Sadia Bari, Johan Bielecki, Sandor Brockhauser, Mathew A. Coleman, Francisco Cruz-Mazo, Cyril Danilevski, Katerina Doerner, Alfonso M. Ganan-Calvo, Rita Graceffa, Hans Fanghor, Michael Heymann, Matthias Frank, Alexander Kaukher, Yoonhee Kim, Bostjan Kobe, Juraj Knoska, Torsten Laurus, Romain Letrun, Luis Maia, Marc Messerschmidt, Markus Metz, Thomas Michelat, Grant Mills, Serguei Molodtsov, Diana C. F. Monteiro, Andrew J. Morgan, Astrid Muennich, Gisel E. Pena Murillo, Gianpietro Previtali, Adam Round, Tokushi Sato, Robin Schubert, Joachim Schulz, Megan Shelby, Carolin Seuring, Jonas A. Sellberg, Marcin Sikorski, Alessandro Silenzi, Stephan Stern, Jola Sztuk-Dambietz, Janusz Szuba, Martin Trebbin, Patrick Vagovic, Thomas Ve, Britta Weinhausen, Krzysztof Wrona, Paul Lourdu Xavier, Chen Xu, Oleksandr Yefanov, Keith A. Nugent, Henry N. Chapman, Adrian P. Mancuso, Anton Barty, Brian Abbey, Connie Darmanin
Summary: The European XFEL MHz SFX technique enables tracking of sub-microsecond structural changes in individual crystals, allowing for multi-hit serial crystallography. This technique overcomes the issue of radiation damage in traditional methods.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Griffin M. Wright, Natalie R. Gassman
Summary: Dysregulation of DNA repair is a characteristic of cancer. This study identifies STAT3 as a novel transcriptional regulator of XRCC1 in triple-negative breast cancers. Glucose challenge increases STAT3 activation, promoting XRCC1 expression in different cell types. Prolonged exposure to high glucose leads to overexpression of XRCC1, which can be reversed by restricting glucose intake and down-regulating STAT3 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Marina Rodriguez-Munoz, Martina Serrat, David Soler, Anna Genesca, Teresa Anglada
Summary: Chromosome bridges in cancer cells are often formed and may break during mitosis, with a direct correlation between the distance between bridge kinetochores and bridge breakage. The mechanisms responsible for chromosome bridge breakage during mitosis may depend on the separation between the bridge kinetochores. Previous studies have suggested mechanical stress or biochemical digestion as possible causes of bridge breakage in interphase cells, suggesting a multifactorial model for bridge breakage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liang Wu, Fuhai Su, Tian Liu, Guo-Qiang Liu, Yi Li, Tao Ma, Yunfeng Wang, Chong Zhang, Yuan Yang, Shu-Hong Yu
Summary: By doping phosphorus into two-dimensional single-crystalline quaternary sulfide nanobelts, this study achieved significantly enhanced photocatalytic hydrogen production efficiency. The introduction of phosphorus led to a narrowed band gap, inhibited carrier recombination, and increased electric conductivity, contributing to the improved catalytic performance.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Jolanta Kwasniewska, Adrianna Wiktoria Bara
Summary: Cytogenetic approaches are important for evaluating the genetic effects of mutagenic treatments, and although they are time-consuming, they are essential for studying cytotoxic and genotoxic effects and environmental monitoring. The micronucleus test is an important method for studying genotoxicity in plants, and recent advancements have expanded the scope of cytogenetic techniques beyond the detection of chromosome aberrations. However, there is limited knowledge about micronuclei in plants compared to humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Candice Qiu Xia Yam, Hong Hwa Lim, Uttam Surana
Summary: The article mainly discusses the role of the DNA damage checkpoint in cell cycle regulation, and how cells repair and continue cell cycle progression when damaged. It also mentions a potential unusual cellular response that cells may take when corrective measures fail.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaobing Qing, Guangyu Zhang, Zhao-Qi Wang
Summary: The central nervous system is highly susceptible to DNA repair deficiency, leading to various neurodevelopmental and neurodegenerative disorders. While there are gaps in our understanding of the mechanisms and specificity of DNA damage and repair in neural development and homeostasis, recent studies have identified significant findings in this field.
Editorial Material
Biochemical Research Methods
Yafei Mao, Guojie Zhang
Summary: The release of the first telomere-to-telomere human genome sequence is a significant milestone in human genomics research, offering potential insights for evolutionary genomics. This article describes the advances of this new genome assembly and discusses the challenges of applying this sequencing strategy to various extant species.
Review
Oncology
Sebastian Omar Siri, Julieta Martino, Vanesa Gottifredi
Summary: Chromosome instability (CIN) involves increased numerical and structural changes in chromosomes, playing a pivotal role in tumor progression and potential therapeutic targeting. The review delves into the origins of structural CIN, cellular mechanisms, relationships between different CIN phenotypes, and the consequences of structural CIN in cells. The discussion also explores strategies to either prevent or amplify CIN for tumor treatment.
Article
Immunology
Kerstin Felgentreff, Ulrich Baumann, Christian Klemann, Catharina Schuetz, Dorothee Viemann, Martin Wetzke, Ulrich Pannicke, Sandra von Hardenberg, Bernd Auber, Klaus-Michael Debatin, Eva-Maria Jacobsen, Manfred Hoenig, Ansgar Schulz, Klaus Schwarz
Summary: DNA damage is a common event in every cell, and proteins of the DNA damage response network play a crucial role in sensing and repairing DNA lesions. Genetic defects in DNA repair proteins can lead to immunodeficiency, bone marrow failure syndromes, and increased cancer susceptibility. DDR biomarkers are useful for diagnosing NHEJ defects and AT, with some limitations depending on the specific DNA repair deficiency.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jun Li, Adnan Ozden, Mingyu Wan, Yongfeng Hu, Fengwang Li, Yuhang Wang, Reza R. Zamani, Dan Ren, Ziyun Wang, Yi Xu, Dae-Hyun Nam, Joshua Wicks, Bin Chen, Xue Wang, Mingchuan Luo, Michael Graetzel, Fanglin Che, Edward H. Sargent, David Sinton
Summary: The oxide modulation strategy introduced silica on copper to create active Cu-SiOx interface sites, reducing the formation energies of key intermediates along the pathway to ethylene formation. The Cu-SiOx catalyst integrated in the MEA electrolyzer showed high ethylene Faradaic efficiencies and sustained operation, offering a sustainable route to produce valuable chemicals.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Anis Meschichi, Lihua Zhao, Svenja Reeck, Charles White, Olivier Da Ines, Adrien Sicard, Frederic Pontvianne, Stefanie Rosa
Summary: The study investigated the mobility of chromosomes and double-strand break (DSB) sites in response to DNA damage in Arabidopsis thaliana. The results showed an increase in chromatin mobility, particularly in the S/G2 phases of the cell cycle. This increased mobility was dependent on the DNA damage response transcription factor sog1-1 and the HR factor RAD54, suggesting a role of chromatin mobility in the early steps of the DNA damage response.
Article
Clinical Neurology
Yue Leng, Amy L. Byers, Deborah E. Barnes, Carrie B. Peltz, Yixia Li, Kristine Yaffe
Summary: The study found that veterans with traumatic brain injury (TBI) are more likely to develop sleep disorders, including sleep apnea, insomnia, hypersomnia, and sleep-related movement disorders. This association is stronger in mild TBI patients and remains even after a 2-year time lag, regardless of the presence of posttraumatic stress disorder.
Article
Biology
Swathy Babu, Yuki Takeuchi, Ichiro Masai, Katharina Schlacher
Summary: Banp plays crucial roles in DNA damage response and chromosome segregation, especially during embryonic development. It regulates cell cycle progression and cell survival by controlling DNA replication and DNA damage repair.
Article
Genetics & Heredity
Mai A. Rahmoon, Reem A. Elghaish, Aya A. Ibrahim, Zina Alaswad, Mohamed Z. Gad, Sherif F. El-Khamisy, Menattallah Elserafy
Summary: The DNA damage response (DDR) pathways are important for sensing DNA damage and coordinating repair mechanisms. This study investigated the dysregulation of the transcriptome in breast cell lines under different glucose levels. Bioinformatics analysis revealed that multiple DDR genes were significantly upregulated in both normal and cancerous breast cell lines grown in high glucose (HG). Wet lab experiments confirmed that HG induced severe DNA damage in triple-negative breast cancer (TNBC) cells, and qPCR analysis confirmed the upregulation of DDR genes. These results suggest that DDR pathways are crucial for counteracting DNA damage induced by high glucose.
Article
Endocrinology & Metabolism
Talia Levitas-Djerbi, Dana Sagi, Ilana Lebenthal-Loinger, Tali Lerer-Goldshtein, Lior Appelbaum
NEUROENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Inbal Admati, Talya Wasserman-Bartov, Adi Tovin, Rotem Rozenblat, Einat Blitz, David Zada, Tali Lerer-Goldshtein, Lior Appelbaum
Article
Biophysics
Anat Vivante, Irena Bronshtein, Yuval Garini
BIOPHYSICAL JOURNAL
(2020)
Article
Multidisciplinary Sciences
Jakob Biran, Michael Gliksberg, Ido Shirat, Amrutha Swaminathan, Talia Levitas-Djerbi, Lior Appelbaum, Gil Levkowitz
SCIENTIFIC REPORTS
(2020)
Correction
Multidisciplinary Sciences
Jakob Biran, Michael Gliksberg, Ido Shirat, Amrutha Swaminathan, Talia Levitas-Djerbi, Lior Appelbaum, Gil Levkowitz
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Haruna Nakajo, Ming-Yi Chou, Masae Kinoshita, Lior Appelbaum, Hideaki Shimazaki, Takashi Tsuboi, Hitoshi Okamoto
Article
Multidisciplinary Sciences
James B. Jaggard, Evan Lloyd, Anders Yuiska, Adam Patch, Yaouen Fily, Johanna E. Kowalko, Lior Appelbaum, Erik R. Duboue, Alex C. Keene
Article
Endocrinology & Metabolism
Einat Blitz, Hiroki Matsuda, Stefan Guenther, Takuto Morikawa, Yukihiko Kubota, David Zada, Tali Lerer-Goldshtein, Didier Y. R. Stainier, Lior Appelbaum
Summary: Hypothyroidism is characterized by insufficient thyroid hormone activity, leading to reduced goblet cells in the intestine, which can be rescued by T3 treatment. Transcriptome profiling revealed differential gene expression in the intestine of hypothyroid adults, with Fgf19-Fgfr4 signaling pathway being associated with inhibition of goblet cell differentiation in hypothyroidism. Targeting the TH and Fgf19-Fgfr4 signaling pathways could be a potential treatment for TH-related gastro-intestinal diseases.
Article
Biology
Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner
Summary: The loss of LAP2 alpha leads to the formation of larger, biochemically stable lamin A/C structures in the nuclear interior that are inaccessible to lamin A/C antibodies. Binding of LAP2 alpha to lamin A/C inhibits the formation of higher order structures, keeping nucleoplasmic lamin A/C in a mobile state. This suggests that LAP2 alpha is essential for maintaining a mobile lamin A/C pool in the nuclear interior, necessary for proper nuclear functions.
Article
Biochemistry & Molecular Biology
Ilana Buchumenski, Karoline Holler, Lior Appelbaum, Eli Eisenberg, Jan Philipp Junker, Erez Y. Levanon
Summary: A-to-I RNA editing, mediated by ADAR enzymes, increases transcript and protein diversity. Studying zebrafish editing sites revealed high editing levels in early embryos and reproductive organs, providing insights into editing roles during development and maturity.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Noa Simon-Blecher, Avi Jacob, Oren Levy, Lior Appelbaum, Shiran Elbaz-Ifrah, Yair Achituv
Summary: Morphological and genetic analyses identified four clusters of Chthamalus species in the Western Indian Ocean. A newly identified species, C. barilani, was found in Madagascar, Zanzibar, and Tanzania. Genetic distance analyses confirmed the presence of multiple cryptic species within C. malayensis and revealed additional genetic diversity among Chthamalus populations in the region.
Article
Biochemistry & Molecular Biology
David Zada, Yaniv Sela, Noa Matosevich, Adir Monsonego, Tali Lerer-Goldshtein, Yuval Nir, Lior Appelbaum
Summary: This study reveals that DNA damage is a homeostatic driver for sleep, with neuronal activity and mutagens triggering repair during sleep. DDR proteins show increased activity during sleep, while Parp1 promotes sleep and repair, sensing cellular pressure for sleep.
Article
Biochemistry & Molecular Biology
Rotem Rozenblat, Adi Tovin, David Zada, Ilana Lebenthal-Loinger, Tali Lerer-Goldshtein, Lior Appelbaum
Summary: MCT8 and thyroid hormones play a role in regulating visual system development, and their deficiency may lead to abnormalities in the visual system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shir Confino, Talya Dor, Adi Tovin, Yair Wexler, Zohar Ben-Moshe Livne, Michaela Kolker, Odelia Pisanty, Sohyun Kathy Park, Nathalie Geyer, Joel Reiter, Shimon Edvardson, Hagar Mor-Shaked, Orly Elpeleg, Daniela Vallone, Lior Appelbaum, Nicholas S. Foulkes, Yoav Gothilf
Summary: The circadian clock is a mechanism that regulates various physiological rhythms with a period of approximately 24 hours. A mutation in FBXL3 has been found in patients with syndromic developmental delay, morphological abnormalities, and intellectual disability. Using zebrafish as a model, it was discovered that loss of fbxl3a function disrupts the circadian rhythms, locomotor activity, and sleep-wake cycles, but does not cause morphological effects. These findings suggest a conserved role for FBXL3 in the circadian clock system across vertebrates and its acquisition of developmental roles in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Talya Wasserman-Bartov, Inbal Admati, Ilana Lebenthal-Loinger, Julia Sharabany, Tali Lerer-Goldshtein, Lior Appelbaum
Summary: Thyroid hormones play a critical role in growth, metabolism, and neurodevelopment. Mutation in OATP1C1 is associated with brain hypometabolism and impaired cognitive and motor function, while Tsh promotes the proliferation of Agrp1 neurons and increases food consumption in zebrafish.
JOURNAL OF NEUROSCIENCE
(2022)
