Article
Multidisciplinary Sciences
Jin Meng, Ling Fu, Keke Liu, Caiping Tian, Ziyun Wu, Youngeun Jung, Renan B. Ferreira, Kate S. Carroll, T. Keith Blackwell, Jing Yang
Summary: The study provides a comprehensive assessment of cysteine reactivity and oxidative modifications in C. elegans, shedding light on redox signaling at the organismal level.
NATURE COMMUNICATIONS
(2021)
Article
Physics, Fluids & Plasmas
A. C. Quillen, A. Peshkov, Brato Chakrabarti, Nathan Skerrett, Sonia McGaffigan, Rebeca Zapiach
Summary: Recent experiments have shown that the nematode T. aceti can assemble into collectively undulating groups at the edge of fluid drops. The coordinated state consists of metachronal waves and drives fluid circulation inside the drop. A hydrodynamics model suggests that large-amplitude excursions of the nematode tails produce the fluid circulation. The study also discusses the constraints on containers that would enhance fluid motion.
Article
Biochemical Research Methods
Jiunn-Liang Lin, Wei-Liang Kuo, Yi-Hao Huang, Tai-Lang Jong, Ao-Lin Hsu, Wen-Hsing Hsu
Summary: Caenorhabditis elegans is a popular model for aging studies due to its short lifespan. Methods for measuring the physiological age of C. elegans are needed for antiaging drug screening. With image processing and convolution neural networks, the physiological age of C. elegans can be measured with an average testing MAE of 1.58 days.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Biology
Florian Geisler, Sanne Remmelzwaal, Vera Jankowski, Ruben Schmidt, Mike Boxem, Rudolf E. Leube
Summary: Using Caenorhabditis elegans, researchers have identified the IF polypeptide IFB-2 as an efficient suppressor of structural and functional deficiencies in mutants that disrupt the organization of the intestinal IF cytoskeleton. This rescue capability is specific to IF isotypes and extends to mutants that disrupt the function of other cytoskeletal proteins. The findings provide strong evidence for the adverse consequences of deranged IF networks, with implications for diseases characterized by altered IF network organization.
Article
Mathematics, Applied
Claus Kadelka, Benjamin Keilty, Reinhard Laubenbacher
Summary: This paper investigates the mathematical properties of collectively canalizing Boolean functions, which are a class of functions derived from applications in systems biology. The functions studied capture an important aspect of biological network dynamics, where a subset of variables can dominate a Boolean function's value under certain conditions. The paper explores the influence of the number and type of these subsets on a function's behavior and introduces a new measure for canalizing strength.
ADVANCES IN APPLIED MATHEMATICS
(2023)
Article
Biology
Samuel J. P. Taylor, Laura Bel Borja, Flavie Soubigou, Jack Houston, Dhanya K. Cheerambathur, Federico Pelisch
Summary: Phosphorylation is an important post-translational modification used for regulating protein localization and activity. Polo-like kinase 1 (PLK-1) is crucial for mitotic and meiotic cell divisions, but its specific roles and regulation in meiosis have been unclear. In this study, using C. elegans oocytes, we demonstrate that PLK-1 is involved in spindle assembly, chromosome alignment and segregation, and polar body extrusion during meiosis I. We also uncover the mechanisms of PLK-1 recruitment to meiotic chromosomes. Our findings reveal the essential functions of PLK-1 in oocyte meiosis and provide insights into its targeting mechanisms.
Article
Biology
Omar Pena-Ramos, Lucia Chiao, Xianghua Liu, Xiaomeng Yu, Tianyou Yao, Henry He, Zheng Zhou
Summary: Autophagosomes play a crucial role in facilitating the degradation of apoptotic cells. They are recruited to the surfaces of phagosomes containing apoptotic cells and subsequently fuse with them, allowing the inner vesicle to enter the phagosomal lumen. Defects in autophagosome production result in significant defects in the degradation of apoptotic cells.
Article
Cell Biology
Bikash Choudhary, Olivia Marx, Adam D. Norris
Summary: The core splicing regulator PRP-40 is essential for the inclusion of alternatively spliced exons, particularly neuronal microexons, suggesting a central role in microexon splicing regulation. Knockdown of the orthologous PRPF40A in mouse neuroblastoma cells results in widespread dysregulation of microexons but not conventionally sized exons, indicating a highly conserved role of PRP-40 in neuronal microexon regulation.
Article
Physics, Multidisciplinary
Nicholas L. R. Spong, Yuechun Jiao, Oliver D. W. Hughes, Kevin J. Weatherill, Igor Lesanovsky, Charles S. Adams
Summary: This study demonstrates a collectively encoded quantum bit based on a single Rydberg excitation stored in an ensemble of N entangled atoms. Qubit rotations are performed by applying microwave fields, and coherent readout is achieved by mapping the excitation into a single photon. The results show that robust quantum information processing can be achieved via collective encoding using Rydberg polaritons.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biology
Ian G. McLachlan, Talya S. Kramer, Malvika Dua, Elizabeth M. DiLoreto, Matthew A. Gomes, Ugur Dag, Jagan Srinivasan, Steven W. Flavell, Joshua M. Kaplan
Summary: Animals need to balance competing needs and states in order to generate adaptive behavioral responses to the environment. This study found that various states and stimuli converge on a single olfactory neuron in Caenorhabditis elegans to modulate food-seeking behavior. The expression of olfactory receptor genes in this neuron is influenced by feeding state, physiological stress, and recent sensory cues. The study also revealed the molecular and neural circuit pathways through which external sensory information and internal nutritional state are integrated. This provides a general model for how sensory and state-dependent changes in gene expression at the sensory periphery modulate animals' sensorimotor responses to meet their ongoing needs and states.
Article
Biology
Josh Saul, Takashi Hirose, H. Robert Horvitz
Summary: Cell identity is established by gene expression, cell morphology, and cellular function. In this study, the researchers identified two genes, ctbp-1 and egl-13, which are essential for maintaining the identity of the AIA interneurons in Caenorhabditis elegans. They found that ctbp-1 is responsible for maintaining proper AIA gene expression, morphology, and function, while egl-13 regulates AIA function and gene expression. The researchers propose that transcriptional corepressors like CTBP-1 may play a critical role in maintaining cell identities.
Editorial Material
Biochemistry & Molecular Biology
Dominik R. Bach
Summary: This study aimed to understand the impact of aversive learning on sensory cortices and elucidate their crucial role in memory storage, specifically in olfactory disgust conditioning.
Article
Chemistry, Inorganic & Nuclear
Hui Chong, Chuan Tan, Siyu Fang, Xichen Chen, Qi Tao, Xiaohui Yuan, Jinzhi Li, Cunhui Zhai, Chengxin Fei, Di Yang, Hongying Fan, Hongxia Shao, Aijian Qin, Guoxiu Wang, Zhonghua Shi, Ting Z'hang, Hang Yao, Hualing Li, Chengyin Wang
Summary: Two novel BODIPY-bearing complexes with pyridine and pyrimidine motifs showed stronger interactions with DNA compared to cisplatin. They exhibited improved anti-chemoresistance capabilities and significantly decreased lifespan and body length in a cisplatin-resistant model. Upregulation of certain genes related to chemoresistance was observed upon exposure to cisplatin, but not to the synthesized Pt(II) complexes.
INORGANIC CHEMISTRY
(2021)
Article
Economics
Vittorio Bassi, Raffaela Muoio, Tommaso Porzio, Ritwika Sen, Esau Tugume
Summary: This paper finds that rental market interactions play a crucial role in enabling small firms in developing countries to adopt modern technology and increase their productivity. The rental market provides a workaround for other market imperfections and shapes the effectiveness of development policies.
Article
Multidisciplinary Sciences
James Dborin, Vinul Wimalaweera, F. Barratt, Eric Ostby, Thomas E. O'Brien, A. G. Green
Summary: In this paper, the authors propose a method to simulate quantum critical systems using a superconducting quantum processor. By using tensor network techniques and sequential quantum circuits, they successfully simulate quantum critical phenomena and the groundstate of the quantum Ising model.
NATURE COMMUNICATIONS
(2022)
Article
Physics, Multidisciplinary
Ken H. Nagai, Yutaka Sumino, Raul Montagne, Igor S. Aranson, Hugues Chate
PHYSICAL REVIEW LETTERS
(2015)
Article
Chemistry, Physical
Ken H. Nagai, Kunihito Tachibana, Yuta Tobe, Masaki Kazama, Hiroyuki Kitahata, Seiro Omata, Masaharu Nagayama
JOURNAL OF CHEMICAL PHYSICS
(2016)
Article
Chemistry, Multidisciplinary
Kazuki Shigyou, Ken H. Nagai, Tsutomu Hamada
Article
Chemistry, Analytical
Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
Article
Chemistry, Multidisciplinary
Yui Suzuki, Ken H. Nagai, Anatoly Zinchenko, Tsutomu Hamada
Article
Chemistry, Multidisciplinary
Hiroyuki Kitahata, Natsuhiko Yoshinaga, Ken H. Nagai, Yutaka Sumino
Article
Multidisciplinary Sciences
Yutaka Sumino, Ken H. Nagai, Yuji Shitaka, Dan Tanaka, Kenichi Yoshikawa, Hugues Chate, Kazuhiro Oiwa
Article
Physics, Fluids & Plasmas
Hiroyuki Kitahata, Natsuhiko Yoshinaga, Ken H. Nagai, Yutaka Sumino
Article
Physics, Fluids & Plasmas
Natsuhiko Yoshinaga, Ken H. Nagai, Yutaka Sumino, Hiroyuki Kitahata
Article
Physics, Fluids & Plasmas
Ken H. Nagai, Fumi Takabatake, Yutaka Sumino, Hiroyuki Kitahata, Masatoshi Ichikawa, Natsuhiko Yoshinaga
Article
Multidisciplinary Sciences
Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
SCIENTIFIC REPORTS
(2016)
Article
Biology
Masayuki Hayakawa, Satoshi Umeyama, Ken H. Nagai, Hiroaki Onoe, Masahiro Takinoue
Article
Chemistry, Physical
Kazuki Shigyou, Ken H. Nagai, Tsutomu Hamada
Article
Physics, Fluids & Plasmas
Daiki Nishiguchi, Ken H. Nagai, Hugues Chate, Masaki Sano