Article
Neurosciences
Bingmin Luo, Jing Li, Jingpeng Liu, Funi Li, Miaoqing Gu, Haoran Xiao, Shujun Lei, Zhongju Xiao
Summary: The brain regions responsible for the formation of auditory threat memory and perceptual decisions remain uncertain. This study used chemogenetic and optogenetic manipulations to investigate the roles of different brain regions in threat memory learning. The results suggest that the temporal association cortex plays a crucial role in auditory threat memory formation, with inputs from A1, A2, and MGm.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Xiaohui Wang, Yuanqing Zhang, Lin Zhu, Siyi Bai, Rui Li, Hao Sun, Runze Qi, Ruolan Cai, Min Li, Guoqiang Jia, Xinyuan Cao, Kenneth E. Schriver, Xinjian Li, Lixia Gao
Summary: Cortical feedback is crucial for sensory perception and recognition. However, previous studies have found varying effects of the primary auditory cortex (A1) on subcortical neurons' auditory response, making it difficult to interpret the function of A1 in sound perception. This study used cryo-inactivation in A1 to investigate corticothalamic feedback on medial geniculate body (MGB) neurons in awake marmosets. The results showed that A1 inactivation led to a frequency-specific decrease in MGB neurons' auditory response and an increase in spontaneous firing rate, resulting in a decreased signal-to-noise ratio. Additionally, A1 was found to modulate the sustained response of MGB neurons and change their frequency tuning.
Review
Neurosciences
Mor Harpaz, Maciej M. Jankowski, Leila Khouri, Israel Nelken
Summary: The study investigated the emergence of representation of sounds as wholes in the auditory system using stimulus-specific adaptation. The results showed differences in the representation of sounds in different parts of the auditory pathway, with the primary auditory cortex representing sound as abstract entities while other parts mainly representing them in terms of frequency components.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Alex T. L. Leong, Eddie C. Wong, Xunda Wang, Ed X. Wu
Summary: Using optogenetics and functional MRI in rodents, this study investigates how hippocampal activity modulates sound-evoked responses in the auditory midbrain and thalamus. Stimulation of ventral hippocampus excitory neurons enhances auditory responses to natural vocalizations but not to artificial sounds or noise. Pharmacological inactivation of the ventral hippocampus diminishes response selectivity to vocalizations. These findings reveal the importance of hippocampus in sound processing at early centers of the ascending auditory pathway.
Article
Psychiatry
Kangkang Xue, Jingli Chen, Yarui Wei, Yuan Chen, Shaoqiang Han, Caihong Wang, Yong Zhang, Xueqin Song, Jingliang Cheng
Summary: This research used resting state functional magnetic resonance imaging (rs-fMRI) to study schizophrenia patients and found that those with auditory verbal hallucination (AVH) showed abnormal dynamic functional connectivity (dFC) in auditory related regions, mainly involving the occipital lobe, default mode network (DMN), and middle temporal lobe. These findings provide insights into the neurological mechanism of AVH in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Matthias Staib, Sascha Fruhholz
Summary: The study found that the temporal voice area (TVA) shows similar neural responses to textural sound patterns (TSPs) as to natural voice and non-voice sounds, partially explaining activation patterns typically observed during voice processing. This suggests that the human voice area does not only process higher-order voice information, but also evaluates the perceptual and acoustic quality of non-voice sounds, responding to them with a voice-like processing pattern when detecting some rudimentary perceptual similarity with voices.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Faris Almasabi, Gusta van Zwieten, Faisal Alosaimi, Jasper V. Smit, Yasin Temel, Marcus L. F. Janssen, Ali Jahanshahi
Summary: Tinnitus, the phantom perception of sound, currently lacks effective curative treatment. Deep brain stimulation has been suggested as a potential therapy, but the optimal target and stimulation regimens are still unclear. This study investigated metabolic and neuronal activity changes in a rat model of tinnitus and found alterations in multiple brain areas, including the auditory and limbic regions. The study also demonstrated that high-frequency stimulation of the medial geniculate body enhanced neuronal activity in the thalamic reticular nucleus. These findings provide further rationales for targeting the medial geniculate body with high-frequency stimulation as a symptom management tool in tinnitus.
Article
Neurosciences
Nikos Chalas, Christoph Daube, Daniel S. Kluger, Omid Abbasi, Robert Nitsch, Joachim Gross
Summary: When we listen to someone speak, our brain activity aligns with the incoming acoustic input. This study used magnetoencephalographic recordings to investigate the acoustic events that drive this alignment. The results showed that sustained acoustic fluctuations in the speech envelope were associated with speech-brain coupling in the theta-frequency range, while tracking of speech onsets in the low-frequency delta range was strongest. These findings suggest a temporal dissociation of acoustically driven oscillatory activity in auditory areas during speech tracking.
Article
Neurosciences
Sung-Jo Lim, Christiane Thiel, Bernhard Sehm, Lorenz Deserno, Joeran Lepsien
Summary: Redirecting attention to objects in working memory can enhance their representational fidelity. This fMRI study found that valid retro-cues increased neural activation in fronto-parietal and cingulo-opercular networks, resulting in faster and more sensitive recall of acoustic details of memorized syllables. The cued auditory object was decodable from superior temporal sulcus, fronto-parietal, and sensorimotor regions. The neural fidelity in the left superior temporal sulcus and its enhancement through attention to-memory best predicted individuals' gain in auditory memory recall precision.
Review
Neurosciences
Mark Hallett
Summary: Pandya made important contributions to the understanding of cortical auditory pathways in 1969, particularly in regards to the observations on transcallosal connections of the primary auditory cortex. His speculation on the role of spatial localization of sound was later found to be incorrect, although the original observation remains valid based on subsequent literature review.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Cell Biology
Ellen P. Woon, Laura M. Butkovich, Arianna A. Peluso, Aziz Elbasheir, Kian Taylor, Shannon L. Gourley
Summary: We have discovered a connection between the ventral hippocampus and the medial orbitofrontal cortex that plays an important role in the updating of value memories, and this connection is mediated by the neuroplasticity-associated neurotrophin receptor TrkB.
Article
Biology
Aleksandar Z. Ivanov, Andrew J. King, Ben D. B. Willmore, Kerry M. M. Walker, Nicol S. Harper
Summary: This study investigates how the auditory system copes with reverberation by examining the responses of auditory cortical neurons in ferrets. The results show that auditory cortical neurons adapt to reverberation by adjusting their filtering properties, leading to dereverberation.
Article
Neurosciences
Aldis P. Weible, Michael Wehr
Summary: The research found that amyloid pathology in 5XFAD mice starts with intracellular accumulation of A beta(42) in the primary auditory cortex (A1) before progressing to extracellular plaques in A1 and other central auditory system regions. Gap detection deficits in 5XFAD mice appear earlier than cognitive deficits and may be related to the accumulation of A beta(42).
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Emily J. Allen, Juraj Mesik, Kendrick N. Kay, Andrew J. Oxenham
Summary: Tonotopy, an orderly mapping of frequency, is observed throughout the auditory system. Studies have shown evidence for pitch tuning in certain cortical regions that partially overlap with traditional tonotopic maps of spectral content.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Paul Glad Mihai, Nadja Tschentscher, Katharina von Kriegstein
Summary: The study shows that task-dependent modulation in speech recognition increases with sensory uncertainty in the speech signal, particularly in the ventral MGB providing driving input to the auditory cortex for speech in noisy listening conditions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Yue Li, Laijian Wang, Xinxin Zhang, Mengyao Huang, Sitong Li, Xinxing Wang, Lin Chen, Bin Jiang, Yupeng Yang
Review
Clinical Neurology
Xinxing Wang, Rachel Kery, Qiaojie Xiong
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2018)
Article
Neurosciences
Gregory W. Kirschen, Rachel Kery, Hanxiao Liu, Afrinash Ahamad, Liang Chen, Wendy Akmentin, Ramya Kumar, Joel Levine, Qiaojie Xiong, Shaoyu Ge
Article
Neurosciences
Jia Shen, Depeng Wang, Xinxing Wang, Shashank Gupta, Bhargav Ayloo, Song Wu, Paras Prasad, Qiaojie Xiong, Jun Xia, Shaoyu Ge
Article
Neurosciences
Pan-tong Yao, Jia Shen, Liang Chen, Shaoyu Ge, Qiaojie Xiong
Article
Multidisciplinary Sciences
Xinxing Wang, Hanxiao Liu, Johannes Morstein, Alexander J. E. Novak, Dirk Trauner, Qiaojie Xiong, Yuguo Yu, Shaoyu Ge
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Hanxiao Liu, Xinxing Wang, Lu Chen, Liang Chen, Stella E. Tsirka, Shaoyu Ge, Qiaojie Xiong
Summary: The study shows that microglia play a crucial role in maintaining stable wakefulness by regulating transitions between wakefulness and sleep through ceramide signaling. Specific microglia in the thalamic reticular nucleus and anterior TRN neurons are key players in this regulation process.
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Ivan Ge, Gregory Wohl Kirschen, Xinxing Wang
Summary: The study investigates how aging affects glucose metabolism in the mouse hippocampus, particularly during enriched environmental exploration. Elderly mice show more significant changes in glucose metabolism-related metabolites when exposed to enriched environmental exploration, indicating that glucose resources may not provide sufficient energy for hippocampal function in aging.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Allen P. F. Chen, Jeffrey M. Malgady, Lu Chen, Kaiyo W. Shi, Eileen Cheng, Joshua L. Plotkin, Shaoyu Ge, Qiaojie Xiong
Summary: This study reveals the involvement of the nigrostriatal system in auditory decision-making and demonstrates the modulatory effects of dopaminergic projections on striatal tone representations, which are inversely correlated with the evidence strength of tones.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Allen P. F. Chen, Lu Chen, Kaiyo W. Shi, Eileen Cheng, Shaoyu Ge, Qiaojie Xiong
Summary: The auditory striatum plays an important role in auditory-conditioned fear memory formation and expression through the striatal-amygdala pathway. Neuronal responses in the auditory striatum to conditioned tones are potentiated during memory acquisition and expression. Nigrostriatal dopaminergic projections are crucial in modulating striatal potentiation.
NATURE COMMUNICATIONS
(2023)