Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 31, Pages 9065-9069Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201603465
Keywords
asymmetric catalysis; boron; copper; enantioselectivity; reaction mechanisms
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Funding
- United States National Institutes of Health, Institute of General Medical Sciences [GM-116987]
- University of North Carolina at Chapel Hill
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The catalytic enantioselective synthesis of boronate-substituted tertiary alcohols through additions of diborylmethane and substituted 1,1-diborylalkanes to alpha-ketoesters is reported. The reactions are catalyzed by readily available chiral phosphine/copper(I) complexes and produce beta-hydroxyboronates containing up to two contiguous stereogenic centers in up to 99:1 e.r. and greater than 20:1 d.r. The utility of the organoboron products is demonstrated through several chemoselective functionalizations. Evidence indicates the reactions occur via an enantioenriched alpha-boryl-copperalkyl intermediate.
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