Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 17, Issue 4, Pages 2623-2631Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2019.7227
Keywords
galectin-3; missed abortion; apoptosis; pregnancy tissue; placenta
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Funding
- National Natural Science Foundation of Guangdong Province [2015A030313689]
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The success of a pregnancy relies on moderate trophoblast apoptosis. If the inhibition-induction' balance of apoptosis is broken, a pathological pregnancy may occur. Galectin-3 has an important role in numerous biological processes, including tumor cell apoptosis. However, the association between galectin-3 and missed abortion (MA) has remained elusive. In the present study, the mRNA and protein expression levels of galectin-3 in placental villi, and the apoptotic index of placental cells from patients with MA were assessed and compared with those in a normal spontaneous abortion group. The present study investigated the function of galectin-3 in the process of MA and the possible association between placental apoptosis and galectin-3 expression in MA patients. Furthermore, the role of galetin-3 in patients with MA at different times (<4 and >4 weeks) was explored. The present study provided a potential mechanism of MA from a perspective of apoptosis and also provided potential therapeutic approaches to prevent MA.
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