Article
Biochemistry & Molecular Biology
Ran-Ran Ma, Hui Zhang, Hong-Fang Chen, Guo-Hao Zhang, Ya-Ru Tian, Peng Gao
Summary: This study revealed that the decreased expression of KIF26A in gastric cancer patients is associated with disease progression, metastasis, and poor survival. By regulating the focal-adhesion pathway and suppressing the occurrence of epithelial-to-mesenchymal transition, KIF26A can inhibit tumor cell migration and invasion.
Article
Cell Biology
Yi Jin, Daqing Jiang
Summary: This study demonstrates that GATA6-AS1 inhibits gastric cancer cell proliferation and migration as a sponge of miR-543 by regulating the PTEN/AKT signaling axis, providing a new perspective for developing novel gastric cancer therapies.
MEDIATORS OF INFLAMMATION
(2023)
Article
Oncology
Bang Hu, Zhenyu Xian, Qi Zou, Di Zhang, Dan Su, Jiayin Yao, Donglin Ren
Summary: The study reveals that circFAT1 upregulates UHRF1 to affect cell proliferation, apoptosis, and glycolysis in colorectal cancer by targeting miR-520b and miR-302c-3p, providing a theoretical basis for CRC treatment.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Oncology
Leyi Liu, Ting Dong, Jun Sheng
Summary: Propofol exerts anticancer effects in gastric cancer by regulating the circPDSS1/miR-1324/SOX4 axis, inhibiting cell proliferation, migration, and invasion, and inducing apoptosis in GC cells. CircPDSS1 acts as a sponge of miR-1324 to regulate SOX4 expression, weakening the anticancer role of propofol.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Bin Yang, Huijun Yang, Xiaomei Lu, Laiyuan Wang, Hongfan Li, Shufeng Chen, Xianqiang Wang, Chenyang Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: The study demonstrated that miR-520b is expressed in human atherosclerotic plaques and suppresses EC inflammation by down-regulating the NF-KB p65-ICAM1/VCAM1 axis, regulating the interaction between monocytes and ECs, and potentially serving as a therapeutic target for EC dysfunction and atherosclerosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Yan Wang, Huiting Wang, Ruiqi Zheng, Peipei Wu, Zixuan Sun, Jingyan Chen, Leilei Zhang, Chenxiao Zhang, Hui Qian, Jiajia Jiang, Wenrong Xu
Summary: In this study, circ-ITCH was found to suppress GC metastasis by acting as a sponge for miR-199a-5p and increasing Klotho expression, providing potential biomarkers and targets for the diagnosis and therapy of GC.
Article
Biochemistry & Molecular Biology
Hui-Ning Fan, Zhao-Yu Chen, Xiao-Yu Chen, Ming Chen, You-Cai Yi, Jin-Shui Zhu, Jing Zhang
Summary: Our study reveals that METTL14-mediated m(6)A modification of circORC5 suppresses the progression of gastric cancer by regulating the miR-30c-2-3p/AKT1S1 axis.
Article
Biotechnology & Applied Microbiology
Hailin Ke, Songling Wu, Yueyi Zhang, Guowei Zhang
Summary: miR-139-3p suppresses gastric cancer by inhibiting the proliferative, migratory, and invasive abilities of GC cells through targeting KIF18B.
Article
Biotechnology & Applied Microbiology
Yan-Yu Peng, Dan Sun, Yan Xin
Summary: This study found that hsa_circ_0005230 is significantly up-regulated in gastric cancer (GC), and its high expression is positively associated with histological grade, lymph node metastasis, TNM stages, and poor prognosis. Functional experiments showed that silencing hsa_circ_0005230 can significantly decrease GC cell proliferation, invasion, and migration capabilities, and affect the expression of EMT-related proteins. Mechanism studies revealed that hsa_circ_0005230 may interact with miR-1299 and indirectly regulate the expression of RHOT1. These findings suggest that hsa_circ_0005230 may serve as a potential diagnostic biomarker and prognostic target for GC.
Article
Cell Biology
Haifeng Jin, Zheng Wu, Bibo Tan, Zhen Liu, Binqian Zhang
Summary: The research suggests that circITGA7 may play a tumor-suppressive role in gastric cancer by regulating the miR-1471/MTDH signaling pathway. This provides a new potential mechanism involved in the progression of gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hui Zhang, XinWen Qiu, ZhiJie Song, LiXia Lan, Xuan Ren, Bo Ye
Summary: In this study, we found that circCUL2 inhibits the proliferation, invasion, and migration of retinoblastoma cells by regulating the miR-214-5p/E2F2 axis.
Article
Biochemistry & Molecular Biology
Haoran Xie, Qiuyan Zhao, Lanting Yu, Jiawei Lu, Kui Peng, Ni Xie, Jianbo Ni, Baiwen Li
Summary: This study demonstrates that circ_0047744 acts as an anti-oncogene to inhibit PDAC metastasis by regulating the miR-21/SOCS5 axis. Overexpression of circ_0047744 can suppress cell migration and invasion in PDAC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Yao Wang, Yuanyuan Guo, Tianchi Zhuang, Ting Xu, Minghui Ji
Summary: Growing evidence suggests that LINC00659, a newly identified long noncoding RNA, plays a critical role in gastric cancer. Upregulation of LINC00659 is associated with tumor progression, lymphatic metastasis, and poorer prognosis. It functions as a competing endogenous RNA for miR-370, leading to the upregulation of its target gene AQP3. This study provides insights into the pathogenesis of gastric cancer and may contribute to the identification of potential therapeutic targets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ke Shi, Shuaixi Yang, Chen Chen, Bo Shao, Yaxin Guo, Xiaoke Wu, Luyang Zhao, Xiuxiu Yang, Qiuge Zhang, Weitang Yuan, Zhenqiang Sun
Summary: This study uncovers a novel potential mechanism for regulating CRC progression through the LINC01559/miR-10613-5p/PTEN axis and METTL3-mediated m6A modification on LINC01559.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Sifei Yu, Xuelei Ruan, Xiaobai Liu, Fangfang Zhang, Di Wang, Yunhui Liu, Chunqing Yang, Lianqi Shao, Qianshuo Liu, Lu Zhu, Yang Lin, Yixue Xue
Summary: Studies have shown that HNRNPD plays a significant role in the development of glioma by regulating the expression of multiple genes, affecting cell functions and vasculogenic mimicry formation.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hao Liu, Danxiu Li, Lina Sun, Hongqiang Qin, Ahui Fan, Lingnan Meng, Ramona Graves-Deal, Sarah E. Glass, Jeffrey L. Franklin, Qi Liu, Jing Wang, Timothy J. Yeatman, Hao Guo, Hong Zong, Shuilin Jin, Zhiyu Chen, Ting Deng, Ying Fang, Cunxi Li, John Karijolich, James G. Patton, Xin Wang, Yongzhan Nie, Daiming Fan, Robert J. Coffey, Xiaodi Zhao, Yuanyuan Lu
Summary: The study reveals that MIR100HG serves as a positive regulator of EMT in CRC, sustaining cetuximab resistance and promoting invasion and metastasis. It interacts with hnRNPA2B1 to control Wnt signaling transcriptional activity via regulation of TCF7L2 mRNA stability, forming a feedback loop that may contribute to cetuximab resistance and metastasis in CRC.
Correction
Cell Biology
Hao Liu, Feng Du, Lina Sun, Qingfeng Wu, Jian Wu, Mingfu Tong, Xin Wang, Qi Wang, Tianyu Cao, Xiaoliang Gao, Jiayi Cao, Nan Wu, Yongzhan Nie, Daiming Fan, Yuanyuan Lu, Xiaodi Zhao
CELL DEATH & DISEASE
(2022)
Article
Oncology
A-hui Fan, Xiaojuan Zhao, Hao Liu, Danxiu Li, Tongtong Guo, Jiehao Zhang, Lili Duan, Hao Cheng, Yongzhan Nie, Daiming Fan, Xiaodi Zhao, Yuanyuan Lu
Summary: This study found that elevated expression of eEF1A1 is correlated with poor prognosis in colorectal cancer (CRC). Inhibition of eEF1A1 can suppress CRC cell proliferation and induce cell cycle arrest. Analysis identified that mitogen-activated protein kinases (MAPKs) signaling pathway is enriched in the high-eEF1A1 expression group.
Article
Biochemistry & Molecular Biology
Junrong Liang, Lina Sun, Yujun Li, Wanning Liu, Danxiu Li, Ping Chen, Xin Wang, Juan Hui, Jinchi Zhou, Hao Liu, Tianyu Cao, Maogui Pang, Meng Guo, Xin Wang, Xiaodi Zhao, Yuanyuan Lu
Summary: This study investigated the expression and function of DKK4 in colorectal cancer (CRC). The results showed that DKK4 was upregulated in CRC cell lines and tissues, and it inhibited cell metastasis by repressing the Wnt signaling pathway. Through experiments and analysis, the researchers also revealed the regulatory mechanism of DKK4 and its potential therapeutic application.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Yangsong He, Yanan Han, A-Hui Fan, Danxiu Li, Boda Wang, Kun Ji, Xin Wang, Xiaodi Zhao, Yuanyuan Lu
Summary: This study compares the expression profile of immune cells in liver metastases and primary tumors in colorectal cancer patients. The researchers found differences in the spatial distribution of immune cells between these two types of tumors, with more immunosuppressive cells present in liver metastases, particularly macrophages with a CD68(-)CD163(+) phenotype.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Correction
Biochemistry & Molecular Biology
Gui Ren, Qifei Tian, Yanxin An, Bin Feng, Yuanyuan Lu, Jie Liang, Kai Li, Yulong Shang, Yongzhan Nie, Xin Wang, Daiming Fan
Article
Immunology
Yan Pan, Linbin Lu, Huan Liu, Di Chen, Ning Han, Ruirong Yao, Xinlin Wang, Xianchun Gao, Jun Yu, Ling Chen, Fenli Zhou, Guangjun Hao, Yuanyuan Lu, Mengbin Li, Guangbin He, Fei Kang, Zengshan Li, Yongqiang Tang, Jinsong Zhang, Lichun Wei, Yongzhan Nie
Summary: Trastuzumab-containing chemotherapy is the standard first-line treatment for advanced gastric cancer (GC) with HER2 positive. However, few studies have explored the effectiveness of anti-PD-1 therapy in overcoming resistance to trastuzumab plus chemotherapy in advanced Epstein-Barr Virus-associated gastric cancer (EBVaGC) with PD-L1 and HER2 positive. In this case presentation, a 45-year-old man with advanced EBVaGC presented with fatigue, dysphagia, and weight loss. He received trastuzumab plus chemotherapy as first-line treatment, followed by nivolumab monotherapy, total radical gastrectomy plus sequential radiotherapy, and postoperative immunotherapy. The patient achieved a durable clinical benefit with a PFS of 28 months.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Lutao Du, Yuanyuan Lu, Jiayi Wang
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Ma, Jianhui Li, Nan He, Meirui Qian, Yuanyuan Lu, Xin Wang, Kaichun Wu
Summary: This study aimed to characterize the phenotypes of CD8(+) T cells in tumor infiltrating lymphocytes (TILs) and peripheral blood lymphocytes (PBLs) in gastric cancer patients and establish a useful survival prediction model.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Integrative & Complementary Medicine
Ping Wang, Peng Li, Yingxuan Chen, Li Li, Yuanyuan Lu, Weixun Zhou, Liqun Bian, Beihua Zhang, Xiaolan Yin, Junxiang Li, Jie Chen, Shutian Zhang, Yongquan Shi, Xudong Tang
Summary: This guideline, created by 5 traditional Chinese medicine and Western medicine associations, provides specific key points and strategies for the diagnosis and treatment of gastric precancerous conditions and lesions, aiming to achieve effective secondary prevention of gastric cancer.
Article
Biochemistry & Molecular Biology
Wanning Liu, Boda Wang, Mingzhen Zhou, Dan Liu, Fulin Chen, Xiaodi Zhao, Yuanyuan Lu
Summary: Redox dysregulation leads to ROS accumulation, causing oxidative stress and cellular damage. ROS play a dual role in cancer development and survival. Recent studies have shown that ROS impact the behavior of cancer cells and tumor-associated stromal cells in the TME, and these cells have developed complex systems to adapt to high ROS environments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Surgery
Xianchun Gao, Lulu Zhao, Nannan Zhang, Weili Han, Kun Liu, Junya Yan, Ling Chen, Yan Pan, Renlong Li, Wenjiao Li, Haohao Zhang, Hongwei Li, Shibo Wang, Xiaoliang Gao, Penghui Niu, Wanqing Wang, Gang Ji, Qingchuan Zhao, Yuanyuan Lu, Zengshan Li, Lei Shang, Han Liang, Kaichun Wu, Jingyu Deng, Yingtai Chen, Yongzhan Nie
Summary: This multicenter cohort study involving 5622 consecutive stage II/III gastric cancer patients found that HER2 overexpression is associated with a lower 5-year overall survival in stage II patients but not in stage III patients. Further analysis revealed that stage II patients with high HER2 expression had a poorer response to chemotherapy. Prospective trials are needed to validate alternative HER2-targeted adjuvant therapies in stage II gastric cancer patients with high HER2 expression.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Xianchun Gao, Weili Han, Ling Chen, Hongwei Li, Fenli Zhou, Bin Bai, Junya Yan, Yong Guo, Kun Liu, Wenjiao Li, Renlong Li, Qiangqiang Yuan, Jiehao Zhang, Yuanyuan Lu, Xiaodi Zhao, Gang Ji, Mengbin Li, Qingchuan Zhao, Kaichun Wu, Zengshan Li, Yongzhan Nie
Summary: CDX2 expression is associated with prognosis and adjuvant chemotherapy benefits in stage II/III gastric cancer patients. CDX2-negative patients have a poorer prognosis without adjuvant chemotherapy, but their prognosis becomes similar to CDX2-positive patients when receiving postoperative chemotherapy. Therefore, active chemotherapy is more urgent for patients with negative CDX2 expression.
Review
Oncology
Juan Hui, Mingzhen Zhou, Guangzhou An, Hui Zhang, Yuanyuan Lu, Xin Wang, Xiaodi Zhao
Summary: Colorectal cancer (CRC) poses a significant global health challenge, yet its progression mechanism remains poorly understood. Exosomes have been identified as playing a crucial role in CRC progression, attracting extensive research attention. In addition to their role as messengers between CRC cells, exosomes also contribute to CRC immunomodulation and immune function reshaping. As stable carriers of information and a developing liquid biopsy option, exosomes show promise as biomarkers for CRC diagnosis or treatment. This review explores the biogenesis and release of exosomes, current research on their role in immune regulation and metastasis of CRC, and their significance as potential biomarkers and immunotherapy targets in CRC.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Medicine, Research & Experimental
Tianyu Cao, Yuanyuan Lu, Qi Wang, Hongqiang Qin, Hongwei Li, Hao Guo, Minghui Ge, Sarah E. Glass, Bhuminder Singh, Wenyao Zhang, Jiaqiang Dong, Feng Du, Airong Qian, Ye Tian, Xin Wang, Cunxi Li, Kaichun Wu, Daiming Fan, Yongzhan Nie, Robert J. Coffey, Xiaodi Zhao
Summary: De novo and acquired resistance are major impediments to cancer therapy. A study identified CGA as a prognostic biomarker and therapeutic target in chemoresistant gastric cancer (GC). High levels of CGA were found in chemoresistant GC cells and tissues, and elevated plasma CGA levels were correlated with reduced chemotherapy responsiveness and poor survival. CGA promoted survival and activated EGFR signaling in GC cells. Targeting CGA with anti-EGFR therapies or microRNAs restored chemotherapy sensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)