Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway

Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2-/- mice and human cholangiocarcinoma tumorigenesis

(2018) Lindsey Kennedy et al.   HEPATOLOGY

Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma

(2018) Milind Javle et al.   JOURNAL OF CLINICAL ONCOLOGY

SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma

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TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals

(2018) Jian Bai et al.   ONCOGENE

PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway

(2018) Zhong Lei et al.   Cell Death & Disease

An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression

(2018) Peter J. Bosch et al.   Scientific Reports

aPKC-ι/P-Sp1/Snail signaling induces epithelial-mesenchymal transition and immunosuppression in cholangiocarcinoma

(2017) Yawei Qian et al.   HEPATOLOGY

Dual roles of Akirin2 protein duringXenopusneural development

(2017) Xiaoliang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis

(2017) Xianjun Fang et al.   MOLECULAR CARCINOGENESIS

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

(2017) Hayato Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

(2017) Farshad Farshidfar et al.   Cell Reports

Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway

(2016) Kehong Zheng et al.   CANCER LETTERS

Akirin2 is essential for the formation of the cerebral cortex

(2016) Peter J. Bosch et al.   Neural Development

Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise

(2016) Supriya K. Saha et al.   ONCOLOGIST

Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1

(2015) Sebastian Krossa et al.   Oncotarget

FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells

(2014) Yuko Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic significance of epithelial–mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohistochemical study using a tissue microarray

(2014) T Nitta et al.   BRITISH JOURNAL OF CANCER

Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis

(2014) Ruipeng Song et al.   HEPATOLOGY

New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing

(2014) J. S. Ross et al.   ONCOLOGIST

The Wnt Antagonist sFRP1 as a Favorable Prognosticator in Human Biliary Tract Carcinoma

(2014) Pengcheng Kang et al.   PLoS One

Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma

(2013) Tongsen Zheng et al.   HEPATOLOGY

BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma

(2013) Benjamin Goeppert et al.   MODERN PATHOLOGY

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

(2013) Yuchen Jiao et al.   NATURE GENETICS

The FBI1/Akirin2 Target Gene, BCAM, Acts as a Suppressive Oncogene

(2013) Hirotada Akiyama et al.   PLoS One

miR-490-3p Modulates Cell Growth and Epithelial to Mesenchymal Transition of Hepatocellular Carcinoma Cells by Targeting Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 (ERGIC3)

(2012) Ling-yun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing of liver fluke–associated cholangiocarcinoma

(2012) Choon Kiat Ong et al.   NATURE GENETICS

MicroRNAs as regulators of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   CELL CYCLE

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer

(2010) Juan Valle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma

(2009) D Yoshikawa et al.   BRITISH JOURNAL OF CANCER

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

H3 Histamine Receptor-Mediated Activation of Protein Kinase C  Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo

(2009) H. Francis et al.   MOLECULAR CANCER RESEARCH

A Novel Binding Factor of 14-3-3β Functions as a Transcriptional Repressor and Promotes Anchorage-independent Growth, Tumorigenicity, and Metastasis

(2008) Yuko Komiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY