Article
Medicine, Research & Experimental
Kun Wu, Ting Xu, Xudong Song, Jie Shen, Shutao Zheng, Li Zhang, Guoquan Tao, Baofei Jiang
Summary: This study reveals that SLCO4A1-AS1 competitively binds to miR-150-3p, upregulating SLCO4A1 expression and inhibiting migration, invasion, sphere formation, and tumorigenesis of colon cancer stem cells. This research lays a theoretical foundation for a deeper understanding of colon cancer pathogenesis and identifies potential new therapeutic targets.
LABORATORY INVESTIGATION
(2021)
Article
Behavioral Sciences
Xiaoming Wu, Tingting Jiang, Rui Huang, Xue Xiao
Summary: GAS8-AS1 is downregulated while lncRNA NEAT1 is upregulated in GBM patients. Alterations in the expression levels of GAS8-AS1 and NEAT1 can distinguish GBM patients from healthy controls. The expression of GAS8-AS1 and NEAT1 is inversely correlated in GBM patients.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Jinxi Huang, Weiwei Yuan, Beibei Chen, Gaofeng Li, Xiaobing Chen
Summary: The study found that long noncoding RNA (lncRNA) extracellular leucine rich repeat and fibronectin type III domain containing 1-antisense RNA 1 (ELFN1-AS1) is upregulated in various tumors. However, its role in gastric cancer (GC) is not well understood. The study showed that ELFN1-AS1 promotes GC cell proliferation, migration, invasion, and EMT, and inhibits apoptosis by acting as a sponge for miR-211-3p and upregulating TRIM29 expression. Thus, the ELFN1-AS1/miR-211-3p/TRIM29 axis may be a potential target for GC treatment in the future.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Oncology
Haiqing He, Shuiqing Wu, Kai Ai, Ran Xu, Zhaohui Zhong, Yinhuai Wang, Lei Zhang, Xiaokun Zhao, Xuan Zhu
Summary: This study identified ZNF503-AS1 as a potential tumor suppressor in bladder cancer through recruitment of transcription factor GATA6 to up-regulate SLC8A1 expression, leading to increased intracellular Ca(2+) concentration and suppression of proliferation, invasion, and migration while enhancing apoptosis in bladder cancer cells.
Article
Biotechnology & Applied Microbiology
Yang Bai, Chenchen Ren, Baojin Wang, Jingge Xue, Feiyan Li, Jiaxi Liu, Li Yang
Summary: Recent studies have shown that MAFG-AS1 stimulates the malignant progression of OC by upregulating NFKB1-mediated IGF1 via miR-339-5p, highlighting a potential novel therapeutic target against OC.
CANCER GENE THERAPY
(2022)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Jian Xu, Jie Wang, Zhiwei He, Peng Chen, Xueyi Jiang, Yankun Chen, Xinyuan Liu, Jianxin Jiang
Summary: The study reveals that lncRNA CERS6-AS1 is highly expressed in pancreatic cancer and correlates with poor prognosis. Downregulation of CERS6-AS1 significantly inhibits proliferation and migration of pancreatic cancer cells. Furthermore, CERS6-AS1 regulates the proliferation and metastasis of PC cells through the miR-217/YWHAG/RAF1 signaling axis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Wei Zhang, Jingyu Zhang, Zhi Hu, Wei Sun, Lv Xu, Hao Chu, Xiao Wang, Qiao Fu
Summary: This study elucidates the impact of long non-coding RNA ARAP1-AS1 on bladder cancer cell function. ARAP1-AS1 facilitates malignant behavior in bladder cancer cells by sponging miR-3918 and regulating KIF20A expression.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yang Zhang, Yan Yang, Yi Zhang, Zhisu Liu
Summary: This study identified the oncogenic function of ST8SIA6-AS1 in liver cancer by competitively sponging miR-142-3p. The high expression of ST8SIA6-AS1 in liver cancer tissues was associated with poor prognosis, and knockdown of ST8SIA6-AS1 inhibited tumor cell proliferation, metastasis and invasion. Additionally, the tumor-inhibitory effect of ST8SIA6-AS1 silencing was reversed by miR-142-3p depletion.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Hao Li, Jing Jin, Jianchun Xian, Wei Wang
Summary: TPT1-AS1, a long non-coding RNA, is upregulated in liver cancer tissues and cell lines, and its overexpression is associated with poor prognosis, TNM stage lymph node metastasis. Knockdown of TPT1-AS1 inhibits cell proliferation, migration, and invasion, suggesting its potential as a therapeutic target for liver cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Orthopedics
Zhanhu Mi, Yanyun Dong, Zhibiao Wang, Peng Ye
Summary: The study identified that high expression of lncRNA GNAS-AS1 in OS is associated with malignancy and distant metastasis, serving as an independent prognostic predictor. Additionally, inhibition of lncRNA GNAS-AS1 can slow down the progression of OS.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoming Liu, Dandan Peng, Yixin Cao, Yuanzhe Zhu, Jianjun Yin, Guangxing Zhang, Xiaodong Peng, Yanqiu Meng
Summary: Recent studies have highlighted the crucial role of aberrant regulatory interactions in driving malignant phenotypes of hepatocellular carcinoma (HCC) cells. Specifically, the long noncoding RNA DLX6-AS1 was shown to promote HCC progression by modulating the miR-513c/Cul4A/ANXA10 axis, affecting cell viability, migration, invasion, and apoptosis. Silencing DLX6-AS1 could inhibit HCC development and provide potential therapeutic targets for HCC treatment.
CANCER GENE THERAPY
(2021)
Article
Medicine, General & Internal
Yanjiao Ou, Yong Deng, Hong Wang, Qingyi Zhang, Huan Luo, Peng Hu
Summary: This study identified a novel lncRNA PRKAG2-AS1 as a potential therapeutic target in hepatocellular carcinoma, demonstrating its association with clinical implications and malignant behaviors. PRKAG2-AS1 may function through regulating the miR-502-3p/BICD2 axis.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Guodong Liu, Yadong Lan, Xiaoqiang Yin, Tongchui Wu
Summary: This study found that lncRNA EPS15-AS1 can inhibit the proliferation and invasion of LCSCs by down-regulating the expression of EPS15 and promote apoptosis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Xinping Li, Jingyan Yang, Ruiqi Ni, Jintian Chen, Yanhao Zhou, Hao Song, Liang Jin, Yi Pan
Summary: RBM5-AS1 plays a crucial role in breast cancer initiation and progression by regulating the Wnt/β-catenin signaling pathway.
CELL DEATH & DISEASE
(2022)