Article
Plant Sciences
Jialing Zou, Yanjuan Duan, Yi Wang, Aijun Liu, Yuanran Chen, Dongjie Guo, Wanjun Guo, Shuang Li, Zhou Su, Yang Wu, Hanzhi Lu, Yu Deng, Jianyong Zhu, Fulun Li
Summary: The study found that phellopterin has anti-inflammatory effects and promotes diabetic wound healing by attenuating chronic inflammation and promoting re-epithelialization. The potential mechanism of action is through upregulation of SIRT1 protein and downregulation of ICAM-1 protein.
Article
Endocrinology & Metabolism
Nicole Lafontaine, Jane Jolley, Mervyn Kyi, Sophie King, Laura Iacobaccio, Eva Staunton, Brent Wilson, Catherine Seymour, Sonja Rogasch, Paul Wraight
Summary: This study aimed to assess whether silver dressings in acute diabetes-related foot ulcers increased the proportion of ulcers healed. The results showed that silver dressings did not improve wound healing or reduce the need for antibiotics compared with non-silver dressings.
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yen-Hsi Lin, Yen-Chin Chen, Kuo-Sheng Cheng, Po-Jui Yu, Jiun-Ling Wang, Nai-Ying Ko
Summary: This study found a positive correlation between higher periwound temperatures and better wound healing, as well as a link between higher malnutrition scores and poor wound healing. Multivariate analysis showed that changes in periwound temperature can be a useful indicator for predicting pressure ulcer healing outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Laurens Manning, Ivana Bastos Ferreira, Paul Gittings, Jonathan Hiew, Erica Ryan, Mendel Baba, Edward Raby, Keryln Carville, Paul E. Norman, Wendy Angela Davis, Fiona Wood, Emma Jane Hamilton, Jens Carsten Ritter
Summary: Spray-on skin treatment showed high rates of complete healing at 6 months in patients with large diabetes-related foot wounds, but was not significantly better than standard care. Lower body mass index and non-plantar wounds were the only patient- or wound-related factors associated with complete healing at 6 months.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biology
Zhuang Liu, Letian Zhang, Maria A. Toma, Dongqing Li, Xiaowei Bian, Irena Pastar, Marjana Tomic-Canic, Pehr Sommar, Ning Xu Landen
Summary: This study identified 17 pathologically relevant miRNAs that are involved in chronic wound pathology and showed their high cooperativity. By targeting these miRNAs, innovative wound treatments with higher efficacy and specificity could be developed.
Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Dermatology
Laura Swoboda, Jessica Held
Summary: Impaired wound healing in patients with diabetes is influenced by various factors, including hyperglycemia and inflammation. Optimizing glycemic control is the primary intervention to prevent further dysfunction and comorbid disease progression.
JOURNAL OF WOUND CARE
(2022)
Article
Dermatology
Shirin Samsavar, HamidReza Mahmoudi, Reza Shakouri, Mohammad Reza Khani, Behnam Molavi, Jamal Moosavi, Maryam Daneshpazhooh, Ifa Etesami, Babak Shokri
Summary: This study aimed to evaluate the efficacy and safety of cold atmospheric plasma (CAP) as a novel therapy for diabetic foot ulcers. Twenty patients with diabetic foot ulcers were divided into a control group and a plasma group, with the latter receiving CAP twice a week for six consecutive weeks in addition to standard wound care. The results showed that CAP was an effective treatment option for diabetic foot ulcers in terms of wound surface reduction and antibacterial effects.
DERMATOLOGIC THERAPY
(2021)
Article
Pharmacology & Pharmacy
Sujuan Guan, Tingting Hu, Liushan Chen, Zheng Li, Zhenming Lin, Jinping Lei, Juan Shen
Summary: PPARβ/FFA1 dual agonist Y8 promotes the healing of diabetic ulcer wounds in vivo and in vitro. It accelerates wound healing and reduces healing time in diabetic mice. Mechanistically, Y8 activates PPARβ to promote keratinocyte proliferation and activates FFA1 to enhance keratinocyte migration. Y8 also decreases ROS levels in fibroblasts by activating PPARβ.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Nada Bechara, Jenny E. Gunton, Victoria Flood, Tien-Ming Hng, Clare McGloin
Summary: The review found a correlation between poor nutritional status and the presence of foot ulceration or a delay in healing in diabetes. However, it is still unknown whether the relationships are causal or only association. Further research is needed to determine if any forms of nutritional supplementation can improve foot ulcer healing.
Article
Cardiac & Cardiovascular Systems
Kyeong Mi Kim, Hyun-Ju An, Sang-Hoon Kim, JuHee Kim, Changgon Sim, Jaemin Lee, Sin Hyung Park, Hyun Il Lee, Inseok Jang, Soonchul Lee
Summary: This study aimed to investigate the angiogenic potential of pericytes in diabetes-induced wounds. The results showed that pericytes enhanced vascularization and promoted wound healing. Therefore, pericyte transplantation may be a suitable treatment option for ischemic foot ulcers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Dermatology
Richard Hillson Bull, Karen Louise Staines, Agnes Juguilon Collarte, Duncan Shirreffs Bain, Nicola M. Ivins, Keith Gordon Harding
Summary: Complete healing is challenging to be the endpoint for evaluating wound healing interventions due to the complexity and diversity of wounds. Linear trajectories of healing process can help identify and accelerate the effect of interventions, providing statistical power and speed advantages. Among the investigated metrics, wound margin advance was found to be the most linear and independent of initial ulcer size.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Nanoscience & Nanotechnology
Jia-Ying Ji, Dan-Yang Ren, Ying-Zheng Weng
Summary: This review article discusses the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Shan He, Huangding Wen, Nannan Yao, Lu Wang, Junqun Huang, Zhiqing Li
Summary: The composite nano-sustained release system, TTO-NL@PCS, has potential for accelerating the healing of diabetic and MRSA-infected wounds. It disperses biofilms and kills MRSA through the stable and slow release of tea tree oil. Additionally, it improves inflammatory response and wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mostafa Vaghari-Tabari, Davoud Jafari-Gharabaghlou, Fatemeh Sadeghsoltani, Parisa Hassanpour, Durdi Qujeq, Nadereh Rashtchizadeh, Amir Ghorbanihaghjo
Summary: Inflammatory bowel disease is a chronic inflammatory condition with phases of recurrence and remission, potentially caused by an inappropriate immune response to intestinal flora bacteria. Oxidative stress and free radicals play a role in its pathogenesis, and antioxidants as well as trace elements like zinc and selenium are suggested for therapeutic approaches.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Review
Integrative & Complementary Medicine
Saeed Ebrahimi Fana, Fathollah Ahmadpour, Hamid Reza Rasouli, Sadra Samavarchi Tehrani, Mahmood Maniati
Summary: The process of wound healing is complex and Iranian Traditional Medicine (ITM) offers a rich resource of traditional knowledge, including a variety of natural compounds such as herbs, animal products, and minerals which have been studied and verified in the context of wound remedies. The review provides insights into both ITM and its vast experience in wound healing processes.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Sadeghsoltani, Iraj Mohammadzadeh, Mir-Meghdad Safari, Parisa Hassanpour, Melika Izadpanah, Durdi Qujeq, Soheila Moein, Mostafa Vaghari-Tabari
Summary: This narrative review explores the importance of zinc in the anti-viral immune response in the respiratory tract and its defense against influenza, RSV, and SARS-COV2 infections. The findings suggest that zinc plays a role in reducing viral titer, alleviating symptoms, preventing ARDS, and enhancing the effectiveness of treatments in COVID-19 patients. However, the relationship between zinc levels and the effectiveness of respiratory viruses' vaccines remains unclear and somewhat contradictory.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Medical Laboratory Technology
Anvarsadat Kianmehr, Durdi Qujeq, Abouzar Bagheri, Abdolkarim Mahrooz
Summary: Vascular endothelial cells respond to physicochemical stimuli, with oxidized low-density lipoprotein contributing to atherosclerosis. MicroRNAs play a role in cellular homeostasis under stress and can serve as therapeutic targets and biomarkers.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Review
Food Science & Technology
Mostafa Vaghari-Tabari, Iraj Mohammadzadeh, Durdi Qujeq, Maryam Majidinia, Forough Alemi, Simin Younesi, Ata Mahmoodpoor, Masomeh Maleki, Bahman Yousefi, Zatollah Asemi
Summary: Respiratory viral infections are common and unregulated immune response can cause inflammation and tissue damage. Regulating the antiviral immune response in the respiratory tract is important. Recent studies highlight the importance of vitamin D in respiratory viral infections. Vitamin D, in addition to regulating phosphorus and calcium metabolism, can also regulate immune response, providing protection against respiratory viral infections and preventing excessive inflammation and tissue damage.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Seyed Mostafa Mir, Azadeh Aliarab, Golnaz Goodarzi, Moein Shirzad, Seyyed Mehdi Jafari, Durdi Qujeq, Sadra Samavarchi Tehrani, Jahanbakhsh Asadi
Summary: DNA repair is crucial for protecting DNA molecules from damage caused by various factors, and melatonin plays a role in this repair process by acting as an antioxidant. The mechanisms of DNA repair, such as homologous recombination repair and non-homologous end-joining, are important for maintaining DNA integrity.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Review
Biochemistry & Molecular Biology
Niloufar Tavakoli Dastjerd, Ali Valibeik, Sobhan Rahimi Monfared, Golnaz Goodarzi, Mostafa Moradi Sarabi, Faezeh Hajabdollahi, Mahmood Maniati, Jamal Amri, Sadra Samavarchi Tehrani
Summary: Breast cancer is a common malignancy among women worldwide, with gene therapy emerging as an effective treatment approach. Clinical trials have shown that this method is less toxic than traditional therapies, and targeting tumor cells specifically is crucial for successful treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Negin Soghli, Gordon A. Ferns, Fatemeh Sadeghsoltani, Durdi Qujeq, Tooba Yousefi, Mostafa Vaghari-Tabari
Summary: This article discusses the role of various signaling pathways and associated miRNAs in the metastasis of osteosarcoma (OS), aiming to provide a comprehensive review of literature on OS metastasis and chemosensitivity. It highlights the potential of miRNA mimics and antagomiRs in inhibiting OS metastasis and increasing chemosensitivity, suggesting their potential clinical application.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Niloufar Targhazeh, Russel J. Reiter, Mahdi Rahimi, Durdi Qujeq, Tooba Youse, Mohammad Hassan Shahavi, Seyed Mostafa Mir
Summary: Melatonin, as the main secretory product of the pineal gland, not only regulates circadian rhythms, mood, and sleep, but also plays a role in the regulation of neoplastic processes. It can act as a differentiating agent in some cancer cells and reduce the invasive and metastatic status through cytosolic binding sites and nuclear receptors. Melatonin has oncostatic functions and can reduce the invasiveness of various human cancers. It exerts its effects through different biological processes such as antiproliferation, stimulation of anticancer immunity, modulation of the cell cycle, apoptosis, autophagy, modulation of oncogene expression, and antiangiogenesis.
Article
Endocrinology & Metabolism
Ali Nosrati Andevari, Soheila Moein, Durdi Qujeq, Zoleika Moazezi, Karimollah Hajian Tilaki
Summary: This study evaluated the effect of atorvastatin on the concentrations of MGO, GLO-1, and AKR1B10 in patients with T2DM and prediabetes. The results showed that statins decreased MGO levels in patients with T2DM, but increased MGO levels in patients with prediabetes. Additionally, statins increased GLO-1 activity levels, which may help prevent diabetic complications. Assessing the impact of atorvastatin on the levels of these proteins in patients with T2DM and prediabetes is important for preventing diabetic complications.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Biochemistry & Molecular Biology
Golnaz Goodarzi, Sadra Samavarchi Tehrani, Ghodratollah Panahi, Arash Bahramzadeh, Reza Meshkani
Summary: The combination therapy of metformin (MET) and p-coumaric acid (PCA) effectively improves weight gain, fat deposition, liver inflammation, and induces thermogenesis and adipose tissue browning in a high-fat diet-induced NAFLD mouse model.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Orthopedics
Davood Yari, Mohammad Hosein Ebrahimzadeh, Jebrail Movaffagh, Azadeh Shahroodi, Moein Shirzad, Durdi Qujeq, Ali Moradi
Summary: Chondral defects are common causes of pain and disability, and finding ways to regenerate cartilage is crucial. Tissue engineering provides new strategies for the regeneration of functional cartilage tissue through optimized scaffold properties.
ARCHIVES OF BONE AND JOINT SURGERY-ABJS
(2022)
