Article
Cardiac & Cardiovascular Systems
Vincent L. Aengevaeren, Aaron L. Baggish, Eugene H. Chung, Keith George, Oyunn Kleiven, Alma M. A. Mingels, Stein Orn, Rob E. Shave, Paul D. Thompson, Thijs M. H. Eijsvogels
Summary: Serological assessment of cardiac troponins is essential in evaluating myocardial injury, and exercise-induced elevations of cardiac troponins have long been debated for their clinical relevance. Recent studies have shed new light on the mechanisms and implications of exercise-induced cardiac troponin elevations, challenging the previous view of them as benign.
Article
Veterinary Sciences
Anthony Kallassy, Elodie Calendrier, Nora Bouhsina, Marion Fusellier
Summary: The vertebral heart scale (VHS) is an objective method for estimating heart size in dogs, but significant variation exists between breeds. This study evaluated the VHS in Brittany Spaniels and suggested a useful upper limit for normal heart size.
VETERINARY SCIENCES
(2021)
Article
Veterinary Sciences
Sara Dias, Carlo Anselmi, Yvonne Espada, Jaume Martorell
Summary: This study established quantitative radiographic reference range measurements for the vertebral heart score (VHS) in rats, providing a useful tool for clinicians to evaluate cardiac size and improve diagnosis and treatment of cardiac diseases in rats.
VETERINARY RADIOLOGY & ULTRASOUND
(2021)
Article
Veterinary Sciences
Mengni Zhang, Kai Zhang, Deying Yu, Qianru Xie, Binlong Liu, Dacan Chen, Dongxing Xv, Zhiwei Li, Chaofei Liu
Summary: A clinically applicable assisted platform for diagnosing canine cardiomegaly using deep learning was reported, achieving an AP of 90.9% after a post processing procedure. This system effectively assists in evaluating canine cardiomegaly in a real clinical scenario by detecting 16 key points and combining with VHS reference range of all dog breeds.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Oktawia Szpinda, Marta Parzeniecka-Jaworska, Michal Czopowicz, Izabella Jonska, Joanna Bonecka, Michal Jank
Summary: The aim of this study was to establish reference intervals for echocardiography, electrocardiography (ECG), vertebral heart score (VHS) measurement, and arterial systolic blood pressure (SBP) in American Staffordshire Terrier dogs. The results showed that AST dogs had longer duration of P wave and QRS complex, higher VHS, and different dimensions of the heart compared to the general population of dogs. The unique body structure and heart shape of the AST breed had an impact on the cardiological examination results.
Article
Cardiac & Cardiovascular Systems
Qinfeng Li, Chao Li, Abdallah Elnwasany, Gaurav Sharma, Yu A. An, Guangyu Zhang, Waleed M. Elhelaly, Jun Lin, Yingchao Gong, Guihao Chen, Meihui Wang, Shangang Zhao, Chongshan Dai, Charles D. Smart, Juan Liu, Xiang Luo, Yingfeng Deng, Lin Tan, Shuang-Jie Lv, Shawn M. Davidson, Jason W. Locasale, Philip L. Lorenzi, Craig R. Malloy, Thomas G. Gillette, Matthew G. Vander Heiden, Philipp E. Scherer, Luke I. Szweda, Guosheng Fu, Zhao V. Wang
Summary: PKM1 plays a crucial role in maintaining a homeostatic response in the heart under hemodynamic stress, protecting against cardiac dysfunction and fibrosis caused by pressure overload. Furthermore, PKM1 is essential for enhancing glycolytic flux, mitochondrial respiration, and ATP production under pressure overload at a mechanistic level.
Article
Veterinary Sciences
Emilie Boissady, Alois de la Comble, Xiajuan Zhu, Jonathan Abbott, Hespel Adrien-Maxence
Summary: The study evaluated the performance of artificial intelligence in measuring heart disease in cats and dogs, finding a high degree of agreement with measurements by specialists. AI trained to locate VHS reference points agreed with manual calculation by specialists, potentially reducing interobserver variability and improving the comparability of readings.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Developmental Biology
Catherine Pfefferli, Marylene Bonvin, Dogan Grepper, Steve Robatel, Desiree Konig, Heidi E. L. Lischer, Remy Bruggmann, Anna Jazwinska
Summary: In this study, the researchers induced and reversibly expressed HRASG12V gene in zebrafish cardiomyocytes to investigate its effects on myocardial regeneration. They found that inhibiting TOR signaling can suppress the hyperplastic cardiac enlargement caused by oncogene expression. Furthermore, both oncogene expression and cardiac regeneration led to the upregulation of cardiomyocyte dedifferentiation and proliferation factors, as well as similar microenvironmental responses. Preconditioning the heart with short-term oncogene expression accelerated cardiac regeneration, revealing a beneficial synergism between detrimental hyperplasia and advantageous regeneration.
Article
Veterinary Sciences
Matthieu Lebastard, Kevin Le Boedec, Mark Howes, Stephen Joslyn, Jodi S. Matheson, Robert T. O'Brien
Summary: The study found an association between left atrium enlargement and cardiomegaly and bronchial narrowing in coughing dogs with heart murmurs using computed tomography. The results support a relationship between heart size and exacerbated cough in dogs with murmurs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan
Summary: This study reveals the significant role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. DYRK1B promotes impaired mitochondrial bioenergetics by directly binding with STAT3, leading to the downregulation of PGC-1 alpha. Inhibition of DYRK1B or STAT3 activity restores cardiac performance by rejuvenating mitochondrial bioenergetics. These findings may offer new therapeutic options for heart failure patients.
Article
Cardiac & Cardiovascular Systems
Maria Ercu, Michael B. Muecke, Tamara Pallien, Lajos Marko, Anastasiia Sholokh, Carolin Schaechterle, Atakan Aydin, Alexa Kidd, Stephan Walter, Yasmin Esmati, Brandon J. McMurray, Daniella F. Lato, Daniele Yumi Sunaga-Franze, Philip H. Dierks, Barbara Isabel Montesinos Flores, Ryan Walker-Gray, Maolian Gong, Claudia Merticariu, Kerstin Zuehlke, Michael Russwurm, Tiannan Liu, Theda U. P. Batolomaeus, Sabine Pautz, Stefanie Schelenz, Martin Taube, Hanna Napieczynska, Arnd Heuser, Jenny Eichhorst, Martin Lehmann, Duncan C. Miller, Sebastian Diecke, Fatimunnisa Qadri, Elena Popova, Reika Langanki, Matthew A. Movsesian, Friedrich W. Herberg, Sofia K. Forslund, Dominik N. Mueller, Tatiana Borodina, Philipp G. Maass, Sylvia Baehring, Norbert Huebner, Michael Bader, Enno Klussmann
Summary: PDE3A mutations have been found to protect the heart from hypertension-induced cardiac damage by causing adaptive changes and enhancing contractility. These findings could facilitate the development of new treatments to prevent hypertension-induced cardiac damage.
Article
Veterinary Sciences
Margherita De Silva, Pierfrancesco Bo, Elisabetta Dora Genocchi, Claudio Tagliavia, Mariana Roccaro, Annamaria Grandis, Marco Baron Toaldo
Summary: This study aimed to provide reference intervals for cardiac disease research in guinea pigs, describing cardiac dimensions in presumed healthy guinea pigs using objective measurement methods. The results indicated that VHS values were not influenced by sex, age, or body weight, making them useful tools for radiographic interpretation in clinical practice.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Cardiac & Cardiovascular Systems
Gautam K. Singh, Conor McClenaghan, Manish Aggarwal, Hongjie Gu, Maria S. Remedi, Dorothy K. Grange, Colin G. Nichols
Summary: This study characterizes high-output cardiac hypertrophy in subjects with Cantu syndrome caused by gain-of-function variants in ABCC9, indicating that these patients exhibit significant left ventricular hypertrophy and low blood pressure, which may progress to high-output heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Agriculture, Dairy & Animal Science
Marco Russo, Gary C. W. England, Giuseppe Catone, Gabriele Marino
Summary: This article discusses the application of various diagnostic imaging techniques in dogs, emphasizing the important role of imaging in the diagnosis and management of reproductive neoplasia. Factors influencing the choice of imaging modality include level of referral and pathological information required, with tumor behavior also guiding imaging selection.
Article
Cell Biology
Etienne Lelievre, Charlotte Bureau, Yann Bordat, Maxence Fretaud, Christelle Langevin, Chris Jopling, Karima Kissa
Summary: In this study, the zebrafish endoglin locus was characterized and it was found that deficiency of endoglin leads to heart failure and hypochromic anemia. This study also establishes the zebrafish as a valuable model for studying hereditary hemorrhagic telangiectasia (HHT).
DISEASE MODELS & MECHANISMS
(2023)
Article
Veterinary Sciences
A. F. Souza, J. Schade, A. F. Ramos, M. S. M. Albuquerque, G. Fonteque, D. Costa, T. R. Mullers, J. H. Fonteque
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2019)
Article
Veterinary Sciences
M. S. Sombrio, H. M. Cardoso, M. G. Luciani, L. P. Souza, P. E. Ferian, J. A. Withoeft, E. Zoboli, T. R. Muller
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2019)
Article
Veterinary Sciences
Emily B. Elser, Wilfried Mai, Jennifer A. Reetz, Vince Thawley, Hadley Bagshaw, Jantra N. Suran
VETERINARY RADIOLOGY & ULTRASOUND
(2020)
Article
Veterinary Sciences
J. Schade, J. H. Fonteque, T. R. Muller, W. T. Teixeira, A. C. da Rosa, R. A. Casagrande, T. G. de Cristo, N. C. C. de Azevedo Fernandes
Summary: This study presents a case of an 11-year-old Campolina horse with a fibromatous epulis in the rostral region of the mandible. Surgical excision and curettage led to complete healing of the wound at 60 days post-procedure, but relapse was reported by the owner between 1 and 3 years after surgery.
EQUINE VETERINARY EDUCATION
(2021)
Article
Veterinary Sciences
K. S. Fuchs, L. Rosa, R. Tochetto, F. Comassetto, C. D. L. Cancellier, S. J. Ronchi, M. G. Luciane, N. Oleskovicz
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2020)
Article
Veterinary Sciences
Wilfried Mai, Emily E. Burke, Jennifer A. Reetz, Silke Hecht, Matthew Paek, Molly E. Church, Stephen R. Werre, Christopher L. Mariani, John F. Griffin, Eric N. Glass
Summary: This study evaluated the accuracy and reliability of high-field MRI in differentiating between meningioma and histiocytic sarcoma, with moderate to substantial interobserver agreement. The study found that certain imaging features such as the location/type of meningeal enhancement and osseous changes were more useful in making a correct diagnosis.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Veterinary Sciences
Thiago Rinaldi Muller, Mauricio Solano, Mirian Harumi Tsunemi
Summary: The use of AI algorithms in diagnostic radiology is developing in veterinary medicine. This study investigated the performance of an AI algorithm in detecting pleural effusion in dogs' thoracic radiographs. The results showed high accuracy in detecting pleural effusion.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Veterinary Sciences
Candace Tam, Silke Hecht, Wilfried Mai, Nathan Nelson, Annie Chen, John F. Griffin
Summary: This study retrospectively reviewed MRI studies of 35 dogs with cranial or vertebral osteosarcoma and found common features such as signal heterogeneity in T2-weighted images, contrast enhancement, osteolysis, compression of the CNS or cauda equina, associated soft tissue mass, and long zone of transition.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Veterinary Sciences
M. Silvestre Sombrio, W. Mai, D. Buch, G. Costa Grotti, M. Gabriela Luciani, T. Rodrigues Froes
Summary: A study aimed to assess the accuracy and interobserver agreement of tele-ultrasonography for diagnosing gastrointestinal obstruction in small animals. The results showed that tele-ultrasonography had good accuracy but a low positive predictive value and moderate interobserver agreement for detecting gastrointestinal obstruction.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Wilfried Mai
VETERINARY RADIOLOGY & ULTRASOUND
(2020)
