Journal
VIRUSES-BASEL
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/v11020106
Keywords
LCMV; HIV; HCV; MHC restriction; tetramer; checkpoint blockade; immunotherapy; T cell exhaustion
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Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological discoveries. This review discusses two immunological breakthroughs originally identified with the help of the lymphocytic choriomeningitis virus (LCMV) model; immunological restriction by major histocompatibility complex and immunotherapy using checkpoint blockade. In addition, we discuss related discoveries such as development of tetramers, viral escape mutation, and the phenomenon of T-cell exhaustion.
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