Article
Oncology
Serge Evrard, Carine Bellera, Gregoire Desolneux, Coralie Cantarel, Emilie Toulza, Jean-Luc Faucheron, Michel Rivoire, Aurelien Dupre, Jean-Yves Mabrut, Laurent Bresler, Frederic Marchal, Damien Bouriez, Eric Rullier
Summary: The two multicenter single-arm phase II trials showed that delayed colo-anal anastomosis (DCAA) has low rates of anastomotic leakage requiring a diverting ileostomy and acceptable long-term functional results.
Review
Gastroenterology & Hepatology
Sascha Vaghiri, Dimitrios Prassas, Sarah Krieg, Wolfram Trudo Knoefel, Andreas Krieg
Summary: In left-sided minimally-invasive colectomy, intracorporeal anastomosis is associated with lower overall morbidity and s fewer rates of surgical site infection compared to extracorporeal anastomosis. It also results in a smaller incision length and faster postoperative gastrointestinal recovery, despite a longer operative time.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Fabio Carbone, Wanda Petz, Simona Borin, Emilio Bertani, Stefano de Pascale, Maria Giulia Zampino, Uberto Fumagalli Romario
Summary: The results of this meta-analysis show that tumour-specific mesorectal excision (TSME) treatment for rectal cancer has good oncological outcomes and leads to the best-fitted functional results possible for the patient's condition.
Review
Gastroenterology & Hepatology
Rachael Elizabeth Clifford, Hayley Fowler, Nicola Manu, Dale Vimalachandran
Summary: Benign anastomotic strictures following colorectal surgical resection are a common but under-reported complication, affecting up to 30% of patients and significantly impacting their quality of life. Endoscopic techniques, such as balloon dilatation and stenting, show varying success rates in avoiding the need for surgical reintervention, with challenges including the need for repeated treatments and stent migration. Further research is needed to explore novel therapies for improving quality of life in these patients.
COLORECTAL DISEASE
(2021)
Article
Pediatrics
Sameh Shehata, Mohamed ElSawaf, Mostafa Kotb
Summary: This study presents the transanal end-to-end rectoanal anastomosis as a surgical technique for the treatment of rectal atresia. The results showed normal continence and regular bowel movements in the patients who underwent this procedure. It was concluded that transanal recto-anal anastomosis provides a safer and effective approach for anatomical reconstruction of the anorectum.
Article
Gastroenterology & Hepatology
Aaron J. Quyn, Shilpa Murthy, Laura Gould, Hager Said, Jim Tiernan, Peter Sagar, Anthony Antoniou, Ian Jenkins, Elaine M. Burns
Summary: This study investigated the outcomes for patients with anal squamous cell carcinoma (SCC) who underwent pelvic exenteration in two high-volume, high-complexity units in the UK. The results showed that complete R0 resection is possible in the majority of patients with recurrent or persistent anal SCC, and it improves overall and disease-free survival compared to R1/R2 resection.
COLORECTAL DISEASE
(2023)
Article
Surgery
M. A. Majbar, L. Courtot, L. Dahbi-Skali, A. Rafik, P. O. Jouppe, D. Moussata, A. Benkabbou, R. Mohsine, M. Ouaissi, A. Souadka
Summary: This retrospective study compared the short-term outcomes of delayed colo-anal anastomosis (DCA) and classical colo-anal anastomosis (CAA) and found no difference in overall and severe morbidity, but DCA had a higher completion rate.
JOURNAL OF VISCERAL SURGERY
(2022)
Review
Gastroenterology & Hepatology
S. MacDonald, S. Au, M. Thornton, A. Macdonald
Summary: The ileo-anal pouch (IAP) has a 13% failure rate at 10 years post-procedure, leading to pouch excision (P.E.). A systematic review of 14 studies involving 1601 patients found that complications after P.E. are common, with mortality rates ranging from 0.58% to 1.4%. Quality of life is generally lower in P.E. patients compared to the normal population, often experiencing urinary and sexual dysfunction post-operatively. Further research is needed to compare QoL in patients undergoing P.E. and other treatment options to definitively assess post-procedure QoL.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Eren Esen, Michael J. Grieco, Arman Erkan, Erman Aytac, Alton G. Sutter, Patricio Bernardo Lynn, Joanna Esterow, Andre da Luz Moreira, Hasan T. Kirat, Feza H. Remzi
Summary: This retrospective cohort study investigated the management and outcomes of pelvic sepsis after re-do IPAA. It suggests that early detection of pelvic sepsis and appropriate management strategies can improve pouch salvage rates, and there were no significant differences in functional outcomes and quality of life compared to the no sepsis control group.
DISEASES OF THE COLON & RECTUM
(2022)
Review
Biochemistry & Molecular Biology
Roxana Zaharie, Dan Valean, Calin Popa, Alin Fetti, Claudiu Zdrehus, Aida Puia, Lia Usatiuc, Diana Schlanger, Florin Zaharie
Summary: Colitis-associated colo-rectal cancer is the main cause of death in inflammatory bowel diseases, and inflammation plays a key role in connecting the two pathologies. The NLRP3 inflammasome complex is important in innate immunity, but its dysregulation can lead to various pathologies like ulcerative colitis. Our review focuses on understanding the regulation of the NLRP3 complex and its role in current clinical settings. Promising results from 18 studies identified potential pathways for regulating the NLRP3 complex and its involvement in the metastatic process of colo-rectal cancer. However, more research is needed to validate these findings in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Matteo Fermi, Alfredo Lo Manto, Cecilia Lotto, Giulia Cianci, Francesco Mattioli, Daniele Marchioni, Livio Presutti, Ignacio Javier Fernandez
Summary: Horizontal glottectomy (HG) is a safe surgical option for T1a-T1b glottic tumors, with comparable oncological outcomes to other treatments. It can be considered when there is poor laryngeal exposure, patient refusal of radiotherapy, or contraindication for radiation therapy. This systematic review included 14 articles and a total of 420 patients who underwent HG, with a laryngeal preservation rate of 93.6% and a mean post-operative hospitalization duration of 11.7 days.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Rossella Reddavid, Silvia Sofia, Lucia Puca, Jacopo Moro, Simona Ceraolo, Rosa Jimenez-Rodriguez, Maurizio Degiuli
Summary: This meta-analysis examined the feasibility and safety of robotic surgery for elderly patients (>70 years old) undergoing curative treatment for rectal cancer. The study found that elderly patients can undergo robotic resection with similar surgical quality and outcomes as young patients, without increasing postoperative mortality and morbidity. Therefore, robotic surgery is a viable option for elderly patients with rectal cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
Anass Mohammed Majbar, Amine Benkabbou, Laila Amrani, Raouf Mohsine, Amine Souadka
Summary: Delayed colo-anal anastomosis is a technique used in rectal surgery to reduce the risk of complications, with studies showing varying rates of pelvic septic complications and salvage ostomy creation. There is ongoing research comparing delayed anastomosis with one-stage colo-anal anastomosis to determine its role in rectal surgery.
JOURNAL OF MEDICAL AND SURGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Giuseppe Brisinda, Maria Michela Chiarello, Gilda Pepe, Maria Cariati, Valeria Fico, Paolo Mirco, Valentina Bianchi
Summary: This retrospective cohort study examined the risk factors for anastomotic leakage in rectal cancer surgery and identified several clinical, surgical, and pathological features associated with leakage. Anastomotic leakage adversely affects the morbidity and mortality of rectal cancer patients.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Surgery
Shuichiro Uchiyama, Naotaka Ikeda, Tomohiro Oyama, Mayumi Eguchi, Ayaka Ito, Rikiya Sato, Ryoichi Toyosaki, Masaki Kitazono, Toyokuni Suenaga
Summary: This article reports a case of post-operative stenosis caused by colonic ischemia after low anterior resection for rectal cancer, followed by colo-anal anastomosis with a protective loop ileostomy.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Pediatrics
Vincenzo Zanardo, Domenico Tortora, Matteo Parotto, Lorenzo Severino, Pietro Guerrini, Gianluca Straface
Summary: The study found that infants of diabetic mothers experience changes in fluid status during the transition from fetal to neonatal life, with potential excess circulating fluids. Contrary to assumptions, these infants may not necessarily be at risk of wet lung.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Anesthesiology
Chi Pham, Khashayar Poorzargar, Mahesh Nagappa, Aparna Saripella, Matteo Parotto, Marina Englesakis, Kang Lee, Frances Chung
Summary: This systematic review and meta-analysis examined the effectiveness of consumer-friendly contactless vital sign monitors compared to medical grade instruments. The results showed that consumer-grade monitors were accurate in measuring heart rate compared to medical devices, but there are limitations such as motion and poor lighting. More studies are needed to assess the accuracy of contactless blood pressure and respiratory rate monitors, and further validation in larger populations is required for clinical use.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Anesthesiology
Justyna Bartoszko, George Dranitsaris, M. Elizabeth Wilcox, Lorenzo Del Sorbo, Sangeeta Mehta, Miki Peer, Matteo Parotto, Isaac Bogoch, Sheila Riazi
Summary: The COVID-19 pandemic has put a strain on ICU capacities, leading to the need for patient triage. A tool has been developed to predict the mortality risk in ventilated patients with COVID-19, which can inform decision-making, resource allocation, and allow for comparisons across institutions at a population level.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Anesthesiology
Nicola Jarvis, Simone Schiavo, Justyna Bartoszko, Martin Ma, Ki Jinn Chin, Matteo Parotto
Summary: During the COVID-19 pandemic, emergency rapid intubation teams (ERITs) in two Canadian hospitals demonstrated high success rates in airway management for critically ill patients with respiratory failure, along with high adherence to personal protective equipment (PPE) use. Common occurrences of hypoxemia and hemodynamic instability within the first 15 minutes following intubation should be anticipated.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Emergency Medicine
Daniel D. Lee, Matthew Hacker Teper, Lucas B. Chartier, Stephanie Crump, Martin Ma, Matteo Parotto, Pauline Perri, Ki Jinn Chin, Konika Nirmalanathan, Sam Sabbah, Ahmed K. Taher
Summary: This study aimed to assess healthcare providers' experiences and areas for improvement in the emergency response intubation team (ERIT). The results of the survey showed that the ERIT brought both benefits and challenges, indicating opportunities for improvement.
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Surgery
Ryan Chadha, Dhupal Patel, Pooja Bhangui, Annabel Blasi, Victor Xia, Matteo Parotto, Christopher Wray, James Findlay, Michael Spiro, Dimitri Aristotle Raptis, Claus Niemann, Joerg-Matthias Pollok, Marina Berenguer, Pascale Tinguely, Ka Hay Fan, Giselle Farrer
Summary: In this systematic review, the impact of intraoperative anesthetic management on short-term outcomes following liver transplantation was discussed. The review found that there is no clear consensus in the literature regarding the effect of anesthetic management on short-term outcomes. The expert panel made several recommendations based on the available evidence.
CLINICAL TRANSPLANTATION
(2022)
Review
Anesthesiology
Vincenzo Russotto, Lua S. Rahmani, Matteo Parotto, Giacomo Bellani, John G. Laffey
Summary: Tracheal intubation is a common and high-risk procedure in critical care, with potential adverse events that increase the risk of death. Critically ill patients have a higher risk of peri-intubation complications due to their deranged physiology. Preoxy-genation strategies have been studied, but evidence on interventions to mitigate haemodynamic collapse after intubation is inconclusive. Airway management in COVID-19 patients is challenging due to the added risk of infection for healthcare workers. This review aims to update the evidence for intubation in critically ill patients, focusing on understanding peri-intubation risks and evaluating interventions to prevent or mitigate adverse events.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Review
Anesthesiology
Khashayar Poorzargar, Chi Pham, Jennita Ariaratnam, Kang Lee, Matteo Parotto, Marina Englesakis, Frances Chung, Mahesh Nagappa
Summary: One of the most significant limitations of oximeters is their performance under poor perfusion conditions. This systematic review examines pulse oximeter model accuracy in adults under poor perfusion conditions. The review found that most oximeters are accurate in patients with poor perfusion, especially newer models and those placed on earlobes. Further studies are needed to examine multiple oximeter models used on a diverse selection of patients while following FDA recommendations to determine oximeter accuracy.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Public, Environmental & Occupational Health
Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Luciano Azevedo, Tai Pham, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Arjen M. Dondorp, Giacomo Bellani, John G. Laffey, Marcus J. Schultz
Summary: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in middle income countries (MICs) than in high-income countries (HICs), with a strong association with country-level economic status.
LANCET GLOBAL HEALTH
(2022)
Article
Critical Care Medicine
Manoj Maddali, Matthew Churpek, Tai Pham, Emanuele Rezoagli, Hanjing Zhuo, Wendi Zhao, June He, Kevin L. Delucchi, Chunxue Wang, Nancy Wickersham, J. Brennan McNeil, Alejandra Jauregui, Serena Ke, Kathryn Vessel, Antonio Gomez, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Aartik Sarma, Aleksandra Leligdowicz, Kathleen D. Liu, Michael A. Matthay, Lorraine B. Ware, John G. Laffey, Giacomo Bellani, Carolyn S. Calfee, Pratik Sinha
Summary: Clinical classifier models based on machine learning can accurately assign ARDS subphenotypes, providing valuable prognostic information for patients and potentially guiding personalized treatment strategies in clinical practice.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Loic Cailleau, Thomas Geeraerts, Vincent Minville, Olivier Fourcade, Thomas Fernandez, Jean Etienne Bazin, Linden Baxter, Vassilis Athanassoglou, Henry Jefferson, Anika Sud, Tim Davies, Cyprian Mendonca, Matteo Parotto, Matt Kurrek
Summary: A study conducted in 2019 to 2020 investigated the added value of difficult airway scenarios in virtual reality fiberoptic intubation training. The study found that training on difficult airways did not offer an advantage over training on normal airways. This may be due to the learning curve required to reach proficiency in a specific airway scenario.
Article
Surgery
Christian Stoppe, Bernard McDonald, Patrick Meybohm, Kenneth B. Christopher, Stephen Fremes, Richard Whitlock, Siamak Mohammadi, Dimitri Kalavrouziotis, Gunnar Elke, Rolf Rossaint, Philipp Helmer, Kai Zacharowski, Ulf Guenther, Matteo Parotto, Bernd Niemann, Andreas Boening, C. David Mazer, Philip M. Jones, Marion Ferner, Yoan Lamarche, Francois Lamontagne, Oliver J. Liakopoulos, Matthew Cameron, Matthias Mueller, Alexander Zarbock, Maria Wittmann, Andreas Goetzenich, Erich Kilger, Lutz Schomburg, Andrew G. Day, Daren K. Heyland
Summary: High-dose intravenous sodium selenite treatment did not reduce morbidity or mortality in high-risk cardiac surgery patients.
Article
Anesthesiology
Vincenzo Russotto, Jean Baptiste Lascarrou, Elena Tassistro, Matteo Parotto, Laura Antolini, Philippe Bauer, Konstanty Szuldrzynski, Luigi Camporota, Christian Putensen, Paolo Pelosi, Massimiliano Sorbello, Andy Higgs, Robert Greif, Giacomo Grasselli, Maria G. Valsecchi, Roberto Fumagalli, Giuseppe Foti, Pietro Caironi, Giacomo Bellani, John G. Laffey, NTUBE Study Investigators
Summary: Videolaryngoscopy is associated with higher first-pass intubation success rates in critically ill patients and does not increase the risk of major adverse events.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Aaron Conway, Mohammad Goudarzi Rad, Wentao Zhou, Matteo Parotto, Carla Jungquist
Summary: This study aimed to determine the accuracy of a deep learning approach in classifying segments of capnography waveforms as either 'breath' or 'no breath'. By using a convolutional neural network to classify 15 s capnography waveform segments from a group of 400 participants, false breath alarms were suppressed. In internal-external validation, the neural network achieved an accuracy of 0.97, precision of 0.97, and recall of 0.96. Overall, the neural network showed promising results in reducing false capnography alarms. Further research comparing its performance with the standard approach is needed.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Critical Care Medicine
Matteo Parotto, Mariann Gyongyosi, Kathryn Howe, Sheila N. Myatra, Otavio Ranzani, Manu Shankar-Hari, Margaret S. Herridge
Summary: Individuals with SARS-CoV-2 infection can experience persistent symptoms and develop long-term sequelae known as long COVID or post-COVID-19 condition. This multisystem condition has a significant impact on individuals, healthcare systems, and socioeconomic levels.
LANCET RESPIRATORY MEDICINE
(2023)
