4.8 Article

Design of Highly Stable Echogenic Microbubbles through Controlled Assembly of Their Hydrophobin Shell

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 35, Pages 10263-10267

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201603706

Keywords

echogenicity; fluorocarbons; hydrophobin; interfacial films; ultrasound imaging

Funding

  1. French National Research Agency [ANR-14-CE35-0028-01]
  2. Academy of Finland [276537.284508.260565]
  3. French Institute of Finland
  4. Agence Nationale de la Recherche (ANR) [ANR-14-CE35-0028] Funding Source: Agence Nationale de la Recherche (ANR)

Ask authors/readers for more resources

Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-nadsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

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