Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 21, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/tid.13082
Keywords
brain abscesses; Burkholderia cepacia complex; Burkholderia multivorans; ceftazidime-avibactam; cystic fibrosis
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Burkholderia cepacia complex (Bcc) includes several phenotypically similar but genotypically distinct gram-negative bacteria (GNB) that can colonize the respiratory tract of Cystic Fibrosis (CF) patients. Pathogens are difficult to treat due to intrinsic resistance to multiple antibiotics and are associated to a more rapid decline in lung function and to increased mortality, particularly after lung transplantation. For all these reasons, chronic infection by Burkholderia (B) cenocepacia is presently considered a relative or absolute contraindication in almost all lung transplant centres. We report the case of a young adult CF patient chronically colonized by B multivorans genomovar II, with diabetes and end-stage renal disease treated with renal replacement therapy: a few months after lung transplantation, she developed post-surgery B multivorans bacteremia and multiple brain abscesses. This severe infection did not improve despite multiple standard antibiotic regimen. The introduction of ceftazidime-avibactam, a new beta-lactam/ beta-lactamase inhibitor combination resulted in clinical recovery and in radiological and biochemical improvement.
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