Journal
TETRAHEDRON
Volume 75, Issue 17, Pages 2486-2494Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2019.03.020
Keywords
Aplysiatoxin; Cyanobactrium; Structure elucidation; Cytotoxicity
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [16K01911, 15K01798]
- Grants-in-Aid for Scientific Research [16K01911, 15K01798] Funding Source: KAKEN
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The marine cyanobacterium Moorea producens is a rich source of diverse compounds that possess a variety of biological activities. In the present study, eight new aplysiatoxin derivatives, namely 6, 8-13, and 15, along with aplysiatoxin (1), debromoaplysiatoxin (2), 3-methoxyaplysiatoxin (3), anhydroaplysiatoxin (4), anhydrodebromoaplysiatoxin (5), oscillatoxin B2 (7), and 30-methyloscillatoxin D (14) were isolated and identified from the Okinawan M. producens. In cytotoxicity and diatom growth inhibition tests, the fifteen compounds tested (1-15) showed moderate or no activity at a concentration of 10 mu g/mL (C) 2019 Elsevier Ltd. All rights reserved.
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