Review
Veterinary Sciences
Ana Reis-Ferreira, Joana Neto-Mendes, Carmen Bras-Silva, Luis Lobo, Ana Patricia Fontes-Sousa
Summary: MicroRNAs have the potential to be biomarkers for the diagnosis and prognosis of cardiovascular diseases, but further research is needed before their implementation in veterinary clinical practice.
VETERINARY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chan Shan, Xinzhe Chen, Hongjing Cai, Xiaodan Hao, Jing Li, Yinfeng Zhang, Jinning Gao, Zhixia Zhou, Xinmin Li, Cuiyun Liu, Peifeng Li, Kun Wang
Summary: Autophagy is a crucial process in maintaining cell homeostasis and abnormal autophagy is associated with various diseases, including cancer. MicroRNAs (miRNAs) regulate gene expression and play important roles in fundamental biological processes like autophagy. Studying autophagy-related miRNAs in cancer can offer insights into cancer biology and support the development of novel anti-cancer strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Immunology
Ruifu Sun, Xuesong Wang, Xiaohong Sun, Bing Zhao, Xiugong Zhang, Xiaojin Gong, Sunny Hei Wong, Matthew Tak Vai Chan, William Ka Kei Wu
Summary: This article summarizes lncRNA profiling studies on AS and the functional roles and mechanisms of key lncRNAs in AS pathogenesis. They may serve as new biomarkers for the diagnosis and prediction of outcomes in AS, and have the potential to be druggable targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chun Yang, Yuejiao Wang, Pierre Hardy
Summary: miRNAs play crucial roles in uveal melanoma development, with some serving as potential biomarkers for diagnosis and prognosis. Understanding the expression levels and functional mechanisms of these miRNAs is important for developing miRNA-based therapeutics to enhance treatment outcomes.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zongqin Mei, Yahao Mou, Nan Zhang, Xiaoyu Liu, Zuoshun He, Shiyan Gu
Summary: N-6-metyladenosine (m(6)A) is a common RNA methylation modification in mammals and plays regulatory roles in various physiological and pathological processes. This review provides a summary of the specific methyltransferases, demethylases, and methyl-binding proteins involved in m(6)A modification. It also focuses on the roles of m(6)A modification and its regulatory proteins in the production and function of miRNAs in different disease processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Tian-Rong Zhang, Wei-Qiang Huang
Summary: The review article introduces the important role of miRNAs and exosomes in angiogenesis, discussing the potential applications of exosome-derived miRNAs in diagnosing and treating cardiovascular diseases.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Chenggui Miao, Xiao Wang, Wanwan Zhou, Jinling Huang
Summary: Exosomes exist in body fluids and play a role in regulating intercellular communication and biological activity by carrying proteins, nucleic acids, and lipids. They are involved in the pathogenesis of various autoimmune diseases, with exosome-derived microRNAs playing an important role in diseases such as rheumatoid arthritis and systemic lupus erythematosus.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell & Tissue Engineering
Anusree Dey, Sheetal Uppal, Jayeeta Giri, Hari Sharan Misra
Summary: Understanding the mechanism of fate decision in stem cells is crucial for therapeutic applications. BRD4, as an epigenetic regulator, plays a key role in maintaining stem cell potency and controlling lineage commitment, making it a potential target for stem cell therapeutics.
Review
Cardiac & Cardiovascular Systems
Yaxiong Fang, Xiaoyan Dai
Summary: Extracellular vesicles (EVs), secreted by cells, carry various components and can be found in blood and other biofluids. Extracellular non-coding RNAs, mainly encapsulated in EVs, play critical roles in cell-cell communication and human health and disease. Vascular diseases, including hypertension and atherosclerosis, caused by dysregulated vascular functions, are serious medical and public health issues.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Review
Plant Sciences
Meiying He, Xiangjin Kong, Yueming Jiang, Hongxia Qu, Hong Zhu
Summary: MiRNAs, as a major class of endogenous small RNAs in plants, play critical roles in regulating the development and growth of horticultural crops.
TRENDS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Qingkun Dong, Binbin Hu, Cui Zhang
Summary: This review summarizes the research progress in miRNA-mediated gene regulation and its role in plant development, providing the basis for further exploration of miRNA function and elucidation of the molecular mechanism underlying miRNA interaction with other pathways.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Madalina Gabriela Barbu, Dana Claudia Thompson, Nicolae Suciu, Silviu Cristian Voinea, Dragos Cretoiu, Dragos Valentin Predescu
Summary: MicroRNAs play a significant role in male infertility, with their concentration in semen being linked to specific reproductive dysfunctions. Aberrant expression of certain microRNAs has been associated with male reproductive disorders. Additionally, idiopathic male infertility is connected to single nucleotide polymorphisms in microRNA binding sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Danish Saleh, Rebecca T. L. Jones, Samantha L. Schroth, Edward B. Thorp, Matthew J. Feinstein
Summary: The field of cardio-immunology has emerged from discoveries that define roles for immune responses associated with inflammation and heart failure. Dendritic cells (DCs) play an important role in regulating acute and chronic inflammatory responses. However, the specific involvement of DCs in cardiac injury remains poorly understood.
Review
Neurosciences
Chioma Izzi-Engbeaya, Waljit S. Dhillo
Summary: Recent evidence suggests that kisspeptin may regulate metabolic processes indirectly through gonadal hormones or directly through its receptor in various tissues. Studies have shown positive effects on energy expenditure and insulin secretion, but further research is needed to fully understand its mechanisms and potential applications.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Pathology
Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Abbas Salihi, Dana Khdr Sabir, Karzan R. Sidiq, Mohammed Fatih Rasul, Hazha Jamal Hidayat, Soudeh Ghafouri-Fard, Mohammad Taheri, Elena Jamali
Summary: Next-generation sequencing (NGS) has become increasingly popular in genomics studies due to advancements in sequencing technology. It is now being utilized in clinical oncology to improve cancer therapy through various approaches, including finding cancer mutations, identifying carriers of these mutations, and implementing personalized medicine. Personalized medicine has the potential to reduce medical expenses by shifting towards an individualized preventive and predictive approach. NGS can accelerate early disease diagnosis and discover pharmacogenetic markers that aid in personalized therapies. Additionally, NGS provides a more comprehensive understanding of cancer and uncovers pathways of cancer development.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Clinical Neurology
Niklas Thon, Jun Thorsteinsdottir, Sabina Eigenbrod, Ulrich Schueller, Juergen Lutz, Simone Kreth, Claus Belka, Joerg-Christian Tonn, Maximilian Niyazi, Friedrich Wilhelm Kreth
JOURNAL OF NEUROLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Stefan Schmieder, Janek Weisspflog, Norbert Danz, Max Huebner, Simone Kreth, Udo Klotzbach, Frank Sonntag
ENGINEERING IN LIFE SCIENCES
(2017)
Review
Anesthesiology
Simone Kreth, Max Huebner, Ludwig Christian Hinske
ANESTHESIA AND ANALGESIA
(2018)
Review
Oncology
Simon Hirschberger, Ludwig Christian Hinske, Simone Kreth
Article
Oncology
Mathias Kunz, Nathalie Lisa Albert, Marcus Unterrainer, Christian la Fougere, Rupert Egensperger, Ulrich Schueller, Juergen Lutz, Simone Kreth, Joerg-Christian Tonn, Friedrich-Wilhelm Kreth, Niklas Thon
Article
Multidisciplinary Sciences
Michael Koeppen, Jae W. Lee, Seong-Wook Seo, Kelley S. Brodsky, Simone Kreth, Ivana V. Yang, Peter M. Buttrick, Tobias Eckle, Holger K. Eltzschig
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
P. Moehnle, S. Hirschberger, L. C. Hinske, J. Briegel, M. Huebner, S. Weis, G. Dimopoulos, M. Bauer, E. J. Giamarellos-Bourboulis, S. Kreth
MOLECULAR MEDICINE
(2018)
Article
Oncology
Max Huebner, Christian Ludwig Hinske, David Effinger, Tingting Wu, Niklas Thon, Friedrich-Wilhelm Kreth, Simone Kreth
Article
Medicine, General & Internal
Yvonn Heun, Joachim Pircher, Thomas Czermak, Philipp Bluem, Georg Hupel, Monica Bohmer, Bjoern F. Kraemer, Kristin Pogoda, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Max Huebner, Simone Kreth, Ralf A. Claus, Sebastian Weis, Luisa Ungelenk, Florian Kroetz, Ulrich Pohl, Hanna Mannell
Article
Critical Care Medicine
Max Huebner, Roland Tomasi, David Effinger, Tingting Wu, Gregor Klein, Martin Bender, Erich Kilger, Gerd Juchem, Edzard Schwedhelm, Simone Kreth
CRITICAL CARE MEDICINE
(2019)
Article
Multidisciplinary Sciences
Simon Hirschberger, Max Huebner, Gabriele Strauss, David Effinger, Michael Bauer, Sebastian Weis, Evangelos J. Giamarellos-Bourboulis, Simone Kreth
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Tobias Kammerer, Valentina Faihs, Nikolai Hulde, Manfred Stangl, Florian Brettner, Markus Rehm, Mareike Horstmann, Julia Kroepfl, Christina Spengler, Simone Kreth, Simon Schaefer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Max Huebner, David Effinger, Tingting Wu, Gabriele Strauss, Kristin Pogoda, Friedrich-Wilhelm Kreth, Simone Kreth
Article
Biochemistry & Molecular Biology
Ludwig Christian Hinske, Jens Heyn, Max Huebner, Jessica Rink, Simon Hirschberger, Simone Kreth
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Medicine, Research & Experimental
Benjamin Luchting, Ludwig Christian Giuseppe Hinske, Banafscheh Rachinger-Adam, Leo Anthony Celi, Simone Kreth, Shahnaz Christina Azad
BIOMARKERS IN MEDICINE
(2017)