Article
Biochemistry & Molecular Biology
Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth E. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz, Donald J. Vander Griend
Summary: This study investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells. The results revealed that SOX2 expression promotes metastatic progression and therapy resistance in prostate cancer, and affects the metabolic pathways and metabolites of cancer cells. These findings contribute to a better understanding of the role of SOX2 in prostate cancer and suggest its potential as a biomarker and pharmacologic target in clinical settings.
Review
Biochemistry & Molecular Biology
Evelien Eenjes, Dick Tibboel, Rene M. H. Wijnen, Johannes Marco Schnater, Robbert J. Rottier
Summary: The lung originates from the ventral foregut and cells differentiate into various cell lineages under the control of specific transcription factors. Disturbances during lung development can lead to pediatric lung disorders and affect respiratory function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
News Item
Multidisciplinary Sciences
Smriti Mallapaty
Summary: Research on using induced pluripotent stem cells for disease treatment has received substantial investment.
Article
Biology
Evelien Eenjes, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Gabriela G. Edel, Floor Benthem, Lisette de Kreij-de Bruin, Marco Schnater, Dick Tibboel, Jennifer Collins, Robbert J. Rottier
Summary: SOX21 patterns the airway epithelium by antagonizing SOX2, regulating differentiation of airway progenitor cells. It inhibits basal to ciliated cell differentiation in both development and adult tracheal epithelium. The interplay between SOX2 and SOX21 is context and concentration dependent, crucial for regulating differentiation of the airway epithelium.
Article
Biology
John P. Russell, Xinhong Lim, Alice Santambrogio, Val Yianni, Yasmine Kemkem, Bruce Wang, Matthew Fish, Scott Haston, Anaelle Grabek, Shirleen Hallang, Emily J. Lodge, Amanda L. Patist, Andreas Schedl, Patrice Mollard, Roel Nusse, Cynthia L. Andoniadou
Summary: Research has shown that pituitary stem cells play a significant role in pituitary growth and renewal, with SOX2(+) stem cells identified as a key source of WNT ligands. By blocking the secretion of WNTs from SOX2(+) stem cells, the proliferation of nearby committed progenitor cells decreases, demonstrating the dependence of progenitor cell multiplication on paracrine WNT signaling from stem cells.
Article
Audiology & Speech-Language Pathology
Amanda N. Ciani Berlingeri, Remy Pujol, Brandon C. Cox, Jennifer S. Stone
Summary: Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration. Deletion of Sox2 dramatically curtails the regeneration of type II hair cells after damage. Heterozygosity for Sox2 reduces regeneration but allows for partial replacement of hair cells.
Article
Cell Biology
Jun-Tao Lu, Zhao-Yang Yan, Tong-Xin Xu, Fan Zhao, Lei Liu, Fei Li, Wei Guo
Summary: LINC00941 is significantly upregulated in esophageal squamous cell carcinoma (ESCC) and promotes tumor progression through a positive feedback loop involving ILF2/YBX1 and SOX2. By binding to the promoter region of LINC00941, SOX2 activates its transcription, and LINC00941, in turn, upregulates SOX2 through interaction with ILF2 and YBX1 at the transcriptional and post-transcriptional levels. Furthermore, LINC00941 enhances the binding ability of ILF2 and YBX1 on SOX2 mRNA, leading to stabilization of SOX2 mRNA. These findings suggest that LINC00941 may serve as a promising prognostic and therapeutic target for ESCC.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
SeungHye Han, Minho Lee, Youngjin Shin, Regina Giovanni, Ram P. Chakrabarty, Mariana M. Herrerias, Laura A. Dada, Annette S. Flozak, Paul A. Reyfman, Basil Khuder, Colleen R. Reczek, Lin Gao, Jose Lopez-Barneo, Cara J. Gottardi, G. R. Scott Budinger, Navdeep S. Chandel
Summary: Alveolar epithelial type 1 (AT1) cells are necessary for gas exchange, while alveolar epithelial type 2 (AT2) cells play a role in lung development and repair. In this study, deleting a specific subunit of the mitochondrial electron transport chain complex I in lung epithelial cells led to abnormal alveolar development and death. Restoring NAD(+) regeneration was able to correct the developmental defects and prevent lethality. These findings highlight the importance of mitochondrial complex I-dependent NAD(+) regeneration in directing cell fate during lung development.
Article
Biochemistry & Molecular Biology
Xiulin Jiang, Yong Zhang, Yixiao Yuan, Zhixian Jin, Haoqing Zhai, Baiyang Liu, Yao Li, Chun Zhang, Min Chen, Yulin Shi, Dongming Yan, Jun Pu, Yongbin Chen, Cuiping Yang
Summary: In this study, a human-specific long non-coding RNA called GSCAR was found to be highly expressed in glioma cancerous tissues and cell lines. GSCAR was positively correlated with tumor grade and associated with shorter overall survival time in glioma patients. Knockdown of GSCAR reduced tumor cell proliferation, migration, and xenograft tumor formation abilities. Mechanistically, GSCAR acted as a competing endogenous RNA for miR-6760-5p, promoting the expression of oncogene SRSF1. GSCAR also mediated the formation of a protein complex between DHX9 and IGF2BP2, leading to the stabilization of SOX2 mRNA and transcriptional activation of GSCAR. Depleting GSCAR reduced SOX2 expression and glioma stem cell self-renewal ability, but enhanced tumor cell responses to TMZ. These findings suggest that GSCAR may serve as a prognostic biomarker and therapeutic target for glioma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Otorhinolaryngology
Zhexuan Li, Ming Wei, Wenjuan Shen, Heather Kulaga, Mengfei Chen, Andrew P. Lane
Summary: Sox2 expression in GBCs plays a crucial role in olfactory regeneration, increasing the number of neuronal-lineage cells while reducing the proportion of OMP+ OSNs.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Oncology
Ander Saenz-Antonanzas, Veronica Moncho-Amor, Jaione Auzmendi-Iriarte, Alejandro Elua-Pinin, Karine Rizzoti, Robin Lovell-Badge, Ander Matheu
Summary: Deletion of SRR2 halts malignant activity of SOX2 in cancer cells, highlighting the importance of SRR2 enhancer in regulating SOX2 expression.
Article
Multidisciplinary Sciences
Shiv Shah, Caldon Jayson Esdaille, Maumita Bhattacharjee, Ho-Man Kan, Cato T. Laurencin
Summary: Stem cells have the ability to regulate the local microenvironment by secreting bioactive factors, making them a promising approach for tissue regeneration. Researchers have developed a synthetic artificial stem cell system that mimics the paracrine effect of stem cell secretome, providing a customizable treatment for targeted tissue regeneration. In experiments treating osteoarthritis, the synthetic stem cell system showed significant anti-inflammatory and chondroprotective effects both in vitro and in vivo, demonstrating its potential as a new therapeutic strategy for tissue engineering applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, Research & Experimental
Mengyuan Wang, Ying Li, Hongqiao Wang, Meng Li, Xiaomin Wang, Rongzhen Liu, Daijun Zhang, Wenhua Xu
Summary: Corneal epithelial defects and excessive wound healing can cause severe complications. Stem cells offer a promising solution for regenerating the corneal epithelium and treating severe corneal epithelial injury. Biological scaffolds such as the amniotic membrane, fibrin, and hydrogels provide the necessary signals for stem cell proliferation and differentiation. Researchers have evaluated these scaffolds as potential therapeutic interventions for corneal disorders, identifying both benefits and drawbacks. This study provides a comprehensive overview of the history and use of stem cells in corneal repair, focusing on biological scaffolds used in stem cell transplantation and innovative materials under investigation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Marika Sjoqvist, Daniel Antfolk, Freddy Suarez-Rodriguez, Cecilia Sahlgren
Summary: Intermediate filaments have emerged as important regulators of cellular signaling events, beyond providing structural support, by regulating cell differentiation and influencing cell fate decisions in conjunction with stem cell signaling pathways. Lack of IFs causes perturbed stem cell differentiation, and deregulation in these signaling pathways can result in various diseases. Studying the interaction and regulation of IFs with cell signaling helps expand our understanding of IF-linked diseases.
Article
Biochemistry & Molecular Biology
Li Kang, Yujie Liu, Jianzhong He, Yaling Wang, Mengyang Xue, Xin Wu, Zhen Wang, Yunpeng Zhang, Manyu Chu, Jialun Li, Wei Wei, Jiwen Li, Enmin Li, Lujian Liao, Jianru Xiao, Rong Zhang, Liyan Xu, Jiemin Wong
Summary: By screening a small-molecule kinase inhibitor library, GSK3 ss was identified as a critical kinase for promoting the overexpression of SOX2 in ESCC. Inhibition of GSK3 ss selectively impaired the proliferation and stemness of SOX2-positive ESCC cells. Clinical studies also showed a positive correlation between GSK3 ss and SOX2 protein levels in esophageal tumors, indicating the potential of targeting GSK3 ss for the treatment of ESCC.
Article
Cell Biology
Alfonso Urbanucci, Stefan J. Barfeld, Ville Kytola, Harri M. Itkonen, Ilsa M. Coleman, Daniel Vodak, Liisa Sjoblom, Xia Sheng, Teemu Tolonen, Sarah Minner, Christoph Burdelski, Kati K. Kivinummi, Annika Kohvakka, Steven Kregel, Mandeep Takhar, Mohammed Alshalalfa, Elai Davicioni, Nicholas Erho, Paul Lloyd, R. Jeffrey Karnes, Ashley E. Ross, Edward M. Schaeffer, Donald J. Vander Griend, Stefan Knapp, Eva Corey, Felix Y. Feng, Peter S. Nelson, Fahri Saatcioglu, Karen E. Knudsen, Teuvo L. J. Tammela, Guido Sauter, Thorsten Schlomm, Matti Nykter, Tapio Visakorpi, Ian G. Mills
Article
Biochemistry & Molecular Biology
Taylor C. Peak, Prakash R. Praharaj, Gati K. Panigrahi, Michael Doyle, Yixin Su, Isabel R. Schlaepfer, Ravi Singh, Donald J. Vander Griend, Julie Alickson, Ashok Hemal, Anthony Atala, Gagan Deep
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Oncology
Veda N. Giri, Karen E. Knudsen, William K. Kelly, Wassim Abida, Gerald L. Andriole, Chris H. Bangma, Justin E. Bekelman, Mitchell C. Benson, Amie Blanco, Arthur Burnett, William J. Catalona, Kathleen A. Cooney, Matthew Cooperberg, David E. Crawford, Robert B. Den, Adam P. Dicker, Scott Eggener, Neil Fleshner, Matthew L. Freedman, Freddie C. Hamdy, Jean Hoffman-Censits, Mark D. Hurwitz, Colette Hyatt, William B. Isaacs, Christopher J. Kane, Philip Kantoff, R. Jeffrey Karnes, Lawrence I. Karsh, Eric A. Klein, Daniel W. Lin, Kevin R. Loughlin, Grace Lu-Yao, S. Bruce Malkowicz, Mark J. Mann, James R. Mark, Peter A. Mccue, Martin M. Miner, Todd Morgan, Judd W. Moul, Ronald E. Myers, Sarah M. Nielsen, Elias Obeid, Christian P. Pavlovich, Stephen C. Peiper, David F. Penson, Daniel Petrylak, Curtis A. Pettaway, Robert Pilarski, Peter A. Pinto, Wendy Poage, Ganesh V. Raj, Timothy R. Rebbeck, Mark E. Robson, Matt T. Rosenberg, Howard Sandler, Oliver Sartor, Edward Schaeffer, Gordon F. Schwartz, Mark S. Shahin, Neal D. Shore, Brian Shuch, Howard R. Soule, Scott A. Tomlins, Edouard J. Trabulsi, Robert Uzzo, Donald J. Vander Griend, Patrick C. Walsh, Carol J. Weil, Richard Wender, Leonard G. Gomella
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
Eman L. Dadashian, Erin M. McAuley, Delong Liu, Arthur L. Shaffer, Ryan M. Young, Jessica R. Iyer, Michael J. Kruhlak, Louis M. Staudt, Adrian Wiestner, Sarah E. M. Herman
Article
Oncology
Mariya Shapovalova, John K. Lee, Yingming Li, Donald J. Vander Griend, Ilsa M. Coleman, Peter S. Nelson, Scott M. Dehm, Aaron M. LeBeau
Article
Oncology
Hallie M. Hintz, Joseph P. Gallant, Donald J. Vander Griend, Ilsa M. Coleman, Peter S. Nelson, Aaron M. LeBeau
CLINICAL CANCER RESEARCH
(2020)
Article
Biology
Calvin VanOpstall, Srikanth Perike, Hannah Brechka, Marc Gillard, Sophia Lamperis, Baizhen Zhu, Ryan Brown, Raj Bhanvadia, Donald J. Vander Griend
Article
Biochemistry & Molecular Biology
Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth E. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz, Donald J. Vander Griend
Summary: This study investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells. The results revealed that SOX2 expression promotes metastatic progression and therapy resistance in prostate cancer, and affects the metabolic pathways and metabolites of cancer cells. These findings contribute to a better understanding of the role of SOX2 in prostate cancer and suggest its potential as a biomarker and pharmacologic target in clinical settings.
Article
Public, Environmental & Occupational Health
Martin Skarzynski, Erin M. McAuley, Ezekiel J. Maier, Anthony C. Fries, Jameson D. Voss, Richard R. Chapleau
Summary: The study evaluates the real-world capabilities of a genome-based clinical severity predictive algorithm using PCR as a surrogate for viral load. The results suggest that the severity predicted by a genome-based algorithm is related to clinical diagnostic tests and relative severity can be inferred from diagnostic values.
GLOBAL HEALTH EPIDEMIOLOGY AND GENOMICS
(2022)
Article
Oncology
Jordan E. Vellky, Yaqi Wu, Daniel Moline, Jenny Drnevich, Mark Maienschein-Cline, Klara Valyi-Nagy, Andre Kajdacsy-Balla, Donald J. Vander Griend
Summary: This study reveals the gene expression differences in human prostate basal cell populations through single-cell RNA sequencing, providing insights into the potential roles of basal cells in prostatic diseases.
JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hannah Brechka, Raj R. Bhanvadia, Calvin VanOpstall, Donald J. Vander Griend
