Article
Biochemistry & Molecular Biology
Lyudmila V. Bel'skaya, Elena A. Sarf, Alexandra I. Loginova, Dmitry M. Vyushkov, En Djun Choi
Summary: The aim of the study was to determine the content of tumor markers in saliva for different types of cancer and evaluate their diagnostic significance. The concentrations of tumor markers were determined using an ELISA method. The content of tumor markers in saliva varies depending on the stage of cancer and the presence of lymph node metastasis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Cell Biology
Priyakshi Kalita-de Croft, Shayna Sharma, Nihar Godbole, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most diagnosed gynecological cancers in women, often diagnosed at an advanced stage due to the lack of effective early screening. Extracellular vesicles play a crucial role in the tumor microenvironment of ovarian cancer, with potential applications in diagnosis, delivery of therapeutic agents, and disease monitoring.
Article
Reproductive Biology
Wende Hao, Hongyu Zhao, Zhefeng Li, Jie Li, Jiahao Guo, Qi Chen, Yan Gao, Meng Ren, Xiaoting Zhao, Wentao Yue
Summary: By conducting an integrated bioinformatic analysis, potential biomarkers, risk factors, and drugs for EOC were identified, providing new insights for the diagnosis, condition appraisal, prevention, and treatment of EOC in the future.
JOURNAL OF OVARIAN RESEARCH
(2021)
Review
Oncology
Alexandra Laine, Andrea M. Gonzalez-Lopez, Uzma Hasan, Ryotaro Ohkuma, Isabelle Ray-Coquard
Summary: Endometrial and cervical cancers have traditionally been difficult to treat with chemotherapy, and there is a need for alternative therapeutic options. Recently, immunotherapy-based treatments have shown promise in improving outcomes for these types of cancers. However, not all patients respond to immunotherapy, especially in cases of relapse. This review focuses on the immunological features of endometrial and cervical cancers, as well as upcoming clinical trials targeting the immune system to improve patient care. The review also raises important questions that need to be addressed in this field.
Review
Biochemistry & Molecular Biology
Jie Wei Zhu, Parsa Charkhchi, Mohammad R. Akbari
Summary: Liquid biopsy, a novel sampling method analyzing tumor components in the peripheral circulation, has the potential to improve the clinical management of ovarian cancer by enabling early diagnosis, predicting prognosis, detecting recurrence, and monitoring treatment response. Its advantages include non-invasiveness, feasibility, and the ability to capture dynamic tumor changes over time.
Article
Oncology
Namsoo Kim, Yoo-Na Kim, Kyunglim Lee, Eunhyang Park, Yong Jae Lee, So Yoon Hwang, Jihyang Park, Zisun Choi, Sang Wun Kim, Sunghoon Kim, Jong Rak Choi, Seung-Tae Lee, Jung-Yun Lee
Summary: This study investigated the feasibility of genomic profiling based on tumor DNA analysis from cervical smear samples in endometrial cancer patients. It found that cervical swab-based gDNA analysis showed improved detection potential and allowed patient classification, with predictive and prognostic implications.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jan Korbecki, Mateusz Bosiacki, Katarzyna Barczak, Ryta Lagocka, Agnieszka Brodowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: CXCL1, a member of the CXC chemokine subfamily, is mainly responsible for attracting neutrophils in the immune system. This review summarizes the clinical significance and involvement of CXCL1 in major reproductive cancers, including breast cancer, cervical cancer, endometrial cancer, ovarian cancer, and prostate cancer. It focuses on the clinical aspects, molecular contributions, and impact of CXCL1 on the tumor microenvironment. The significance of introducing CXCL1-targeting drugs and the role of ACKR1/DARC in reproductive cancers are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiao-Cui Hong, Qi-Lian Liang, Man Chen, Hai-Xia Yang, Jie Huang, Si-Lin Yi, Zhen-Wei Wang, Hai-Yan Liang, Ding-Yue Zhang, Zeng-Yi Huang
Summary: Epithelial-mesenchymal transition (EMT) is associated with the expression of PRL-3 and MMP9 in circulating tumor cells (CTCs) of colorectal cancer (CRC) patients. Positive expression of PRL-3 and MMP9 in CTCs is associated with distant metastasis, and patients with a higher number of CTCs and mesenchymal CTCs have poorer survival rates. Positive expression of PRL-3 and MMP9 in CTCs may serve as an independent prognostic factor for worse overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Roni Nitecki, Terri Woodard, J. Alejandro Rauh-Hain
Summary: Approximately 21% of gynecologic malignancies are diagnosed in women younger than 40 years, highlighting the importance of discussing future fertility before cancer therapy, although fertility-preserving procedures in cancer patients are relatively uncommon. Access to such procedures is influenced by various factors. Current guidelines provide specific recommendations for fertility-sparing treatment for different types of gynecologic cancers.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2021)
Review
Oncology
Camille Evrard, Jerome Alexandre
Summary: Endometrial cancers are highly affected by microsatellite instability, showing sensitivity to immunotherapy and requiring molecular biology for better understanding. The phenotype is poorly understood in ovarian cancer but does exist. Examination of literature reveals the importance of deficient mismatch repair/microsatellite instability in gynecological cancers and the potential therapeutic and prognostic implications.
Review
Obstetrics & Gynecology
Nicole Minalt, Amy Caldwell, Grace M. Yedlicka, Sophia Joseph, Sharon E. Robertson, Lisa M. Landrum, Jeffrey F. Peipert
Summary: The intrauterine device (IUD) is a highly effective form of contraception and its use has been increasing in the United States. The two types of IUDs available are the levonorgestrel-releasing IUD and the copper IUD. The levonorgestrel IUD suppresses the endometrium and thickens cervical mucus, while the copper IUD creates an inflammatory response to prevent fertilization. The evidence suggests that both types of IUDs reduce the risk of gynecologic cancers, although the effects on cervical and ovarian cancers are less consistent.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Xue Jiao, Tingting Meng, Yiwei Zhai, Lijuan Zhao, Wei Luo, Peihao Liu, Yingying Qin
Summary: Ovarian reserve indicators deteriorate with the progression of ovarian insufficiency, with an increase in FSH and LH but a decrease in AMH, inhibin B, AFC, E-2 and T. AMH has the highest predictive value for POI, and the combination of AMH and AFC is promising for early prediction. Significant differences exist in hormone status among women with different etiologies of POI, with genetic POI showing the worst hormone status.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Jaden R. Kohn, Payam Katebi Kashi, Stefany Acosta-Torres, Anna L. Beavis, Mindy S. Christianson
Summary: Fertility-sparing treatment is a viable option for women with gynecologic cancers, with different surgical and non-surgical approaches available depending on the type and stage of the cancer. Strategies such as progestin therapy, ovarian preservation, and assisted reproductive technology can help preserve fertility while ensuring effective cancer treatment. Ongoing research into methods such as oocyte or embryo cryopreservation provides promising possibilities for the future of fertility preservation in gynecologic oncology.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Immunology
Xiong Li, Qinghua Zhang, Gang Chen, Danfeng Luo
Summary: The C1QC(+) and SPP1(+) TAMs gene signatures provide valuable predictive information for cervical cancer patients, including prognosis, tumor stage, and immune cell infiltration levels. It also shows potential in guiding treatment decisions based on different TAMs gene signatures.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Angiolo Gadducci, Stefania Cosio
Summary: Trabectedin and lurbinectedin are interesting antineoplastic agents with favorable toxicity profiles and unique mechanisms of action. They form adducts in DNA, leading to cell cycle arrest and apoptosis, and interact with the tumor microenvironment. Trabectedin is approved for the treatment of liposarcoma or leiomyosarcoma and platinum-sensitive recurrent ovarian cancer, while lurbinectedin is approved for metastatic small cell lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Pathology
Adhemar Longattho Filho, Fernando C. Schmitt
Article
Surgery
Joana Ferreira, Alexandre Lima Carneiro, Isabel Vila, Cristina Cunha, Cristina Silva, Adhemar Longatto-Filho, Amesqui Mesquita, Jorge Cotter, Armando Mansilha, Margarida Correia-Neves, Pedro Cunha
Summary: There is a relationship between skeletal muscle characteristics (strength, mass, area) and cardiovascular risk factors in patients with lower extremity artery disease (LEAD). Patients with diabetes have lower skeletal muscle density and strength, while smokers have favorable skeletal muscle characteristics.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Cell Biology
Sara Costa Granja, Adhemar Longatto-Filho, Priscila B. de Campos, Claudia P. Oliveira, Jose T. Stefano, Sebastiao N. Martins-Filho, Aline L. Chagas, Paulo Herman, Luiz C. D'Albuquerque, Mario Reis Alvares-da-Silva, Flair Jose Carrilho, Fatima Baltazar, Venancio A. F. Alves
Summary: The expression of glycolytic metabolism-associated markers, especially GLUT1 and MCT4, correlates with the severity of hepatocellular carcinoma occurring in patients with non-alcoholic fatty liver disease (NAFLD).
Article
Oncology
Yasmin Medeiros Guimaraes, Luani Rezende Godoy, Adhemar Longatto-Filho, Ricardo dos Reis
Summary: This article reviews the advances in the surgical management of early-stage cervical cancer, including the update of the FIGO 2018 staging system, conservative treatment, lymph node mapping, fertility preservation, surgical approach, and tumor management for tumors up to 2 cm. These advances aim to provide more tailored treatment to prevent complications and ensure oncologic safety.
Review
Oncology
Luani Rezende Godoy, Julio Cesar Possati-Resende, Yasmin Medeiros Guimaraes, Priscila Grecca Pedrao, Ricardo dos Reis, Adhemar Longatto-Filho
Summary: This review explores the initiatives conducted in Latin American countries to implement or evaluate the implementation of HPV testing, finding that HPV implementation is feasible and promising for reducing cervical cancer morbidity and mortality. However, the cost saving lives and reducing suffering must be pragmatically evaluated by Latin American governments, making improving outcomes a mandatory priority for addressing an organized system of cervical cancer screening.
Article
Gastroenterology & Hepatology
Lourianne Nascimento Cavalcante, Jun Porto, Daniel Mazo, Adhemar Longatto-Filho, Jose Tadeu Stefano, Andre Castro Lyra, Flair Jose Carrilho, Rui Manuel Reis, Venancio A. F. Alves, Arun J. Sanyal, Claudia P. Oliveira
Summary: The PNPLA3 and TM6SF2 variants are associated with non-alcoholic fatty liver disease (NAFLD) and its progression. This study aimed to evaluate the association between genetic ancestry, represented by ancestry informative markers (AIM), and PNPLA3 and TM6SF2 polymorphisms in patients with biopsy-proven NAFLD in an admixed population. The results showed that greater African genetic ancestry was associated with a lower frequency of the PNPLA3 G allele, indicating a potential protective factor against NAFLD in individuals with African ancestry.
ANNALS OF HEPATOLOGY
(2022)
Review
Oncology
Priscila Grecca Pedrao, Yasmin Medeiros Guimaraes, Luani Rezende Godoy, Julio Cesar Possati-Resende, Adriane Cristina Bovo, Carlos Eduardo Mattos Cunha Andrade, Adhemar Longatto-Filho, Ricardo dos Reis
Summary: Vulvar cancer is a rare gynecological malignancy, with two main clinicopathological subtypes linked to different etiologies - one associated with HPV infection, commonly diagnosed in young women, and the other associated with lichen sclerosus, mostly diagnosed in postmenopausal women. Treatment depends on histopathology grade and staging, with surgery often combined with radiotherapy considered the gold standard. Advances in treatment include the use of sentinel lymph node biopsy to reduce surgical morbidity rates.
Article
Cell Biology
Julieta Afonso, Andreia Barbosa, Paula Roberta Aguiar Pastrez, Murilo Bonatelli, Ricardo Filipe Alves da Costa, Celine Pinheiro, Adhemar Longatto-Filho, Fatima Baltazar
Summary: Glycolytic activity is associated with poor clinicopathological profile in esophageal cancer patients. MCT4 and CAIX positivity independently predict a worse prognosis. Further studies are needed to assess the predictive value of these biomarkers in treatment response and explore the impact of MCT1/4 targeting and HKII expression and function.
Article
Oncology
Julieta Afonso, Celine Goncalves, Marta Costa, Debora Ferreira, Lucio Santos, Adhemar Longatto-Filho, Fatima Baltazar
Summary: Glycolysis-related proteins are associated with bladder cancer aggressiveness and poor prognosis. The HK2 inhibitor 2-deoxy-D-glucose can inhibit glycolysis, reduce bladder cancer cell invasion, and increase sensitivity to cisplatin.
Article
Oncology
Paula Roberta Aguiar Pastrez, Ana Margarida Barbosa, Vania Sammartino Mariano, Rhafaela Lima Causin, Antonio Gil Castro, Egidio Torrado, Adhemar Longatto-Filho
Summary: Esophageal squamous cell carcinoma (ESCC) is a rapidly progressing cancer with high mortality rates. In this study, we investigated the levels of inflammatory cytokines in ESCC patients and healthy individuals. We found increased levels of IL-1 beta, IL-6, IL-8, and IL-10 in ESCC patients. Among these cytokines, IL-8 was identified as an independent prognostic factor for ESCC. Additionally, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a higher overall survival rate. Our findings suggest IL-8 as a potential biomarker for ESCC.
Article
Biotechnology & Applied Microbiology
Ana Isabel Mendes, Alexandra Gabriel Fraga, Maria Joao Peixoto, Ivo Aroso, Adhemar Longatto-Filho, Alexandra Pinto Marques, Jorge Pedrosa
Summary: Diabetic foot infection (DFI) is a significant cause of illness and death. Antibiotics are an essential treatment for DFI, but their effectiveness can be reduced due to bacterial biofilm formation and associated pathophysiology. Therefore, improved antibiotic therapies are needed to manage DFI more safely and effectively.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Fabiana L. Vazquez, Henrique C. S. Silveira, Ubirani B. Otero, Thais T. Hosokawa, Jose Humberto T. G. Fregnani, Adhemar Longatto-Filho, Rui M. Reis
Summary: This study aimed to develop an online questionnaire using the REDCap data management platform based on the Work-Related Cancer Surveillance Guidelines reported by the Brazilian National Cancer Institute to obtain a history of occupational exposure in the workplace. The questionnaire was simple and easy to use, allowing for the collection of information on the occupational history of cancer patients and enabling compulsory notification of work-related cancer. The questionnaire included questions about the use of and exposure to carcinogenic factors at work and due to smoking. Additionally, a website was created as a result of this study.
Article
Cardiac & Cardiovascular Systems
Joana Ferreira, Julieta Afonso, Alexandre Lima Carneiro, Isabel Vila, Cristina Cunha, Susana Roque, Cristina Silva, Amilcar Mesquita, Jorge Cotter, Margarida Correia-Neves, Armando Mansilha, Adhemar Longatto-Filho, Pedro Cunha
Summary: This study compared the characteristics of visceral, subcutaneous, and peri-aortic adipose tissue using CT scans and correlated them with cardiovascular risk factors. Peri-aortic adipose tissue had the highest density, while smokers/ex-smokers had lower density of subcutaneous adipose tissue. Sex was found to be a predictor of subcutaneous adipose tissue area, while hypertension was associated with higher visceral adipose tissue area.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shakiba Gholami, Cintia Chamorro-Petronacci, Mario Perez-Sayans, Jose Suarez Penaranda, Adhemar Longatto-Filho, Fatima Baltazar, Julieta Afonso
Summary: Oral potentially malignant disorders (OPMD) are associated with an increased risk of oral squamous cell carcinoma (OSCC), which is characterized by aggressive features and poor prognosis. Cancer cells can reprogram their metabolism through hypoxia-inducible factor (HIF) signaling, leading to upregulation of glycometabolism-related biomarkers. This study aimed to evaluate the expression of HIF targets in OPMD and OSCC samples and identify potential correlations with clinicopathological features and prognosis.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Joana Ferreira, Pedro Cunha, Alexandre Carneiro, Isabel Vila, Cristina Cunha, Cristina Silva, Adhemar Longatto-Filho, Amilcar Mesquita, Jorge Cotter, Margarida Correia-Neves, Armando Mansilha
Summary: Obesity is a risk factor for coronary atherosclerosis, but its influence on carotid atherosclerosis is not well understood. This review investigates the role of different adipose tissue depots in carotid stenosis and finds that overall obesity and visceral fat are not significantly associated with the presence of carotid plaque, while waist-hip ratio is a significant anthropometric measure correlated with the prevalence of carotid plaques.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
