Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors
Authors
Keywords
-
Journal
Science Signaling
Volume 12, Issue 572, Pages eaas9485
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-03-13
DOI
10.1126/scisignal.aas9485
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
- (2016) Dean P. Staus et al. NATURE
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
- (2016) A. J. Venkatakrishnan et al. NATURE
- Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x) 5,6 F motif and helix 8 of the adenosine A 2B receptor in G protein coupling
- (2015) Rongfang Liu et al. BIOCHEMICAL PHARMACOLOGY
- Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling
- (2015) Aashish Manglik et al. CELL
- Structural insights into µ-opioid receptor activation
- (2015) Weijiao Huang et al. NATURE
- Structural basis for nucleotide exchange in heterotrimeric G proteins
- (2015) R. O. Dror et al. SCIENCE
- Molecular control of δ-opioid receptor signalling
- (2014) Gustavo Fenalti et al. NATURE
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
- (2013) Aaron M. Ring et al. NATURE
- Molecular signatures of G-protein-coupled receptors
- (2013) A. J. Venkatakrishnan et al. NATURE
- Activation and dynamic network of the M2 muscarinic receptor
- (2013) Y. Miao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
- (2012) B. Trzaskowski et al. CURRENT MEDICINAL CHEMISTRY
- Conopeptide ρ-TIA Defines a New Allosteric Site on the Extracellular Surface of the α1B-Adrenoceptor
- (2012) Lotten Ragnarsson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the δ-opioid receptor bound to naltrindole
- (2012) Sébastien Granier et al. NATURE
- Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
- (2012) Kazuko Haga et al. NATURE
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
- (2012) Aashish Manglik et al. NATURE
- Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
- (2012) Amélie Bonnefond et al. NATURE GENETICS
- Congenital Hypogonadotropic Hypogonadism Due to GNRH Receptor Mutations in Three Brothers Reveal Sites Affecting Conformation and Coupling
- (2012) Javier A. Tello et al. PLoS One
- Dissecting the Conserved NPxxY Motif of the M3 Muscarinic Acetylcholine Receptor: Critical Role of Asp-7.49 for Receptor Signaling and Multiprotein Complex Formation
- (2011) Dasiel O. Borroto-Escuela et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Crystal structure of metarhodopsin II
- (2011) Hui-Woog Choe et al. NATURE
- The structural basis of agonist-induced activation in constitutively active rhodopsin
- (2011) Jörg Standfuss et al. NATURE
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Structure and function of an irreversible agonist-β2 adrenoceptor complex
- (2011) Daniel M. Rosenbaum et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Activation mechanism of the 2-adrenergic receptor
- (2011) R. O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The structure and function of G-protein-coupled receptors
- (2009) Daniel M. Rosenbaum et al. NATURE
- Gα-Subunits Differentially Alter the Conformation and Agonist Affinity of κ-Opioid Receptors†
- (2008) Feng Yan et al. BIOCHEMISTRY
- The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
- (2008) V.-P. Jaakola et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search