Article
Biochemistry & Molecular Biology
Xin Yue, Wen-ying Wu, Ma Dong, Meng Guo
Summary: MALAT1 is highly expressed in breast cancer tissues and cells, promoting proliferation, migration, invasion, and doxorubicin resistance. Through targeting miR-570-3p, MALAT1 plays a pivotal role in regulating breast cancer progression and drug resistance.
BIOMEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Ju-Chuan Hu, Shian-Shiang Wang, Ying-Erh Chou, Kun-Yuan Chiu, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Cheng-Kuang Yang, Yen-Chuan Ou, Chen-Li Cheng, Chia-Yen Lin, Shun-Fa Yang
Summary: Evidence suggests that certain SNPs of MALAT1 are significantly associated with the susceptibility to advanced Gleason grade and nodal metastasis in prostate cancer, indicating an enhanced oncogenic potential in the presence of these SNPs.
Article
Cell Biology
Hibah Shaath, Radhakrishnan Vishnubalaji, Ramesh Elango, Shahryar Khattak, Nehad M. Alajez
Summary: Cumulative evidence suggests that neoadjuvant chemotherapy (NAC) can benefit a subset of triple-negative breast cancer (TNBC) patients. In this study, the lncRNA landscape associated with TNBC resistance to NAC was identified, with a focus on the key role of MALAT1 in regulating resistance mechanisms.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Minmin Xiong, Mengshi Wu, Dan Peng, Weijun Huang, Zehong Chen, Haoxian Ke, Zewen Chen, Wu Song, Yonghua Zhao, Andy P. Xiang, Xiaomin Zhong
Summary: DANCR plays a critical role in Doxorubicin-induced apoptosis by interacting with QK to enhance the expression of MALAT1 in colorectal cancer cells. Through modulation of RNA stability, DANCR and QK jointly suppress the process of apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Tsui-Lien Mao, Ming-Huei Fan, Nhlanhla Dlamini, Chao-Lien Liu
Summary: The upregulation of MALAT1 in epithelial ovarian cancer is associated with activation of tumor-related signaling pathways, influencing apoptosis, inflammation, proliferation, and invasion processes in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yongye Huang, Ziyan Zhou, Jin Zhang, Zhenzhen Hao, Yunhao He, Zihan Wu, Yiquan Song, Kexun Yuan, Shanyu Zheng, Qi Zhao, Tianye Li, Bing Wang
Summary: The study demonstrates that metformin inhibits cell proliferation, promotes apoptosis, and induces cell cycle arrest in breast cancer cells, while modulating the expression of epigenetic-related genes, providing a promising repurposed strategy for cancer treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Oncology
Junhui Hou, Gong Zhang, Xia Wang, Yuan Wang, Kefeng Wang
Summary: Chemotherapy is a crucial treatment for cancer, but the emergence of resistance poses a major challenge. Recent studies have identified a link between long non-coding RNA MALAT1 and chemotherapy resistance, suggesting its potential as a target for overcoming resistance. This review explores the mechanisms underlying MALAT1-mediated resistance and presents new possibilities for cancer treatment.
BIOMARKER RESEARCH
(2023)
Article
Oncology
Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin, Ping Zhou
Summary: The study revealed that lncRNA APOC1P1-3 promotes breast cancer metastasis by regulating apoptosis and anoikis resistance-related protein expression. It acts as a sponge to block the inhibition of Bcl-2 by specifically binding to miRNA-188-3p.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yunxiang Zhang, Xiaotong Dong, Xiangyu Guo, Chunsen Li, Yanping Fan, Pengju Liu, Dawei Yuan, Xialin Ma, Jingru Wang, Jie Zheng, Hongli Li, Peng Gao
Summary: It was found that lncRNA BC069792 is down-regulated in breast cancer tissues and decreases significantly in breast cancer with high pathological grade, lymph node metastasis, and high Ki-67 index. BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, up-regulates the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits JAK2 and p-AKT activities, and thus suppresses breast cancer growth in vitro and in vivo.
Article
Pharmacology & Pharmacy
Chuan-jian Shi, Yan-biao Zheng, Fei-fei Pan, Feng-wei Zhang, Peng Zhuang, Wei-ming Fu
Summary: Gallic acid (GA) exerts anti-tumor effects on hepatocellular carcinoma (HCC) by suppressing the MALAT1-Wnt/beta-catenin signaling axis, suggesting its potential as a chemo-prevention and chemotherapy agent for HCC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoli Zhang, Shu Du, Defeng Yang, Xuemei Jin, Yuan Zhang, Diya Wang, Huixia Wang, Yan Zhang, Manhui Zhu
Summary: This study investigates the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the progression of choroidal neovascularization (CNV) and suggests that MALAT1 regulates CNV development through the miR-17-5p/VEGFA or ETS1 axis.
Article
Multidisciplinary Sciences
Saba Iordanishvili, Tornike Metreveli, Elene Lipartia, Konstantine Gachechiladze, Irakli Khuntsaria, Tamar Qobulashvili, Mariam Jorbenadze, Tamaz Revazishvili, Ekaterina Kldiashvili, Andreas Martin Kaufmann
Summary: The study reveals a significant connection between HR-HPV infection, TP53 polymorphism, and MALAT1 expression in cervical cancer. MALAT1 overexpression is correlated with HR-HPV positivity, especially in cases with the TP53 Pro72Pro polymorphism. HPV-negative invasive cervical carcinoma samples do not show any notable changes in MALAT1 expression.
Article
Biochemistry & Molecular Biology
Mariam Naveed, Ayesha Malik, Hamza Anjum, Bushra Ijaz
Summary: Breast cancer is a significant health challenge for women globally. This study reveals the important role of lncRNA MALAT1 in the development and metastasis of breast cancer, suggesting it as a potential therapeutic target.
BIOCHEMICAL GENETICS
(2023)
Article
Oncology
Yu Hu, Yuqiong He, Na Luo, Xin Li, Lei Guo, Kejing Zhang
Summary: This study investigated the role of long non-coding RNA (lncRNA) MALAT1 in regulating triple-negative breast cancer (TNBC) stemness and tumorigenesis. The results revealed that MALAT1 positively regulated BCL11A expression through targeting miR-137, and inhibited DNMT1 expression, thereby enhancing TNBC stemness and tumorigenesis. Additionally, high MALAT1 expression in TNBC was associated with DNMT1-mediated hypomethylation of MALAT1. In conclusion, MALAT1 downregulated DNMT1 through the miR-137/BCL11A pathway to enhance TNBC stemness and tumorigenesis, forming a positive feedback loop with DNMT1/MALAT1 to continuously promote TNBC malignant behaviors.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
Tian Liang, Tong Lu, Weiwei Jia, Runze Li, Min Jiang, Yu Jiao, Yuchen Wang, Shanshan Cong, Xinyan Jiang, Lina Dong, Yingyu Zhou, Guangmei Zhang, Dan Xiao
Summary: This study elucidated the role and downstream mechanism of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of pyroptosis in cervical cancer cells. The findings demonstrated that lncRNA MALAT1 was upregulated in cervical carcinoma cells and its knockdown induced pyroptosis-mediated cell death, while its overexpression blocked lipopolysaccharide-induced pyroptosis. The study also identified the involvement of the microRNA-124/sirtuin 1 axis in mediating the effects of lncRNA MALAT1 on cervical cancer cell pyroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)